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1 cation and the mechanisms by which it can be inherited.
2 erentiation, either stochastic or maternally inherited.
3 ed, exhibiting large effects when paternally inherited.
4 ns-acting variants are most often dominantly inherited.
5 n response to emotion is learned rather than inherited.
6                                   Maternally inherited 15q11-13 chromosomal triplications cause a fre
7 rdation, and hypotonia, and we identified an inherited 2 bp deletion causing a frameshift in BRPF1 (c
8 SIGNIFICANCE STATEMENT People who maternally inherit a deletion or nonfunctional copy of the UBE3A ge
9                                  Genetically inherited absence epilepsy in humans is typically charac
10 kills, beliefs, and practices that have been inherited, accumulated, and modified over generations.
11  methylated regions in the genome are stably inherited across each generation indicating that spontan
12                                 Early humans inherited activating KIR2DS4 and an inhibitory lineage I
13 99 to generate Abeta, leading to recessively inherited AD.
14  structure during mitosis, is asymmetrically inherited after mitosis, and relocates to the recently f
15 upported by the identification of dominantly inherited alpha-syn (SNCA) gene mutations in rare cases
16          Indeed, treatment of a rat model of inherited ALS (caused by a mutation in Sod1) with ASOs a
17 t DNA methylation being conserved and stably inherited, alterations likely due to hybridization and d
18 es with ADAD participating in the Dominantly Inherited Alzheimer Network (DIAN) study including 120 p
19 reduction of LoxP recombination in mice that inherit an already deleted LoxP allele in trans A simila
20  critical for preventing daughter cells from inheriting an abnormal number of chromosomes, a conditio
21 ar (CV) disease, CAHAP remain susceptible to inherited and acquired CV disease, and may be most at ri
22    ABSTRACT: Female sex is a risk factor for inherited and acquired long-QT associated torsade de poi
23 ischarge was applied in the settings of both inherited and acquired long-QT syndrome.
24 tion that induces arrhythmia in females with inherited and acquired long-QT.
25                                              Inherited and acquired mtDNA mutations have recently bee
26 step toward the understanding of the role of inherited and acquired variation in disease.
27                         Usher syndrome is an inherited and irreversible disease that manifests as ret
28 h can be explained by genomic variants, both inherited and somatic.
29 perexcitability, a prominent feature of both inherited and sporadic variants of the disease, but the
30   Object manufacture in insects is typically inherited, and believed to be highly stereotyped.
31   beta-Thalassemia is one of the most common inherited anemias, with no effective cure for most patie
32 high doses, and (iii) neither phenotypic nor inherited antibiotic resistance generated during therapy
33           The engineering of mouse models of inherited aortopathies has identified potential therapeu
34                                   These yaks inherited approximately 1.3% of their genome from bovine
35  generation sequencing panel incorporated 38 inherited arrhythmia syndrome candidate genes and anothe
36 xplained cardiac arrest may be because of an inherited arrhythmia syndrome.
37 of relatives identifies a high proportion of inherited arrhythmia syndrome.
38                                              Inherited arrhythmia syndromes are responsible for a sig
39 ted, and arrhythmogenic cardiomyopathies and inherited arrhythmias.
40 tive patients presented data consistent with inherited arrhythmogenic cardiomyopathy/dysplasia phenot
41 ES mutations were described in patients with inherited arrhythmogenic right ventricular cardiomyopath
42 somally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait.
43 ze for published ASD genes and uncover novel inherited ASD susceptibility genes specific to the Leban
44       Wolbachia are intracellular maternally inherited bacteria that can spread through insect popula
45 d is usually thought to be incompatible with inherited behaviour.
46  Willebrand disease (VWD) is the most common inherited bleeding disorder, yet diagnosis and managemen
47 asvir/grazoprevir (EBR/GZR) in patients with inherited bleeding disorders and HCV infection.
48 ial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder characterized by the abnorma
49 ominant retinitis pigmentosa (RP), a type of inherited blindness caused by the dysfunction and death
50 ot been studied exclusively in patients with inherited blood disorders and hepatitis C virus (HCV) in
51  found mutations in genes seldom reported in inherited BMF (IBMF), such as SAMD9 and SAMD9L (N = 16 o
52 mond syndrome (SDS) (OMIM #260400) is a rare inherited bone marrow failure syndrome (IBMFS) that is p
53                    Fanconi anemia (FA) is an inherited bone marrow failure syndrome characterized by
54 en and young adults is often suspected to be inherited, but in many cases diagnosis remains uncertain
55 ndividual cone receptive fields, a signature inherited by downstream neurons and implicated in color
56  or merely reflecting transcriptional states inherited by other means.
57  missense variant c.625C>T (p.Arg209Trp) was inherited by two affected siblings from their healthy mo
58                    Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized b
59 ng for mutations in 25 genes associated with inherited cancer risk.
60 t have a cancer family history to suggest an inherited cancer syndrome.
61 ygous rare variants in genes associated with inherited cardiomyopathies were significantly enriched i
62 etic testing is a valuable tool for managing inherited cardiovascular disease in patients and familie
63 nical practice requires (1) recognizing when inherited cardiovascular disease may be present, (2) ide
64 s of the FMR1 gene, is the most common known inherited cause of developmental disability.
65           Although FXS is the most prevalent inherited cause of intellectual disability, its mechanis
66 is a co-stimulatory molecule of T cells, and inherited CD27 deficiency is characterized by high susce
67  and EBV-associated diseases, reminiscent of inherited CD27 deficiency.
68      The epidemiology and clinical effect of inherited chromosomally integrated HHV-6 (iciHHV-6) in h
69                                              Inherited ciHHV-6 status did not significantly affect ri
70 wn to co-segregate with autosomal dominantly inherited coloboma.
71 ngs of neuroblastoma, demonstrating that the inherited common variants reported contribute to the ori
72 ous Albinism (OCA) is an autosomal recessive inherited condition that affects the pigmentation of eye
73 l cortex specialization is driven largely by inherited connectivity constraints that do not require s
74 RC risk to identify variants associated with inherited CRC.
75 owever, in this study we show that Mendelian inherited CTNNB1 mutations can cause non-syndromic FEVR
76 unt for 25-50% of DCM cases and up to 25% of inherited DCM has been attributed to truncating mutation
77 (aHUS) is a disorder most commonly caused by inherited defects of the alternative pathway of compleme
78 DA) is a neurodegenerative disease caused by inherited deficiency of the mitochondrial protein Fratax
79 CE STATEMENT Retinitis pigmentosa (RP) is an inherited, degenerative retinal disease that leads to bl
80 KDMs as additional candidates for dominantly inherited developmental disorders.
81  ancestral charophycean alga from which they inherited developmental, biochemical, and cell biologica
82 o episodic ataxia type 2 (EA2), a dominantly inherited disease characterized by paroxysmal attacks of
83 o acid decarboxylase (AADC) deficiency is an inherited disease that causes depletion of neurotransmit
84 r pathways in fibroblasts from subjects with inherited disease.
85 Copper is an essential biometal, and several inherited diseases are directly associated with a disrup
86        Primary immunodeficiencies (PIDs) are inherited diseases associated with a considerable increa
87                                              Inherited diseases caused by unstable repeated DNA seque
88  The primary immunodeficiencies (PIDs), rare inherited diseases characterized by severe dysfunction o
89 been implicated in a broad spectrum of human inherited diseases.
90 ing human noncoding variants associated with inherited diseases.
91 sinophilia (FE) is a rare autosomal dominant inherited disorder characterized by the presence of life
92 osis, a clinically heterogeneous, dominantly inherited disorder of erythrocyte dehydration.
93 rythropoietic protoporphyria (EPP) is a rare inherited disorder of the heme biosynthesis pathway resu
94 ic Kidney Disease (ADPKD) is the most common inherited disorder of the kidneys.
95                                              Inherited disorders of oxidative phosphorylation cause t
96     Amelogenesis imperfecta (AI) is group of inherited disorders resulting in enamel pathologies.
97 acute hepatic porphyrias are a group of four inherited disorders, each resulting from a deficiency in
98 diovascular disease, cancer progression, and inherited disorders.
99 this issue indicating that climate feedbacks inherit diversity from the model control climate, beside
100                The water vapor feedback also inherits diversity from the control climate but in an op
101                                   Paternally inherited Dp/+ (patDp/+) mice showed expected increases
102 rapeutic strategies such as for treatment of inherited early childhood neurodegenerative diseases.
103 curs exclusively in EBs and newborn ECs that inherit EGFR and active MAPK from fast-dividing progenit
104        The importance of transgenerationally inherited epigenetic states to organismal fitness remain
105 tain their own DNA, known as mtDNA, which is inherited exclusively from the mother.
106 th disease progression, interactions between inherited factors and phenotype driver mutations, and ef
107 rial cell shape is a genetically encoded and inherited feature that is optimized for efficient growth
108  associated with motor neuron toxicity in an inherited form of amyotrophic lateral sclerosis (ALS).
109 nome-editing approach to target a dominantly inherited form of genetic deafness.
110 ALE: Duchenne muscular dystrophy is a severe inherited form of muscular dystrophy caused by mutations
111 as come from the identification and study of inherited forms of early-onset AD and genetic risk facto
112                                              Inherited forms of FSGS are caused by Rac1-activating mu
113 r understanding of the mechanisms underlying inherited forms of inner ear deficits has considerably i
114 the C9orf72 gene is the most common cause of inherited forms of the neurodegenerative disease amyotro
115 P begins as soon as childhood, with frequent inherited forms.
116  each, supportive of a single mutation event inherited from a common ancestor.
117 vealed de novo CNVs in 11 (47.8%), with CNVs inherited from a parent in 4 probands (17.4%).
118 efers to a haplotype segment of a chromosome inherited from a shared common ancestor.
119 gested that the multidomain architecture was inherited from bacterial ancestors, probably simultaneou
120 is saliency representation is unlikely to be inherited from fronto-parietal cortices, which do not pr
121 nosheets exhibit strong mechanical stability inherited from graphene oxide, displaying minimal struct
122 biogeochemical background corresponding to P inherited from natural soils at the conversion to agricu
123       Mitochondrial DNA (mtDNA) is typically inherited from only one parent [1-3].
124 These morphologies are inferred to have been inherited from Pleistocene fluvial systems reactivated a
125    Finally, orientation tuning in V1 was not inherited from single presynaptic LGN cells, suggesting
126 effect of source LD (SLD), which is directly inherited from source populations.
127 afish suggest that these characteristics are inherited from the common ancestor of the Osteichthyes.
128 anisotropic directional permeability that is inherited from the depositional layering of sedimentary
129  and fibroblast subclones were rare variants inherited from the parental fibroblasts.
130 mRNAs), ribosomes, and regulatory small RNAs inherited from the precursor megakaryocyte (MK).
131 caffolds, in contrast, possess uniform pores inheriting from the template comprised of a closely pack
132 clonal evolution and relapse and the role of inherited genetic variants in leukemogenesis.
133 ly retained in HD-ALL blasts consistent with inherited genetic variation contributing to arrest of no
134  With thorough validation, quantification of inherited genetic variation may prove useful for stratif
135                                The impact of inherited genetic variation on gene expression in humans
136 ationship between individual common maternal/inherited genotypes and risk for heart defects, we condu
137                                              Inherited germline ABL1 changes have not been associated
138                                     Coupling inherited germline silencing to somatic silencing may en
139 ormone deficiency associated with maternally inherited gingival fibromatosis is an allelic disorder w
140 ith growth hormone deficiency and maternally inherited gingival fibromatosis.
141                                              Inherited haemoglobin disorders, including thalassaemia
142 are AUTS2 variant in combination with a rare inherited haplotype affecting STARD9, while another carr
143     Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disease associated with point mut
144          Arrhythmogenic cardiomyopathy is an inherited heart muscle disorder, predisposing to sudden
145  be adapted to their thermal environment and inherit heat tolerance across generations.
146           The recognition that patients with inherited hematologic malignancy syndromes may present w
147                              All carriers of inherited heterozygous germline BAP1-inactivating mutati
148 n early-onset form of neurodegeneration when inherited homozygously.
149 reclinical models of neuropathic pain and in inherited human pain phenotypes, and its gene expression
150 errors of immune-related genes that underlie inherited human susceptibility to opportunistic mycoses
151                                 Maternal and inherited (ie, case) genetic factors likely contribute t
152        Heterochromatin can be epigenetically inherited in cis, leading to stable gene silencing.
153 the genome, effectively expressed and stably inherited in the offspring.
154        Due to the great in vivo complexities inherited in this pathway, there is an unmet need for wh
155 hatic vessel (LV) disorder that is caused by inherited inactivating mutations of the RASA1 gene, whic
156 cerebellar Ataxia Type 3 (SCA3), one of nine inherited, incurable diseases caused by similar mutation
157 enus Wolbachia is an archetype of maternally inherited intracellular bacteria that infect the germlin
158  evaluations of the clinical consequences of inherited IRAK-1 deficiency.
159                                   Dominantly inherited isolated polycystic liver disease (PCLD) consi
160 lculate reward prediction error, rather than inherit it passively from upstream regions; that they co
161  kidney disease (ADPKD) constitutes the most inherited kidney disease.
162 inal muscular atrophy (SMA), the most common inherited killer of infants, is caused by insufficient e
163 st time, the results of this study show that inherited LAT deficiency should be considered in patient
164 n p.Glu401Asp in a large Spanish family with inherited left ventricular arrhythmogenic cardiomyopathy
165 novel DES-p.Glu401Asp mutation as a cause of inherited left ventricular arrhythmogenic cardiomyopathy
166  DES-p.Glu401Asp mutation causes predominant inherited left ventricular arrhythmogenic cardiomyopathy
167 redicts that appropriate rRNA fragments have inherited local autonomy of folding and local autonomy o
168 d the resulting AuNR-loaded PLTs (PLT-AuNRs) inherited long blood circulation and cancer targeting ch
169 c inhibition of SGK1 in a zebrafish model of inherited long QT syndrome rescues the long QT phenotype
170 eveloped mathematical models of acquired and inherited long-QT syndrome in male and female ventricula
171 ytes of approximately 5% of individuals with inherited loss-of-function coding mutations in TERT or p
172                                              Inherited loss-of-function mutations in SCN5A lead to de
173 eep-seated seismogenic features coupled with inherited lower plate serpentinite diapirs, provides con
174  residue on CaM that is mutated in a form of inherited LQTS.
175 eds to thousands of copies of the maternally inherited mitochondrial DNA (mtDNA).
176 el termed MNX, we tested the hypothesis that inherited mitochondrial haplotypes alter primary tumor l
177                                              Inherited mitochondrial optic neuropathies, such as Lebe
178                                        Cells inherit molecular 'memories' of previously experienced c
179 ane repair and underlies a recessive form of inherited muscular dystrophy.
180 fide vascular endothelial cells (GEC), which inherit mutations present in GSC and are resistant to tr
181  mutations (53/63 solved cases), followed by inherited mutations (6/63 solved cases) and de novo CNVs
182 time, leads to age-related cataract, whereas inherited mutations are associated with congenital or ea
183                       Individuals with these inherited mutations demonstrate incomplete penetrance of
184                    Patients with recessively inherited mutations had a more severe phenotype, and cer
185                                   Dominantly inherited mutations had prominent clinical variability r
186 ,645 parent-offspring trios, implicated rare inherited mutations in 1.8%, including a recessive found
187 ely 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectivel
188                   Probands with DNMs or rare inherited mutations in the 67 candidate genes exhibited
189                 Protein misfolding caused by inherited mutations leads to loss of protein function an
190                                 Frequency of inherited mutations was related to case mix, stage, and
191          Patients with clinically actionable inherited mutations whose genetic test results would not
192 ypertrophic obstructive cardiomyopathy is an inherited myocardial disease defined by cardiac hypertro
193  underlies human genetic diseases, including inherited myopathies, neurological disorders, and cancer
194              Huntington's disease (HD) is an inherited neurodegenerative disease affecting predominan
195    Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by an expande
196  adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease caused by defects in
197         Huntington's disease is a dominantly inherited neurodegenerative disease caused by the expans
198 tions in the CLN3 gene is the most prevalent inherited neurodegenerative disease in childhood resulti
199              Retinitis pigmentosa (RP) is an inherited neurodegenerative disease, in which the death
200  of spinocerebellar ataxia type 6 (SCA6), an inherited neurodegenerative disease.
201              Huntington's disease (HD) is an inherited neurodegenerative disorder of which skeletal m
202 gton's disease (HD) is an autosomal dominant inherited neurodegenerative disorder, and no cure is ava
203   Huntington disease (HD) is the most common inherited neurodegenerative disorder.
204                          Autosomal recessive inherited neurodevelopmental disorders are highly hetero
205 is a common finding in patients with complex inherited neurological diseases and may be subclinical o
206 channels are sufficient to cause devastating inherited neurological diseases, such as epilepsy and pa
207 in an additional 79 Taiwanese pedigrees with inherited neuropathies and 163 index cases from Australi
208 motor neuropathy is a heterogeneous group of inherited neuropathies characterized by distal limb musc
209 ticipants aged 3 to 20 years enrolled in the Inherited Neuropathies Consortium were assessed at basel
210         Mutations in the DNAJB2 gene lead to inherited neuropathies such as Charcot-Marie-Tooth type-
211 h disease type 1A (CMT1A) is the most common inherited neuropathy, a debilitating disease without kno
212                           CMT1X, an X-linked inherited neuropathy, is caused by mutations in GJB1, wh
213 rated that under certain conditions cues can inherit occasion setting properties whereby they modulat
214     Congenital cataract is the most frequent inherited ocular disorder and the most leading cause of
215                                              Inherited or acquired ADAMTS13 deficiency allows the unr
216  (RP) gene mutations, mostly associated with inherited or acquired bone marrow failure, are believed
217 ely arise from a single driver event, either inherited or acquired.
218  disability disorder in ten individuals with inherited or de novo monoallelic BRPF1 mutations.
219 tive disease variant(s) for individuals with inherited or de novo mutations presents one of the main
220                Long QT syndrome (LQTS) is an inherited or drug induced condition associated with dela
221 ts (from 173 families) with BMF of suspected inherited origin but unresolved diagnosis after medical
222  loci that differ in chromatin state and are inherited over generations.
223                          Thus, newborn cells inherit partially duplicated chromosomes.
224 work for comprehensive genetic evaluation of inherited PCA in the multigene testing era addressing ge
225 o address a genetic evaluation framework for inherited PCA in the multigene testing era.
226 ilial variants of alphaS are correlated with inherited PD.
227                                              Inherited peroxisomal biogenesis disorders (PBDs) are ch
228 ith infectious prion diseases in mammals and inherited phenotypes in yeast.
229 , diffusion ensures that both daughter cells inherit plasmids after cell division.
230  in hematopoietic TFs in the pathobiology of inherited platelet defects.
231                                       Of all inherited predispositions to breast cancer in the NYBCS,
232 sarcomeric proteins are the leading cause of inherited primary cardiomyopathies.
233       Primary hyperoxaluria type 1 (PH1), an inherited rare disease of glyoxylate metabolism, arises
234 tions in KDSR have recently been reported in inherited recessive forms of progressive symmetric eryth
235  also include a separate category of complex inherited relapsing neuropathy syndromes, some of which
236              Retinitis pigmentosa (RP) is an inherited retinal degeneration (RD) that leads to blindn
237 n IFT43 as the underlying cause of recessive inherited retinal degeneration.
238 white-light exposure, and Fam161a-associated inherited retinal degeneration.
239 ) are in clinical trial for the treatment of inherited retinal degeneration.
240 d molecular genetic findings in nonsyndromic inherited retinal degenerations associated with CLN3 mut
241      Retinitis pigmentosa (RP) is a group of inherited retinal degenerations that lead to progressive
242 are increasingly found to cause nonsyndromic inherited retinal degenerations.
243 mentation therapy shows promise for treating inherited retinal degenerations; however, relevant anima
244 netic testing in a pediatric population with inherited retinal disease (IRD).
245 e multiplatform genetic testing strategy for inherited retinal disease and to describe its performanc
246                                              Inherited retinal disease is a common cause of visual im
247                          Genetic testing for inherited retinal disease is now more than 75% sensitive
248 s not previously known to be associated with inherited retinal disease, which harbor biallelic predic
249 h which to investigate the genetic causes of inherited retinal disease.
250  Retinal dystrophy (IRD) is a broad group of inherited retinal disorders with heterogeneous genotypes
251 cing panel targeting 105 genes implicated in inherited retinal disorders.
252                                           As inherited retinal dystrophies (IRD) are characterized by
253                                              Inherited retinal dystrophies (IRDs) are a clinically an
254 ls who exhibit partial loss of vision due to inherited retinal dystrophies (IRDs).
255 such as age-related macular degeneration and inherited retinal dystrophies, aoong others.
256                                              Inherited Retinal dystrophy (IRD) is a broad group of in
257 improved functional vision in RPE65-mediated inherited retinal dystrophy previously medically untreat
258 R) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature blin
259 enefit of gene replacement in RPE65-mediated inherited retinal dystrophy.
260 s pigmentosa (RP) is the most common form of inherited retinal dystrophy.
261 ons in more than 250 genes are implicated in inherited retinal dystrophy; the encoded proteins are in
262 tal amaurosis (LCA), the most severe form of inherited retinopathy in early childhood.
263 protein Merlin is found in most sporadic and inherited schwannomas, but the molecular mechanisms unde
264      Our study demonstrates that Neanderthal-inherited sequences are not silent remnants of ancient i
265 in segmentation act as windows through which inherited serpentinites rise to the sub-seafloor.
266  genetic evidence that small RNAs embody the inherited silencing signal.
267  we demonstrate that individual ring neurons inherit simple-cell-like receptive fields from their ups
268     The discovery of pathogenic mutations in inherited skin diseases represents one of the major land
269 st cases of BCC are sporadic, some forms are inherited, such as Bazex-Dupre-Christol syndrome (BDCS)-
270 ia remain unclear, but there is evidence for inherited susceptibility.
271    Additionally, genome-wide surveillance of inherited SVs reveals novel variants, missed in short-re
272 M in mothers of infants with CMA may reflect inherited systemic immunogenicity of CM proteins in thes
273 R-tau has been found in several sporadic and inherited tauopathies, suggesting that dysregulation of
274 metes (known as spores in yeast) that do not inherit the gene from heterozygotes.
275          Our data suggests that PrP and ZIP6 inherited the ability to interact with NCAM1 from their
276 ere, we show a series of Li-containing foils inheriting the desirable properties of alloy anodes and
277 thin-film morphology of a conjugated polymer inherits the features of its solution-state supramolecul
278 genetic characterization of 79 patients with inherited thiamine defects causing encephalopathy in chi
279                      As these components are inherited, this should also cause lineage-to-lineage var
280 e of albinism in European populations and is inherited through autosomal recessive mutations in the T
281 nto the problem of how epigenetic states are inherited through cell division, with intriguing mechani
282 e established early in the visual system and inherited throughout later stages to affect a range of h
283 ndels and fragment deletion were both stably inherited to the next generations, and transgene-free mu
284                    All mutations were stably inherited to the T2 progeny.
285 value representations in the striatum may be inherited, to some extent, from the amygdala.
286 nes in recombination-poor regions tend to be inherited together, hindering the generation of novel al
287 d a natural experiment involving genetically inherited traits, and find evidence that malaria parasit
288                 We conclude that land plants inherited two Pi uptake mechanisms - mediated by the PTB
289 isorder caused by deletion of the maternally inherited UBE3A allele and is characterized by developme
290 rtion and potential clinical implications of inherited variants detected using simultaneous sequencin
291 ral evolution can be described as systems of inherited variation that change over time in response to
292 a ADAMTS13 autoantibodies, but rarely, it is inherited via mutations of the ADAMTS13 gene.
293          These domains can be epigenetically inherited when epe1(+) , encoding an enzyme that promote
294 sis that unidentified nevogenic genes are co-inherited with CDKN2A and may influence carcinogenesis.
295                           In contrast, it is inherited with half the mother's genome during normal re
296 s but result in less severe bleeding when co-inherited with hemophilia.
297  confers a silenced state that is metastably inherited, with memory held in the local chromatin.
298 ametes are poisoned, whereas only those that inherit wtf4 are rescued by the antidote.
299 ixture model to compare the sex-specifically-inherited X chromosome with the autosomes in 20 early Ne
300 mpt, and is likely to be achieved through an inherited yet highly accurate behavioural heuristic.

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