ライフサイエンスコーパス: initial step

1 he 40S P site remains unoccupied during this initial step.

2 tion for the observed cis selectivity in the initial step.

3 the substrate activation is suggested as an initial step.

4 redundancy of the enzymes involved in these initial steps.

5 uced by a cascade of two catalytic steps: an initial step acting at unattached kinetochores to produc

6 III subdomains under force may constitute an initial step along the transition pathway.

7 We take an initial step along this path proposing an encoded qubit

8 es: Mre11-Rad50-Xrs2, which functions at the initial step and also stimulates the two processive path

9 rimental findings, we discuss both ultrafast initial steps and longer-time-scale structural dynamics

10 olecular motors to facilitate transport, the initial steps and neuronal responses to infection are po

11 merous times in all domains of life, yet its initial steps are poorly understood.

12 improved mutagenesis analysis pipeline, the initial steps are the same as in the supF mutation assay

13 nd H2O2 via a two-electron transfer with the initial step being rate-limiting (k = 26 M(-1) s(-1) at

14 ences of host association for symbionts, the initial steps facilitating their incorporation into a ho

15 formation occurs via alkene insertion as the initial step for all three metals, without involving hig

16 With the aim of investigating the initial step for C-F hydroxylation, two new ligands were

17 ipid desorption from membranes, likely as an initial step for lipid transfer, and binds to Tom40, sug

18 we propose that such clustering is a useful initial step for other assembly pipelines.

19 Molecular recognition is an important initial step for the biomolecular interactions and their

20 d represent the successful completion of the initial step for the preclinical development of 12/15LO

21 The initial step for the successful establishment of urinary

22 The work represents an important initial step for understanding the evolutionary history

23 We describe initial steps for interrogating whole-genome sequence da

24 NAs (lncRNAs) in erythropoiesis.1 This is an initial step forward in our understanding of the many ro

25 Based on these initial steps, further progress in probe chemistry and t

26 Bypassing or altering this initial step has significant consequences for infection.

27 Initial steps have been taken to understand such issues

28 We previously reported that the initial step in 5-nitroanthranilic acid (5NAA) degradati

29 a 1,3 dipolar cyclo-addition reaction as the initial step in a novel type of enzymatic reaction.

30 (FOBs) were extensively characterized as an initial step in assessing potential inhalation exposure

31 tric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis.

32 cesses of surgeons, this study represents an initial step in attempting to decrease the morbidity ass

33 ype IV pili facilitate surface adhesion, the initial step in biofilm formation.

34 The initial step in cellular Cu handling is its transport ac

35 Here, we demonstrate that an initial step in ClpXP unfolding of the 11-stranded beta

36 faces is generally thought to constitute the initial step in colonization, requiring adherence factor

37 l of development: Anthropocentrism is not an initial step in conceptual development, but is instead a

38 This review focuses on the initial step in Cu homeostasis, the properties of the ma

39 iated at the epigenetic level may provide an initial step in delivering an appropriate response to en

40 As an initial step in designing a simplified bryostatin hybrid

41 ng the expression patterns of snoRNAs is the initial step in determining their functional significanc

42 Damage recognition is a key initial step in DNA repair.

43 agination of the epithelium are an important initial step in ectodermal organ development.

44 hizont development, our findings identify an initial step in egress and show that host cell cytoskele

45 The initial step in eukaryotic DNA replication is the assemb

46 study implicates accumulation of IMCs as an initial step in facilitation of tumor formation, followe

47 The initial step in FAK activation is autophosphorylation of

48 ach encoded by a separate gene, catalyze the initial step in glycerolipid synthesis; in liver, the ma

49 The initial step in HIV-1 infection occurs with the binding

50 r the processivity of deep end-resection-the initial step in HRR.

51 lls on antigen presenting cells is a crucial initial step in immune response.

52 The initial step in initiation of eukaryotic DNA replication

53 droxylases (JBP1 and JBP2) that catalyze the initial step in J synthesis.

54 that recessive mutations in ISPD abolish the initial step in laminin-binding glycan synthesis by disr

55 of ADPH and membrane phospholipids may be an initial step in milk lipid secretion.

56 The initial step in mobilization is the derepression of the

57 We hypothesize that damage recognition is an initial step in NER that senses conformational anomalies

58 n induces H4K16 acetylation, which may be an initial step in nucleosome removal.

59 As an initial step in our efforts to unify the expression of p

60 The initial step in poxvirus morphogenesis, the formation of

61 impact mitochondrial function represents an initial step in predicting exposure-related toxicity and

62 These results can be considered as an initial step in predicting tumor response to nCRT in loc

63 As an initial step in redressing this neglect, we measured the

64 The Ku heterodimer serves in the initial step in repairing DNA double-strand breaks by th

65 steoblasts to sites of bone resorption as an initial step in replacing lost bone.

66 ndensation of serine with palmitoyl-CoA, the initial step in sphingolipid biogenesis.

67 The initial step in stereoscopic 3D vision is generally thou

68 t it can act as a proton acceptor during the initial step in substrate proteolysis.

69 These findings demonstrate that the initial step in synapse disassembly involves postsynapti

70 chanisms by which the C2 domain controls the initial step in the activation of PKC.

71 ion of Bak dephosphorylation constitutes the initial step in the activation process, which reveals a

72 ), an alpha2beta2gamma2hexamer, mediates the initial step in the addition of the mannose 6-phosphate

73 an uracil-DNA glycosylase (hUNG) perform the initial step in the base excision repair (BER) pathway.

74 Oxygenation of aromatic rings is a frequent initial step in the biodegradation of persistent contami

75 This is the initial step in the biosynthesis of the plant growth hor

76 as first proposed over 50 years ago that the initial step in the catalytic cycle is facilitated by a

77 We hypothesized that MIF triggers an initial step in the chemotaxis of IFN-gamma-producing ce

78 The initial step in the degradation of pentachlorophenol by

79 ase, encoded by the gene speG, catalyzes the initial step in the degradation of polyamines and is a c

80 The initial step in the demethylation process can be deamina

81 This work represents an initial step in the development of a statistically rigor

82 Nuclei detection is often a critical initial step in the development of computer aided diagno

83 n of mu opioid receptors is thought to be an initial step in the development of tolerance to opioids.

84 id receptor desensitization is considered an initial step in the development of tolerance.

85 nsing of cytosolic nucleotides is a critical initial step in the elaboration of type I IFN.

86 the electrode surface, which is a necessary initial step in the electrocatalytic oxidation of CO on

87 extensive group-level adaptation during the initial step in the evolution of multicellularity.

88 s suggest that SAS-6 self-assembly may be an initial step in the formation of the cartwheel that prov

89 2beta2gamma2 heterohexamer that mediates the initial step in the formation of the mannose 6-phosphate

90 ion of the maternal decidua appears to be an initial step in the maternal component of the disease as

91 Such an addition is also the initial step in the mechanism most widely proposed for o

92 clooxygenases, COX-1 and COX-2, catalyze the initial step in the metabolism of arachidonic acid to pr

93 The initial step in the metabolism of intracellular FA is th

94 identify the release of HMGB1 as a critical initial step in the pathogenesis of asbestos-related dis

95 enzyme cleaving GPC to produce choline, the initial step in the pathway controlling the GPC/PC ratio

96 a to dental implant surfaces is the critical initial step in the process of biofilm colonization; how

97 e produced was used to remove arsenic as the initial step in the process, and other chalcophilic meta

98 uity and the formation of progenitors as the initial step in the production of differentiated cells.

99 Evidence suggests that AAH represents an initial step in the progression to adenocarcinoma in sit

100 intermediate formation that constitutes the initial step in the proposed LRAT catalytic reaction.

101 The single-electron transfer proposed as an initial step in the reaction of these hexamers with cert

102 at there is no kinetic isotope effect on the initial step in the reaction, which is the same for the

103 m binding site Na2 had been identified as an initial step in the transport cycle which prepares the t

104 marine environments, representing a critical initial step in the trophic chain.

105 The initial step in their synthesis is the activation of fat

106 As an initial step in this effort, we believe that the researc

107 An initial step in this process is the loss of glandular st

108 The initial step in this technique involves cell disruption

109 The critical initial step in V(D)J recombination, binding of RAG1 and

110 lling glutamate receptor assembly involve an initial step in which the amino terminal domains (ATD) a

111 retinoschisin deficiency could represent an initial step in XLRS pathogenesis.

112 anization is essential for understanding the initial steps in cell signaling and trafficking mechanis

113 Initial steps in flagellar biosynthesis in Campylobacter

114 As the initial steps in FVIII inhibitor development remain inco

115 ons of biological hypotheses surrounding the initial steps in GPVI-stimulated signal transduction.

116 netic effects which are most critical at the initial steps in infection.

117 In initial steps in MMR, Msh2-Msh6 binds mispairs and small

118 ortant roles in carcinogenesis and influence initial steps in neoplastic transformation by altering g

119 The initial steps in photosystem II (PSII) assembly are thou

120 A direct quantitative analysis of the initial steps in primosome assembly, involving PriA and

121 Initial steps in protein synthesis are highly regulated

122 The initial steps in T-87 cell lipid assembly were evaluated

123 This platform exploits the fact that the initial steps in the biosynthesis of most bacterial glyc

124 These studies mark the initial steps in the characterization of the mammalian g

125 An improved understanding of the initial steps in the development of RA would provide ins

126 in the triggering of bud outgrowth and that initial steps in the light signaling pathway involve cyt

127 The initial steps in the micromolar concentration range foll

128 hydrolytic dehalogenations, respectively, as initial steps in the mineralization also convert beta- a

129 a and thus provide a molecular basis for the initial steps in the misfolding process.

130 mer maturation in vitro is believed to mimic initial steps in the RNA maturation in vivo, which is co

131 The initial steps in this process can be traced back to the

132 The initial steps in this protocol involve optimization of c

133 This constitutes one of the initial steps in translesion synthesis (TLS)--a critical

134 In this study, we addressed the initial steps in virus binding and infection and found t

135 As an initial step, in this trial we assessed the effect of an

136 s thought to occur at the cell surface, with initial steps including proprotein processing, multimeri

137 required to inhibit ATM activation, the key initial step involved in the activation of a DNA-damage

138 The initial step involves adenylation of the enzyme by ATP,

139 The initial step is often the photoisomerization of a conjug

140 Diagnostically, the initial step is to differentiate hypotonic from nonhypot

141 tumor development have been discovered, the initial steps mutant cells take to escape tissue integri

142 that the detection pathway proceeds via the initial step of a five-membered ring formation upon atta

143 hydrophobic bacterium, S. wittichii RW1, the initial step of adhesion and maturation of bacteria-subs

144 The initial step of assembly-binding of X-targeting factors

145 Moreover, we show that this initial step of atRA synthesis occurs predominantly in a

146 -selective CRISPR array expansion during the initial step of bacterial adaptive immunity.

147 genation of aromatic rings is frequently the initial step of biodegradation of organic subsurface pol

148 nonheme iron dioxygenases is frequently the initial step of biodegradation, O2 activation kinetics m

149 methods to prevent microbial adhesion as the initial step of biofilm formation.

150 The initial step of bone digestion is the adhesion of osteoc

151 nd human brain endothelial CD44 could be the initial step of brain invasion.

152 In the initial step of colonization, FimH, a lectin located at

153 et(flox/flox)), we show that Met acts on the initial step of DC release from skin tissue.

154 ate contractility with F-actin severing, the initial step of F-actin turnover.

155 the following four proteins involved in the initial step of Fe-S cluster synthesis: FXN(42-210) (iro

156 Glycolysis is the initial step of glucose catabolism and is up-regulated i

157 ide glucosyltransferase (Ugcg) catalyzes the initial step of GSL biosynthesis.

158 e entrance are conceivably essential for the initial step of H(+)-PPase proton translocation.

159 (Hb) and muscle components of fish may be an initial step of Hb-mediated lipid oxidation.

160 Phospholipase C (Plc1p) is required for the initial step of inositol polyphosphate (InsP) synthesis,

161 In the initial step of integration, retroviral integrase (IN) i

162 The initial step of integrin redistribution is thought to re

163 The initial step of metastasis is the local invasion of tumo

164 peutics for suppressing cancer invasion, the initial step of metastasis.

165 and MMP-9 act synergistically mainly at the initial step of neutrophil recruitment into the peritone

166 We used an in vitro assay that models the initial step of ovarian cancer metastasis, clearance of

167 Fe-dependent dioxygenase that catalyzes the initial step of oxidative cysteine catabolism.

168 Whereas the initial step of parenchymal cell proliferation was not a

169 The initial step of photocatalytic water oxidation reaction

170 e-->CaI and activation thermodynamics of the initial step of proton reduction in CaI.

171 It has been established that the initial step of rapid oxidation of Fe(2+) (ferroxidation

172 lmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis.

173 The initial step of sporulation is asymmetric cell division,

174 tly identified and suggested to catalyze the initial step of straight chain fatty acid alpha-oxidatio

175 ells is primarily achieved by modulating the initial step of the base excision repair process.

176 ferases (NDSTs), the enzymes involved in the initial step of the biosynthetic pathway.

177 tional approaches were combined to study the initial step of the catalytic cycle.

178 particular, the simulations suggest that the initial step of the catalytic process is the formation o

179 In mammalian mitochondria, the initial step of the Fe-S cluster assembly process is ass

180 oxia (SAH) mouse model of DWMI activates the initial step of the ISR.

181 The initial step of the method is to liberate chemically and

182 ed by NiSOD, we computationally explored the initial step of the O2(-) reduction mechanism catalyzed

183 An initial step of the pathogenesis is an epithelial-mesenc

184 udies identify a key role for Asp-128 in the initial step of the phosphobase methylation pathway in P

185 All previous work on the initial step of the targeting reaction, when SRP binds t

186 g of two pyrrole molecues is found to be the initial step of this reaction.

187 omplex only on precleaved ends mimicking the initial step of transposition.

188 eride lipase (ATGL) is rate-limiting for the initial step of triacylglycerol (TAG) hydrolysis, genera

189 The initial step of violacein biosynthesis is the oxidative

190 chment of the virus to the cell surface, the initial step of virus entry, raises questions concerning

191 are biochemically capable of catalyzing the initial step of Vitamin A oxidation, but the precise con

192 In this study we characterized the initial steps of aggregation from a native-like state of

193 The genetic changes underlying the initial steps of animal domestication are still poorly u

194 The initial steps of atrial primordium invagination are simi

195 autophagic effectors, like WIPI2, during the initial steps of autophagosome biogenesis and thereby re

196 NA glycosylases are enzymes that perform the initial steps of base excision repair, the principal rep

197 The initial steps of BIR occur normally in Pif1-deficient ce

198 podia function in SCC cells, controlling the initial steps of cancer cell invasion.

199 g on the endothelium plays a key role in the initial steps of cancer metastasis, i.e., extravasation

200 hat loss of Lkb1 was sufficient to drive the initial steps of carcinogenesis ex vivo.

201 ronmental responsiveness by representing the initial steps of cell signaling pathways.

202 new structural and mechanistic insight into initial steps of cell-driven FN fibrillogenesis.

203 by obtaining a detailed understanding of the initial steps of CO2 electroreduction on copper surfaces

204 These results suggest that initial steps of DNA replication require centrosomally l

205 hat hormones likely play a minor role in the initial steps of early embryo development in maize.

206 BRD4 is a kinase involved in numerous initial steps of gene induction.

207 rd UV-damaged DNA, and it is involved in the initial steps of global genome nucleotide excision repai

208 ucosidase inhibitors, can interfere with the initial steps of glycan processing on proteins and inhib

209 nt parasites lacking enzymes involved in the initial steps of Hb proteolysis.

210 hogens, bind cell-surface glycans during the initial steps of infection.

211 that the events we report here represent the initial steps of insertion and assembly of these translo

212 found that cAb29 did not interfere with the initial steps of intoxication, namely its ability to bin

213 response to fatty acids to characterize the initial steps of LD formation occurring in lipid-starved

214 -selectin glycoprotein receptor mediates the initial steps of leukocyte migration into secondary lymp

215 -binding adhesion molecules that mediate the initial steps of leukocyte recognition of endothelium.

216 ) dehydrochlorinase (LinA2), involved in the initial steps of lindane (gamma-HCH) biotransformation,

217 of vitamin C together with indicators of the initial steps of Maillard reaction (2-furoylmethyl amino

218 ead changes in gene expression and marks the initial steps of metamorphosis.

219 The initial steps of metastasis are regulated by a controlle

220 igher formation of furosine, as indicator of initial steps of MR, was observed together with more adv

221 se C2C12 myocytes, MYF5 is implicated in the initial steps of myoblast differentiation into myotubes.

222 y cathepsin D was shown to be crucial in the initial steps of neutrophil apoptosis.

223 reveal a detailed nanoscopic picture of the initial steps of nonphotochemical quenching.

224 ing input patterns and may contribute to the initial steps of olfactory discrimination.

225 d its alkyl substituents are often competing initial steps of organic pollutant transformation.

226 helial cells promote colonization during the initial steps of OvCa metastasis and suggest that mesoth

227 s of esterified linoleate proceed beyond the initial steps of oxidation and epoxyalcohol synthesis ca

228 hanolamine kinase (CEK) family catalyzes the initial steps of phospholipid biosynthesis.

229 e first time-domain theoretical study of the initial steps of photocatalytic water splitting on a GaN

230 plast thylakoid membrane is the site for the initial steps of photosynthesis that convert solar energ

231 mechanistic framework for understanding the initial steps of recombinational DNA repair in eukaryote

232 s particle, variation in the kinetics of the initial steps of replication contributed significantly t

233 PriA helicase catalyzes the initial steps of replisome reloading onto repaired DNA r

234 lth of the parasite protein machinery at the initial steps of ribosome biogenesis and conveys that in

235 on studies were conducted to investigate the initial steps of Rous sarcoma virus (RSV) assembly by ex

236 coat protein complex II (COPII) mediates the initial steps of secretory protein trafficking by assemb

237 ovide a useful tool for future assessment of initial steps of sensory processing in S1.

238 ol transport and metabolism machinery in the initial steps of steroid and/or oxysterol biosynthesis p

239 e hydrogen abstraction, thereby refining the initial steps of the carbide insertion pathway.

240 he enzyme, which will help to understand the initial steps of the catalytic mechanism.

241 ings highlight a new mechanism in one of the initial steps of the dentin-pulp regeneration process, l

242 harmonic fluctuations can be considered the initial steps of the DNA melting pathway.

243 to DNA provides mechanistic insight into the initial steps of the establishment of sister chromatid c

244 The initial steps of the protocol describe how to modify an

245 tes (dark, batho, BSI, lumi) involved in the initial steps of the rhodopsin photoactivation mechanism

246 the foldamer (tau = 150 ps), indicating the initial steps of unfolding of the helical conformation,

247 le for facultative anaerobic bacteria in the initial steps of unsaturated LCFA biodegradation.

248 As the initial steps of unsaturated LCFA degradation proceed un

249 egraded by aerobic microorganisms, where the initial steps of various biodegradation pathways include

250 The initial steps of viral capsid self-assembly require weak

251 lly, the nuclear RNA exosome coordinates the initial steps of viral transcription with RNAPII at host

252 The retina is responsible for the initial steps of visual processing, which is further ref

253 ns contribute to a mechanistic basis for the initial steps of VP1 and VP4 externalization and uncoati

254 ZGA) is thought to occur gradually, with the initial steps of zygote and embryo development being pri

255 n per reaction, but require 10,000 cells for initial steps or require a highly specialized microfluid

256 In an initial step, receptor interaction with G(alpha) acts to

257 very different from that of NtQ42P10, as the initial steps require a monomer to 7-mer transition stag

258 Identifying orthologous genes is an initial step required for phylogenetics, and it is also

259 res, dendrimers are ideally suited for these initial steps, since they consist of arrays of chromopho

260 Thus targeting UNC-84 requires an initial step that actively transports UNC-84 from the pe

261 Nevertheless, these results represent an initial step that makes the resting state of a VSD acces

262 The initial steps that govern Bak activation are poorly unde

263 lly observed isotope pattern requires, as an initial step, the calculation of the theoretical isotope

264 e time-evolution of excitons requires, as an initial step, the calculation of their spectra, which ha

265 ent phosphorylation of Ser65 is an important initial step, the molecular mechanisms underlying the ac

266 An initial step to capture the fingerprint of the core netw

267 As an initial step to near real-time clinical learning during

268 The initial step to transformation, namely the uptake of DNA

269 cal blow against wild Cucurbita, and we take initial steps to consider this hypothesis through cross-

270 yoxal, and IEPOX to partition to ALW, as the initial step toward aqSOA formation.

271 As an initial step toward assessing the cis-regulatory activit

272 These results constitute an initial step toward detailed molecular theory of additio

273 These studies represent an initial step toward determining the overall architecture

274 y low sulfated heparan sulfate, can take the initial step toward differentiation into all three germ

275 Our study serves as an initial step toward functional analyses of Sema 1a and F

276 These results represent an initial step toward generating a platform to evaluate B

277 As an initial step toward identifying novel biased KOR agonist

278 disease progression as well as providing an initial step toward more personalized therapy for cancer

279 requires external validation but provides an initial step toward the development of the specific VTE

280 review its surgical treatment as a potential initial step toward the establishment of a definition of

281 Although representing only an initial step toward the ultimate goal of generating full

282 The initial step toward understanding the environmental impa

283 This work is an initial step toward unraveling the importance of the int

284 and ischemic disease models is an important initial step toward using them for heart disease treatme

285 We describe initial steps toward a minimum-sized, soluble model syst

286 In initial steps toward achieving these goals, we construct

287 roliferation and survival that may represent initial steps toward NB development.

288 The initial steps toward optical detection and spectroscopy

289 Therefore, in an initial step towards an improved understanding of MMP fu

290 re with a spatially dependent bandgap, as an initial step towards the creation of diverse lateral jun

291 /alphavbeta3 integrin binding, we provide an initial step towards understanding how the neuron-astroc

292 As initial steps towards establishing a human cellular and

293 ional quantum dynamical studies representing initial steps towards obtaining CO-H(2) rovibrational qu

294 /or in the Met chain elongation pathway, the initial steps towards the biosynthesis of Met-derived gl

295 These results provide initial steps towards the development of a quantitative

296 nsisting of billions of atoms, represent the initial steps towards the use of mechanical devices as t

297 often considered to be a prerequisite to the initial step (transimination) of the enzyme-catalyzed re

298 This review summarizes the initial steps undertaken in clinical implementation of p

299 The initial step was ganglioside dependent, while the subseq

300 The initial step would consist of the coupled folding and bi