ライフサイエンスコーパス: inhibin

1 s on cells that are otherwise insensitive to inhibin.

2 unctional interactions with both activin and inhibin.

3 itive model for the antagonism of activin by inhibin.

4 nized by endocrine acting, gonadally derived inhibin.

5 ct and often opposed actions of TGFbetas and inhibins.

6 32] ng/mL, p < 0.001; pro alpha C-containing inhibins 2.2 [0.81] vs 0.71 [0.33] ng/mL, p < 0.001).

7 Molecular-weight forms of inhibin A (32 kDa) and activin A (> 100 kDa) were simila

8 -eclampsia than in control normal pregnancy (inhibin A 3.05 [1.8] vs 0.36 [0.14] ng/mL, p < 0.001; ac

9 nd binding using iodinated recombinant human inhibin A and 125I-labeled recombinant human inhibin A.

10 Inhibin A and activin A are produced by the placenta dur

11 sh the molecular-weight forms of circulating inhibin A and activin A in pre-eclampsia.

12 ysis to assess the molecular-weight forms of inhibin A and activin A.

13 Although inhibin A and B binding was 20-fold lower compared with

14 ng of follicle-stimulating hormone (FSH) and inhibin A and B levels.

15 onic gonadotropin, unconjugated estriol, and inhibin A at 15 through 18 weeks of gestation).

16 contrast, infusion of the activin antagonist inhibin A did not influence behavior but blocked the eff

17 sitively correlated with a high activin A to inhibin A ratio.

18 Serum concentrations of inhibin A, activin A, and pro alpha C were significantly

19 Biotinylated inhibin A, but not activin A, bound ALK4.

20 ines (granulocyte colony-stimulating factor, inhibin A, Epstein-Barr virus-induced gene 3, interleuki

21 Serum samples were analysed for inhibin A, inhibin B, pro alpha C, and activin A.

22 Higher maternal serum concentrations of inhibin A, pro alpha C, and total activin A in pre-eclam

23 med to measure circulating concentrations of inhibin A, pro alpha C-containing inhibins, and activin

24 lion and trigeminal ganglion-bound iodinated inhibin A.

25 inhibin A and 125I-labeled recombinant human inhibin A.

26 okeratins 8 and 19, and the absence of alpha-inhibin, a protein characteristically expressed in norma

27 via a distinct site, but are unable to bind inhibin-A.

28 Inhibin abrogates BMP-induced Smad signaling and transcr

29 ta expand our understanding of how endocrine inhibin achieves potent antagonism of local, constitutiv

30 ivins, which are structurally related to the inhibins, act within the pituitary to stimulate FSH prod

31 These findings demonstrate that inhibin, acting through betaglycan, can function as an a

32 that additional components are required for inhibin action.

33 pression profiling has uncovered a defective inhibin-activin signaling pathway in TAFII105-deficient

34 detailed immunohistochemical localization of inhibin/activin alpha-, beta A-, and beta B-subunits thr

35 receptors (alone and in combination) for the inhibin/activin subfamily, we developed a cell-free assa

36 4) mRNAs encoding each of the inhibin/activin subunits are expressed in all major brai

37 ogenase, luteinization hormone receptor, and inhibin/activin subunits.

38 y evidence to suggest that regulation of the inhibin/activin system is essential for early folliculog

39 ive inhibin receptors were isolated using an inhibin affinity column.

40 superfamily members, TGF-beta, activin, and inhibin, all have prominent roles in regulating normal o

41 rum testosterone levels and intra-testicular inhibin alpha and inhibin beta B levels are not altered

42 activation of Fshb inhibitory factors (e.g. inhibin alpha and VGF nerve growth factor-inducible), 2)

43 Targeted disruption of the inhibin alpha gene (Inha(-)(/)(-)) in mice results in an

44 n Inha(-)(/)(-) mice, which demonstrate that inhibin alpha has important consequences upon follicle d

45 Absence of inhibin alpha resulted in advanced follicular maturation

46 o activation of serum glucocorticoid kinase, inhibin alpha, and c-fos genes.

47 Activin stimulates endogenous inhibin alpha- and betaB-subunit mRNA, protein, and prot

48 The inhibin alpha-subunit mature domain (N terminus) arose r

49 stromal tumors, derived from male and female inhibin alpha-subunit-deficient mice, were also identifi

50 with the p215-234 peptide derived from mouse inhibin-alpha activates CD4(+) T cells and induces exper

51 Our inhibin-alpha autoimmune model of POF shows how prematur

52 tive FOXO1 mutant also suppressed cyclin D2, inhibin-alpha, and epiregulin promoter-reporter activiti

53 p-regulation of reporter activities for LHR, inhibin-alpha, and vascular endothelial growth factor is

54 mutant to attenuate induction of cyclin D2, inhibin-alpha, aromatase, SCC, SF-1, and epiregulin.

55 enhanced expression of cyclin D2 as well as inhibin-alpha, aromatase, steroidogenic factor-1 (SF-1),

56 ncluding luteinizing-hormone receptor (LHR), inhibin-alpha, microtubule-associated protein 2D, and th

57 uppressed induction of cyclin D2, aromatase, inhibin-alpha, SF-1, and epiregulin.

58 h1 T cells that stimulate B cells to produce inhibin-alpha-neutralizing Abs directly capable of media

59 Affected mice show high serum levels of inhibin-alpha-neutralizing Abs that prevent inhibin-medi

60 Thus, inhibin-alpha-targeted experimental autoimmune oophoriti

61 Inhibin also binds type II activin receptors and antagon

62 Inhibin also forms crosslinked complexes with both recom

63 Inhibins also bind type II activin receptors but do not

64 Inhibin and activin are best known as gonadal glycoprote

65 Inhibin and activin are members of the transforming grow

66 m pituitary gonadotrope cells, and together, inhibin and activin control the pituitary gonadal axis e

67 The results suggest that central inhibin and activin proteins are produced in the brain w

68 BMP responses, suggesting a broader role for inhibin and betaglycan in restricting and refining a wid

69 Abundant inhibin and few activin binding sites were identified in

70 Mutation of Val614 to Tyr abolishes both inhibin and TGFbeta binding to this domain.

71 the co-receptor actions of betaglycan toward inhibin and TGFbeta will allow the clarification of the

72 We show that the inhibin and TGFbeta-binding residues of this domain over

73 ically enhances the antimigratory effects of inhibin and the ability of inhibin to repress matrix met

74 transforming growth factor beta superfamily, inhibins and activins are a physiologically relevant pai

75 Inhibins and activins are dimeric proteins that are func

76 Inhibins and activins are members of the transforming gr

77 as a cell surface receptor and mediate BMP, inhibin, and TGF-beta signaling suggests a broader role

78 rations of inhibin A, pro alpha C-containing inhibins, and activin A in the serum of women with pre-e

79 The ability of betaglycan to facilitate inhibin antagonism of activin provides a variation on th

80 These betaglycan mutants fail to mediate inhibin antagonism of activin signaling but can present

81 eceptor binding and activity, as well as for inhibin antagonism of activin through its receptors.

82 recise structural aspects that contribute to inhibin antagonism of activin.

83 and ActRIB or ActRIB only, we show that the inhibin antagonistic effects on activin-induced biologic

84 Inhibins are endogenous antagonists of activin signaling

85 The inhibins are gonadal transforming growth factor beta sup

86 decrease in antimullerian hormone (AMH) and inhibin B and an increase in FSH with age corresponding

87 lysis was performed to determine the optimal inhibin B and FSH values for identifying patients with a

88 MH), follicle-stimulating hormone (FSH), and inhibin B and urinary level of FSH.

89 ls of follicle-stimulating hormone (FSH) and inhibin B are correlated with sperm concentration, their

90 7+/-0.7 nmol per liter], P=0.004), and serum inhibin B concentrations (119+/-52 vs. 60+/-21 pg per mi

91 Inhibin B concentrations in maternal serum were not incr

92 n the non-azoospermic cancer survivor group, inhibin B concentrations were lower than in controls (me

93 on of bioactive mature activin B, as well as inhibin B dimers, necessary for local follicle-stimulati

94 ocytosis may have had resulted in changes in inhibin B expression.

95 alues, the specificity of the serum level of inhibin B for identifying azoospermic survivors was 45.0

96 sate for the absence of activin B and AB and inhibin B in the process of mammogenesis.

97 evels (LR+ 3.06; 95% CI, 2.06-4.54), and low inhibin B levels (LR+ 2.05; 95% CI, 0.96-4.39).

98 Inhibin B levels (n = 737) were not associated with the

99 jury that caused diminished testosterone and inhibin B levels and oligospermia.

100 ulating hormone, anti-Mullerian hormone, and inhibin B levels correlated significantly with therapy i

101 FSH and inhibin B levels correlated with menstrual status.

102 Although serum inhibin B levels were increased overall in low-dose anim

103 Neither serum inhibin B nor FSH is a suitable surrogate for determinat

104 secretion, indicating a status of pituitary inhibin B resistance.

105 Inhibin B was dichotomized as </= 31 ng/L or more than 3

106 His markedly elevated inhibin B was unable to inhibit FSH secretion, indicatin

107 is was performed and serum levels of FSH and inhibin B were measured in 275 adult male survivors of c

108 Age less than 45 years and inhibin B were significant multivariable baseline predic

109 n type IB receptor, ALK4, and participate in inhibin B's antagonism of activin signaling.

110 e changes were not observed; rather FSH, LH, inhibin B, and anti-Mullerian hormone were temporally al

111 ts of testicular volume, serum testosterone, inhibin B, and gonadotropins in these men with the resul

112 Serum samples were analysed for inhibin A, inhibin B, pro alpha C, and activin A.

113 Activins and inhibins belong to the transforming growth factor beta (

114 In this study, we identified inhibin beta A (or Inhba) as a regional paracrine factor

115 evels and intra-testicular inhibin alpha and inhibin beta B levels are not altered in the Six5 mutant

116 y and gene ontology (GO) analysis identified inhibin beta-B (Inhbb), an activin subunit and member of

117 The inhibin beta-subunit interacts with the activin type II

118 a calcium/phosphate homeostatic hormone; and inhibin-beta B, a TGF-beta-like factor.

119 Amphiregulin, follistatin, and inhibin-beta-A and epiregulin were activated by an autoc

120 rticularly COX-2, amphiregulin, follistatin, inhibin-beta-A, and CYR61.

121 identified; pro-inhibin betaA and processed inhibin betaA (which dimerizes to activin A) were produc

122 Growing GCT cells expressed high levels of inhibin betaA and nuclear SMAD3, and the proliferation r

123 ules novel to cartilage were identified; pro-inhibin betaA and processed inhibin betaA (which dimeriz

124 e introduced mutations in the context of the inhibin betaA cDNA and assessed the signaling activity o

125 icate that the translational upregulation of inhibin betaA enhances the migration and invasion of cel

126 rotein expression and secreted levels of the inhibin betaA homodimer, activin A.

127 One such transcript inhibin betaA is a member of the TGFbeta superfamily.

128 Here, we show by polysome profiling that inhibin betaA is translationally regulated by TGFbeta vi

129 ckdown of hnRNP E1 relieves silencing of the inhibin betaA transcript, resulting in increased protein

130 male mice in which both alleles encoding the inhibin betaB subunit have been deleted are unable to nu

131 site is within the betaglycan ZP domain, but inhibin binding is not integral to the ZP motif of other

132 Recently, betaglycan and inhibin binding protein (InhBP/p120, also known as the p

133 eceptor, cause the disruption of activin and inhibin binding to ActRII.

134 h necessary and sufficient for high affinity inhibin binding.

135 betaglycan extracellular domain as the only inhibin-binding region in betaglycan.

136 nhBP/p120 does not play an essential role in inhibin biology.

137 hat BMP signaling might also be sensitive to inhibin blockade.

138 Here we show that inhibin blocks cellular responses to diverse BMP family

139 Activin stimulates whereas inhibin blocks follicle-stimulating hormone biosynthesis

140 e eluted from the column that bind iodinated inhibin but not iodinated activin.

141 InhBP/p120 may not directly bind inhibins but may interact with the activin type IB recep

142 eta receptor, betaglycan, can function as an inhibin co-receptor with ActRII.

143 Inhibin competes with BMPs for type II activin receptors

144 Activins and inhibins compose a heterogeneous subfamily within the tr

145 gene 1 [IGSF1]) were identified as candidate inhibin coreceptors, shedding light on the molecular bas

146 tability of down-regulated let-7a targets in inhibin-deficient mice (Inha-/-).

147 les, whereas the affinity of the heterodimer inhibin does not.

148 MIS receptor/alpha-inhibin double mutant males developed testicular stromal

149 e identical in phenotype to MIS ligand/alpha-inhibin double mutant males.

150 Inhibins fail to antagonize activin in some tissues and

151 the affinities of activin and its antagonist inhibin for ActRIIb-ECD and found that the affinity of t

152 Betaglycan increases the affinity of inhibins for the activin type IIA (ACVR2) receptor, ther

153 rly during the evolution of the hormone, and inhibin function is decreased by an antibody directed ag

154 GF-beta2 near normal fusion, but activin and inhibin had no effect.

155 both ActRII and ALK4 by each subunit of the inhibin heterodimer, in conjunction with the co-receptor

156 ing a similar beta-subunit, the secretion of inhibin heterodimers (alpha/beta) or activin homodimers

157 type II receptor BMPRII, which does not bind inhibin in the absence of betaglycan.

158 Inhibin, in concert with its co-receptor, betaglycan, ca

159 ); the betaB subunit of the hormone known as inhibin; interleukin-2 enhancer binding factor; an endop

160 Inhibin is a heterodimeric peptide hormone produced in t

161 nd serum tumor markers such as estradiol and inhibin is reasonable.

162 -antagonist relationship between activin and inhibin is unique and critical to integrated reproductiv

163 of gonadotropin-regulating proteins known as inhibins, is a tumor suppressor for testicular stromal c

164 6 mouse ovaries under direction of the alpha-inhibin large promoter.

165 shedding light on the molecular basis of how inhibins may affect target cells.

166 inhibin-alpha-neutralizing Abs that prevent inhibin-mediated down-regulation of activin-induced pitu

167 Inhibin-null (INH(-/-)) mice develop gonadal tumors and-

168 line, we analyzed the effects of activin and inhibin on human erythroid differentiation.

169 s not known whether genetic variation in the inhibin pathway also influences susceptibility to testic

170 cleotide polymorphisms (SNP) in genes in the inhibin pathway among participants in the U.S. Serviceme

171 that distinct, though related, activins and inhibins perform unique functions and are not able to co

172 n synergizes with SF-1 to activate the alpha-inhibin promoter through formation of a transcriptional

173 ized with beta-catenin to activate the alpha-inhibin promoter through functional and physical interac

174 pport a cooperative model of binding for the inhibin receptor (ActRII.sTbetaRIII complex) but not for

175 d in this paper indicate that an independent inhibin receptor exists.

176 an)-Fc reconstituted a soluble high affinity inhibin receptor.

177 nt mice, were also identified as a source of inhibin receptor.

178 as been well characterized as a TGF-beta and inhibin receptor.

179 nd signaling pathways, little is known about inhibin receptors or the mechanism by which this molecul

180 embrane proteins were purified, and putative inhibin receptors were isolated using an inhibin affinit

181 Although activins and inhibins regulate follicle-stimulating hormone (FSH) syn

182 Betaglycan can confer inhibin responsiveness on cells that are otherwise insen

183 Finally, betaglycan confers inhibin sensitivity to cell lines that otherwise respond

184 ceptor that regulates TGF-beta, activin, and inhibin signaling.

185 during puberty and pregnancy require activin/inhibin signalling from the stroma.

186 receptor but also require the presence of an inhibin-specific binding component.

187 Numerous tissues were examined for inhibin-specific binding sites, including the developing

188 These data suggest that inhibin-specific membrane-associated proteins (receptors

189 Activins and inhibins, structurally related members of the TGF-beta s

190 n situ hybridization have shown that activin/inhibin subunits alpha, betaA, and betaB; receptors II a

191 mechanism where the regulation of furin and inhibin subunits cooperates in an important positive sho

192 Betaglycan also enables inhibin to bind to and compete with BMPs for binding to

193 ratory effects of inhibin and the ability of inhibin to repress matrix metalloproteinase levels in th

194 l significance, we examined ER expression in inhibin transgenic mice that have decreased activin expr

195 eromeric complex of type II, type I, and for inhibin, type III receptors.

196 p) TGF-beta2, rh TGF-beta3, rh activin, or p inhibin was added to the medium in different concentrati

197 Betaglycan binds inhibin with high affinity and enhances binding in cells

198 beta-glycan, binds all 3 TGFbeta ligands and inhibin with high affinity but lacks the serine/threonin