ライフサイエンスコーパス: inhibition of apoptosis

1 wn-regulation of inflammatory mediators, and inhibition of apoptosis.

2 hroid progenitors in the bone marrow through inhibition of apoptosis.

3 important effect of HBx activation of AKT is inhibition of apoptosis.

4 activity that contributed to Op-IAP-mediated inhibition of apoptosis.

5 This resistance may be in part due to inhibition of apoptosis.

6 e of this activated pathway is the transient inhibition of apoptosis.

7 st cell death 1 as well as a reversal of the inhibition of apoptosis.

8 gets, leading to altered cell metabolism and inhibition of apoptosis.

9 sulted in maintenance of BCL2 expression and inhibition of apoptosis.

10 eonatal lung from acute hyperoxic injury via inhibition of apoptosis.

11 le of the NF-kappaB signaling pathway in the inhibition of apoptosis.

12 ll (HSC) phenotype by both proliferation and inhibition of apoptosis.

13 dentify the default death resulting from the inhibition of apoptosis.

14 es induced by ischemia or 6-OHDA through the inhibition of apoptosis.

15 n resulted in mutation-specific and variable inhibition of apoptosis.

16 eral stages of tumour development, including inhibition of apoptosis.

17 CMV MIEPs can activate Akt, resulting in the inhibition of apoptosis.

18 hatidylinositol 3-kinase (PI3K)/Akt-mediated inhibition of apoptosis.

19 activation and myelin degradation as well as inhibition of apoptosis.

20 activator of the PI3K/AKT pathway leading to inhibition of apoptosis.

21 ration, monocyte adhesion, angiogenesis, and inhibition of apoptosis.

22 decrease of c-FLIP(L) expression results in inhibition of apoptosis.

23 ization of cellular calcium homeostasis, and inhibition of apoptosis.

24 to require both increased proliferation and inhibition of apoptosis.

25 ith CAML is required for its function in the inhibition of apoptosis.

26 tion by interleukin-1 (IL-1), contributes to inhibition of apoptosis.

27 lpha (TGF-alpha)-dependent cell recovery and inhibition of apoptosis.

28 ediate mitogenesis, cell transformation, and inhibition of apoptosis.

29 osphorylation of Akt, a key event leading to inhibition of apoptosis.

30 coordinated promotion of cell migration and inhibition of apoptosis.

31 urea and creatinine that were not altered by inhibition of apoptosis.

32 sociated previously with cell growth and the inhibition of apoptosis.

33 tion of cyclin D1, was also required for the inhibition of apoptosis.

34 ted and result in cellular proliferation and inhibition of apoptosis.

35 o-caspase-9 as a new target for IAP-mediated inhibition of apoptosis.

36 system, cell signaling, immune function and inhibition of apoptosis.

37 acity of MEQ-transformed Rat-2 cells through inhibition of apoptosis.

38 ressor function, cellular proliferation, and inhibition of apoptosis.

39 agonized both SCF-mediated proliferation and inhibition of apoptosis.

40 on of GATA-1 had no detectable effect on Epo inhibition of apoptosis.

41 ell proliferation by IGF-1, but rather to an inhibition of apoptosis.

42 , even though it abrogated the IGF-I-induced inhibition of apoptosis.

43 bcl-2, an oncogene with known potential for inhibition of apoptosis.

44 rst data associating TAM resistance with the inhibition of apoptosis.

45 by promoting pre-adipocyte proliferation and inhibition of apoptosis.

46 of genes implicated in both stimulation and inhibition of apoptosis.

47 cogene in many tumors, primarily through the inhibition of apoptosis.

48 nitric-oxide synthase (eNOS) expression, and inhibition of apoptosis.

49 -stimulated AKT Thr(308) phosphorylation and inhibition of apoptosis.

50 inhibiting Chk1 activation with concomitant inhibition of apoptosis.

51 rough accelerated cellular proliferation and inhibition of apoptosis.

52 absence of this microRNA by dorsal-specific inhibition of apoptosis.

53 ent activation of beta-catenin signaling and inhibition of apoptosis.

54 gene products and may be associated with the inhibition of apoptosis.

55 RNA processing, growth factor recycling, and inhibition of apoptosis.

56 emotaxis, stress response, angiogenesis, and inhibition of apoptosis.

57 IL-6, which enhances tumor growth in vivo by inhibition of apoptosis.

58 These results suggest myocardial salvage by inhibition of apoptosis.

59 ting other cellular processes in addition to inhibition of apoptosis.

60 fluidity, promotion of neurite extension and inhibition of apoptosis.

61 maintenance of cellular viability in part by inhibition of apoptosis.

62 ected zymogen procaspase 3, concomitant with inhibition of apoptosis.

63 up-regulation of antiapoptotic Bcl(xL), and inhibition of apoptosis.

64 proteins and contribute to commitment to or inhibition of apoptosis.

65 E-BP1, leading to cell cycle progression and inhibition of apoptosis.

66 angiogenesis through the decline of TSP1 and inhibition of apoptosis.

67 ent via its stimulation of proliferation and inhibition of apoptosis.

68 , 9%; P = 0.009) that was associated with an inhibition of apoptosis.

69 e changes in the integrin signaling pathway, inhibition of apoptosis, acquisition of tumorigenic cell

70 In addition to the inhibition of apoptosis, activation of either the CSF1R/

71 ent phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2.

72 nes associated with cell cycle induction and inhibition of apoptosis, alters the expression of genes

73 3-kinase (PI 3-kinase) is essential for the inhibition of apoptosis, although this enzyme does not b

74 It can further prevent inhibition of apoptosis and allow cells to survive nutri

75 The possibilities are also discussed that inhibition of apoptosis and altered adhesive properties

76 TIPRL, such as regulation of mTOR signaling, inhibition of apoptosis and biogenesis and recycling of

77 This pro-survival function involves inhibition of apoptosis and caspase activation.

78 This was achieved in part through inhibition of apoptosis and caspase cleavage.

79 me c release occurred in association with an inhibition of apoptosis and caspase-3-like activation.

80 le progression but reduced estrogen-mediated inhibition of apoptosis and cell growth.

81 e relationship between LFG and Bcl-XL in the inhibition of apoptosis and found that LFG protects only

82 ivity of the p38 MAPK, provided only partial inhibition of apoptosis and had no effect on necrosis.

83 lular thioredoxin has been implicated in the inhibition of apoptosis and in a decrease in the sensiti

84 terotetramer, thus resulting in irreversible inhibition of apoptosis and inflammation.

85 combinant human activated protein C, such as inhibition of apoptosis and leukocyte recruitment, remai

86 The inhibition of apoptosis and maintenance of cell function

87 Persistent infection can be a by-product of inhibition of apoptosis and may significantly impact the

88 Pharmacological and genetic inhibition of apoptosis and necrosis lessens infarct siz

89 s, our data suggest that CK2 participates in inhibition of apoptosis and negatively regulates caspase

90 MAPKK function is necessary for optimal IL-3 inhibition of apoptosis and optimal IL-3 stimulation of

91 uctural basis for a dual role of survivin in inhibition of apoptosis and regulation of cell division.

92 t of impaired akt2 expression results in the inhibition of apoptosis and rescue of the morphant embry

93 ation by other mechanisms than BCL2-mediated inhibition of apoptosis and suggesting a shared biologic

94 lts of more complex mapping studies in which inhibition of apoptosis and the enhanced spontaneous rea

95 n of maintenance of proliferation potential, inhibition of apoptosis, and blocking of differentiation

96 AKT/PKB is implicated in the inhibition of apoptosis, and cell lines and tumors with

97 upregulation of survivin was associated with inhibition of apoptosis, and downregulation of survivin

98 expression of genes involved in cell growth, inhibition of apoptosis, and embryogenesis and by increa

99 effects are accompanied by the p38-mediated inhibition of apoptosis, and if so, what signaling pathw

100 cers (CRCs) frequently display APC mutation, inhibition of apoptosis, and increased expression of the

101 and ERK, is crucial for cell proliferation, inhibition of apoptosis, and migration of cells.

102 ement of Msi-1 in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, sugges

103 volve the reduction of oxidative stress, the inhibition of apoptosis, and possibly the maintenance of

104 e activation of the survival signal PKB/Akt, inhibition of apoptosis, and promotion of cell cycle pro

105 omains, mediated phosphorylation of PKB/akt, inhibition of apoptosis, and replication of 32DIR cells

106 10 expression in B-cell NHL and, through the inhibition of apoptosis, appears responsible for the neg

107 therapies designed to ameliorate disease by inhibition of apoptosis are more likely to succeed in MD

108 st that domains of the receptor required for inhibition of apoptosis are necessary but not sufficient

109 ell cycle checkpoint in combination with the inhibition of apoptosis are two principal requirements f

110 Despite its stability and effect on the inhibition of apoptosis, arginine GlcNAcylation did not

111 t VDAC1 oligomerization, concomitant with an inhibition of apoptosis as induced by various means and

112 gnaling, stimulation of cellular growth, and inhibition of apoptosis as well as transformation of cel

113 of 3-aminobenzamide cannot be attributed to inhibition of apoptosis, as apoptotic parameters (caspas

114 SF/HGF occurred at least in part through an inhibition of apoptosis, as evidenced by diminished term

115 B. henselae-mediated inhibition of apoptosis, as indicated by gene expression

116 Sustained inhibition of apoptosis at 72 h was seen only with R1881

117 ease in cell proliferation and a significant inhibition of apoptosis at day 4 after injury compared t

118 Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of

119 ontributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immun

120 ficantly improved cellular viability through inhibition of apoptosis but had minimal effect on hypoxi

121 in with essential roles in cell division and inhibition of apoptosis, but the molecular underpinnings

122 ent of caspases was confirmed by significant inhibition of apoptosis by a caspase inhibitor, and by d

123 By contrast inhibition of apoptosis by anti-CD40 occurs even though

124 ntrast, upregulation of Bcl-2 expression and inhibition of apoptosis by Brn-3a is antagonized more by

125 It is likely that inhibition of apoptosis by C. burnetii represents an imp

126 o reduced 65 to 69% by aLLN, indicating that inhibition of apoptosis by calpain inhibitors is indepen

127 Reduced levels of CARP-1 result in inhibition of apoptosis by CD437 or adriamycin, whereas

128 The inhibition of apoptosis by COX-2 was concomitant with pr

129 s directly demonstrating that the targets of inhibition of apoptosis by CrmA and Bcl-2 are upstream o

130 with E1A conserved regions (CR) 1 and 2, and inhibition of apoptosis by E1B proteins are required for

131 tisense-dependent depletion of CARP-1 causes inhibition of apoptosis by ERRP.

132 Rather than promoting inflammation, inhibition of apoptosis by expression of the Bcl-X(L) pr

133 role in the pathogenesis of asthma with the inhibition of apoptosis by GM-CSF and IL-5 proposed as a

134 Inhibition of apoptosis by HSV was accompanied by marked

135 In contrast, inhibition of apoptosis by IGF-1 in DiFi cells was sensi

136 The inhibition of apoptosis by IGF-I is believed to be parti

137 In summary, inhibition of apoptosis by Nef can lead to persistence o

138 Inhibition of apoptosis by NMDA was blocked by the phosp

139 We postulated that the mechanism of the inhibition of apoptosis by NO would include an effect on

140 The mechanism of inhibition of apoptosis by Nr13 is likely to involve a c

141 Inhibition of apoptosis by overexpression of the insulin

142 The inhibition of apoptosis by Pgp was associated, however,

143 In our previous study, we established that inhibition of apoptosis by the general caspase inhibitor

144 caspase cleavages, electron microscopy, and inhibition of apoptosis by the pancaspase inhibitor qVD-

145 nces were required for kinase activation and inhibition of apoptosis by transfecting wild-type (AT1Rw

146 rsion rate of benign tumors, suggesting that inhibition of apoptosis can contribute to tumor progress

147 Conversely, inhibition of apoptosis can lead to the development of a

148 Here, we address whether transient inhibition of apoptosis can serve as a safe but efficien

149 tributable to stimulation of cell growth and inhibition of apoptosis caused by serum starvation.

150 ells cultured in the presence of zinc showed inhibition of apoptosis coincident with a marked increas

151 Within these cells, EBV-mediated inhibition of apoptosis correlates with an up-regulation

152 infected cells as part of the "lethal hit," inhibition of apoptosis could represent an effective imm

153 ocardium participate in survival mechanisms (inhibition of apoptosis, cytoprotection, cell growth, an

154 In embryos, however, inhibition of apoptosis decreases the length of the noto

155 Y294002 and PD98059 did not produce additive inhibition of apoptosis delay.

156 a direct link between kinase activation and inhibition of apoptosis dependent on amino acids 221 and

157 f c-rel-deficient B cells, and show that the inhibition of apoptosis does not necessarily confer hype

158 Partial inhibition of apoptosis due to LAQ824 or Apo-2L/TRAIL ex

159 Thus, Epo-dependent mitogenesis and inhibition of apoptosis each depend critically upon only

160 ns lead to increased proliferation, enhanced inhibition of apoptosis, escape from immune surveillance

161 PI 3-kinase mediates IL-3- and IGF-I-induced inhibition of apoptosis, FDCP-1/Mac-1 cells were incubat

162 1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT

163 Akt survival signaling pathways, leading to inhibition of apoptosis, hyperplasia, and tumor formatio

164 Hsp70s have been linked to inhibition of apoptosis (i.e., cancer) and diseases asso

165 ts in astrocytes were prevented, namely: (i) inhibition of apoptosis, (ii) increase on ATP generation

166 results, which define a novel mechanism for inhibition of apoptosis, implicate parallel, interacting

167 ase activities and increased GSH levels with inhibition of apoptosis in all five model systems.

168 f the 8.3-kb LAT gene is sufficient for both inhibition of apoptosis in an in vitro transient-transfe

169 studies are associated with the induction or inhibition of apoptosis in azoxymethane (AOM)-induced co

170 Inhibition of apoptosis in C. burnetii-infected cells di

171 nism of 17beta-estradiol (estrogen)-mediated inhibition of apoptosis in C6 (rat glioma) cells followi

172 pression of the HDAC7 target, Nur77, and the inhibition of apoptosis in CD4+CD8+ thymocytes.

173 ed link between antigen-receptor binding and inhibition of apoptosis in CLL.

174 Inhibition of apoptosis in corneas stored at 4 degrees C

175 Permanent inhibition of apoptosis in donor cells caused by the los

176 related protein 1 (SFRP1) contributes to the inhibition of apoptosis in fibroblast populations.

177 the addition of SFRP1 may contribute to the inhibition of apoptosis in fibroblast-related cells.

178 mutants may be functionally important in the inhibition of apoptosis in Msx1/2 mutants.

179 cles are positive for apoptosis markers, and inhibition of apoptosis in muscles prevents to a signifi

180 ystemically increased cell proliferation and inhibition of apoptosis in myeloid lineage cells.

181 Inhibition of apoptosis in normal cultures resulted in e

182 ent than their wild-type counterparts in the inhibition of apoptosis in primary mouse T cells and in

183 pression promotes cell growth, invasion, and inhibition of apoptosis in renal cancer cells.

184 ogenous HSH2 expression within 12 h, whereas inhibition of apoptosis in response to CD40-mediated sig

185 the activities of all family members led to inhibition of apoptosis in T cells.

186 of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL.

187 mplementary functions in MyoD activation and inhibition of apoptosis in the somitic mesoderm and in r

188 middle T antigen was partially defective for inhibition of apoptosis in these cells.

189 Inhibition of apoptosis in vitro delayed, but did not pr

190 The AhR-mediated inhibition of apoptosis in vitro was associated with a c

191 Importantly, deliberate inhibition of apoptosis in wild-type animals significant

192 Several HSV genes are involved in the inhibition of apoptosis, including Us5, which encodes gl

193 l advantage to transformed cells through the inhibition of apoptosis, increased attachment to extrace

194 pithelial cells resulted in a dose-dependent inhibition of apoptosis induced by etoposide, UV-irradia

195 DBC1 expression potentiates SIRT1-dependent inhibition of apoptosis induced by genotoxic stress.

196 sufficient for physical interaction with and inhibition of apoptosis induced by HID.

197 ar-4 in HeLa cells resulted in a significant inhibition of apoptosis induced by various proapoptotic

198 n this report, we investigated whether bcl-2 inhibition of apoptosis involves regulation of TIMP expr

199 are the ability to induce apoptosis and that inhibition of apoptosis is a mechanism of tumor promoter

200 We demonstrate that TolC-mediated inhibition of apoptosis is an active process and not due

201 We demonstrate that this robust inhibition of apoptosis is caused by Q97-mediated accumu

202 Inhibition of apoptosis is critical for carcinogenesis.

203 These results suggest that the inhibition of apoptosis is essential for this mode of vi

204 The inhibition of apoptosis is generally believed to be a ma

205 This inhibition of apoptosis is in part dependent on the acti

206 TIMP-1 inhibition of apoptosis is not IL-10 dependent.

207 However, inhibition of apoptosis is not sufficient to prevent eth

208 Inhibition of apoptosis is used as an example of the pro

209 This indicates Bcl2 inhibition of apoptosis is, therefore, downstream of cas

210 , whereas RB tumor promoting function, i.e., inhibition of apoptosis, is inactivated by caspase cleav

211 Inhibition of apoptosis leads to a switch to the RIP1-de

212 This inhibition of apoptosis led to significantly more macros

213 Because inhibition of apoptosis may be an essential step in tumo

214 Securing an intracellular niche through the inhibition of apoptosis may be an important mechanism ut

215 show that abnormal cell differentiation and inhibition of apoptosis may contribute to the developmen

216 ollectively, these findings suggest that the inhibition of apoptosis may lead to an increased express

217 the induction of apoptosis and vMIA-mediated inhibition of apoptosis may occur subsequent to this eve

218 Inhibition of apoptosis may represent a major aspect of

219 and proteasomal degradation and so releases inhibition of apoptosis mediated by cIAP.

220 Toso appeared limited to inhibition of apoptosis mediated by members of the TNF r

221 - or extracellular mutations caused dominant inhibition of apoptosis mediated by wild-type Fas.

222 ative therapeutic intervention for RA is the inhibition of apoptosis-mediated cartilage degradation.

223 nucleotide exchange factors (Map and EspM), inhibition of apoptosis (NleH and NleD), interference wi

224 (e) Anti-CD40 inhibition of apoptosis occurs without alteration in ant

225 arvedilol on the ischemic myocardium include inhibition of apoptosis of cardiomyocytes and, if so, to

226 The inhibition of apoptosis of infected host cells is a well

227 ng vacuoles with lysosomal compartments, ii) inhibition of apoptosis of infected mononuclear cells, a

228 d intermediate PRLr were equivalent in their inhibition of apoptosis of the Ba/F3 transfectants after

229 Inhibition of apoptosis or abnormal cell survival can re

230 ion of nonalcoholic fatty liver disease, and inhibition of apoptosis partially protects against liver

231 Correlating with the inhibition of apoptosis, PKC-alpha transfectants exhibit

232 Inhibition of apoptosis plays an important role in the c

233 (HSP70) protects the gastric mucosa through inhibition of apoptosis, proinflammatory cytokines, and

234 ngosine-1-phosphate plays important roles in inhibition of apoptosis, promotion of cell proliferation

235 Activation of PI3-kinase leads to inhibition of apoptosis, promotion of cell survival, and

236 Inhibition of apoptosis resulted in more persistent self

237 nhibition of caspase activity and subsequent inhibition of apoptosis results in increased viral expre

238 If this postulate is correct, then inhibition of apoptosis should allow recovery of beta-ce

239 JNK inhibition correlated with inhibition of apoptosis signal-regulating kinase 1 (ASK1

240 Inhibition of apoptosis signal-regulating kinase 1, a se

241 ion by PP1 of SCF-mediated proliferation and inhibition of apoptosis suggests that Src family kinases

242 In addition to its role in inhibition of apoptosis, survivin also regulates mitosis

243 y described an alternative mechanism of XIAP inhibition of apoptosis that depends on the selective ac

244 ization of PTHrP has been associated with an inhibition of apoptosis, the ability of full-length PTHr

245 h was characterized by genes involved in the inhibition of apoptosis, the actin cytoskeleton, and NF-

246 Despite inhibition of apoptosis, the immunotoxin is still capabl

247 he first included Akt and Bad, leading to an inhibition of apoptosis; the second included the mitogen

248 ys important roles in cell proliferation and inhibition of apoptosis, this pathway has emerged as a p

249 These results provide evidence that inhibition of apoptosis through Bcl-x(L) overexpression

250 ed that ischemic preconditioning protects by inhibition of apoptosis through down-regulation of caspa

251 ic protection against prolonged ischemia via inhibition of apoptosis through down-regulation of caspa

252 ould or would not occur allowed us to relate inhibition of apoptosis to a complete withdrawal from th

253 onstrate a therapeutic benefit of late-stage inhibition of apoptosis to flies, and suggest that simil

254 cordingly, PI-3K is involved in TPO-mediated inhibition of apoptosis, TPO- and SDF-1-regulated adhesi

255 Furthermore, inhibition of apoptosis using the peptide caspase inhibi

256 The inhibition of apoptosis was associated with a decrease i

257 MKP-1-mediated inhibition of apoptosis was associated with decreased ph

258 Inhibition of apoptosis was associated with reduced indu

259 We hypothesized that TCDD-mediated inhibition of apoptosis was due to its ability to stimul

260 ng the ALPS-associated Fas mutants, dominant inhibition of apoptosis was much more pronounced in muta

261 Inhibition of apoptosis was observed in WT MEFs overexpr

262 ing Bcl2 and BclXL, in which 25- to 150-fold inhibition of apoptosis was observed.

263 GM-CSF-dependent inhibition of apoptosis was significantly attenuated by

264 Inhibition of apoptosis was temporary, because all the c

265 Moreover, both Akt phosphorylation and inhibition of apoptosis were abrogated by mutation of ty

266 anchorage-independent growth, as well as by inhibition of apoptosis, whereas the PDZ1 domain promote

267 tion/proteasomal destruction and synergistic inhibition of apoptosis, which is abolished in XIAP(-/-)

268 Interestingly, inhibition of apoptosis with a caspase 3 inhibitor also

269 The importance of H(2)O(2) was confirmed by inhibition of apoptosis with catalase.

270 Inhibition of apoptosis with cycloheximide inhibits the

271 Inhibition of apoptosis with the caspase inhibitor ZVAD.

272 hat targeting of Akt to the nucleus mediates inhibition of apoptosis without hypertrophic remodeling,

273 Inhibition of apoptosis would result in increasing accum