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1 is widely thought to be essential for their inhibitory action.
2 nd (viii) dominant negative PP2A blocks cAMP-inhibitory action.
3 1) activation by specific siRNAs blocked OGF inhibitory action.
4 e association of golli was essential for its inhibitory action.
5 nd define the mechanism responsible for this inhibitory action.
6 owed us to probe novel aspects of indolmycin inhibitory action.
7 yl may be beneficial for increased TNF-alpha inhibitory action.
8 promoter and not by NF-kappaB, which has an inhibitory action.
9 cellular glycine concentrations can exert an inhibitory action.
10 Co-application of NT and AID peptide negated inhibitory actions.
11 tivation also require PKA activity for their inhibitory actions.
12 wth is not simply the opposite of its growth inhibitory actions.
13 etylcholine agonist muscarine, evoked direct inhibitory actions.
14 ing actions for LNO2 in mediating its potent inhibitory actions.
15 BA are complex involving both excitatory and inhibitory actions.
16 ioid receptor antagonists prevented morphine inhibitory actions.
19 do)benzenesulfonamides, showed low nanomolar inhibitory action against hCA II, being less effective a
20 (Rv1284, Rv3273, and Rv3588c), whereas their inhibitory action against hCA III, IV, VA, VB, VI, VII,
21 ing click chemistry and showed low nanomolar inhibitory action against the tumor-associated isoforms
22 ther cell type is sufficient to overcome the inhibitory action and promote differentiation and myelin
23 These effects are independent of its COX-2 inhibitory actions and may explain the differential risk
24 t degradation of s80(HER4) limits its growth-inhibitory action, and stabilization of s80(HER4) enhanc
25 identify a novel P2X7 variant with apoptosis-inhibitory actions, and demonstrate a distinct regulator
27 demonstrate that Mg(2+) is not unique in its inhibitory action, as Ba(2+), Sr(2+), Zn(2+), and Mn(2+)
28 7SK-binding motif was essential for HEXIM1's inhibitory action, as the HEXIM1 mutants with this motif
29 MDA receptor channels but show that its main inhibitory action at pharmaceutically relevant concentra
31 be difficult to induce because of reciprocal inhibitory actions between type 1 and type 2 responses.
32 These peptides are thought to exert their inhibitory action by disrupting the proper assembly of P
34 ns, it is now clear that Imatinib exerts its inhibitory action by stabilizing the inactive non ATP-bi
35 ragment was capable of selective competitive inhibitory action, disrupting endogenous F-actin-Syntaxi
36 te that A(2A) receptor activation has strong inhibitory actions during early developmental, as well a
37 , as well as a molecular explanation for its inhibitory action, emphasizing the oxidative metabolism
38 At the cellular level, we found that the inhibitory action exerted by KYNA in the PFC occurred pr
40 and PDK1, are not the target(s) of the cAMP inhibitory action; (ii) constitutively active Akt and ca
42 gated GABAergic activity and observed mainly inhibitory action in SCN neurons of mice exposed to a sh
46 ta suggest that BTLA and PD-1 exert distinct inhibitory actions in vivo, with the BTLA/herpesvirus en
51 its regulatory gamma-subunits (Pgamma) whose inhibitory action is released upon binding to the G-prot
53 ocytes, indicating that at least part of its inhibitory action is unrelated to its antiplatelet prope
56 ments highlight the importance of the potent inhibitory action mediated by parvalbumin cells in the h
60 ty evoked by 1-100 nm Ang II and blocked the inhibitory action of [Ca(2+)](i) on TRPC6 channel activi
61 m of light activation that initiates protein inhibitory action of a biologically inert Co(III) Schiff
62 t not avirulent, Mtb can overcome the growth inhibitory action of a Th1-dependent, NOS2-independent m
63 ligand exchange reaction is proposed for the inhibitory action of a tight-binding inhibitor possessin
64 Ca2+ via nAChRs, revealing that the apparent inhibitory action of Abeta1-42 was the result of an occl
65 n of either enzyme or substrate reverses the inhibitory action of acetaminophen, as does the addition
66 us-mediated Fstl3 overexpression blocked the inhibitory action of activin A on hypertrophy and Smad2
67 GABAergic mechanisms may be involved in this inhibitory action of adenosine, via their A(2A) receptor
69 The COX-2 inhibitor Dup-697 prevented the inhibitory action of adiponectin on preadipocyte differe
71 te the molecular mechanism(s) underlying the inhibitory action of AMX on the release of FGF-1, using
72 balance between estrogen stimulation and the inhibitory action of androgens on breast tissue prolifer
74 These effects are mediated by the enzyme inhibitory action of antithrombin and its ability to fun
76 s), which counterbalance the nearly constant inhibitory action of ATP on the K(+) inwardly rectifying
79 lengths below 488 nm rapidly inactivates the inhibitory action of blebbistatin using the in vitro mot
83 chromatin is restricted to G1 phase through inhibitory action of Cdk1/2 kinases in other phases of t
84 endrocytes, contributes to the axonal growth inhibitory action of central myelin in growth cone colla
86 for the observed high affinity and enhanced inhibitory action of CIP when compared to either p25 or
87 h increasing CLE3 mRNA levels; however, this inhibitory action of CLE3 was abrogated in the clv1 muta
88 s of HO-1 activity may be attributable to an inhibitory action of CO on cardiac L-type Ca2+ channels.
89 -molecule approaches require blockade of the inhibitory action of cocaine on a diverse array of monoa
90 oliferation and migration correlated with an inhibitory action of cortistatin on the neointimal forma
93 uculline and picrotoxin, suggesting that the inhibitory action of D2 receptors on NMDA-induced respon
98 ct is intriguing in that it does not require inhibitory action of either presynaptic muscarinic recep
99 n adequately addressed is whether the direct inhibitory action of erlotinib on the HER2 kinase might
103 ation serves a role in removing the inherent inhibitory action of flavonoids on an MTI signaling bran
104 restingly, the expression of aP2 escapes the inhibitory action of FoxC2 under conditions that promote
107 repetitive postsynaptic spiking reduces the inhibitory action of GABA through a Ca2+-dependent downr
108 rine cells, and picrotoxin, which blocks the inhibitory action of GABA, only slightly reduced the sur
109 ibition, which has a general implication for inhibitory action of general anesthetics on pLGICs.
110 er, it remains to be determined whether this inhibitory action of GH is due to direct regulation of h
111 prostate shrinkage is induced by the direct inhibitory action of GHRH and of LHRH antagonists exerte
112 we provide evidence for the existence of an inhibitory action of Gi3 on Gs that is under the control
113 signal transduction pathway that conveys the inhibitory action of GnIH in GnRH neurons by using the G
114 odulators strongly demonstrated the specific inhibitory action of GnIH on the adenylate cyclase/cAMP/
118 and experimental approach, we found that the inhibitory action of I(h) was caused by its interaction
119 acid (15(S)-HETE) production, indicating an inhibitory action of I3MO on 12/15-LO and consequently o
120 hanism of hIAPP amyloid fiber formation, the inhibitory action of IAPP variants, and the competition
121 that differ in their ability to support the inhibitory action of IFN-alpha at early steps of the HIV
129 metamorphosis on a normal schedule, and the inhibitory action of juvenile hormone on this checkpoint
133 ectly show the predicted dual fast- and slow-inhibitory action of LNs, which was predicted to be key
142 down in POSH function were refractory to the inhibitory action of Nogo66, indicating that a POSH-depe
144 rolytic conformations able to antagonize the inhibitory action of nucleotide binding at the Kir6.2 po
145 reveal that the target of cell proliferative inhibitory action of OGF in human HNSCC is a cyclin-depe
146 Such specificity may imply that the central inhibitory action of opioid peptides on gastrointestinal
148 that phosphorylation by Src impairs the Cdk2 inhibitory action of p27 and reduces its steady-state bi
156 conditions when most GABAA Rs were open, an inhibitory action of R-mTFD-MPPB was revealed that had a
158 a T cell function is directly related to the inhibitory action of rapamycin on mammalian target of ra
159 nregulation of Bcl-xL was caused by the mTOR inhibitory action of rapamycin, which prevented cap-depe
164 stabilized by S-S bonds is required for the inhibitory action of S1b on prolactin-induced LF-mediate
167 This particular conformation explains the inhibitory action of sordarin and suggests that eEF2 is
168 ated that in a single hippocampal slice, the inhibitory action of strongly, tonically activated nAChR
170 eous mucin accumulation, consistent with the inhibitory action of Syt2 at resting cytoplasmic Ca(2+)
173 berates their protein kinase domain from the inhibitory action of the amino-terminal photosensory por
174 enhances in vitro sensitivity to the growth-inhibitory action of the antiandrogen Casodex and inhibi
178 Both MRN and SOSS1 also act to mitigate the inhibitory action of the Ku70/80 heterodimer on Exo1 act
183 oledronic acid (ZOL) in order to enhance the inhibitory action of this miRNA on its canonical targets
191 own to have a role in the development of the inhibitory actions of amine transmitters, whereas KCC3 a
193 finding has significant implications for the inhibitory actions of annexin A1 on exocytosis in other
194 ivo, as exemplified by the weak and/or short inhibitory actions of antagonists JV-1-65 and MZ-J-7-72
195 vents dsRNA-induced iNOS expression, and the inhibitory actions of BEL on dsRNA-induced iNOS expressi
198 of CIS-R107K for blocking the GHR signaling inhibitory actions of CIS, but not those of other SOCS/C
199 ected COLO-357 cells and enhanced the growth inhibitory actions of cis-diamminedichloroplatinum(II) (
202 nel activity, thereby demonstrating that the inhibitory actions of ESCAs reported here are unlikely t
205 could contribute towards the stimulatory and inhibitory actions of FFAs on pancreatic beta-cell funct
211 FP, vGluT2-GFP and GAD67-GFP mice, we report inhibitory actions of GnIH/RFRP-3 on kisspeptin-activate
212 ivator CREB-binding protein/p300 reduced the inhibitory actions of IFN-gamma on the Abca1 promoter, s
213 show that the apoptosis-promoting and growth-inhibitory actions of IGFBP-3 are completely abrogated i
218 ase property of the MIF molecule, mimics the inhibitory actions of MIF on Ang II-stimulated neuronal
222 LR-MSCs also demonstrated resistance to the inhibitory actions of PGE2 in association with a reducti
223 on system, and the steady-state kinetics and inhibitory actions of phenothiazines were characterized.
224 tion was used to evoke dopamine release, and inhibitory actions of quinpirole on this release were ex
229 ioral adaptation to both the stimulatory and inhibitory actions of the neurotransmitter, indicating t
230 t stress, while CRF(2) receptors mediate the inhibitory actions of these peptides on gastric transit.
232 ts with transfected cells confirmed that the inhibitory actions of thrombin and Rho kinase on P-selec
235 gly, ectopic expression of IRF9 reverses the inhibitory actions of TSA, suggesting that IRF9 function
237 arguing against the possibility that the PKC inhibitory actions of UCN-01 are responsible for synergi
241 charges suggesting dual, both excitatory and inhibitory, actions of GABA in the immature hippocampal
243 cytes might be the combination of its direct inhibitory action on astrocyte MMP2 expression and the s
244 on with the plasma membrane and reversed its inhibitory action on Ca2+ influx, indicating that membra
245 These results suggest that ethanol via the inhibitory action on D2S receptor activity suppresses Gi
246 whose phosphorylation by mTORC1 reverses its inhibitory action on eIF4E, resulting in the promotion o
248 , 3b and 3f (IC50 approximately 84 nM), lack inhibitory action on ENPP6 and ENPP7 but possess weak an
253 ct of fingolimod in vivo may result from its inhibitory action on key astrocyte activation steps.
255 onal receptor complex that mediates myelin's inhibitory action on nerve fiber regeneration has at las
257 t suppression of NF-kappaB depended on HGF's inhibitory action on NF-kappaB and IkappaB phosphorylati
260 minescence assay was employed to study their inhibitory action on protein synthesis, which identified
263 ductance of the neurons, consistent with its inhibitory action on spike rate, whereas serotonin decre
265 y demonstrating that PACAP exerts a powerful inhibitory action on the induction, growth or survival o
267 atin A, an HDAC inhibitor, prevents IFNgamma inhibitory action on TNFalpha-induced gene expression.
269 ata suggest that catecholamines evoke strong inhibitory actions on hypocretin neurons and suggest neg
270 well as the course of the disease because of inhibitory actions on Kv and ASIC channels, respectively
272 t suppresses the gastric mill rhythm via its inhibitory actions on MCN1 and CPN2, to inhibit the GPR-
273 ults indicate that rapamycin exerts variable inhibitory actions on mTOR signaling functions and sugge
274 is agent does not have additional downstream inhibitory actions on this activated NF-kappaB subunit.
280 a marked (although not complete) decrease in inhibitory action, suggesting a role of Mad2 in MCC for
282 ivation could be caused by the removal of an inhibitory action that CFs exert on the intrinsic pacema
283 explains several effects associated with its inhibitory action: the negative shift in heme c(n) midpo
284 e same binding region; rather, it exerts its inhibitory action through an allosteric mechanism, preve
286 ctive inhibitor rofecoxib, owe part of their inhibitory actions to effects on oxidation state of cycl
287 the smaller fragments and demonstrate their inhibitory action toward the Na(+)-K(+)-2Cl(-) cotranspo
288 9 and dominant negative Epac 279E block cAMP-inhibitory action; (vi) Epac associates in a complex wit
292 ts were seen in 32D cells arguing the growth inhibitory action was not because of the blockade of aut
293 de shift and GABA switch, from excitatory to inhibitory action, was accelerated by REST inhibition an
296 hereas resolvin E1 and 10,17S-docosatriene's inhibitory actions were maximal at 12 h (30-80% inhibiti
297 CC neurons, and examined the effects of this inhibitory action with the attention-based five-choice s
298 creasing carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action with the increase of the number of sul
299 esensitization is an unexplored mechanism of inhibitory action with the potential to endow drugs with
300 nstituent possessing potent aldose reductase inhibitory action, with an IC50 value of 3.8mug/ml.
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