ライフサイエンスコーパス: inhibitory mechanism

1 ghput screening, and characterization of its inhibitory mechanism.

2 hmatic subjects, and investigate further the inhibitory mechanism.

3 ively) revealed the molecular details of the inhibitory mechanism.

4 PsiB is unique in using sequestration as an inhibitory mechanism.

5 d different RNA viruses, suggesting a common inhibitory mechanism.

6 hese enzymes and exhibits a fast-on/fast-off inhibitory mechanism.

7 and reveals an unsuspected component of the inhibitory mechanism.

8 ich is thought to play a central role in the inhibitory mechanism.

9 ivity were not additive, indicating a common inhibitory mechanism.

10 d their molecular interactions and potential inhibitory mechanism.

11 replication assays, suggesting a stochastic inhibitory mechanism.

12 doxal phosphate, suggesting a noncompetitive inhibitory mechanism.

13 moter activity, suggesting a CRE-independent inhibitory mechanism.

14 , suggesting that there may be more than one inhibitory mechanism.

15 involved not only in binding but also in the inhibitory mechanism.

16 an important role for the S-S linkage in the inhibitory mechanism.

17 lease factors 1 and 3 (eRF1 and eRF3) in the inhibitory mechanism.

18 ne proteinases by employing an RSL-dependent inhibitory mechanism.

19 their dephosphorylation represents a potent inhibitory mechanism.

20 nto the unique structural intricacies of the inhibitory mechanism.

21 ccumulation of intracellular Ca(2+), a novel inhibitory mechanism.

22 ansactivator response element as part of the inhibitory mechanism.

23 tail, zfPLN appears to use a hybrid PLN-SLN inhibitory mechanism.

24 tive drug-like inhibitors that show a unique inhibitory mechanism.

25 nce that secreted LPS is a key factor in the inhibitory mechanism.

26 ortical output in this period is gated by an inhibitory mechanism.

27 ziflam as a CBI and provide insight into its inhibitory mechanism.

28 logical advantages of such a two-transmitter inhibitory mechanism.

29 g activity is regulated by an intramolecular inhibitory mechanism.

30 A from D. indica and explored its tyrosinase inhibitory mechanism.

31 he presence of activating macromolecules and inhibitory mechanisms.

32 unosuppressive activity because of different inhibitory mechanisms.

33 the high tumor-antigen load and accompanying inhibitory mechanisms.

34 lated at the level of Vav1 by a hierarchy of inhibitory mechanisms.

35 se in latencies suggest an important role of inhibitory mechanisms.

36 c T cells and make them resistant to certain inhibitory mechanisms.

37 ocytosis is orchestrated by facilitatory and inhibitory mechanisms.

38 inhibition and the GABA and glycine modes of inhibitory mechanisms.

39 ene silencing through largely nonoverlapping inhibitory mechanisms.

40 differences in the development of underlying inhibitory mechanisms.

41 ophysical techniques, we also examined their inhibitory mechanisms.

42 tion can occur unconsciously via unconscious inhibitory mechanisms.

43 ly regulated process involving inductive and inhibitory mechanisms.

44 of local gamma-aminobutyratergic (GABAergic) inhibitory mechanisms.

45 ay require a balance between stimulatory and inhibitory mechanisms.

46 th tyrosine kinase-dependent and independent inhibitory mechanisms.

47 ory to inhibition by Th1 cells or endogenous inhibitory mechanisms.

48 Kir6.1 and Kir6.2 are regulated by distinct inhibitory mechanisms.

49 ling via G(s)-cAMP stimulatory and G(i)-cAMP inhibitory mechanisms.

50 llaboration of different combinations of TBP inhibitory mechanisms.

51 from colobus SIV (SIVcol) evolved different inhibitory mechanisms.

52 arly bind cGAS and DNA, suggesting conserved inhibitory mechanisms.

53 mented by directionally tuned excitatory and inhibitory mechanisms.

54 onset, likely reflecting the contribution of inhibitory mechanisms.

55 ic) and extracellular (catecholamine release-inhibitory) mechanisms.

56 sual signals during blinks are suppressed by inhibitory mechanisms [3-6], so that small changes acros

57 e is not enough to play the role as the late inhibitory mechanism: a second mechanism, hypothetically

58 spatiotemporal feature of currently unknown inhibitory mechanisms acting locally on the PI3K activat

59 In summary, BsAbs that bridge multiple inhibitory mechanisms against a single target may genera

60 s APOBEC3 proteins may have evolved distinct inhibitory mechanisms against retroelements.

61 tively in rpn12a-1, indicating that feedback-inhibitory mechanisms also may be altered.

62 ates, now show that serpins and their unique inhibitory mechanism and conformational flexibility are

63 cture provides a detailed description of the inhibitory mechanism and gives insights into interaction

64 ed potassium channels is a common endogenous inhibitory mechanism and may represent the best therapeu

65 es through the combined recruitment of local inhibitory mechanisms and activation of presynaptic KORs

66 the distinction between automatic, reflexive inhibitory mechanisms and controlled inhibitory mechanis

67 Basic research on striatal inhibitory mechanisms and dopaminergic function compleme

68 t for the idea that SPP is a useful model of inhibitory mechanisms and structure in the SPP/presenili

69 nteractions will inform our understanding of inhibitory mechanisms and the ways in which regulatory p

70 It was found that whilst most inhibitory mechanisms are affected by the disorder, some

71 Inhibitory mechanisms are critically involved in goal-di

72 , no specific assumptions about hypothetical inhibitory mechanisms are needed.

73 s for signal activation have been described, inhibitory mechanisms are not well characterized.

74 se results demonstrate that distinct sets of inhibitory mechanisms are recruited to generate directio

75 Inhibitory mechanisms are reflected by reductions in neu

76 The structural basis for these RLR inhibitory mechanisms, as well as the multifunctional na

77 rrent experiments address the specificity of inhibitory mechanisms, asking whether preparatory inhibi

78 action, implicating this GTPase in a growth-inhibitory mechanism associated with antiestrogen treatm

79 Fast and slow inhibitory mechanisms at synapses between LNs and PNs ca

80 tion between feed-forward thalamic input and inhibitory mechanisms at the level of cortex.

81 We show that the inhibitory mechanisms at these very early times involve

82 Moreover, we report a novel inhibitory mechanism because TGA stimulates the producti

83 Without the efficient operation of these inhibitory mechanisms behaviour can become maladaptive,

84 ncy and extend our understanding of the auto-inhibitory mechanism by identifying that auto-inhibition

85 nd RDS 2197 all appear to encompass a common inhibitory mechanism by modifying IN-viral DNA interacti

86 cofactor-dependent and substrate-competitive inhibitory mechanism by occupying the substrate peptide

87 f the adaptor protein may provide a feedback inhibitory mechanism by which Grb10 regulates insulin si

88 The induction of SOCS3 provides a potent inhibitory mechanism by which intracellular microorganis

89 Our study provides new insight into the inhibitory mechanism by which the PI3K-Akt pathway ensur

90 The present study further evaluated the inhibitory mechanisms by murine vaginal epithelial cells

91 g and redistribution are additional indirect inhibitory mechanisms by which polyclonal IgG inhibits i

92 induced forgetting (RIF) phenomenon reflects inhibitory mechanisms called into play to decrease retri

93 uggest a common evolutionary origin for both inhibitory mechanisms, called decay acceleration and cof

94 The demonstration that multiple inhibitory mechanisms can be suppressed and myogenic dif

95 Here we show that such inhibitory mechanisms can be systematically discovered i

96 We review inhibitory mechanisms considered to play a crucial role

97 ocal store depletion and some time-dependent inhibitory mechanism contribute to spark termination and

98 Inhibitory mechanisms contribute to directional tuning i

99 of activators of the cytotoxic program, this inhibitory mechanism contributes to the instability of I

100 5-HT(1A) receptors are involved in multiple inhibitory mechanisms controlling the spinobulbospinal m

101 Capturing this inhibitory mechanism could fuel the design of more effec

102 We suggest that miRNA-mediated inhibitory mechanisms could be targeted by methods simil

103 ory center response; however, the underlying inhibitory mechanisms differ.

104 studies indicated that M2-2 targets MAVS, an inhibitory mechanism different from what we previously r

105 ride stromal inhibition, suggesting that the inhibitory mechanism does not involve GAP up-regulation

106 ebound and provide insight into how feedback inhibitory mechanisms dominate in the long-term.

107 activated T cells thus providing a feedback inhibitory mechanism during T cell activation.

108 ults suggest the concurrent operation of two inhibitory mechanisms during response preparation: one d

109 an increased efficiency in the activation of inhibitory mechanisms during the Up state.

110 To determine this inhibitory mechanism, effects of Fsk on IL-2 signaling w

111 lish whether Alzheimer's disease affects all inhibitory mechanisms equally, and (ii) where possible,

112 Our results show that inhibitory mechanisms, expressed predominantly by strong

113 ICANCE: The present study has identified key inhibitory mechanisms featuring miRNAs that regulate utr

114 res, suggesting a cell-autonomous or lateral-inhibitory mechanism for impeding mesenchymal differenti

115 mogenic inhibition of RgpB by way of a novel inhibitory mechanism for peptidases in general and open

116 r findings indicate that SOCS1 represents an inhibitory mechanism for qualitatively and quantitativel

117 cular MrgprC11, may constitute an endogenous inhibitory mechanism for regulating persistent pain in m

118 Oct-2 induction of MiR-210 provides a novel inhibitory mechanism for the control of B cells and auto

119 ClC-0, suggesting a fundamentally different inhibitory mechanism for the ion on hClC-4.

120 ovel lipoprotein-associated phospholipase A2 inhibitory mechanism for the treatment of DME.

121 The role of adenylyl cyclase inhibitory mechanisms for memory has not been addressed.

122 proteasomal degradation, which differs from inhibitory mechanisms for some neurotransmitter transpor

123 Thus, local inhibitory mechanisms govern synapse formation.

124 A similar inhibitory mechanism has been described in invertebrate

125 Its inhibitory mechanism has been extensively characterized;

126 This inhibitory mechanism has been investigated further to id

127 equire p115-GM130 tethering, and its mitotic inhibitory mechanism has been unclear.

128 rgic neurons responsible for this unorthodox inhibitory mechanism has left unresolved the contributio

129 d, and multiple presynaptic and postsynaptic inhibitory mechanisms have been implicated.

130 onfirmed the physiological relevance of this inhibitory mechanism in a neuronal differentiation syste

131 These results suggest that an auto-inhibitory mechanism in C termini may be universal among

132 n viral replication and implicate a cellular inhibitory mechanism in its CD4(+) T cells.

133 the active site Cys has been suggested as an inhibitory mechanism in patients with hyperhomocysteinem

134 scores the crucial involvement of a putative inhibitory mechanism in sensory plasticity.

135 e, has been implicated to serve as a general inhibitory mechanism in the cognitive control of behavio

136 pring is determined by a two-step epigenetic inhibitory mechanism in which CpG methylation is linked

137 These results indicate an inhibitory mechanism in which EB site-specifically binds

138 mplexes, and biochemical analysis suggest an inhibitory mechanism in which Stl stabilizes catalytical

139 ses, this model overlooks other adaptive but inhibitory mechanisms in alternative threat emotions suc

140 be critical when predicting the integrity of inhibitory mechanisms in Alzheimer's disease.

141 , our results suggest an unexpected role for inhibitory mechanisms in efficient decoding of neural po

142 interpreted as evidence for a causal role of inhibitory mechanisms in episodic retrieval and forgetti

143 the involvement of brainstem endogenous pain inhibitory mechanisms in ingestion analgesia.

144 the view that differential engagement of HPA inhibitory mechanisms in the aBST may contribute to alte

145 ring stress, resulting in collapse of potent inhibitory mechanisms in the amygdala and heightened aut

146 ses in network excitability and compensatory inhibitory mechanisms in the hippocampus may contribute

147 e further showed that running enhances local inhibitory mechanisms in the hippocampus, including incr

148 ging topographically specific excitatory and inhibitory mechanisms in the thalamus.

149 mproves anxiety regulation by engaging local inhibitory mechanisms in the ventral hippocampus.

150 st, demonstrating that reversal of GABAergic inhibitory mechanisms in the VTA can reverse the inhibit

151 However, the role of these inhibitory mechanisms in vivo is unknown.

152 Other recently identified inhibitory mechanisms include exposure to elevated tempe

153 urce such as hemin, suggesting an additional inhibitory mechanism independent of iron availability.

154 Stimuli that engaged inhibitory mechanisms induced the largest gamma LFP osci

155 The studies reveal that the argininamide inhibitory mechanism involves a shift of the secondary s

156 o tested the alternative hypothesis that the inhibitory mechanism involves formation of covalent addu

157 One inhibitory mechanism involves the ability of LBP to neut

158 nd wild-type RET kinase domains reveal a cis-inhibitory mechanism involving tethering contacts betwee

159 tPA-treated stroke model is mediated by two inhibitory mechanisms involving CCL2 and MMP9.

160 These results reveal that the unusual uORF2 inhibitory mechanism is a principal determinant of the a

161 The specificity of the inhibitory mechanism is also emphasized by the observati

162 This natural inhibitory mechanism is based on the presence of an inac

163 wild-type DR4 protein can be overcome if the inhibitory mechanism is bypassed by using a DR4-agonisti

164 This inhibitory mechanism is different from the iron-sequestr

165 The specificity of the TG inhibitory mechanism is emphasized by the finding that t

166 rine 5 phosphorylation, and that this second inhibitory mechanism is essential for transcriptional re

167 Our data imply that the inhibitory mechanism is reliant on BRICHOS interfering w

168 One inhibitory mechanism is thought to be binding of bone mo

169 e neuron cell toxicity in vitro, their exact inhibitory mechanism is unknown.

170 One inhibitory mechanism is up-regulation of programmed deat

171 During studies investigating this inhibitory mechanism, it was discovered that the LspA pr

172 ker; instead we propose a wide-dynamic-range inhibitory mechanism locked to sound offset as an explan

173 This inhibitory mechanism manifested at the ER, where phospho

174 A similar inhibitory mechanism may apply to other antibodies, incl

175 The inhibitory mechanism may be due to the inhibition of cel

176 In contrast, the muscarinic presynaptic inhibitory mechanism may be engaged primarily during lon

177 olation of small molecules that exploit this inhibitory mechanism may be possible.

178 and in matched controls on the grounds that inhibitory mechanisms may also be required to switch tas

179 flexive inhibitory mechanisms and controlled inhibitory mechanisms may be critical when predicting th

180 processing aversive taste, and suggests that inhibitory mechanisms may play an important role in such

181 tional modeling previously have suggested an inhibitory mechanism mediated by binding to the RNA poly

182 tion of constitutive ERK-1/2, and suggest an inhibitory mechanism mediated by the lipid peroxidation

183 We describe a novel postsynaptic inhibitory mechanism mediated by the mGlu2 subtype that

184 ) mice suggests that an endogenous apoptosis inhibitory mechanism mediated by TNFR activation, NF-kap

185 uromasts in the lateral line has revealed an inhibitory mechanism, mediated by glial cells, that repr

186 ins of infected animals, suggesting that the inhibitory mechanisms observed in vitro are not enough t

187 This study is to understand the inhibitory mechanism of a previously identified human TM

188 ponent necessary for the rapid and efficient inhibitory mechanism of alpha2AP.

189 Taken together, the findings reveal an inhibitory mechanism of alpha7 on cytoskeletal growth vi

190 Here, we investigated the inhibitory mechanism of an antibody (17B1.3) against hum

191 The inhibitory mechanism of ATP on PARP-1 consists of a nonc

192 Here we delineated an inflammation-driven inhibitory mechanism of beige adipogenesis in obesity th

193 Then we explored the uncompetitive inhibitory mechanism of brefeldin A (BFA) that conducts

194 These results reveal the inhibitory mechanism of CaM-KIIN and establish a powerfu

195 ociation of F-actin from p35, suggesting the inhibitory mechanism of CDK5/p35 complex formation by F-

196 76; 100 nmol, i.c.v.), to assess whether the inhibitory mechanism of cocaine differed in the two regi

197 These findings not only illustrated how the inhibitory mechanism of Gd@C82(OH)22 is distinguished be

198 rotein kinase A pathway, suggesting a common inhibitory mechanism of GnIH action in GnRH neurons and

199 A mutagenesis study and the inhibitory mechanism of guanidine analogues support the

200 We have now examined the inhibitory mechanism of helenalin acetate in more detail

201 To elucidate the inhibitory mechanism of insulin in apoC-III expression,

202 ion that is consistent with a noncompetitive inhibitory mechanism of Met signal transduction.

203 erived provide quantitative insight into the inhibitory mechanism of NPA and help anticipate its effe

204 Here we detail the inhibitory mechanism of nucleozin, finding that the drug

205 tructures to shed light on the still unclear inhibitory mechanism of one such inhibitor, named bt10.

206 However, this Notch-dependent inhibitory mechanism of Pitx2 gene transcription still r

207 f IKK activity in vitro does not reflect the inhibitory mechanism of salicylate in intact cells, whic

208 The suicide inhibitory mechanism of serine protease inhibitors of th

209 This novel inhibitory mechanism of T cell activation may provide ne

210 This novel component of the inhibitory mechanism of the 100K protein identifies a di

211 The detailed inhibitory mechanism of the JM domain is revealed, which

212 The inhibitory mechanism of this compound is unique and invo

213 nd to the epsilon-subunit is involved in the inhibitory mechanism of this particular enzyme.

214 rmational heterogeneity, shed light into the inhibitory mechanisms of anti-HIV-1 chemokine analogs, a

215 Given the proposed immune-inhibitory mechanisms of B7-H3 and B7x, these molecules

216 To understand the growth-inhibitory mechanisms of FGF, we analyzed the effects of

217 The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2.

218 These data provide information about trans-inhibitory mechanisms of mutant p185 species and also in

219 is that it is sustained by a loss of normal inhibitory mechanisms of neuronal activity.

220 altered signaling, contribute to the growth inhibitory mechanisms of S179D PRL.

221 The present study investigated the inhibitory mechanisms of the anti-gp120(CD4BD) MAbs.

222 In this study, the inhibitory mechanisms of the cell-permeable recombinant

223 d be linked to the disruption of one or more inhibitory mechanisms of the thalamocortical circuit.

224 However, the inhibitory mechanisms of these drugs remain elusive.

225 cilitate detailed analysis of the cell cycle inhibitory mechanisms of this CDI in human melanoma cell

226 Understanding inhibitory mechanisms of transforming growth factor beta

227 Thus the inhibitory mechanisms of UL97 for Rb family protein-medi

228 unpleasant stimuli is caused by a selective inhibitory mechanism on emotional processing.

229 ere that rapamycin and TPCK display distinct inhibitory mechanisms on S6K1 as a rapamycin-resistant f

230 can be explained in terms of two alternative inhibitory mechanisms: one involving blocking of surface

231 nal changes are due to a relaxation in tonic inhibitory mechanisms permitting the expression of forme

232 results suggest the existence of alternative inhibitory mechanisms, possibly in trans, for the autore

233 Our discovery of drugs with a dual-inhibitory mechanism provides a unique pharmacological s

234 ether, these results indicate that different inhibitory mechanisms regulate various manifestations of

235 Our co-crystal structure shows that the inhibitory mechanism relies on stabilizing NRR quiescenc

236 se domain of Hsp90, certain aspects of their inhibitory mechanism remain unresolved.

237 to C. difficile infection and their in vivo inhibitory mechanisms remain unclear.

238 er, many details about the exact binding and inhibitory mechanism remained unclear.

239 of IKK inhibition by A20 is lacking, and the inhibitory mechanism remains poorly understood.

240 Thus, we have uncovered an inhibitory mechanism required for adaptation and long-ra

241 Investigation of the inhibitory mechanism revealed that the inhibition could

242 was undertaken to delineate the tumor growth inhibitory mechanism(s) of ERRP in pancreatic cancer cel

243 This inhibitory mechanism seems to act through steric hindran

244 The inhibitory mechanism seems to be independent of phosphol

245 c utility of memantine probably results from inhibitory mechanisms shared with ketamine, combined wit

246 st that competitive retrieval is governed by inhibitory mechanisms similar to those employed in selec

247 ing it to plasma lipoproteins, whereas other inhibitory mechanisms, such as the one described here, d

248 emporal principle of integration suggests an inhibitory mechanism that better accounts for the sensit

249 These results implicate a broadly tuned inhibitory mechanism that facilitates response preparati

250 -12 Hz) are increasingly viewed as an active inhibitory mechanism that gates and controls sensory inf

251 This suggests the existence of an inhibitory mechanism that involves lysine acetylation, a

252 These results support an inhibitory mechanism that is consistent with the require

253 that eIF4E3 underlies a clinically relevant inhibitory mechanism that is lost in some malignancies.

254 hosphorylation of Cdc20 constitutes an APC/C-inhibitory mechanism that is parallel, but not redundant

255 confirmed that the compounds possess a novel inhibitory mechanism that is unique among known FabI inh

256 t threshold sensitivities of RGCs reflect an inhibitory mechanism that masks inputs from certain rod

257 tion is gated into the auditory system by an inhibitory mechanism that operates at a higher level in

258 (100 nM), flecainide possesses an additional inhibitory mechanism that reduces RyR2 burst duration.

259 al domains of PrP(C), revealing a novel auto-inhibitory mechanism that regulates the functional activ

260 cessing is also affected by gain control, an inhibitory mechanism that underlies saturation of neural

261 is we reveal a previously undisclosed, novel inhibitory mechanism that utilizes distinct regulatory e

262 ented MOG35-55 to MOG-specific T cells by an inhibitory mechanism that was mediated in part by IFN-ga

263 where potentially disturbing stimuli trigger inhibitory mechanisms that block access to the native la

264 t of this impairment is under the control of inhibitory mechanisms that can be blocked to improve the

265 Our immediate aim was to explore the inhibitory mechanisms that contribute to orientation sel

266 Ca(2+)-CaM overcomes potent isoform E inhibitory mechanisms that function to maintain the tota

267 kotriene type 1 receptor (CysLT(1))-mediated inhibitory mechanisms that have been demonstrated for th

268 This review will focus on the inhibitory mechanisms that keep RTK-mediated signals in

269 In humans, these processes include two inhibitory mechanisms that operate during response selec

270 mutational analyses revealed extensive auto-inhibitory mechanisms that prevent free FtsY from engagi

271 ORs may play an important role in endogenous inhibitory mechanisms that regulate the development of s

272 To determine the inhibitory mechanism, the influence of A. phagocytophila

273 y, in addition to being a target of both CDK inhibitory mechanisms, the Orc6 RXL/cyclin-binding motif

274 s SCN neurons by both pre- and post-synaptic inhibitory mechanisms; the latter may play a key role in

275 many studies have sought to characterize the inhibitory mechanisms thought to be at work in the task,

276 receptor activation suggesting a structural inhibitory mechanism to prevent unwarranted phosphorylat

277 ate with microtubules, possibly providing an inhibitory mechanism to promote polarization of the cell

278 tration coupled with an FcgammaRIIb-mediated inhibitory mechanism to suppress the formation of IgE-se

279 e report that ARHGAP36 combines two distinct inhibitory mechanisms to antagonise PKA signalling.

280 Removing inhibitory mechanisms to permit HIV-1 transcription is a

281 heric activation, combined with a failure of inhibitory mechanisms to prevent bilateral perceptual ex

282 the proposed physiological relevance of this inhibitory mechanism, unlike CO, NO(*) was reported to b

283 Kinetic dissection of the PAI-1 inhibitory mechanism using multiple target proteinases m

284 This inhibitory mechanism was not observed in TB, probably be

285 In contrast, an allosteric inhibitory mechanism was supported by an enhancement of

286 Al(2)O(3) or SiO(2), indicating the dominant inhibitory mechanism was surface complexation/precipitat

287 et the RSV large polymerase subunit, but its inhibitory mechanism was unknown.

288 The functional impact of the differing inhibitory mechanisms was revealed in macroscopic Ca(2+)

289 To clarify the underlying inhibitory mechanism, we analyzed the actin-activated AT

290 To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1

291 To test the significance of this inhibitory mechanism, we generated knock-in mice that ex

292 With further studies of its inhibitory mechanisms, we demonstrated that 103 carries

293 To identify additional Cdc6-mediated, APC-inhibitory mechanisms, we looked for mutants that revers

294 However, inhibitory mechanisms, which function to limit the recal

295 uppression of ipsilateral neural activity by inhibitory mechanisms whose functioning is poorly unders

296 tivity in this system that occurs through an inhibitory mechanism with PKCalpha.

297 etic behavior, implying that there is no cis-inhibitory mechanism within the RET intracellular domain

298 se observations suggest the existence of TNF inhibitory mechanisms within the eye during retinal proc

299 In this study, we found that STDT depends on inhibitory mechanisms within the primary somatosensory a

300 These voltage- and ligand-dependent inhibitory mechanisms would be expected to contribute to