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1 s in HeLa cells, which are more sensitive to inhibition by 1 in the presence of the glycolysis inhibi
2 acosamide block was very weak at -120 mV (3% inhibition by 100 microM lacosamide) but greatly enhance
3 osamide) but greatly enhanced at -80 mV (43% inhibition by 100 microM lacosamide), where there is par
6 rate specificity, allosteric regulation, and inhibition by a class of small molecules that are curren
8 we examined the adaptive response to VEGF-A inhibition by a loss-of-function analysis using plasmid-
10 al vector injection with chronic 4 week PREP inhibition by a potent small-molecule PREP inhibitor, 4-
11 , we investigated the impact of chronic PREP inhibition by a small molecule inhibitor, 4-phenylbutano
12 ed for both the MDM2-p53 interaction and its inhibition by a small-molecule Nutlin-3 drug analogue kn
21 ons showed significant differences in pSTAT6 inhibition by all concentrations of indomethacin and asp
24 ble aggregate-bound plasmin is shielded from inhibition by alpha2-antiplasmin and degrades amorphous
25 form of the complex, allowing more efficient inhibition by an inhibitor whose quantity is limited.
29 ibutes to clot stability and is resistant to inhibition by antithrombin/heparin while still susceptib
31 This study demonstrated that dual PI3K/mTOR inhibition by apitolisib was less effective than was eve
33 ts on the dynamics of HIV-1 protease and the inhibition by APV and DRV, providing useful information
34 ral basis of the mechanism underlying fusion inhibition by Arbidol has remained obscure, thereby hind
37 donate during physiological activation, with inhibition by aspirin in vitro or in vivo, implicating c
38 atelets by anti-CD41 mAb treatment, platelet inhibition by aspirin, and adoptive transfer of wild-typ
39 s conferred either reduced or highly reduced inhibition by at least 1 NA inhibitor; half of them caus
41 II in isolated mitochondria: (a) complex II inhibition by atpenin A5 or complex III inhibition by st
42 ost completely ameliorated the disease (>97% inhibition) by augmenting nitric oxide generation and sh
43 o-culture challenge assays, we quantified Bd inhibition by bacterial isolates collected from the skin
49 and [(3)H]C2 transport and decreased growth inhibition by C1 and C2, and to a lesser extent by PMX.
50 on of either the eagD or cNBHD abolished the inhibition by Ca(2+) i However, deletion of just the PAS
51 Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory
52 us cell-based models by short hairpin RNA or inhibition by cabozantinib, the multi-tyrosine kinases i
53 may explain the stronger CaM-dependent RyR2 inhibition by CaM-F142L, despite its reduced Ca(2+) bind
54 basis of tissue-specific enzyme activity and inhibition by catalytic products, Hans Krebs first demon
55 s of RECON activity, via genetic ablation or inhibition by cdNs, increased NF-kappaB activation and r
60 e provides an insight into RNA targeting and inhibition by cisplatin, which can help predict cisplati
63 tal and subcortical brain areas for response inhibition, by comparing 20 dynamic causal models of the
64 e, Q77 and T86, may also play a role in NaCT inhibition by compounds 2: and 4: Our results provide ne
65 mutant cancer cells in the presence of PI3K inhibition by conducting a genome scale shRNA-based apop
67 ented AML cell death in response to FLT3-ITD inhibition by crenolanib, which was restored by wild-typ
71 give insight into transposase overproduction inhibition by demonstrating that the appearance of trans
72 this lipid is a major determinant of channel inhibition by depletion of PI(4,5)P2 upon phospholipase
74 In this study, we revisited the mechanism of inhibition by diminazene and its binding site on ASIC1a,
77 R1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond no
79 e recently defined by two other groups using inhibition by Dkk1 mRNA or Wnt8 morpholinos, which indic
82 0 mV the net effect of the co-application is inhibition by dynorphin-A, whereas at -70 mV the excitat
83 0 mV the net effect of the co-application is inhibition by dynorphin-A, whereas at -70 mV the excitat
85 NMDAR inhibition was not responsible for LTP inhibition by either agent when applied for only 20 minu
87 subset of MCLs is addicted to MALT1, as its inhibition by either RNA or pharmacologic interference i
90 luR1 increases the strength of this efferent inhibition by enhancing the presynaptic release of acety
98 rtase in amplifying complement cascades, its inhibition by FACIN results in a very potent downregulat
101 basis of the observation of selective DYRK1A inhibition by firefly d-luciferin, we have explored stat
102 eaminase activity protect plants from growth inhibition by flooding and anoxia, drought, high salt, t
103 mechanistic component of substrate-selective inhibition by flufenamic acid, mefenamic acid, and tolfe
107 despite high levels of exhaustion and likely inhibition by Foxp3(+) cells, a subset of follicular SIV
108 Notably, systemic pharmacologic Gbetagamma inhibition by gallein, which we previously showed allevi
109 pression, were sensitive to hedgehog pathway inhibition by GANT61 or GDC-0449 (vismodegib) using ex v
110 l subtype of triple-negative tumors, and its inhibition by genetic or pharmacological methods suppres
111 itus, 14 days of ileal bile acid transporter inhibition by GSK2330672 was generally well tolerated wi
116 We conclude that AMPK mediates Kv channel inhibition by hypoxia in pulmonary arterial myocytes, at
117 ich is insensitive to Bruton tyrosine kinase inhibition by ibrutinib, and the activated B-cell (ABC)
118 n contrast to NP mRNA, remained sensitive to inhibition by IFIT1 following in vitro 2'O methylation,
119 nzymes, we show biochemically that efficient inhibition by IFIT1 is dependent upon a 5' guanosine nuc
126 reviously reported that cyclooxygenase (COX) inhibition by indomethacin augmented allergic airway inf
127 line PANC-1 and exhibited cell proliferation inhibition by inducing cells to undergo G2/M arrest.
128 on the ICP0 gene (0DeltaNLS) is sensitive to inhibition by interferon beta (IFN-beta) in vitro and fu
129 1 (hEAG1) channel is remarkably sensitive to inhibition by intracellular calcium (Ca(2+) i) through b
130 rTRPM7 has two protein domains that regulate inhibition by intracellular magnesium and nucleotides, a
131 th systemic NBQX, or selective AMPA receptor inhibition by intramuscular perampanel restored myelinat
133 of the cellular metabolome showed that FLT3 inhibition by itself causes profound alterations in cent
137 ve homologues, the MtDapE was insensitive to inhibition by L-captopril which we show is consistent wi
143 activation is persistently enhanced, and its inhibition by low-dose aspirin is impaired in type 2 dia
144 mains (VSD2) encodes voltage sensitivity and inhibition by luminal Ca(2+) and adopts a conformation d
145 ability of dbcAMP and putrescine to overcome inhibition by MAG is abolished in the presence of roscov
148 period, reducing its sensitivity to feedback inhibition by malate and thus enhancing nocturnal CO2 fi
149 re and on the pharmacophore for ASIC channel inhibition by mambalgins that could have therapeutic val
152 nstitution, we show that Mps1 promotes APC/C inhibition by MCC components through phosphorylating Bub
155 repancy has been hypothesized to result from inhibition by memantine and ketamine of overlapping but
161 nt of MOPs, DOPs, beta-arr2 and c-Src in the inhibition by morphine of GABAergic inhibitory postsynap
162 c inhibitor, PP2, to WT neurons also reduced inhibition by morphine, while the inactive PP3, and the
163 In support of this notion, we find that sAHP inhibition by muscarinic receptors that increase phospho
165 D and A105T, both of which allow escape from inhibition by MX2 and the truncated version of cleavage
167 report a remarkable stereoselectivity of NKA inhibition by native 3beta-hydroxy bufalin over the 3alp
169 Here, we show that AMPA-kainate receptor inhibition by NBQX suppresses inflammation, attenuates a
170 a metabolic liability of NSCLC and that ACC inhibition by ND-646 is detrimental to NSCLC growth, sup
171 ac1 deletion in SMCs or pharmacological Rac1 inhibition by nebulization of NSC23766 prevented AHR in
172 ght to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -
173 eterotrophic perchlorate reducers and direct inhibition by nitrite produced from heterotrophic nitrat
174 nd neither TNF-alpha nor IL-6 secretion, nor inhibition by NO-np was found to be dependent on this pa
175 echanisms accounting for NF-kappaB signaling inhibition by NO2-OA in TNBC cells were multifaceted, as
176 nesis of GluN1-Glu781 reduced the potency of inhibition by NVP-AAM077, thus confirming the involvemen
177 determined the structural basis for receptor inhibition by obtaining the first co-crystal structure o
179 nistration and laser preference, whereas CeA inhibition by optogenetic halorhodopsin suppressed cocai
182 conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 resu
183 its selectivity for anterograde DCVs and its inhibition by overexpression of the fragile X retardatio
186 al repressor, suppresses the effects of EGFR inhibition by partially restoring the EGFR-promoted gene
188 ential sensitivity of phase 1 and phase 2 to inhibition by pentobarbital and NBQX mirrors the differe
193 ction of both noncooperative and cooperative inhibition by PF74 is regulated by interactions of cellu
195 t as repressors of photomorphogenesis; their inhibition by PHYs leads to substantial changes in gene
197 t genetic deficiency of p53 or pharmacologic inhibition by pifithrin impairs thrombus resolution and
198 rthered our understanding of how HCMV evades inhibition by PKR and identified new strategies for how
199 xclusively be attributed to Ile-Trp, the ACE inhibition by plant protein hydrolysates is caused by a
200 ve studies included analysis of in vivo FLT3 inhibition by plasma inhibitory activity assay and indic
201 we investigated the molecular basis of PME3 inhibition by PMEI7 in Arabidopsis thaliana Our compleme
206 er that the enhancement of TFPI-mediated FXa inhibition by protein S and FV depends on a direct prote
214 uction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO
217 m contributes to the homeostasis of synaptic inhibition by rapidly adjusting neuronal [Cl(-)]i to GAB
220 also rendered the virus more susceptible to inhibition by ribavirin, coincident with the accumulatio
222 csin C-insensitive pathway and the increased inhibition by rosiglitazone G confirmed the sensitivity
223 that PHF11 stimulates EXO1 by overcoming its inhibition by RPA, suggesting that PHF11 acts (in part)
224 lude cytoreduction by hydroxyurea and JAK1/2 inhibition by ruxolitinib, both of which are not curativ
227 logical and molecular effects of correlative inhibition by seeds on Arabidopsis (Arabidopsis thaliana
228 s is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process
232 , although both IC50 titers and percent C179 inhibition by sera diluted 1:5 or 1:10 correlated with h
233 porcine surfactant made it more resistant to inhibition by serum than the addition of equivalent amou
235 These results indicate that MEV cascade inhibition by simvastatin induced the intrinsic apoptosi
237 The assays were employed to measure enzyme inhibition by small molecules and activity in cell lysat
238 enes is commonly observed in cancer, and its inhibition by small molecules is promising for their rea
241 alidated by site-directed mutagenesis and by inhibition by small peptides that mimic the loop residue
244 hibition with the susceptibility of HIV-1 to inhibition by soluble CD4 and the 17b antibody that reco
247 to quantify because the degree of isoprenoid inhibition by statins correlates to some extent with the
248 x II inhibition by atpenin A5 or complex III inhibition by stigmatellin that results in succinate-dep
251 ion, we hypothesized that PIN1 relieves CDK2 inhibition by suppressing the CDK inhibitory activity of
252 VAMP8(-/-) acini are resistant to secretory inhibition by supramaximal CCK-8, and despite a 4.5-fold
253 nd in solution conditions; while the mode of inhibition by tannic acid was found to be purely non-com
255 bined results reveal the potential for KDM5B inhibition by TCA cycle intermediates, but suggest that
256 ntly escape the slow kinetics of Kunitz-type inhibition by TF pathway inhibitor and preferentially ac
257 , TEM can be maintained in the face of IL-15 inhibition by the activity of other homeostatic regulato
260 aturable process that is highly sensitive to inhibition by the classic nucleoside transporter inhibit
261 ts to a mechanistic difference in ice growth inhibition by the different classes of AFPs: blocking fa
264 n by phosphatidylserine, and pharmacological inhibition by the lipid-competitive inhibitor GW4869.
267 higher level of ALPs are more susceptible to inhibition by the phosphorylated D-tetrapeptides; the pr
268 and indicate that the catalyst is subject to inhibition by the product of the chloroacylation reactio
269 r cellular entry and are thus susceptible to inhibition by the same antivirals and cellular defenses.
270 f KCNQ1 was limited to 40% at +40 mV vs. 80% inhibition by the shorter form, and augmentation of KCNQ
273 he immune system with the combination of IDO inhibition by the small-molecule immunotherapy agent and
274 d the responses of these channel variants to inhibition by the sulfonylurea drug glibenclamide, a pot
275 ated rare variant (M2145T) in TGEF2 impaired inhibition by the TGEF2 pleckstrin-homology domain, resu
276 tablish the structural basis of differential inhibition by the widely used Wee1 inhibitor MK-1775.
278 find that Mtb's ETC rapidly reroutes around inhibition by these drugs and increases total respiratio
280 ght on the mechanism of thrombin binding and inhibition by this family of salivary anticoagulants fro
285 n viral replication, sensitivity to mutagen, inhibition by type I interferon (IFN), and translation e
287 nism through which pCPI-17 and MLCP interact inhibition by unfair competition: MLCP protects pCPI-17
289 to investigate the effect of single TLR4-MD2 inhibition by using eritoran, compared with the effect o
291 nhibition of Bcl-xL with ABT737 or molecular inhibition by using the D61A and D76A Bcl-xL mutant lead
296 We found that the probability of ribosome inhibition by viomycin depends on competition between vi
298 posite roles in GSK3beta phosphorylation and inhibition, by which mTORC2 and pAKT-S473 negatively reg
299 kinase M zeta (PKMzeta), mainly because its inhibition by zeta inhibitory peptide (ZIP) interferes w
300 nvestigated the effect of pharmacologic 5-LO inhibition by zileuton and LTB4 inhibition by CP-105,696
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