ライフサイエンスコーパス: initial

1 d, placebo-controlled trial consisting of an initial 12- to 16-week open-label period and a 26-week d

2 After the initial 6 months, the intensive group had a slightly hig

3 hs of MPH medication was correlated with the initial 90-minute MPH-mediated FC changes.

4 sequent re-learning, and already late during initial acquisition.

5 n reverse key platelet functions after their initial activation and identifies a novel mechanism for

6 oid cells have been studied extensively, the initial activation of the Gata1 gene in early hematopoie

7 icient catalyst for HER in this series, with initial activity that is slightly worse compared to the

8 By combining an initial acylation, alkylation, or glycosylation step wit

9 irds had infection at the same site as their initial admission.

10 rich nitrogen simultaneously facilitates the initial adsorption of water via the electron-deficient H

11 mata that lend themselves to distancing have initial affective reactions similar to those of novices,

12 and its effect begins several minutes after initial agonist application.

13 ostic factors found to be most prognostic on initial analysis were PRETreatment EXTent of disease (PR

14 nanotubes mimics exposure to asbestos, from initial and chronic inflammation, through loss of the sa

15 hospital eye services were extracted at the initial and follow-up visits between 2007 and 2014.

16 primary FSGS, and glucocorticoids remain the initial and often, the primary treatment of choice for t

17 nd in 26% and 18% of anal biopsies following initial and secondary screening, respectively.

18 To describe initial and serial multimodal imaging findings in AMN, w

19 Raltegravir and efavirenz-based initial antiretroviral therapy have similar 4-year clini

20 eappear in the bloodstream 10 days after the initial appearance of gametocyte rings.

21 age that was constant and independent of the initial ascorbate or dehydroascorbic acid concentration

22 tion of climate change, support a convenient initial assessment of potential threats to and opportuni

23 CF-ALF induced Psl reduction does not alter initial bacterial attachment to surfaces but reduces bio

24 by premature senescence in primary cells, an initial barrier to tumor development.

25 consistent with a loop-capture mechanism for initial binding and compaction.

26 ns, and most of the folding occurs after the initial binding event.

27 cetuximab vs bevacizumab to chemotherapy as initial biologic treatment.

28 , and FSGS or diffuse mesangial sclerosis on initial biopsy as well as age, serum albumin concentrati

29 wed for a median of 49 months; 74% underwent initial biopsy at a referring institution.

30 Among 237 patients with initial biopsy-proved N1 disease, 69 of 77 (89.6%) with

31 surgery strategy, patients remained at their initial body mass index (calculated as weight in kilogra

32 ed an average weight loss of 10.5 kg (10% of initial body weight).

33 n of antibiotics and to the completion of an initial bolus of intravenous fluid.

34 n with invasive breast cancer, median age at initial breast cancer diagnosis was 60.6 years (age rang

35 cages exhibited the same progression from an initial bright singlet state (species I) to a delocalize

36 frozen-food industry account for 45% of the initial broccoli heads.

37 engthening) of passive muscle, including the initial burst, the dynamic response to lengthening, and

38 These include acceleration-dependent initial bursts, increased dynamic response to stretch ve

39 scence of the 5 and 3 sites in a complex (I, initial), but if this cannot form the components show un

40 The initial C-H bond activation remains as the sole kinetica

41 lly considered, with emphasis on controlling initial C3 activation under physiological conditions.

42 Initial cases affected mainly wild birds and mixed backy

43 intermediates of the cascade reaction and an initial catalytic asymmetric example that generates a ca

44 ressing cells were identical to the expected initial cell density, indicating that the reduction in C

45 We examined the extent to which initial changes in brain functional connectivity (FC) as

46 This initial characterization of T-MOC indicates its transfor

47 orrelated A(-*)-R(*) radical pair, where the initial charge separation yields a 3:1 statistical mixtu

48 n be run directly on FASTQ files for a quick initial check.

49 ib or placebo after completion of first-line/initial chemotherapy for metastatic disease.

50 and had available data on the date of their initial cholecystectomy were included.

51 ppears to be between 4 and 8 weeks after the initial cholecystectomy.

52 Continuation of prolonged antivirals beyond initial clearance was not associated with a reduced risk

53 At initial clinic visit, her blood pressure was 138/84 with

54 marily diagnosed visually, beginning with an initial clinical screening and followed potentially by d

55 ifying batch cultures under four conditions: initial COD:N ratios of 11:1 and 4:1 with and without ni

56 CSA) mechanism is at play, which combines an initial Collisionless Shock Acceleration (CSA) to a boos

57 ere is currently little understanding of how initial community structure may drive the microbiota tra

58 ic activity of PARP1 is not required for the initial complex formation with XPC in the nucleoplasm bu

59 in model solution starting with an elevated initial concentration.

60 (2+), and Pb(2+)) from aqueous solution with initial concentrations (60-6000 ppm) chosen to simulate

61 ormwater was independent of target-adsorbate initial concentrations (C0) when C0s were below concentr

62 The initial concentrations of oleic acid and polyphenols in

63 with apparent coherence only due to similar initial conditions and quasi homogeneity of the medium t

64 ization techniques are strongly sensitive to initial conditions due to high dimensionality and noncon

65 Accordingly, variation in initial conditions may explain divergent population resp

66 ther deciduous or evergreen depending on the initial conditions of plant trait abundance (i.e., found

67 The parasite makes initial contact with the erythrocyte followed by dramati

68 Initial correlation between OSA and ocular surface and e

69 Altogether, our work provides initial correlative support for a previously hypothesize

70 e of total area approximately 0.03 mm(2) The initial corrosion proceeds as self-catalyzed pitting, vi

71 uma concolor coryi) in Florida following the initial cross-species infection from bobcats.

72 2) determine the association between time to initial crystalloid resuscitation with hospital mortalit

73 After an initial CT attenuation scan, (11)C-nicotine was administ

74 gy, concepts, methodological approaches, and initial data pertaining to engrams.

75 We observed an initial decrease in myocardial and endocardial cavity vo

76 Our results show an initial decrease of SVZ proliferation at 24 h, followed

77 entional dendritic cells to facilitate their initial delivery toward follicular dendritic cells to es

78 longed activation of these synapses leads to initial depression, which is followed by steady-state re

79 ny studies are only snapshot analyses of the initial design or the emergent structure of polycentric

80 the spring of 2016-several months before its initial detection.

81 of an anti-PAR2 antibody, SAM-11, after the initial development of airway inflammation significantly

82 undergo an eye examination by 6 years after initial diabetes diagnosis (net worth of >/=$500000 vs <

83 osis, 7.7 years; 46% female) the most common initial diagnoses were acute lymphoblastic leukemia, Hod

84 ospital who survived 10 years or longer from initial diagnosis and were 18 years or older as of June

85 in which postshunt benefits in patients with initial diagnosis of idiopathic NPH persist in only 32%

86 es in two sets of experiments at the time of initial diagnosis.

87 The initial diagnostic imaging findings were concordant with

88 consistent and timely access to Xpert as an initial diagnostic test and to drug resistance screening

89 hoice representing the maximal reward (i.e., initial dip).

90 eakdown is a two-phase process involving the initial disassembly of desmin filaments by Trim32, which

91 ntical subunits has been a mystery since its initial discovery.

92 An initial discussion of QD materials along with key concep

93 are determined at the time of the patient's initial disease presentation.

94 virus or death of the host, depending on the initial dosage of the virus.

95 Baseline severities and features of initial DR are prognostic for PDR development.

96 EKi) trametinib illustrated a time-course of initial drug response and persistence, followed by the d

97 of nail permitting a 10(3)-fold increase in initial drug uptake.

98 Our findings indicate that the initial effect of SSRI treatment is to alter processing

99 Initial EMT was induced by prolonged exposure to IL6, a

100 Evolution of homochirality requires an initial enantiomeric excess (EE) between right and left-

101 tro group is bonded to the 4-position of the initial enantiomerically enriched pyrrolidine ring.

102 While initial endocrine interventions are successful, resistan

103 pecific deletion in mice of glutaminase, the initial enzyme in glutamine catabolism, markedly blunts

104 e continuous, dynamic, and evolving from the initial establishment of a cancer cell to the developmen

105 The initial estimate of the attenuation map was obtained usi

106 studies, molecular data have yielded robust initial estimates of relationships both within and among

107 quent generations that never experienced the initial event.

108 al responses in monosexual men, and provides initial evidence for distinct brain activity patterns in

109 We further find initial evidence for home-lab links: common noun "copres

110 od is demonstrated in tissue phantoms and in initial experiments in vivo.

111 Loss of dysbindin-1A resulted in heightened initial exploration and disruption in subsequent habitua

112 Together, these results provide an initial facility-specific survey of methane emissions fr

113 were obtained with a workflow that included initial fast, high-energy HCD (Orbitrap, FT) scans, whic

114 d changes in cancer cell metabolism, with an initial focus on HIF-mediated effects, and will highligh

115 In its initial form, T-BAS v1.0 uses a core phylogeny of 979 ta

116 TP release indicate that G100V/C103V retards initial fusion-pore opening, hinders its expansion and l

117 not receive a molecular diagnosis after the initial genetics evaluation, that rate is much lower.

118 The initial genome-wide association study (GWAS) included 17

119 Based on our initial genome-wide association study (GWAS) on esophage

120 After adjusting for age, initial Glasgow Coma Scale, and mean intracranial pressu

121 pressure reverses structural changes and the initial glassy state is recovered.

122 ethane starvation and recovery, and lays the initial groundwork to develop Methyloprofundus as a mode

123 rode strips was analysed over Days 0-3 after initial haemorrhage and magnetic resonance imaging studi

124 tro, and vessel wall platelet deposition and initial hemostasis in vivo.

125 ransfer inhibitors (INSTIs) as components of initial HIV therapy.

126 y disorders more broadly, have postulated an initial hypervigilance or facilitation to clinically rel

127 nd 28% (CI, 26% to 30%) recovered from their initial impairment and remained independent throughout t

128 In the 10 years after the initial impairment, 16% (CI, 14% to 18%) had 1 or more e

129 between IG and CG (P = 0.042), with a slight initial increase in the IG during the first year and sma

130 d in close spatial proximity, we observed an initial increase in the local H2O2 concentration of appr

131 oxygen (hypoxia) is biphasic, comprising an initial increase in ventilation followed by a secondary

132 temporal trends for the PTOS and NTDB showed initial increases in filter placement followed by signif

133 After initial infection, the virus establishes latent reservoi

134 device removal and reimplantation during the initial infection.

135 ycles with a probability that is function of initial inoculum, plant population size and nodulation c

136 te approximate oligomer solutions quickly as initial inputs for further refinement using the MD/SA me

137 lex biochemical processes beginning with the initial insult and lasting for days, months and even yea

138 pilepsy (TLE) generally takes years after an initial insult during which maladaptation of hippocampal

139 how they respond transcriptionally upon the initial insult is incompletely understood.

140 xisting consensus is that GABA regulates the initial integration of adult-born neurons, similar to ne

141 The initial intervention site was randomly chosen using a co

142 Our results provide initial intracranial evidence for the neurophysiological

143 ely 10% to 20% of patients do not respond to initial intravenous immune globulin, and recommendations

144 ation of resistance and susceptibility after initial isolation of bacteria from a clinical specimen.

145 Similar initial laser energy settings were used in both groups (

146 In an initial learning phase participants were exposed to a su

147 with older age at diagnosis, male sex, poor initial levodopa treatment response, and postural instab

148 iver Disease (MELD) score within 3 months of initial liver CT imaging between January 3, 2006, and Ma

149 mpared with patients admitted for dofetilide initial loading.

150 ve emerged as an accurate and cost-effective initial localization study for patients with primary hyp

151 ignificantly more spontaneous termination of initial long-duration VF was observed (66.67%; P=0.01).

152 Surgery after initial lumpectomy to obtain more widely clear margins i

153 cluding pulmonary arterial compliance, after initial management in PAH.

154 Active surveillance should be an initial management option for patients who have signific

155 Initial mechanistic studies have suggested that mavacamt

156 An initial meta-analysis identified 14 randomized clinical

157 ar how twitching motility emerges from these initial minimal conditions.

158 stitution on January 1, 2011, with US as the initial modality followed by unenhanced MR imaging when

159 Plain radiograph is the initial modality used to evaluate patients with painful

160 confidence Interval [CI] 33.1%-34.5%) after initial monoinfection with P. vivax and 29.2% (95% CI 28

161 ients who were randomly assigned either to 3 initial months of VIM-only or VO-only stimulation.

162 stomes, reveal preconditions that suggest an initial morpho-functional basis for the derived chimaero

163 The absence of LIMP reduces initial mosquito infection by 50%, impedes salivary glan

164 age III disease at first melanoma diagnosis (initial; n = 2,042), or who developed locoregional metas

165 n a Danish nationwide register who underwent initial noninvasive cardiac testing with either coronary

166 In patients with initial normal lactate (< 2.2 mmol/L), elevated lactate

167 le-molecule refolding experiments reveal the initial nucleation of folding while simulations corrobor

168 eloped employing soft ketone enolates as the initial nucleophile for anion relay chemistry (ARC).

169 All emulsions had similar initial oil droplet sizes and were submitted to simulate

170 In the sexual stages, zygote formation and initial ookinete differentiation precede MyoA synthesis

171 were randomly assigned to receive either an initial oral dose of 200 000 IU (5.0 mg) colecalciferol

172 mycocyclosin, implicating compound I as the initial oxidizing species.

173 Using confocal microscopy, we observe the initial particle attachment to the membrane, then partic

174 on and molecular control might have made the initial pathways to prebiotic systems evolution more int

175 Initial patient data indicate its comparable or even sup

176 gional identity of organoids is stable after initial patterning occurs.

177 riteria were missing data for either race or initial PD modality.

178 onths in both subgroups, 5 to 7 and >7 mm of initial PD.

179 ulations across the continent, following the initial peopling of the Americas.

180 that occur in the crop Brassica rapa during initial perception of drought, we applied a co-expressio

181 determine whether the genetic background of initial periodontitis and caries could be detected using

182 The mean values of the initial PET/CT parameters in the LABC group were signifi

183 nce of strong westerly crosswinds during the initial phase of their autumn transatlantic journey may

184 the exposure to light in the first 115 h by initial photosolubilization of HC components and their p

185 However, the exact nature of the initial plasma-tissue interactions remains unknown, incl

186 An initial population of patients with an admission to a me

187 In vivo imaging further revealed that in the initial post-ONC period, rtACS induced dendritic pruning

188 A widely used strategy relies on initial prediction of human leukocyte antigen-binding pe

189 vided to sepsis and septic shock patients at initial presentation and 2) determine the association be

190 with multiple sclerosis (MS), either as the initial presenting complaint prior to a definitive neuro

191 -deficient mutants may be conditional on the initial pretreatment stomatal conductance.

192 igands that deliver a TLR9 agonist induce an initial proliferative burst that is followed by apoptoti

193 Stopped-flow measurements suggest that initial PROPPIN-membrane binding is driven by non-specif

194 The initial prostate-specific antigen response showed no cor

195 e lipid environment is also a determinant of initial protein topology, which is dynamically responsiv

196 The results with our initial prototype instrument demonstrate that the integr

197 apped ions, which can be prepared in various initial pure states.

198 findings from index biopsies at the time of initial PVN diagnosis.

199 pump pulse of 266 nm light, we determined an initial radical formation time of 1.3 +/- 0.2 ps, which

200 Although patients who do not receive initial radiotherapy for DCIS are candidates for subsequ

201 rth before 34 weeks were characterized by an initial rapid decrease in risk with increasing intake (P

202 Combining these results with a study of initial rates of phenol formation, and of substituent el

203 Besides initial reactivity studies of 2 toward CO2 and methanol,

204 cytes into the joint are responsible for the initial reduction of macrophages following infliximab tr

205 Mortality fell from the initial registry to the subsequent continued access regi

206 However, after three initial reports of NECD from the cytochrome c dimer comp

207 Despite initial response to induction therapy, nearly 50% of hig

208 e to individual differences in the timing of initial response to sound onset.

209 pants (21 males and 28 females) underwent an initial resting-state scan, followed by a cognitive reas

210 y on P. diadema fecal DNA, and report robust initial results and suggestions for future implementatio

211 These initial results challenge the belief that metastatic uve

212 rging MRI methods and outlines the promising initial results obtained with each as well as current li

213 or outcome were independent of age, sex, and initial rhythm but higher for out-of-hospital cardiac ar

214 CAM2038 produces a rapid initial rise of buprenorphine in plasma with maximum con

215 INTERPRETATION: The initial risk of seizures on CEEG is dependent on history

216 dministered in combination were evaluated as initial salvage therapy in patients with relapsed or ref

217 establish a temporary state that limits the initial SAM-encoded Ag expression.

218 valid for human blood samples as the optimum initial sample amount for a real sample is more than 3 t

219 With the exception of the initial sample mass (0.15 g for blood, 0.5 g for urine,

220 METHOD: The Recovery After an Initial Schizophrenia Episode-Early Treatment Program (R

221 From an initial screen of 1.5 million compounds, followed by in

222 The initial screen of small molecule compound libraries iden

223 Initial screening of a series of over 50 newly character

224 ving potent neutralization activity based on initial screening or to evaluate neutralization magnitud

225 candidate miRNAs were identified during the initial screening, and we subsequently validated upregul

226 .52), and 0.45% (P = .17), respectively, at initial screening.

227 , compared with 0.5% (P < .001) confirmed at initial screening.

228 REVIEW The initial search yielded 2243.

229 sembly of excitable domains such as the axon initial segment (AIS) and nodes of Ranvier.

230 The axon initial segment (AIS) is the site of initiation of actio

231 in a nucleotide-free, apo state, with the NL initial segment (NIS) adopting a backward-docked conform

232 IP1 is a cytoplasmic protein present in axon initial segments and nodes of Ranvier.

233 tivity is lower, whereas the density of axon initial segments detectable by immunoreactivity for the

234 t sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes

235 t odor molecules in the nose and provide the initial sensory input to the brain's olfactory bulb.

236 to be from the same site and organism as the initial sepsis hospitalization.

237 8.6%) were for infection at the same site as initial sepsis hospitalization.

238 re more frequently women, had lower rates of initial shockable rhythm, and less frequently experience

239 rival increased during the SAED protocol for initial shockable rhythms (from 58.9% to 69.2%; P<0.001)

240 [Pi] induced a biphasic force decay with an initial slow decline (phase 1) and a subsequent 3-5-fold

241 nt to increases of 73% and 56% compared with initial SOC stocks in the 1980s.

242 ons and increased solubility relative to the initial solid phases.

243 Thus, regardless of initial speciation, Ag was readily available to duckweed

244 ed from CO2 and H2 are carbon sources in the initial stage of biological evolution of cells leading t

245 , their functional characterization is at an initial stage.

246 f GATA6 and NANOG is not fundamental for the initial stages of PrE versus EPI specification in mammal

247 Neonatal imitation illuminates how the initial state engenders and supports rapid social learni

248 nt T2 hyperintensity was associated with the initial STEMI severity, adverse remodeling, and long-ter

249 we propose that such clustering is a useful initial step for other assembly pipelines.

250 ng the expression patterns of snoRNAs is the initial step in determining their functional significanc

251 ion of the maternal decidua appears to be an initial step in the maternal component of the disease as

252 oxia (SAH) mouse model of DWMI activates the initial step of the ISR.

253 The initial steps in this process can be traced back to the

254 by obtaining a detailed understanding of the initial steps of CO2 electroreduction on copper surfaces

255 Initial structure-activity relationship studies have res

256 Our initial structure-activity relationship studies on 7-met

257 Microarray-based initial studies on the mechanism of action suggest that

258 Across an initial study and two preregistered experiments (N = 262

259 study a mean (SD) of 10 (3) months after the initial study closeout.

260 t viral rebound in people that have achieved initial suppression with ART, to determine factors assoc

261 lly considered to involve endocytosis and an initial surface-binding event.

262 Used alone, without initial susceptibility tests, Rapidec Carba NP can provi

263 A complex assembly pathway conducts their initial synthesis and subsequent binding to recipient pr

264 cruitment into secondary lymphoid organs nor initial T cell activation was affected by Dll1/4 loss.

265 anized into specialized sensory areas, whose initial territory is determined by intracortical molecul

266 In an initial test of this new inhibitor class, alpha-(1'-fluo

267 rning by embedding educational material, and initial (test 1) and additional test questions (test 2)

268 Death within 1 year after initial therapy for AML.

269 strate a beam-like hot electron transport at initial time-scales that may be attributed to the local

270 hus, the sampling method does not detect the initial timing of reactivation, and results obtained usi

271 After an initial titration period, the dose was adjusted to attai

272 d the Dominican Republic, surgeons completed initial training programs in hernia repair, underwent in

273 evidence and developed recommendations about initial treatment approaches by using the Grading of Rec

274 The initial treatment included intravitreal vancomycin and c

275 Recommendation 1: For initial treatment of seasonal allergic rhinitis in perso

276 The initial treatment plan was based on the results from con

277 Health states were defined for initial treatment, first and second progression, and dea

278 osteroid and an intranasal antihistamine for initial treatment.

279 ovascular events by 25% (P=0.037) during the initial trial phase and the risk of coronary heart disea

280 tricular ejection fraction [LVEF] </=40%) on initial TTE that resolved (LVEF >/=50%) during donor man

281 Only a subset of functions deregulated in initial tumors was similarly deregulated in recurrent tu

282 They underwent PET/CT imaging for the initial tumour staging and had no evidence of distant me

283 espite this, it has become apparent that our initial understanding of AT1R signaling is oversimplifie

284 When stratified by initial UNOS status, women had a higher mortality than m

285 While the initial uptake rate of the small molecule tracer was slo

286 0 degrees C decreased simply to 90.9% of the initial value at room temperature.

287 nance frequency increases up to twice of the initial value while the third resonance frequency decrea

288 gorithm that quantifies CEST images based on initial values from multi-pool Lorentzian fitting of ite

289 The initial vasodilation appears caused by respiratory depre

290 % CI, 2.1-3.7) and receive norepinephrine as initial vasopressor (adjusted odds ratio quartile 4 vs q

291 Above the CVC, initial vesicle formation rates were faster in the prese

292 On the initial visit to our hospital, serum total IgE level was

293 and other biomarkers measured at the time of initial VTE with recurrent VTE in a prespecified analysi

294 rvative treatment algorithm-consisting of an initial wait-and-see strategy, non-mutilating surgery, a

295 iming program was present that predicted the initial wave of zygotic transcription.

296 need to identify key players of the storm's initial wave.

297 separately among those with 3-9% and >/=10% initial weight loss.Regainers had higher body weight at

298 cing thermal gradients in fluid systems with initial, well-defined density gradients results in the f

299 s were significantly reduced relative to the initial wine.

300 over time, in particular among patients with initial worse prognoses.