ライフサイエンスコーパス: inheritance

1 maternally specified germ-line determinants (inheritance).

2 ormation processing, embryo development, and inheritance).

3 genesis in 2 families, suggesting oligogenic inheritance.

4 entation following a strict dominant mode of inheritance.

5 l muscle disorder through different modes of inheritance.

6 with distinct disease processes and modes of inheritance.

7 milies showing an autosomal dominant mode of inheritance.

8 ders Study with a 78.5% accuracy for mode of inheritance.

9 cellent model with which to study epigenetic inheritance.

10 mediate vertical transmission of epigenetic inheritance.

11 eral cases, suggesting an oligogenic mode of inheritance.

12 d a third of cases having autosomal dominant inheritance.

13 a in ovary tissue, indicating their maternal inheritance.

14 purifying selection benefits of uniparental inheritance.

15 in affected males, consistent with X-linked inheritance.

16 families with an autosomal dominant mode of inheritance.

17 ticists argue both for and against polygenic inheritance.

18 amutation and for defining transgenerational inheritance.

19 ic lateral sclerosis with a dominant mode of inheritance.

20 mplete penetrance is the most likely mode of inheritance.

21 lastids may lead to selection for biparental inheritance.

22 lt has sparked interest in transgenerational inheritance.

23 ort were consistent with autosomal recessive inheritance.

24 -term implications of non-DNA sequence-based inheritance.

25 ess consequences of diploid vs. haplodiploid inheritance.

26 solution in determining the fetus's maternal inheritance.

27 ting, H3 ubiquitylation, and DNA methylation inheritance.

28 l cancer (CRC) displays a complex pattern of inheritance.

29 mbly of OM proteins and in mitochondrial DNA inheritance.

30 ndamental to genome integrity and epigenetic inheritance.

31 by a lack of recombination and male-limited inheritance.

32 ear to be particularly prone to this type of inheritance.

33 ndrial protein import with mitochondrial DNA inheritance.

34 However, ID displays a complex pattern of inheritance.

35 be involved in transgenerational epigenetic inheritance.

36 re of mitochondria is their maternal mode of inheritance.

37 ed for in model organisms showing epigenetic inheritance.

38 nsistent with an autosomal-recessive mode of inheritance.

39 ween parents and offspring traits to capture inheritance.

40 in whom oligodontia segregates with dominant inheritance.

41 g mammalian evolution, possibly via maternal inheritance.

42 molecular mechanisms governing this type of inheritance.

43 transmission into gametes, defying Mendelian inheritance.

44 pigenetics with transgenerational epigenetic inheritance.

45 r followed an autosomal recessive pattern of inheritance.

46 hat each individual carries, and the mode of inheritance.

47 n overlapping genodermatosis after recessive inheritance.

48 malformation with a multifactorial model of inheritance.

49 /or brain and consistent with the pattern of inheritance.

50 , 19 de novo events, and 6 events of unknown inheritance, a significant enrichment in affected versus

51 recise and intricate regulation of small RNA inheritance across generations.

52 ere, we examine the breadth of protein-based inheritance across the yeast proteome by assessing the a

53 may act as the prime element for epigenetic inheritance after replication, as DNA methylation was ex

54 ease mechanism, gene constraint, and mode of inheritance, although poorer performing algorithms are m

55 s, mainly a high rate of autosomal recessive inheritance and a unique composition of causative genes.

56 We examine the interplay between biparental inheritance and cytonuclear incompatibility in Campanula

57 enotypic variance among mothers, strength of inheritance and developmental variation.

58 tification, including pronounced educational inheritance and disparities in participation and degree

59 Different patterns of inheritance and genetic heterogeneity are known in this

60 sm and propose potential consequences of the inheritance and induction modes to animal evolutionary b

61 The genetic variant and its inheritance and information on the patient's symptoms an

62 olled admixtures plays a central role in the inheritance and onset of genetic disease.

63 ved species tree that considers all modes of inheritance and overcomes systematic problems due to rap

64 nic cosegregation was suggestive for complex inheritance and potentially complex gene product interac

65 s genomic integrity and unaltered chromosome inheritance and serves as a major target of several anti

66 nt evidence for transgenerational epigenetic inheritance and summarize the data linking epigenetics t

67 ts, and several studies support more complex inheritance and the role of environmental factors and/or

68 that fused mitochondria become critical for inheritance and transport across the bud neck in myo2 mu

69 numerical simulations to show how structural inheritance and variations in extension velocity control

70 (in 81% of patients with autosomal dominant inheritance) and p.Q163X (in 73% of autosomal recessive

71 source elements, (2) diverse patterns of MEI inheritance, and (3) the introgression of ancient MEIs i

72 is including age, baseline EZ width, mode of inheritance, and cataract surgery status showed that the

73 nse mutation in Gatm in a recessive model of inheritance, and causation was confirmed by CRISPR/Cas9

74 guided variation or transformation, blending inheritance, and one-to-many transmission.

75 ccurring through assortative mating, genetic inheritance, and the inheritance of physical and social

76 ion, and the mechanisms of transgenerational inheritance are inferred from such studies.

77 Alzheimer's disease with autosomal dominant inheritance are not well understood.

78 NA; however, the neural implications of this inheritance are uncertain.

79 ification of germ cells lies at the heart of inheritance, as germ cells contain all of the genetic an

80 however, active programs enforce uniparental inheritance at two levels, eliminating paternal mitochon

81 disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the

82 nal asymmetry, tubular ER generation, and ER inheritance blocks.

83 nexpectedly, morc-1 is dispensable for siRNA inheritance but is required for target silencing and mai

84 variety of mating type numbers and modes of inheritance, but only recently have the genes involved b

85 of retrotransposons ensure transgenerational inheritance by invading presumptive germ cells before th

86 plays a role in COPD and pulmonary function inheritance by potentially altering expression of HCG4B.

87 needed to perform a large-scale genome-wide inheritance-by-descent (IBD) scan, but accurate assessme

88 ion emerging in recent decades that cultural inheritance can be a significant factor in the lives not

89 athogenicity of each variant and the mode of inheritance can be inferred in a Bayesian framework.

90 n of mitochondrial genomes under uniparental inheritance can effectively combat the mutational meltdo

91 We explain how the components of inheritance can influence phenotypic variance and thus t

92 ence supporting epigenetic transgenerational inheritance caused by endocrine disrupter chemicals.

93 genetic hypothesis on 3 key aspects: mode of inheritance, clinical penetrance, and genetic heterogene

94 environmental effects, including epigenetic inheritance, contribute to adaptive evolution.

95 Furthermore, MAPPIN predicts mode of inheritance correctly for 70.3% of nsSNVs.

96 asm inheritance, such that higher germ plasm inheritance correlates with higher primordial germ cell

97 ER in the mother cell, the first step in ER inheritance, depends on functional symmetry between the

98 Consistent with these later observations, inheritance does not require the silenced locus, and we

99 Doubly uniparental inheritance (DUI) describes a mode of mtDNA transmission

100 nisms for protein/lipid import and organelle inheritance during parasite replication.

101 ent changes in ER structure are linked to ER inheritance during the yeast cell cycle.

102 the extent to which the results of cultural inheritance echo a suite of core principles that underli

103 ly onset disease (before age 40) and complex inheritance evident in common adult-onset forms of disea

104 here represents an unusual recessive mode of inheritance for missense-mediated tubulinopathies and re

105 ating, Predicting Pathogenicity, and mode of Inheritance for Nonsynonymous variants), a prediction me

106 Unconventional inheritance for testicular germ cell tumor (TGCT) risk b

107 ase followed by a series of LRRs, suggesting inheritance from a common ancestor with that architectur

108 lgal fermentative enzyme supports a vertical inheritance from a cyanobacterial-related ancestor.

109 s animals and plants, biparental chloroplast inheritance has arisen multiple times in the angiosperms

110 thought to be rare, protein-based epigenetic inheritance has now been uncovered in all domains of lif

111 This transgenerational inheritance has significant implications for understandi

112 Biparental inheritance has the potential to impact the evolutionary

113 P) genes while <1% of patients with X-linked inheritance have been identified with mutations in the t

114 65% of DBA patients with autosomal dominant inheritance have heterozygous mutations or deletions in

115 Biparental inheritance helps to mitigate cytonuclear incompatibilit

116 that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 x 10(

117 trast to recessive conditions with biallelic inheritance, identification of dominant (monoallelic) mu

118 e de novo assembly also supported oligogenic inheritance; implicating 13 genes involved in hindlimb d

119 Oligogenic inheritance implies a role for several genetic factors i

120 report that Nup2 is required for mitotic NPC inheritance in A. nidulans Interestingly, the role of Nu

121 Building upon OMIA (Online Mendelian Inheritance in Animals), we introduced a curated set of

122 -Rho functions as a protein-based element of inheritance in bacteria, suggesting that the emergence o

123 There is substantial biparental inheritance in C. americanum.

124 egates that act as protein-based elements of inheritance in fungi.

125 We first determine patterns of chloroplast inheritance in genetically similar and divergent crosses

126 ric carpotarsal osteolysis (Online Mendelian Inheritance in Man #166300), a pathology caused by mutat

127 Kleefstra syndrome (KS) (Mendelian Inheritance in Man (MIM) no.

128 EIEE13 [Online Mendelian Inheritance in Man (OMIM) # 614558] is caused by de novo

129 familial dysautonomia [FD; Online Mendelian Inheritance in Man (OMIM) 223900], affects the developme

130 nonsynonymous singletons in Online Mendelian Inheritance in Man (OMIM) disease genes compared with Af

131 nship networks based on the Online Mendelian Inheritance in Man database and our identified significa

132 er, our findings unveil a role for organelle inheritance in mitosis, spindle alignment, and the choic

133 els) that are consistent with the pattern of inheritance in the parents and 11 children of this pedig

134 atments of gene-culture coevolution and dual inheritance, in addition to purely cultural evolution.

135 e of network structure as a result of social inheritance, in which newborns are likely to bond with m

136 Mice models suggest epigenetic inheritance induced by parental allergic disease activit

137 Although strict recessive inheritance is assumed, patients carrying a single mutat

138 Inheritance is either autosomal dominant or autosomal re

139 Maternal inheritance is exhibited within the hybrids, such that t

140 The frequency of biparental inheritance is greater in divergent crosses and in the p

141 When mitochondrial inheritance is inhibited, Num1 clusters are not assemble

142 ored sustained susceptibility, but even when inheritance is not recessive, abundant refuges of non-Bt

143 Maternal inheritance is often presented as the passive outcome of

144 During cell division, genome inheritance is orchestrated by microtubule attachments f

145 Although organelle inheritance is predominantly maternal across animals and

146 etic model, defined according to the mode of inheritance, is known, the NPT derived under the given g

147 r requirements and apply different models of inheritance (iv) perform downstream functional enrichmen

148 esis, abnormalities in asymmetric centrosome inheritance leading to neuronal migration delays, and al

149 nts following a model of autosomal recessive inheritance led to the identification of eleven differen

150 While this asymmetric inheritance maintains the efficacy of purifying selectio

151 for Huntington's disease, but its monogenic inheritance makes it an appealing candidate for the deve

152 Therefore, contaminant-induced epigenetic inheritance may be less common than is reported in the l

153 Epigenetic inheritance mechanisms play fundamental roles in maintai

154 n of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survival.

155 < 0.05) under the recessive and overdominant inheritance models, respectively.

156 inferred from genetic markers with different inheritance modes also need to be interpreted cautiously

157 SIPI takes non-hierarchical models, inheritance modes and mode coding direction into conside

158 erforms CADD and Eigen in predicting disease inheritance modes for all validation datasets.

159 However, it is now clear that inheritance not based on DNA sequence exists in multiple

160 A gene drive biases inheritance of a gene so that it increases in frequency

161 Inheritance of a less than critical mitochondrial quanti

162 yzes the H3K27me3 modification that warrants inheritance of a repressive chromatin structure during c

163 Non-Mendelian inheritance of a selectable marker (neo), used to identi

164 ethylation at the DNA level or highly stable inheritance of an epigenetic signal in Nasonia.

165 ns during the lifespan and transgenerational inheritance of an organism.

166 rees displaying apparent autosomal recessive inheritance of an uncharacterized skeletal dysplasia.

167 smission but also promotes transgenerational inheritance of antiviral immunity.

168 date, in support of the classical Mendelian inheritance of Bardet-Biedl syndrome and other ciliopath

169 emia and beta-thalassaemia, including the co-inheritance of beta-thalassaemia with haemoglobin E resu

170 icrotubules and that these are necessary for inheritance of centrioles from one cell cycle to the nex

171 isting CENP-A nucleosomes for the epigenetic inheritance of centromeres.

172 dle assembly checkpoint ensures the faithful inheritance of chromosomes by arresting mitotic progress

173 tive model is one in which transgenerational inheritance of disease risk requires the presence of exp

174 oss generations seems limited in plants, the inheritance of DNA methylation defects results from the

175 evated in the thalamus of F1 mice due to the inheritance of DNA methylation patterns from the paterna

176 The epigenetic inheritance of DNA methylation requires UHRF1, a histone

177 Inheritance of DNA methylation states from gametes deter

178 ying mechanisms of initiation, spreading and inheritance of DNA methylation, and for therapeutic gene

179 Mutations in PS1 lead to dominant-inheritance of early-onset familial Alzheimer's disease

180 the first unambiguous evidence for maternal inheritance of egg colouration in the brood-parasitic co

181 Inheritance of either allele independently results in in

182 abditis elegans, nuclear RNAi ensures robust inheritance of endo-siRNAs and deposition of repressive

183 UHRF1 is a key mediator of inheritance of epigenetic DNA methylation patterns durin

184 ities is required to ensure long-term stable inheritance of epigenetic information.

185 totipotency and to prevent transgenerational inheritance of epimutations.

186 In the absence of recombination, uniparental inheritance of freely-segregating genomes mitigates muta

187 w insights into the features determining the inheritance of gene body methylation and demonstrate tha

188 isely duplicates the genome to ensure stable inheritance of genetic information.

189 rapid DNA segregation is required for proper inheritance of genetic material.

190 Inheritance of genetic SRNS may be autosomal dominant or

191 Inheritance of genomic information independent of the DN

192 In mammals, faithful inheritance of genomic methylation patterns ensures prop

193 /6 methyltransferase activity and epigenetic inheritance of H3.1 K27me1 mark in plants.

194 Hence, in this context, the inheritance of H3K27 trimethylation conveys epigenetic m

195 us, specific DNA sequences contribute to cis inheritance of H3K9me and silent epigenetic states.

196 is required for RNAi-independent epigenetic inheritance of H3K9me domains.

197 s a conserved factor critical for epigenetic inheritance of heterochromatin and describes a mechanism

198 retinopathy in a 16 year-old patient with co-inheritance of heterozygous alpha + -thalassemia and sic

199 expression and full reactivation.IMPORTANCE Inheritance of HHV-6A or HHV-6B integrated into a telome

200 Co-inheritance of HPFH with beta-thalassemia- or SCD-associ

201 s-SF) converted from layered hydroxides with inheritance of included anion groups (OH(-) , NO3(-) , C

202 fective [PAR] proteins) controls the unequal inheritance of key cell fate determinants.

203 nds and bodies and has provided a cumulative inheritance of knowledge, skills, institutions, and arti

204 d during cell division and led to an unequal inheritance of LFA-1 in divided T cells.

205 principles that govern the architecture and inheritance of liquid-like organelles.

206 Separate inheritance of mania and depression together with high r

207 Metabolite content and genetic inheritance of metabolites varied broadly, both within a

208 Using epigenotype maps, we explore the inheritance of methylation states in regions of differen

209 regions in Nasonia, together with the stable inheritance of methylation status between generations, s

210 Maternal inheritance of mitochondria and mtDNA is a universal pri

211 Genes that specifically control the inheritance of mitochondria in the germline are unknown.

212 hia is maternally inherited, resulting in co-inheritance of mitochondrial organelles such as mtDNA.

213 uctive technologies designed to uncouple the inheritance of mtDNA from nuclear DNA may enable affecte

214 dystrophy caused by the autosomal recessive inheritance of mutations in ABCA4.

215 or have been associated with mostly dominant inheritance of mutations in more than 30 genes.

216 rable, attention has focused on limiting the inheritance of pathogenic mtDNA by mitochondrial replace

217 Recessive inheritance of pest resistance has favored sustained sus

218 rtative mating, genetic inheritance, and the inheritance of physical and social environmental conditi

219 iRNAs in oocytes is further required for the inheritance of piRNA-mediated transposon defence.

220 ndensed mitotic chromatin to ensure faithful inheritance of prior accessibility status across cell di

221 Thus, differential inheritance of proteins like Munc13-2 has broad implicat

222 scription of a case of compound-heterozygous inheritance of pRTA.

223 after accounting for segregation and de novo inheritance of rare variants (joint p = 2.3 x 10(-7)).

224 ploid karyotypes in yeast disrupt the stable inheritance of silenced chromatin during cell proliferat

225 mechanisms that propagate H3K9me, epigenetic inheritance of silencing requires binding sites for sequ

226 identified factors that are required for the inheritance of small RNAs and for heritable RNAi in worm

227 at control the duration of transgenerational inheritance of small RNAs.

228 ility that preconception alcohol affects the inheritance of stress-related diseases possibly by epige

229 ot differ from that expected given Mendelian inheritance of such an allele.

230 inct progeny, presumably due to differential inheritance of temporal factors.

231 Although our data show a complex inheritance of TH, we predict that homozygous variants i

232 Inheritance of the apolipoprotein E4 (apoE4) genotype ha

233 t this locus obey simple Mendelian recessive inheritance of the black-throated phenotype characterist

234 her eukaryotes are defined by the epigenetic inheritance of the centromere-specific CENP-A nucleosome

235 at the end of prophase I to ensure faithful inheritance of the genome.

236 Inheritance of the HSD3B1 (1245C) allele that enhances d

237 aternal diet may result in transgenerational inheritance of the insulin-resistant phenotype.

238 ning the unpatterned phenotype and recessive inheritance of the M. cardinalis allele.

239 vision is often accompanied by stereotypical inheritance of the mother and daughter centrosomes.

240 fect offspring phenotype but resulted in the inheritance of the same stress-coping traits in the offs

241 a mechanism to integrate the positioning and inheritance of the two essential organelles and expands

242 species tree as a result of the uniparental inheritance of these genomic regions.

243 The asymmetric inheritance of these protein deposits is mediated by org

244 Maternal inheritance of this mutation resulted in absence of DNA

245 rimental crosses have revealed the Mendelian inheritance of this trait, its genetic basis remains unk

246 Inheritance of this variant is associated with suppressi

247 De novo occurrence and autosomal-dominant inheritance of variants, including paternal mosaicism in

248 gly, MEK1 appeared to control the asymmetric inheritance of Ventx2 protein following cell division.

249 omozygous mutation associated with recessive inheritance only rarely co-acts with a dominant mutation

250 such as identifying variants with Mendelian inheritance or identifying shared chromosomal regions am

251 re a commitment to either gene-like cultural inheritance or to the view that cultures are like verteb

252 Inheritance pattern and causative mutation; retinal func

253 prion drives" that reverse the non-Mendelian inheritance pattern of prions and eliminate them from ye

254 x-determining region (SDR), and to trace the inheritance pattern of the transgene in relation to sex.

255 s, as well as the common autosomal recessive inheritance pattern of thin corpus callosum and axonal C

256 ntly, explaining the seemingly non-mendelian inheritance pattern.

257 GF trait observed to segregate in a dominant inheritance pattern.

258 stemic lupus erythematosus, show a polygenic inheritance pattern.

259 ne genodermatosis with an X-linked, dominant inheritance pattern.

260 g process on 985 genes with well-established inheritance patterns for Mendelian conditions, and repea

261 ing mtDNA mutation, explaining the different inheritance patterns observed in human pedigrees transmi

262 has been reported in families with dominant inheritance patterns of Parkinson's disease, suggesting

263 .8 years) and their parents to determine the inheritance patterns of ultrarare, nonsynonymous variant

264 LAMMS and four other algorithms to Mendelian inheritance patterns on a pedigree; we compare calls fro

265 tic signal of genomic regions with different inheritance patterns using genome skimming and ddRAD-seq

266 y prediction algorithm that provides mode of inheritance predictions, adding another layer of informa

267 factor uniquely required for heterochromatin inheritance, rather than for de novo assembly.

268 r, the mechanisms underlying heterochromatin inheritance remain unclear.

269 mplications including polyploidy, multisomic inheritance, self-incompatibility, and high levels of he

270 Inheritance shapes the distribution of newborn phenotype

271 ed to quantitative differences in germ plasm inheritance, such that higher germ plasm inheritance cor

272 n SNX14, with an autosomal recessive mode of inheritance suspected.

273 Does cultural transmission constitute an inheritance system that can evolve in a Darwinian fashio

274 itial notion of the concept, replacing G by 'inheritance system'.

275 Transgenerational epigenetic inheritance (TEI) describes the transmission of alternat

276 te systems, for transgenerational epigenetic inheritance (TEI), the transmission of epigenetic gene r

277 olution and the secondary system of cultural inheritance that is based on social learning from others

278 et of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian proper

279 s a growing source for understanding complex inheritance, the elucidation of disease mechanisms, and

280 ggests that HLH may have a polygenic mode of inheritance, the latter is very difficult to prove in hu

281 ases, while correctly inferring the modes of inheritance, the likely pathogenic variants, and the var

282 gulatory mechanisms: those that prolong RNAi inheritance through amplification and maintenance of her

283 Continuous and error-free chromosome inheritance through the cell cycle is essential for geno

284 ulate insect reproduction by enhancing their inheritance through the female germline.

285 ata establish a common type of protein-based inheritance through which intrinsically disordered prote

286 tes the potential for biparental chloroplast inheritance to rescue cytonuclear compatibility, reducin

287 aucoma can occur at all ages, with Mendelian inheritance typical for the rare early onset disease (be

288 gating), Gly2539 missense (five de novo, one inheritance uncertain), and Lys2596 in-frame deletion (f

289 tested whether mutants defective in vacuole inheritance, vac8Delta and vac17Delta, tune vacuole biog

290 Mendelian inheritance via gametocyte integration results in HHV-6

291 order can likely be attributed to epigenetic inheritance via the oocyte.

292 Mode of inheritance was associated with RP progression, with aut

293 The most likely mechanism of inheritance was concluded to be autosomal dominant.

294 by MET1, plays a central role in epigenetic inheritance, we examined genomewide DNA methylation in p

295 Assuming autosomal recessive inheritance, we identify 27 genes that have homozygous o

296 were beneficial, had prion-like patterns of inheritance, were common in wild yeasts, and could be tr

297 show methylation levels consistent with cis inheritance, whereas the other half show evidence of tra

298 s-acting variants generally exhibit additive inheritance, while those linked to trans-acting variants

299 ing Tudor, Aub piRNPs and mRNAs couple piRNA inheritance with germline specification.

300 ar and divergent crosses, and then associate inheritance with hybrid survival across multiple generat