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6 osed of Az and geldanamycin, which have high inhibitory activities towards both Hsp70 and Hsp90, exhi
7 wever, the Az and imatinib hybrids have weak inhibitory activities towards Hsp70 and Abl, and display
8 lase and angiotensin converting enzyme (ACE) inhibitory activities were successfully identified using
9 N-FIV (3-1kDa) fractions showed the best ACE-inhibitory activities with IC50 values of 53.31 and 75.0
12 othelial progenitor EP cells) and the kinase inhibitory activity (toward both isolated kinases and EP
13 ur compounds were further screened for their inhibitory activity against recombinant HDAC1-3, HDAC6,
14 nalysis of in vivo FLT3 inhibition by plasma inhibitory activity assay and indicated improved overall
15 basophil activation and measurement of serum inhibitory activity for allergen-IgE binding to B cells
16 he absence of vivax invasion assays, binding-inhibitory activity of antibodies has been reported to b
17 ion.IMPORTANCE The greater ex vivo antiviral inhibitory activity of CD8(+) T cells from elite control
18 of this study was to evaluate the potential inhibitory activity of guarana extracts, after digestion
20 tioxidant capacity and the alpha-glucosidase inhibitory activity of the duodenal extract correlated w
22 ed comparable antioxidant capacity, stronger inhibitory activity on pancreatic lipase and comparable
34 y arises in the inner plexiform layer, where inhibitory amacrine cells modulate the excitatory signal
35 ological character is dependent on vesicular inhibitory amino acid transporter-mediated signaling.
36 for additional research on the mitochondrial inhibitory and antiestrogenic effects of QUATS, includin
38 s and specificities, we predicted and tested inhibitory and cytotoxic NK potential on the basis of KI
39 We show that nAChRs are located on ascending inhibitory and descending excitatory presynaptic inputs
41 combinations of intrinsic ion conductances, inhibitory and excitatory synaptic inputs that differ am
42 ested that C3b is responsible for the growth inhibitory and neurotoxic or anti-adhesion activities of
44 cement factor can lead to the development of inhibitory antibodies, requiring the use of bypassing ag
46 ficiently expressed in Escherichia coli, and inhibitory assays demonstrated that it was a potent inhi
47 essed in amygdalar neurons of mice during an inhibitory avoidance task revealed that CaMKII activity
49 tatively anti-Bd bacteria to determine if Bd-inhibitory bacteria are dominant microbiome members.
54 electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely l
59 though experience-dependent changes in brain inhibitory circuits are thought to play a key role durin
60 e variety of odorants.SIGNIFICANCE STATEMENT Inhibitory circuits in the olfactory bulb (OB) play a ma
62 omplement activation and genetic variants in inhibitory complement factor H (CFH) are also features o
63 prefrontal infusions of KYNA attenuated the inhibitory component of PFC LFP responses, a disruption
65 ment function identified a single complement inhibitory compound, termed cmp-5, and mechanistic studi
66 ore potent antimicrobial agents [VRE minimum inhibitory concentration (MIC) = 0.01-0.005 mug/mL] with
69 bility testing, and determination of minimum inhibitory concentration is conventionally performed by
70 ith a KD of 76 nM against BioA and a minimum inhibitory concentration of 1.7 muM (0.6 mug/mL) against
75 azyl (DPPH) radical quenching potential (50% inhibitory concentration, IC50 approximately 0.59mg/mL)
78 Syt1 and Syt2 at two types of fast-releasing inhibitory connections in the mammalian CNS: the medial
79 was as follows: processing speed ( r = .39), inhibitory control ( r = .34), working memory ( r = .28)
81 the first to show associations between poor inhibitory control and amphetamine reward sensitivity at
83 ed actions or interfering information (i.e., inhibitory control) are essential human cognitive abilit
84 reward-value coupled with an underdeveloped inhibitory control, and thus a hypersensitivity to rewar
87 eases in excitability in both excitatory and inhibitory cortical neurons show that selective dysfunct
90 Cardiomyocyte-directed expression of the inhibitory CREM isoform CREM-IbDeltaC-X in transgenic mi
92 pectroscopy demonstrated that the N-terminal inhibitory domain (NID) is intrinsically disordered, yet
93 pecific APP isoforms contain Kunitz protease-inhibitory domains, which regulate the proteolytic activ
94 made by CCK(+)VGlut3(+) basket cells and the inhibitory drive they exerted on pyramidal cells were re
95 slational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropa
102 ct of codon reassignment in the SGC, and the inhibitory effect of changes in the code on horizontal g
103 Moreover, Y470H and Y88F hDAT potentiate the inhibitory effect of cocaine on DA uptake and attenuate
107 nase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-acti
109 these findings provide new insights into the inhibitory effect of SFN on HCC tumor angiogenesis as we
110 evidence for the enhancement of rapamycin's inhibitory effect on IL-1beta secretion by the IL-1 rece
111 ient to explain Pre1a's potent and selective inhibitory effect on the fast inactivation process of Na
112 r NOM) alone, whereas Zn+NOM showed a lesser inhibitory effect than its individual component (NOM) al
115 letely ablated the activity of LLO, and this inhibitory effect was fully reversible by treatment with
117 ter the expiry date and retained significant inhibitory effects against colon carcinoma (CaCo-2) cell
118 as a combination of terpenes, exerts growth inhibitory effects against colon carcinoma, suggesting a
120 hate and Zn+NOM+orthophosphate) had stronger inhibitory effects compared to each inhibitor (Zn, ortho
123 protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by
125 of culture conditions was further seen when inhibitory effects of short wavelength light were reduce
127 e to non-targeted NPs showed markedly better inhibitory effects on apoptosis and oxidative/inflammato
128 ral stimulation and LHb lesions reversed the inhibitory effects on cocaine locomotion produced by per
130 n in iPMd induced more frequent and powerful inhibitory effects on M1 outputs compared with iPMv.
132 e selected for their robust and reproducible inhibitory effects within the primary screening assay.
133 Interestingly, we observed the aggregation inhibitory efficacy of alpha/beta and alpha/gamma BSBHps
134 e inhibitor (CHMFL-BTK-11) which exerted its inhibitory efficacy through a covalent bond with BTK Cys
137 ate activation of excitatory memory engrams, inhibitory engrams can make memories quiescent, stored i
139 neural networks with balanced excitatory and inhibitory engrams, the release of innate responses and
140 suggested downregulated macrophage migration inhibitory factor (MIF) to be the most pertinent mediato
142 kine (C-C motif) ligands 2 and 3, macrophage inhibitory factor, and chemokines mediating neutrophil a
143 tical models: 1) parallel activation of Fshb inhibitory factors (e.g. inhibin alpha and VGF nerve gro
144 Putative excitatory regular-spiking (RS) and inhibitory fast-spiking (FS) V1 cells had similar EPSP c
145 vestigated relative levels of activating and inhibitory FcgammaRs on brain-resident microglia followi
150 to ILD processing (excitatory from one ear, inhibitory from the other: EI cells) compare ILDs separa
152 n, directly interacts with, and relieves the inhibitory function of eukaryotic initiation factor 3f,
153 genetic evidence that Lrp4 mediates the Wnt inhibitory function of Wise and also modulates Wnt/beta-
156 ment of the major excitatory (glutamate) and inhibitory (gamma aminobutyric acid (GABA)) neurotransmi
157 alpha oscillations, believed to exert active inhibitory gating, downmodulate the temporal width of LR
158 t the phage genome-which encodes potentially inhibitory gene products-is still allowed to enter the c
160 aRIIA, hFcgammaRIIIA, and hFcgammaRIIIB) and inhibitory (hFcgammaRIIB) hFcgammaR genes, has been inse
161 using a chemogenetic approach expressing the inhibitory hM4Di designer receptor exclusively activated
162 may offer diverse mechanisms for maintaining inhibitory homeostasis.SIGNIFICANCE STATEMENT Corelease
163 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of
164 a network rate model with excitatory (E) and inhibitory (I) populations exhibiting a novel bistable r
166 pmental disorder characterized by excitatory/inhibitory imbalance and dopamine (DA) dysfunction.
170 lly different, but neither had a significant inhibitory influence on the endogenous rate of aerobic o
171 e a long-held view concerning the pattern of inhibitory input and provide results that agree with cur
172 pathway contains projections that convey an inhibitory input from the periphery to mesolimbic reward
173 indings on the integration of excitatory and inhibitory inputs in healthy cortical circuits and discu
174 nd precision (0-4 ms jitter) of synchrony of inhibitory inputs, along with the rates (0-100 spikes s(
175 g a ring network, we show how excitatory and inhibitory interactions can implement different computat
176 vation of p110delta (>300-fold) and disrupts inhibitory interactions from the nSH2, iSH2, and cSH2 do
177 ty between excitatory mitral cells (MCs) and inhibitory internal granule cells (IGCs), but the physio
180 k-related synchronization of oscillations in inhibitory interneuronal circuits, supporting the hypoth
181 growth and synaptic integration of GABAergic inhibitory interneurons are essential for functional neu
182 perineuronal nets (PNNs) around fast-spiking inhibitory interneurons, in a rat model of TBI as well a
186 labeled axon terminals, which, in turn, form inhibitory-like synapses on auditory efferent somata.
187 y humans inherited activating KIR2DS4 and an inhibitory lineage III KIR, likely encoding a C1-specifi
189 t targeting FimH with M4284, a high-affinity inhibitory mannoside, reduces intestinal colonization of
190 Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity th
191 sual signals during blinks are suppressed by inhibitory mechanisms [3-6], so that small changes acros
192 These findings highlight the role of the inhibitory microenvironment and how CAR T cells can be f
193 cmp-5, and mechanistic studies of the cmp-5 inhibitory mode revealed it acts at the level of C5 acti
195 RNA editing, localize to >20 excitatory and inhibitory neocortical neuron types defined by physiolog
198 erential and cooperative roles of SOM and PV inhibitory neurons in orchestrating specific cortical os
199 experimental designs targeting a majority of inhibitory neurons may be able to resolve this question.
201 edict that top-down signals primarily affect inhibitory neurons, whereas excitatory neurons are more
202 ominantly composed of fast-spiking, putative inhibitory neurons, which displayed unusually strong cou
205 escued the imbalances between excitatory and inhibitory neurotransmission evident in Fmr1-KO mice.
206 nes do significantly alter the maturation of inhibitory neurotransmission in the cingulate region of
207 Accumulating evidence shows that glycinergic inhibitory neurotransmission in the spinal cord dorsal h
209 ila olfactory sensory neurons and found that inhibitory odors triggered outward receptor currents by
210 rents to MNTB neurons should lead to greater inhibitory output to the projections from this nucleus.
211 t that VISTA represents another compensatory inhibitory pathway in prostate tumors after ipilimumab t
212 ) are a unique form of endogenous descending inhibitory pathway since they can be easily evoked and q
214 those targeting CTLA-4/B7 and the PD-1/PD-L1 inhibitory pathways, are now available for clinical use
215 ed PDH-E1alpha protein content and increased inhibitory PDH-E1alpha Ser(300) phosphorylation and FA o
217 Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASPY, ILDKEGIDY, ILELA, L
220 conditional KO/knockdown of GSK3beta reduced inhibitory phosphorylation of CRMP2 in RGCs and improved
221 tment of adherent platelets with PGI2 caused inhibitory phosphorylation of RhoA, reduced RhoA GTP-loa
222 g CDK inhibitors to reverse the constitutive inhibitory phosphorylation of T387 of U-STAT2 might enha
224 ts reveal that nonmating behaviors drive AOB inhibitory plasticity and indicate that increased MC inh
225 he target of clinical investigation, gastric inhibitory polypeptide (GIP), as proof-of-principle pept
226 glucagon, ghrelin, cholecystokinin, gastric inhibitory polypeptide (GIP), glucagon-like peptide 1 (G
227 nscription factor 7-like 2 (TCF7L2), gastric inhibitory polypeptide receptor (GIPR), caveolin 2 (CAV2
228 n about both innocuous and painful touch and inhibitory populations that serve as a gate to prevent i
230 neurons presented frequencies of spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneou
232 ffered an explanation for the differences in inhibitory potency between glucosyl and glucosaminyl der
233 ompatibility, and significantly enhanced the inhibitory potency of ATRA on HCC cell growth, improving
234 in vitro sliding velocity and attenuated the inhibitory potential of the allosteric myosin inhibitor
236 ription to be presented, including off-cycle inhibitory processes, the source of amine and organoboro
238 chizophrenia, increasing confidence that P50 inhibitory processing can inform the development of inte
241 CS family genes encoding the STAT signalling inhibitory proteins SOCS1, SOCS3 and CISH were marked by
242 acrophages (TAM), which favors expression of inhibitory rather than activating Fcgamma receptors (Fcg
243 an in LPFC, resulting in a lower excitatory: inhibitory ratio and a greater dynamic range for signal
245 g T cell activation by stimulating a natural inhibitory receptor called leukocyte-associated Ig-like
247 y using Cal-Light to drive expression of the inhibitory receptor halorhodopsin (eNpHR), which respond
250 k mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce b
251 is has provided impetus to identify other co-inhibitory receptors that could be exploited to enhance
252 t, precedes the expression of MHC-I-specific inhibitory receptors, and is modulated in an education-d
253 CD4 T cells following blocking of different inhibitory receptors, and we confirmed our results in a
257 oinhibited at a single site by either of two inhibitory regions, CBD and LAVP, which block substrate
258 e view that the lateral habenula establishes inhibitory relationships between stimuli and food outcom
259 etary rewards, and by applying excitatory or inhibitory repetitive transcranial magnetic stimulation
262 mic neurons gradually develop new, primarily inhibitory responses to reward-predictive cues across le
263 the decoy receptor IL-1R2 plays an important inhibitory role in local IL-1- and neutrophil-dependent
264 ess during wound healing, alpha9beta1 has an inhibitory role, suggesting that regulation of basement
265 ecedented resolution the distribution of the inhibitory scaffold protein gephyrin in response to prot
266 present the identification of new Cruzipain inhibitory scaffolds within the GlaxoSmithKline HAT (Hum
269 cells with small interfering RNAs targeting inhibitory SMADs to analyze gene expression profiles.
270 that pharmacotherapies capable of increasing inhibitory spinal glycinergic neurotransmission hold in
271 This establishment of neuropil excitatory-inhibitory structure largely precedes dendritic arboriza
272 ty in the LTMR-RZ: seven excitatory and four inhibitory subtypes of interneurons exhibiting unique mo
276 oride transporter function at excitatory and inhibitory synapses and facilitate inhibitory synapse ad
277 how that Syt1 is weakly coexpressed at these inhibitory synapses and must be genetically inactivated
278 napses, with neuroligin 2 (NLGN2) limited to inhibitory synapses and neuroligin 1 (NLGN1) dominating
279 1 adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the
285 rs but differentially impaired excitatory or inhibitory synaptic functions in an isoform-specific man
286 e their selectivity both from excitatory and inhibitory synaptic inputs from other neurons and from t
290 inoid-dependent effects of corticosterone on inhibitory synaptic transmission in the rat PL were dete
292 in acute rat OB slices from both sexes, that inhibitory synchrony is evident in the spontaneous synap
296 have little effect on evoked responses from inhibitory thalamic reticular nucleus and excitatory tec
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