ライフサイエンスコーパス: inhibition of

1 splayed a similar decrease (30%) in IC50 for inhibition of [(3)H]DA uptake by cocaine in WT hDAT.

2 as modification of actin polymerization and inhibition of a broad range of actin-dependent functions

3 d dopamine release, suggesting that feedback inhibition of acetylcholine release was not involved.

4 Moderate inhibition of acetylcholinesterase by extracts of all in

5 n vitro, which is blocked by pharmacological inhibition of acid sphingomyelinase.

6 actin regulates microtubule organization as inhibition of actin polymerization with a low dose of la

7 cell death protein ligand 1 (PD-L1)-mediated inhibition of activated PD-1(+) T lymphocytes plays a ma

8 However, both inhibition of adenylate cyclase A (ACA) with SQ22536 and

9 SPGs are required for Nogo-A-Delta20-induced inhibition of adhesion, cell spreading, and neurite outg

10 SiRNA knockdown of integrin beta3 and inhibition of Akt activity significantly abolished plate

11 ondingly, sestrin deficiency or simultaneous inhibition of all three MAPKs enhanced vaccine responsiv

12 tantly, insulin prevented the AbetaO-induced inhibition of AMPK.

13 esses FAO through direct phosphorylation and inhibition of AMPKalpha2.

14 ompromising host defenses, pathogen-mediated inhibition of anorexia increased host survival.

15 jection, providing biochemical evidence that inhibition of apoptotic activity by the Diap1 gene produ

16 ndicated activation of caspase proteases and inhibition of arginine-specific proteases.

17 Genetic ablation and selective pharmacologic inhibition of ASIC1a reduces neuronal death following is

18 Rather, inhibition of ATP synthesis caused massive spontaneous v

19 duction of IBTKalpha and the UPR, along with inhibition of autophagic flux, was associated with progr

20 es and induced podocyte apoptosis, while the inhibition of autophagy by chloroquine (CQ) enhanced pal

21 We found that inhibition of autophagy by knocking down the core autoph

22 mice via alteration of mTORC1 signaling and inhibition of Bcl6 expression.

23 Inhibition of BET bromodomain proteins attenuated NF-kap

24 plicate selected experiments from the paper "Inhibition of BET recruitment to chromatin as an effecti

25 We show that brief optogenetic inhibition of BLA neurons around moments of aversive rei

26 ying pathophysiology is not well understood, inhibition of bladder sensory afferents temporarily reli

27 ion activates the PARP pathway in vivo, thus inhibition of both AR and PARP is required for effective

28 K exerts its anti-tumor activity through the inhibition of c-Met-Ras-HO-1 axis; and it can have signi

29 Inhibition of c-Myc mimicked the effects of severe hypox

30 We therefore conclude that inhibition of C5 cleavage during the bacteremic stage of

31 he dendritic shaft of neurons, triggering an inhibition of calcium signaling.

32 in-dependent kinase 2 (CaMKII) and also that inhibition of CaMKII abolishes 8-pCPT-AM-induced increas

33 In cultured H9c2 myoblasts, pharmacological inhibition of cathepsin K, or treatment with calcineurin

34 Finally, inhibition of CCK neurons mimics the antidepressant beha

35 The inhibition of CD4(+) T cells is dependent on TGF-beta, w

36 +) T cells is dependent on TGF-beta, whereas inhibition of CD8(+) T cells is dependent on TGF-beta an

37 ndergo cell death and tumour regression upon inhibition of CDK4 and CDK6.

38 Selective inhibition of cell adhesion, wound healing, and invasion

39 ocessing, apoptosis, and caspase-2-dependent inhibition of cell growth, demonstrating that the NPM1-d

40 ne up-regulated gene 1 (TUG1) induces marked inhibition of cell migration, invasion, and glycolysis t

41 12 was able to cause concentration-dependent inhibition of cell proliferation, yielding an IC50 value

42 Our results indicate that HIV-1 Nef-mediated inhibition of cellular PQC is one possible mechanism inv

43 In cells, pharmacologic inhibition of ceramide synthase reduced lipid accumulati

44 Inhibition of CEs significantly modulates the efficacy o

45 Inhibition of chaperone expression, autophagy or the pro

46 n of the loops and facilitating the feedback inhibition of cholesterol synthesis.

47 The inhibition of cholesteryl ester transfer protein (CETP)

48 In contrast, inhibition of CIN firing with the mu/delta selective opi

49 Importantly, dual inhibition of CK1alpha and the proteasome synergisticall

50 Thus, inhibition of Clks might become a novel anticancer strat

51 tabilizing substitutions compromise the full inhibition of contraction in the relaxed state.

52 Inhibition of cortisol signaling in males, or increase o

53 These findings demonstrate that the inhibition of COX-2 suppresses vasculogenesis in endomet

54 osomes into the cytosol, suggesting that the inhibition of cross-presentation was not related to eith

55 The pharmacological inhibition of CYP4A reduced lung pre-metastatic niche fo

56 Suppression of NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis

57 r these points describes the linkage between inhibition of cytochrome P450 19A aromatase (the MIE) an

58 tin ligase complex) is not essential for the inhibition of cytokine-induced JAK/STAT signalling activ

59 blastoma (Rb) and may, therefore, respond to inhibition of D-cyclin-dependent Rb kinases, CDK4 and CD

60 uclei, is believed to underlie the transient inhibition of DA neurons attributed to activation of the

61 restingly, DDR2 knockdown or pharmacological inhibition of DDR2 also inhibited the MT1-MMP-dependent

62 etrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis.

63 he concentration of FAEs and ECs through the inhibition of degrading enzymes has been considered to b

64 model, suggesting the importance of systemic inhibition of DGAT1 for body weight control.

65 These properties may contribute to inhibition of distinct NMDAR subpopulations by memantine

66 Inhibition of DNA methylation triggers changes in the hi

67 megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors

68 The direct inhibition of downstream components of innate immune pat

69 (high) macrophages is strongly suppressed by inhibition of dynamin.

70 nd they show different susceptibility to the inhibition of early and immediate early viral gene expre

71 timicrobial resistance is represented by the inhibition of efflux pumps.

72 Genetic or pharmacologic inhibition of EGFR tyrosine kinase activity or downstrea

73 Pharmacological and genetic inhibition of either mitophagy or glycolysis consistentl

74 ulated in GBM patient tumors, and functional inhibition of either protein or BRD4 in in vitro and in

75 and synergism of all possible combinatorial inhibitions of eleven currently targetable kinases in th

76 Furthermore, the inhibition of EMT prevented the generation of myofibrobl

77 Here, we report that silencing or inhibition of endogenous TAK1 in hepatoma cell lines lea

78 ger quantity of PPO at pH 4.00 and offers an inhibition of enzymatic activity close the 50% in apple

79 suggest that DUSP5 functions in the feedback inhibition of ERK1/2 signaling in response to TNFalpha,

80 eration of cSCC cells and resulted in potent inhibition of extracellular signal-regulated kinase 1/2

81 Inhibition of FAO by re-purposing existing drugs approve

82 Inhibition of FAS resulted in decreased production of ex

83 ed here using isolated squid axoplasm reveal inhibition of FAT as a common toxic effect elicited by s

84 increase in gemcitabine responsiveness upon inhibition of fatty acid biosynthesis with orlistat.

85 und that partial genetic and pharmacological inhibition of fatty acid synthase (FASN) suppresses toxi

86 Restoration of pyruvate production or inhibition of fatty acid synthesis corrected the tissue-

87 This result was true for the inhibition of FcgammaR signaling as well.

88 lated the same intermediate, suggesting that inhibition of Fe-S cluster synthesis is the primary caus

89 Impaired inhibition of fear or behavioral responses is thought to

90 nhances complement activation by competitive inhibition of FH binding to some surfaces and immune pro

91 ndings establish a new modality for covalent inhibition of fibril formation and illuminate a path for

92 Inhibition of focal adhesion kinase (FAK) rescued SERT f

93 d NDI-010976 exposure was observed with >90% inhibition of fractional DNL associated with plasma conc

94 thrombin or FXa also enhanced TFPI-mediated inhibition of FXa approximately 12-fold in the presence

95 ompanied by release of soluble BCMA (sBCMA); inhibition of gamma-secretase enhanced surface expressio

96 Inhibition of GAP-43 expression by shRNA significantly r

97 or C57BL/6 mice (controls), with or without inhibition of gastric acid by omeprazole.

98 nding site parameters and mechanism of P-CAB inhibition of gastric acid secretion.

99 initiation factor 2 (eIF2alpha) resulting in inhibition of general protein synthesis.

100 H3 lysine 27 trimethylation (H3K27me3), and inhibition of genes related to epithelial-to-mesenchymal

101 ing FOXO1-dependent activation of G6pase and inhibition of glucokinase, respectively.

102 Inhibition of glutamine metabolism in ECs did not cause

103 xposure to low levels of oxidants or genetic inhibition of glycogen synthase depletes glycogen stores

104 et of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3beta (GSK3beta).

105 n, while mutation of target serines and drug inhibition of GSK-3 activity coordinately induce both fo

106 hat dynein is a GSK-3beta substrate and that inhibition of GSK-3beta promotes dynein-dependent transp

107 All four compounds showed potent inhibition of HDAC1-3 as well as significant inhibition

108 We show that inhibition of HDAC6 activity significantly increases CD2

109 In vivo, pharmacological inhibition of HDAC6 improved established PAH in two expe

110 inhibition of HDAC1-3 as well as significant inhibition of HDAC6 with IC50 values in the submicromola

111 -related growth deficits can be improved via inhibition of HDAC6, further implicating it as a potenti

112 specific antagonist that caused a pronounced inhibition of HDM-induced airway inflammation and goblet

113 Inhibition of hepatic mTOR in Am mice increased hepatic

114 ed with the overexpression of HIFs, specific inhibition of HIFs might represent a new powerful treatm

115 partly account for fremanezumab's selective inhibition of high-threshold, as a result of a predomina

116 ass-I APM is due to histone deacetylation as inhibition of histone deacetylases (HDACs) not only indu

117 y antagonize infection with cell-free virus, inhibition of HIV-1 transmission from infected to uninfe

118 Inhibition of Hsp104 function in yeast cells leads to a

119 n in SKMEL28 human melanoma cells, following inhibition of Hsp90 and BRAF signaling using 17-AAG and

120 vated protein kinase, leading to synergistic inhibition of human leukemia cell viability.

121 -inflammatory activation by LPS, through the inhibition of Iba1 expression, TNF-alpha release and NO

122 for the important viral gene activator ICP0, inhibition of ICP0 expression by miR-H2 has been a major

123 ve activity, promoting: (i) early correlated inhibition of IFN-gamma and TNF-alpha production, along

124 IGF-1-induced chemotaxis in association with inhibition of IGF1R phosphorylation, suppression of Rac1

125 Pharmacological inhibition of IL-1R activation by Anakinra corrects tran

126 We observed similar inhibition of il27p28 expression in vivo in splenic DC f

127 Inhibition of ILK signaling, which is involved in cell m

128 Selective inhibition of individual ligands revealed that this sign

129 However, this can be reversed by inhibition of inflammatory cytokine production that can

130 that IKKepsilon is crucial for SPL-mediated inhibition of influenza virus replication.

131 the effect of MMB is not mediated by direct inhibition of JAK2-mediated ferroportin (FPN1) degradati

132 tervention and ion replacement, we show that inhibition of K(+) transport abolishes RBC electrophysio

133 Inhibition of KCC2 activity in clonal MIN6 beta-cells in

134 Inhibition of KLK5-mediated effects may offer potential

135 n 7 (KLK7) are heparin-binding proteins, and inhibition of KLK7 by vaspin is accelerated by heparin.

136 Inhibition of Kv may provide a mechanism to enhance the

137 , biochemical, and functional studies on the inhibition of Lactococcus lactis PC (LlPC) by c-di-AMP.

138 one A-ring backbone are essential for potent inhibition of LasR/RhlR.

139 Inhibition of LDH activity by small hairpin ribonucleic

140 7 deficiency resolved plaque inflammation by inhibition of lesional inflammasome activation and reduc

141 BAA receptors was responsible for the direct inhibition of light-evoked spike responses, the slow inh

142 omenological cell behaviors, such as contact inhibition of locomotion and force-induced cell repolari

143 e explain how cells characterized by contact inhibition of locomotion can display coherent collective

144 Inhibition of locomotion was independent of measures of

145 HIF-1 Conversely, silencing or pharmacologic inhibition of LOX activity blocked dissemination of colo

146 ding to LRP6 in in vitro binding assays, and inhibition of LRP6 or critical signaling cascades downst

147 17 beta-estradiol (E2) resulted in monotonic inhibition of mammary buds ductal growth.

148 ry effect of F4 was not mediated through the inhibition of MAPKs and NF-kappaB activation but was med

149 Further, inhibition of MARKs led to increased pathological alpha-

150 (MGDG) in the plastid via posttranslational inhibition of MGDG synthase enzymatic activity by NO.

151 In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD).

152 Inhibition of miR-142-3p could be neuroprotective in MS.

153 Inhibition of miR-204 protects against tunicamycin-induc

154 ing induced by metformin was reversed by the inhibition of mitochondrial calcium uniporter (MCU).

155 Mechanistically, inhibition of mitochondrial function increased autophagy

156 uclear localization of TFPI-2 contributed to inhibition of MMP-2 mRNA expression, which could be reve

157 emical studies to elucidate the mechanism of inhibition of MMP9 by GS-5745.

158 rial compounds; however, evidence for direct inhibition of MmpL3 activity is also lacking.

159 inductions of Na(+)K(+)/ATPases, and strong inhibitions of molt-related proteins such as chitinase a

160 o cell death, over-acetylated tubulin led to inhibition of motility and mitosis.

161 Inhibition of MRE11 nuclease activity increased DNA dama

162 ediated synaptotoxicity and demonstrate that inhibition of MT dynamics and accumulation of PTMs are d

163 Pharmacological inhibition of mTOR signaling resulted in phosphorylation

164 Inhibition of mTOR strongly reduced the lysosomal efflux

165 Inhibition of mTORC1 with rapamycin induces PIM3 transcr

166 , by individual and combined pharmacological inhibition of muscarinic and/or beta-adrenergic receptor

167 ddition, induction of a dormant state by the inhibition of MYC, resembling diapause, requires the pre

168 The library was evaluated for inhibition of Mycobacterium tuberculosis (Mtb) growth an

169 g the rho pathway rather than through direct inhibition of myosin.

170 with planktonic organisms, and pharmacologic inhibition of NADPH-oxidase partially impairs NET produc

171 ether, our data suggest that pharmacological inhibition of necroptosis with Nec-1s stabilizes pre-exi

172 Inversely, inhibition of NEDDylation by MLN4924 blocked proinflamma

173 Either genetic knockdown of p62 or inhibition of NF-kappaB sensitized tumor cells to CQ, re

174 D(+) synthesis in response to FK866-mediated inhibition of nicotinamide phosphoribosyltransferase and

175 Pharmacological inhibition of NLRP3 inflammasome activation may offer a

176 creted nitric oxide after Mtb infection, and inhibition of NO by N(G)-monomethyl-L-arginine enhanced

177 an antioxidant, mitochondrial inhibitors, or inhibition of NO formation.

178 innervate the brainstem to drive feedforward inhibition of nociceptive neurons.

179 20% and 22% with increasing shear stress and inhibition of non-muscle myosin II motors, respectively.

180 Inhibition of NOS2 and COX2 using amino-guanidine and as

181 d primary tumor-derived cells resulted in an inhibition of Notch signaling that was more potent than

182 Inhibition of NPM1 impairs caspase-2 processing, apoptos

183 neurobiology of NRG3 isoforms and highlight inhibition of NRG3 signaling as a potential target for p

184 re, selective blockade of interleukin-23 via inhibition of p19 might be a viable therapeutic approach

185 C6 or Orai1 channels and caused only a minor inhibition of P2X1-dependent Ca(2+) entry.

186 eas a non-phosphorylatable S561A mutation or inhibition of Par1 kinase activity decreases SH3-GK inte

187 or of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a sim

188 of the glycine receptor properties mediating inhibition of parvalbumin neurons, as well as single cha

189 Optogenetic inhibition of PBel(CGRP) terminals identified a network

190 Optogenetic inhibition of pBNST CRFR2 neurons yielded opposite effec

191 We further demonstrate that inhibition of PDE2A, by enhancing the hormone-dependent

192 B and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 woul

193 almost completely blocked by pharmacological inhibition of phosphorylation of Akt.

194 Inhibition of PI3K-dependent exocytosis of TRPC6 is thou

195 , Ru-thio-chrysin displayed a 4-fold greater inhibition of platelet function and thrombus formation i

196 Inhibition of PLCgamma/PKC-induced mTOR activation impai

197 a detailed picture of how this pH-dependent inhibition of PME occurs at the molecular level is missi

198 rs could help unveil the mechanisms by which inhibition of poly(ADP-ribose) polymerases (PARPs) elici

199 hallenges in achieving effective, persistent inhibition of polymerization of hemoglobin S.

200 Phosphorylation by PKA also acts to prevent inhibition of PP2A by ARPP-16 phosphorylated by MAST3.

201 Finally, we observed that pharmacological inhibition of PPARgamma is therapeutically effective in

202 The pharmacological inhibition of PPP canceled the UCHL1-mediated radioresis

203 Selective inhibition of PRDX6 blocks Galphai depalmitoylation, pre

204 n and omega-conotoxin-MVIIC, consistent with inhibition of presynaptic TRPV1 channels by alpha2 adren

205 polar-lipid, and specifically phospholipid, inhibition of prion-seeded amyloid formation highlight t

206 Additionally, prediction analysis showed inhibition of proinflammatory regulators and activation

207 e TKI nilotinib (NIL) significantly enhanced inhibition of proliferation and colony-forming potential

208 -mediated activation of protein kinase A and inhibition of Protein kinase B (AKT).

209 crophages in kidneys of mice with GN and the inhibition of proteinuria by anti-PD-L1 mAb supported th

210 Hydroxytyrosol induced a shift toward inhibition of proteolysis in endothelial cells, with dec

211 However, inhibition of PV(+) cells in either CA1 or mPFC eliminat

212 Post-CFC inhibition of PV+ interneurons blocks fear memory consol

213 Inhibition of Pxn phosphorylation with saracatinib in th

214 Inhibition of RAF kinases can induce a dose-dependent "p

215 Inhibition of Ras nucleotide exchange is a promising new

216 Another function of Doc2B - inhibition of release during sustained calcium elevation

217 Genetic, physiological, or chemical inhibition of respiratory processes elicited increased b

218 Inhibition of Rho-associated kinase (ROCK) prevented cyt

219 Targeted inhibition of Rho-associated kinase (ROCK)2 downregulate

220 ke receptor (RLR) signaling pathway involves inhibition of RIG-I K63-linked polyubiquitination and th

221 ain circuitries previously implicated in the inhibition of risky behavior and impulsiveness, emotiona

222 The destabilization was rescued by inhibition of ROCK and histone deacetylase 6 but not by

223 ed resistance to 2,4-D compared with IAA for inhibition of root growth, were also found to have less

224 : A tonically active, muscarinic cholinergic inhibition of rostral raphe pallidus (rRPa) neurons infl

225 Pharmacological inhibition of Rpn11 with O-phenanthroline (OPA) blocks c

226 ucose deprivation, which could be rescued by inhibition of rRNA processing or ER stress.

227 xamined the neural pathways activated during inhibition of sexual behavior in male rats and the effec

228 Inhibition of SFKs using PP2 blocked BDNF-mediated phosp

229 Inhibition of signaling after ligand exposure selectivel

230 ed SIRT1/LC3B expression, whereas adjunctive inhibition of SIRT1 signaling diminished HO-1-mediated h

231 on of TRAF1 in mice results in a significant inhibition of skin tumor formation.

232 Furthermore, selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-

233 ed enkephalin- and GABA-mediated presynaptic inhibition of somatosensory neurons.

234 on of light-evoked spike responses, the slow inhibition of spiking activity required the activation o

235 Genetic or pharmacological inhibition of SRPK2 blunts de novo lipid synthesis, ther

236 n important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelia

237 Furthermore, in vivo inhibition of STAT6 phosphorylation restores Notch1 expr

238 These effects translated into inhibition of superantigen-induced Th1 cell recruitment.

239 NgR1-3) acts as Abeta receptors mediating an inhibition of synapse assembly, plasticity, and learning

240 Selective inhibition of T-channels and global deletion of CaV 3.1

241 Inhibition of targetable proteins associated with drug r

242 VMH-specific inhibition of TBK-1 in mice with diet-induced obesity im

243 ker gene transcription and, consequently, in inhibition of TGF-beta/Smad3-mediated SMC differentiatio

244 n of the ergosterol biosynthetic pathway via inhibition of the 14alpha-demethylase enzyme present in

245 uppress autoimmune responses in vivo through inhibition of the autophagic machinery in DCs in a cytot

246 Here we show that optogenetic inhibition of the BLA has opposite effects on choice beh

247 de-sensitive guanylyl cyclase activation and inhibition of the cGMP-degrading phosphodiesterase-5, is

248 Thus, inhibition of the coactivation-function of Stat3 resulte

249 Inhibition of the conversion of glutamate to alpha-ketog

250 s prevented by genetic deletion of Slc6a2 or inhibition of the encoded transporter.

251 l potency to lineage priming is prevented by inhibition of the FGF/MAPK signalling pathway.

252 Silencing or acute inhibition of the formin mDia1 suppresses these activiti

253 Additionally, inhibition of the H3K27 demethylase JMJD3 in naive CD4 T

254 show that this fusion event is prevented by inhibition of the IKKbeta2 kinase, however, neither a ph

255 Inhibition of the insulin-like growth factor I receptor

256 e considerations regarding the mechanisms of inhibition of the lipid peroxidation in micelles, in vie

257 Inhibition of the mechanotransductive pathways abrogated

258 t mouse brains, we find an acute and chronic inhibition of the molecular clearance of protein product

259 The current study examined whether inhibition of the neurokinin-1 receptor with a specific

260 , we show here that, besides its role in the inhibition of the NF-kappaB pathway, NLRC3 interferes wi

261 ect of ILT3.Fc on tumor cell growth involves inhibition of the p70S6K signaling pathway.

262 nd Yes-associated protein (YAP) proteins via inhibition of the phosphatidylinositol 3 kinase/protein

263 n directly activated by cAMP (Epac) provokes inhibition of the phospholipase C by an as yet unknown m

264 further decreases in ubiquitin production by inhibition of the polyubiquitin gene UBC.

265 Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAK(SLMAP) as a key m

266 We predict that inhibition of the proposed static cross-linker will prod

267 We show that stimulation of OXPHOS, inhibition of the PTP, or deletion of CypD increased hig

268 d promiscuous mechanisms of action including inhibition of the QcrB subunit of the cytochrome bc1 com

269 ther experiments suggested that NS1-mediated inhibition of the RIG-I-like receptor (RLR) signaling pa

270 Inhibition of the sarcoendoplasmic reticulum calcium tra

271 trophy was associated with both the complete inhibition of the Smad2/3 pathway and activation of the

272 treatment of cancer and might be overcome by inhibition of the transporter.

273 electron transfer, was indicated by specific inhibition of their activity that fully stopped iron-cou

274 ain acyl-CoA dehydrogenase activity and that inhibition of this axis results in suppression of tumour

275 to consider for obtaining potent cell-based inhibition of this cancer metabolism target.

276 for the pro-metastatic effect of MSCs since inhibition of this chemotaxis abolished increased neutro

277 Inhibition of this reductive pathway prevents the correc

278 TNBS-induced colitis, at least in part, via inhibition of TLR4/MyD88 signaling cascade as well as in

279 Inhibition of TNFR signaling prevented the induced expre

280 y influence clinical response to therapeutic inhibition of tonic BCR signaling in DLBCL.

281 a genome-wide approach, we demonstrate that inhibition of transcription is the primary mechanism for

282 res: a reference protein and a gene-specific inhibition of translation.

283 ading to enhanced degradation of the mRNA or inhibition of translation.

284 This induces a tonic inhibition of transmission at direct pathway synapses an

285 ing soluble CD40 agonist and pharmacological inhibition of Trx-1 was functionally equivalent to the s

286 histochemical analysis demonstrated that the inhibition of tumor growth and metastasis was associated

287 C-derived xenografts resulted in significant inhibition of tumor progression in early and late-stage

288 ation of RIPK1, RIPK3, TRIF and ZBP1/DAI and inhibition of tumour necrosis factor (TNF), lipopolysacc

289 Inhibition of type 4 phosphodiesterase (PDE4) and elevat

290 e to modulation of host responses, including inhibition of type I interferon responses, suppression o

291 ary, absence of D2S but not D2L prevents the inhibition of tyrosine hydroxylase phosphorylation and,

292 For example, the inhibition of ubiquitin-specific protease 7 (USP7) resul

293 Inhibition of ubiquitination with small molecules also s

294 Inhibition of uPA expression in Tsc2-null cells reduced

295 ssed by a fluorescence-based assay measuring inhibition of UTP-induced intracellular calcium release

296 s no significant difference in the levels of inhibition of UVB-induced immunosuppression amongst mice

297 These effects were not mimicked by selective inhibition of VEGFR2 despite equivalent vascular pruning

298 f different primary isolates of HIV-1 to the inhibition of viral infectivity by IFITMs.

299 Thus, we evaluated inhibition of virulence in P. aeruginosa by a designed p

300 es to uncontrolled cSCC growth by preventing inhibition of YAP/WBP2.