ライフサイエンスコーパス: initial response

1 /-63%, respectively (each P<0.001 versus the initial response).

2 a stable response after 4 weeks (96% of the initial response).

3 t baseline) or acquired (ie, developed after initial response).

4 or near-normal swallowing (excellent or good initial responses).

5 tinib but some fail to respond or lose their initial response.

6 apy cycles was determined by rapidity of the initial response.

7 ese early time points, reflecting a rigorous initial response.

8 e develops rapidly in most patients after an initial response.

9 teristics of depression predicted time until initial response.

10 ited to patients with a true drug pattern of initial response.

11 of afferents from those activated during the initial response.

12 in (0.5 mg kg-1), which had no effect on the initial response.

13 with IL-4 involved in downregulation of the initial response.

14 ic) examined the details and outcomes of the initial response.

15 day or 400 mg twice per day if there was no initial response.

16 late residual multiple myeloma (MM) after an initial response.

17 d viral breakthrough within 15 days after an initial response.

18 itable recurrence of resistant disease after initial responses.

19 ed drug resistance frequently develops after initial responses.

20 In spite of this initial response, Ag presentation by ProAd-ICAM is a tol

21 ough medical or surgical castration leads to initial response and durable remission, but resistance i

22 Loss of initial response and infusion reactions post-infliximab

23 ateau level that was typically 10-40% of the initial response and persisted at this level for at leas

24 racterizing the ratio of time scales for the initial response and recovery time of the system which c

25 course of an outbreak can change the optimal initial response and result in significant cost savings.

26 ATM is critical for the initial response and the subsequent ATR activation.

27 ly differentiates true drug from nonspecific initial responses and extend its use to the continuation

28 After the initial response, antiandrogens lose their efficacy and

29 During quiet wakefulness, an initial response (approximately 15 milliseconds) at the

30 Factors that trigger this initial response are not well understood.

31 However, such initial responses are almost always followed by relapse,

32 sms involved in producing habituation of the initial responses are located more centrally than the pe

33 Initial response assessments 12 wk after radioimmunother

34 spherules in order to better understand the initial response between Coccidioides and the human host

35 assess outcomes in patients who have a poor initial response but continue treatment without switchin

36 assess outcomes in patients who have a poor initial response but continue treatment without switchin

37 ive cytotoxic chemotherapy results in a good initial response but limited long-term survival.

38 and conjunctiva may be associated with good initial response, but the risk of distant relapse is abo

39 ilarly treated TNF-/- mice show little or no initial response, but then develop a vigorous, disorgani

40 ing at lower frequencies (<20 Hz) during the initial response, but was limited (<20% of the explained

41 preincubated for 10 s, it decreased the peak initial response by approximately 15%.

42 While initial response can be favorable, the disease typically

43 However, despite these remarkable initial responses, cancers eventually develop resistance

44 amental alone were also abnormal, in that an initial response component normally present in the ERG w

45 contrast, bipolar cell synapses with strong initial responses depressed, whereas synapses with weak

46 front-line therapies or who relapse after an initial response die from progressive disease.

47 y, thus suggesting cortical amplification of initial responses driven by thalamocortical inputs.

48 e dark, which could be essential for a rapid initial response during dark-to-light transition.

49 ial phase of the response (the phenomenon of initial response enhancement).

50 ponses depressed, whereas synapses with weak initial responses facilitated.

51 re decreased in two phases: an instantaneous initial response, followed by a slower change in length

52 Dark pretreatment did not change the lag to initial response following hormone application to vertic

53 on is essential for boosting and shaping the initial response following signaling through the antigen

54 (IL4) to the IL4 receptor (IL4R) induces the initial response for Th2 lymphocyte polarization.

55 tial response to treatment and those with an initial response for whom treatment later failed) or fro

56 a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand poten

57 rapy therapy or who experience relapse after initial response have dismal outcomes.

58 However, initial responses have not been sustained, with a median

59 Despite initial response, his disease progressed after 4 months,

60 Regardless of the specificity of initial responses, IE1-specific responses predominated b

61 ytic methods to separate the strength of the initial response impulse from the proficiency of inhibit

62 Rituximab produces an initial response in approximately 60% of cases, with no

63 After an initial response in most patients, tumors invariably pro

64 anced both the magnitude and duration of the initial response in preclinical models of EML4-ALK lung

65 We observed an initial response in the hemisphere contralateral to the

66 These receptors mediate initial responses in innate immunity and are required fo

67 The molecular events mediating the initial responses in mDC remain unclear.

68 nts who underwent stem cell transplantation, initial responses in most patients were good to excellen

69 Flutamide altered initial response, increasing latency to enter the pup ca

70 ation, sequential herbivory counteracted the initial responses induced by O3, resulting in a phenotyp

71 t was predominantly in patients for whom the initial response interval was 4 minutes or longer (survi

72 are stable, resistance to treatment after an initial response is common in more advanced phases of th

73 The mechanism for this initial response is unclear.

74 improved response with longer therapy beyond initial response, leading to continued improvement in ov

75 Eyes with poor initial response may benefit from continued treatment wi

76 binding suggest a role for the protein as an initial response mechanism for chitin perception in soyb

77 ve malignancy with poor survival rates, with initial responses nearly invariably followed by rapid re

78 Typically, the initial response of a prostate cancer patient to androge

79 pacia are associated with differences in the initial response of alveolar macrophages (AM) to these p

80 res, we have identified genes central to the initial response of Arabidopsis to hypobaria.

81 results give a comprehensive picture of the initial response of E. coli to hyperosmotic shock and of

82 We examined the initial response of freshly isolated human leukocytes to

83 The initial response of heart rate to dynamic exercise has b

84 i) increased membrane fluidity following the initial response of increased rigidity, and (iv) no chan

85 The initial response of liver cells to insulin is mediated t

86 vo biotinylation in zebrafish to analyse the initial response of neutrophils to Mycobacterium marinum

87 Mg2+ affects the initial response of PC12 cells to 2MeSATP in a manner si

88 Importantly, collagen I induced a similar initial response of protrusions and dissemination in bot

89 cs due to hydrophobic mismatch, in which the initial response of the apposed leaflets upon quenching

90 We sought to understand the initial response of the BBB to the human meningeal patho

91 cadian clock, and Tim degradation may be the initial response of the clock to light.

92 Interestingly, the initial response of the cyclic AMP response element prom

93 ay be of pathophysiological relevance in the initial response of the organism to infection.

94 We concluded that the robust initial response of the p53 pathway to GART inhibitors i

95 e that the snky+ product is required for the initial response of the sperm to cytoplasmic cues in the

96 ell enables time-resolved measurement of the initial response of VVD to illumination.

97 It should be noted that the initial responses of IL-6 and IL-8 up to T = 4 hours wer

98 lasting hyperpolarization and suppresses the initial responses of input from layer 4 and that this in

99 However, the initial responses of the ONH to elevated IOP are unknown

100 engthening were national preparedness plans, initial response, plans for securing vaccine supply, and

101 total, 152 patients (61%) showed an overall initial response (platelet count >/=30 x 10(9)/L and >/=

102 ins are deleterious, cells downregulate this initial response rapidly.

103 selective BRAF inhibitors results in a high initial response rate but limited duration of response.

104 The overall initial response rate of 94% included 74% complete remis

105 ng cancer (LSCLC) is characterized by a high initial response rate to chemoradiotherapy, but local or

106 The initial response rate to fludarabine was 82% (94 of 115

107 Despite initial response rates of greater than 90%, 15%-30% of p

108 patient in the neostigmine group without an initial response received open-label neostigmine; all ha

109 that observed on response trials (where the initial response remains appropriate and no control is i

110 that these early changes reflect changes in initial response selection, possibly by alterations in t

111 However, despite their initial response, such cancers almost invariably develop

112 C neurons gave an identical initial response that remained steady, declining only 6%

113 nd a specific binding response on top of the initial response, the magnitude of which is dependent on

114 Despite initial responses, the development of resistance limits

115 After encouraging initial responses, the study was expanded to further eva

116 he addition of Ca(2+) was associated with an initial response time (IRT) of mV(O(2)) that was dose-de

117 n single units from these bundles during the initial response to 10 micrograms 5-HT was 13.0 +/- 1.8

118 The initial response to 5-HT was unaffected by the L-type ca

119 The initial response to activated Notch1 was proliferation a

120 ber of LHPA alterations, including a blunted initial response to acute restraint stress followed by a

121 investigated whether characterization of the initial response to adrenocortical steroids and the cour

122 Surprisingly, we determined that the initial response to Ag at day 3 (d3) in the mediastinal

123 We find that as an initial response to altered culture conditions, hESCs ch

124 0% mortality by week 10, and (iii) while the initial response to AmB and miltefosine was intact, kill

125 The initial response to an ischemic event is the rapid relea

126 etastatic prostate cancer who achieve a good initial response to androgen deprivation.

127 lioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy.

128 ing CD8(+) T cells is to set the size of the initial response to antigen by promoting T cell prolifer

129 severity is more closely associated with the initial response to antirejection therapy and long-term

130 y a significant risk for graft loss, and the initial response to antirejection therapy can predict lo

131 The initial response to ASHAP before subsequent ABMT consoli

132 ffect basal VP release and did not alter the initial response to ATP.

133 red superficial dermal nerve bundles was the initial response to axotomy.

134 reduction in TGF-beta activity augments the initial response to BCG vaccination, early bacterial cle

135 An initial response to BCT was not found to be predictive f

136 movement were negatively correlated and the initial response to BT treatment positively correlated w

137 3), we examined the relationship between the initial response to changes in PEEP after randomization

138 d regrowth than control xenografts following initial response to chemotherapy suggesting that a high

139 After an initial response to chemotherapy, many patients with tri

140 This study supports the notion that initial response to clozapine occurs within the first fe

141 ned these results with respect to each rat's initial response to cocaine, response to a novel environ

142 men could sustain viral suppression after an initial response to combination therapy.

143 both point to the key role of nucleus in the initial response to copper overload and suggest time-dep

144 response modifiers in early disease or after initial response to cytotoxic chemotherapy.

145 We defined a poor initial response to darbepoetin alfa (which occurred in

146 Patients who had a poor initial response to darbepoetin alfa had a lower average

147 larly in cases of toxoplasmosis in which the initial response to drug treatment is poor.

148 itates significant Fe(III) uptake during the initial response to Fe limitation.

149 Despite an excellent initial response to first-line hormonal treatment, most

150 ge proportion of solid tumor cell lines, the initial response to flavopiridol is cell cycle arrest.

151 t subjects with an ff genotype had the least initial response to fructan.

152 loblastoma patient who had relapsed after an initial response to GDC-0449, we determined the mutation

153 However, despite their initial response to genetic EGFR* extinction, all tumors

154 ly myelopathic symptoms and had a favourable initial response to high dose glucocorticosteroids.

155 This initial response to hyperosmolarity precedes and tempora

156 in which the CML cell line KCL-22, following initial response to imatinib, develops resistant T315I B

157 Initial response to induction chemotherapy predicts fail

158 asured by BH3 profiling was a determinant of initial response to induction chemotherapy, relapse afte

159 has shown that in this past era, absence of initial response to induction therapy had no impact on p

160 Despite initial response to induction therapy, nearly 50% of hig

161 infliximab (primary nonresponse), 38 had an initial response to infliximab but relapsed (secondary n

162 f an individual may profoundly influence the initial response to inhaled Ag, and that aerosol-induced

163 In many cases, the initial response to inhibition of replication was a pers

164 We conclude that the initial response to interferon in patients with chronic

165 n Group 2, oral steroids were added after an initial response to intravenous antibiotics.

166 hether Ag presentation is decreased after an initial response to Leishmania major.

167 The initial response to ligand stimulation was increased and

168 ptides, and resident effector cells form the initial response to mechanical injury of the skin.

169 ation of the anterior-posterior axis and the initial response to mesoderm-inducing signals is intact

170 s, although unburned grassland showed little initial response to multiple ecological presses, our res

171 Two patients who had an initial response to neostigmine required colonoscopic de

172 Therefore, strategies to improve on the initial response to nucleoside analog therapy are likely

173 Although the initial response to partial hepatectomy at the priming p

174 TRM orchestrate the initial response to pathogens re-encountered at these lo

175 onse to therapy in patients with an adequate initial response to peginterferon.

176 ed superoxide production as well as a weaker initial response to phorbol ester.

177 Initial response to photoexcitation is assigned to local

178 than heat shock proteins, which changes the initial response to poliovirus infections from persisten

179 Among smokers who did not show a sufficient initial response to prequit nicotine patch treatment, co

180 arboring BRAF V600E was a biomarker of worse initial response to RAF and MEK inhibition in patients,

181 Chronic graft-versus-host disease and an initial response to SCT predicted longer OS.

182 e to individual differences in the timing of initial response to sound onset.

183 While the amplitude of the initial response to stimulation at attended peripheral l

184 r/lpr mice occurs in two phases: an abortive initial response to T help followed by full loss of tole

185 for breast cancer commonly develops after an initial response to tamoxifen or aromatase inhibitors.

186 This reflects in part the fact that the initial response to TH induction in both tissues is cell

187 re particularly responsible for mounting the initial response to the cGVH stimulus.

188 not respond or eventually relapse after the initial response to the current treatments.

189 The initial response to the gene deletions was flux reroutin

190 U.S. Navy internists who participated in the initial response to the Haitian earthquake disaster onbo

191 higher dose in patients progressing after an initial response to the standard dose therapy.

192 nous imageable murine model of melanoma from initial response to therapeutic resistance, offering new

193 gender, extent of cutaneous involvement, and initial response to therapy had no statistically signifi

194 Initial response to therapy was excellent, with 99% clea

195 In the analysis of this subgroup, initial response to therapy was similar for both drugs (

196 as at diagnosis perhaps accounting for their initial response to therapy, but advanced neuroblastoma

197 Despite an initial response to therapy, drug resistance remains a p

198 ich contribute to tumor recurrence following initial response to therapy.

199 Although the initial response to these inhibitors can be dramatic, so

200 Forty percent of patients have an initial response to this therapy, but most subsequently

201 onding patients (defined as patients with no initial response to treatment and those with an initial

202 who delivered the interventions and reported initial response to treatment was not possible.

203 Despite the high rate of initial response to treatment, these low-grade B-cell no

204 measures were response to treatment, time to initial response to treatment, time to complete resoluti

205 Patients with an initial response to ustekinumab had significantly increa

206 P (TC-PTP) activity is stimulated during the initial response to UVB irradiation, which leads to supp

207 ate of a metastatic lesion progressing after initial response to vaccination.

208 t CD49b T(EM) expansion is restricted to the initial response to vaccine.

209 The initial response to viral infection is characterized by

210 The initial response to WNV resulted in the expression of in

211 he protective role of basal autophagy in the initial responses to a subset of neurodegenerative chall

212 However, while initial responses to B-raf inhibitors are impressive, re

213 stinent cigarette smokers, nicotine augments initial responses to both gradual and rapid non-painful

214 Patients with EVI-1-positive AML have poor initial responses to chemotherapy and high relapse rates

215 Initial responses to conspecific song and calls and to h

216 Although initial responses to FLT3 tyrosine kinase inhibitors (TK

217 ment of schizophrenic patients who show poor initial responses to haloperidol.

218 ying the signaling pathways that mediate the initial responses to interferons (IFNs), much less is kn

219 stress hyporesponsiveness suggest that these initial responses to MDMA may contribute to the long-ter

220 Initial responses to P limitation showed increased expre

221 Initial responses to P6 were CR/VGPR in 19 patients, but

222 daily for up to 5 doses; 3 patients who had initial responses to SL-401 received a second course in

223 nction of glucagon-like peptide-1 (GLP-1) in initial responses to taste stimulation.

224 ignificantly shorter than the latency of the initial responses to the search display, with approximat

225 Initial responses to tilt were comparable; however, duri

226 sure changes below resting levels but normal initial responses to upright tilt.

227 lation state of receptors is likely to be an initial response upon ethylene binding since treatments

228 Patients who had a poor initial response (VA 20/40 or worse with persistent flui

229 is model is a mechanistic description of how initial response variability is generated.

230 Initial response was determined with findings of decreas

231 The cohort included 2 subjects whose initial response was followed by drug-sensitive relapse.

232 This initial response was mimicked by the 5-HT3 receptor agon

233 (ala) was expressed in sensory neurons, the initial response was reduced, followed by facilitation.

234 3), The initial response was reversibly reduced by 5-mM 2,3-buta

235 The initial response was similar in high flow and low flow M

236 During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguish

237 ate binding and to investigate the protein's initial response, we performed equilibrium simulations o

238 Eleven of 15 patients (73%) who lost their initial response were ATI positive compared with none of

239 However, initial responses were followed by subsequent tumor re-g

240 Although initial responses were lower, accelerated adequate immun

241 By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas

242 pidly dissociates from the genome during the initial response when the cytoplasmic K(+) accumulates t

243 where CD8(+) T cells are limiting during the initial response whereas antigen is limiting in the seco

244 d imaging techniques, we determined that the initial response, which occurs within the first second o

245 ogic response or viral rebound subsequent to initial response while on treatment with lopinavir-riton

246 bsequently increased to levels exceeding the initial response, while mean EMG responses increased thr