ライフサイエンスコーパス: initiation

1 to emerge often months to years after their initiation.

2 ss of Arf promotes tumor progression but not initiation.

3 growth increments) that start at replication initiation.

4 e enhanced and account for CD4 levels at ART initiation.

5 tributing to both lung homeostasis and tumor initiation.

6 uided dosing improves the safety of warfarin initiation.

7 esponse maxima culminating in leaf primordia initiation.

8 el is not a necessary condition for movement initiation.

9 D8 T-cell responses within 4 wk of treatment initiation.

10 mplications of such noncanonical translation initiation.

11 tinal bleeding, thereby expediting treatment initiation.

12 committed step in eukaryotic DNA replication initiation.

13 lled primarily at the level of transcription initiation.

14 also promotes efficient and timely resection initiation.

15 results and adverse events proximate to MRA initiation.

16 ected individuals for 10 years following ART initiation.

17 usually stabilize or improve after treatment initiation.

18 cations, regardless of timing of prophylaxis initiation.

19 T initiation or same-day HIV testing and ART initiation.

20 in biologically plausible models of saccade initiation.

21 ion of the PABP-eIF4G complex in translation initiation.

22 bable RNA-binding domain mediate translation initiation.

23 g that these mutations contribute to disease initiation.

24 ssion yeast cells by promoting transcription initiation.

25 were infected at baseline, before treatment initiation.

26 ult return, and antiretroviral therapy (ART) initiation (100%).

27 TE events were comparable after enoxaparin initiation (14% PAG v 10% AG).

28 ere 0.14 tests (95% CI, 0.09-0.19), 0.05 new initiations (95% CI, 0.03-0.08), and 0.02 initiations wi

29 in mouse lung cells markedly enhances tumour initiation, a phenomenon mediated by Craf kinase activit

30 and that this memory requires cap-dependent initiation, a primary point of translational control in

31 of oral prescription abandonment and delayed initiation across cancers.

32 ment of a refractory period for Ca(2+) spark initiation after Ca(2+) release in cardiac myocytes shou

33 f adjuvant chemotherapy according to time to initiation after surgery.

34 e time of intravitreal aflibercept injection initiation (an increase of 3.9 mum in VISTA and a decrea

35 -142, 26 miRNAs are involved in cotton fiber initiation and 48 miRNAs are related to primary wall syn

36 In addition to control of initiation and assembly of CCPs, EGF stimulation also el

37 nt branching patterns regulating both branch initiation and branch outgrowth.

38 tedly large roles in directing transcription initiation and constitute a previously unrecognized type

39 ns of these residues reduce bulk translation initiation and diminish initiation at near-cognate UUG s

40 or intestine) disclosed that PKC-2 regulates initiation and duration of cryophilic drive.

41 Transcription factors promoting initiation and elongation have been characterized in eac

42 regulating RNAPII occupancy, transcriptional initiation and elongation, and alternative splicing even

43 Smoking initiation and escalation are affected differentially by

44 he brain selects actions, regulates movement initiation and execution, and switches from one state to

45 be dissociated from motor effects on saccade initiation and execution.SIGNIFICANCE STATEMENT Despite

46 nal design of agents that interfere with the initiation and formation of a P. gingivalis-induced path

47 TLR2 antagonism effectively suppressed initiation and growth of spontaneous choroidal neovascul

48 o contribute to early atherosclerotic plaque initiation and growth.

49 Shisa7 KO mice showed reduced initiation and maintenance of long-term potentiation of

50 and how translational control affects tumour initiation and malignancy.

51 c pattern of activation occurring during the initiation and maturation stage of reprogramming in part

52 and genetic factors are critical for smoking initiation and nicotine addiction.

53 nscription factor required for transcription initiation and nucleotide excision repair.

54 reater risk for subsequent cigarette smoking initiation and past 30-day cigarette smoking.

55 e logistical challenges that delay treatment initiation and prevent improvements in morbidity and mor

56 n naked RNA and that P serves to enhance the initiation and processivity of the RdRP.

57 ficance of LKB1 mutations in cervical cancer initiation and progress has not been examined.

58 cancer gene expression program during cancer initiation and progression is not fully understood.

59 ctional impact of these mutations on disease initiation and progression is not well understood.

60 h potential to enable mechanistic studies of initiation and progression of clinically relevant lower

61 udy the effects of Ras pathway activation on initiation and progression of IPMNs.

62 AEG-1 might be a key molecule regulating initiation and progression of NASH.

63 Loss of IKBKE inhibits the initiation and progression of pancreatic tumors in mice

64 s of the cell cycle and are required for the initiation and progression of various malignancies.

65 aberrant expression of miRNAs promotes tumor initiation and progression, is linked with cardiac dysfu

66 , including STATs, is known to promote tumor initiation and progression.

67 olecular aberrations contributing to disease initiation and progression.

68 pants in carcinogenesis mediating both tumor initiation and progression.

69 echanical stress likely influences emphysema initiation and progression.

70 ing to genetic changes permissive for cancer initiation and progression.

71 ocarcinoma (PDAC) and the key drivers of its initiation and progression.

72 ng a role for the innate immune system in AD initiation and progression.

73 cell phenotypes that are critical for cancer initiation and progression.

74 ing outcomes-loss of p53 promotes both tumor initiation and progression; loss of Arf promotes tumor p

75 We demonstrate imaging of the fast initiation and propagation of action potential within si

76 ction plays a critical role in transcription initiation and provides a novel target for the developme

77 Initiation and regulation of transcription by RNA polyme

78 ort that fasting alone robustly inhibits the initiation and reverses the leukemic progression of both

79 ence of a causal association between smoking initiation and schizophrenia, in either direction.

80 Timely initiation and subsequent titration of antihypertensive

81 of a ventricular myocyte model, we show that initiation and termination are inherently random events.

82 n enables us to compute the probabilities of initiation and termination of bursts of triggered activi

83 confounder measurements relative to exposure initiation and the rate of change in the confounder in o

84 tem cells (GSCs), which contributes to tumor initiation and treatment resistance.

85 r, loss of cell identity occurs during tumor initiation and upon injury response.

86 Deletion of EDE1 results in fewer CME initiations and defects in the timing of vesicle maturat

87 ng cell self-renewal, a surrogate for tumour initiation, and activated P-Stat3.

88 mutations play an important role in disease initiation as well as disease progression such as germ l

89 Among women aged 50-59 years at HT initiation, associations of CEE alone or CEE+MPA with mo

90 ted substitutions, in yeast eIF1A suppresses initiation at near-cognate UUG codons and AUGs in poor c

91 uce bulk translation initiation and diminish initiation at near-cognate UUG start codons in yeast mut

92 udy provides evidence of protein translation initiation at noncanonical TISs and argues that further

93 plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with additio

94 cancer progression, during which it mediates initiation at these upstream sites, differentially skewi

95 ons such as multimodal integration, movement initiation, bottom-up, and top-down attention.

96 O (solvent), is responsible for inducing the initiation by a photo-BHAS process on alkyl halides.

97 ified mRNAs renders them more permissive for initiation by favoring either ribosome recycling on the

98 n of the mitochondrial genome, transcription initiation by mtRNAP remains poorly understood.

99 MRN also facilitates resection initiation by promoting the recruitment of Dna2 and CtIP

100 9ac may function downstream of transcription initiation by recruiting proteins important for the next

101 We found that transcription initiation by RNA polymerase 2 resulted in confinement o

102 262090 during rhizobial infection and nodule initiation by using RNA-seq technology.

103 st peatland yet discovered in Amazonia (peat initiation ca. 8.9 ka BP), and developed in three stages

104 own that non-AUG or noncanonical translation initiation can also occur.

105 reporters harboring stall sequences near the initiation codon, which cannot accommodate multiple ribo

106 of the pathogen activates the host autophagy initiation complex (AIC) and the upstream regulatory com

107 l structure of a mycobacterial transcription initiation complex (TIC) with RbpA as well as a CarD/Rbp

108 II genes, suggesting multiple rounds of pre-initiation complex assembly and disassembly before produ

109 ediate membranes and show that the autophagy-initiation complex containing ULK and FIP200 first assoc

110 located in similar positions to those of the initiation complex for the hepatitis C virus polymerase.

111 nd by chromatin modifications to promote pre-initiation complex formation.

112 DNA sequence and shape analysis of initiation complex sites suggest that both sequence and

113 These findings suggest that the autophagy-initiation complex, the PIS-enriched ER subdomain, and A

114 id and myeloid leukemia as a driver of tumor initiation, disease progression and relapse.

115 a suite of range shift parameters: times of initiation, duration of transitions, centroids and areas

116 We aimed to determine whether ART initiation during acute HIV infection would attenuate ch

117 bligatory role of natural enemies across the initiation, expansion and recovery stages of a natural e

118 nsing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

119 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

120 es phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in inhibition

121 ) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse embryonic fib

122 pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

123 inase R, which phosphorylates the eukaryotic initiation factor 2alpha to inhibit global protein trans

124 lieves the inhibitory function of eukaryotic initiation factor 3f, a repressive component in the 43S

125 a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently inhibited Sin

126 rtance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production downstream o

127 mycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein

128 Conversely, the alternative initiation factor eIF2A is essential for cancer progress

129 , different kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the translation of

130 encodes an RNA polymerase III transcription initiation factor subunit for further analysis, based on

131 n phosphorylation of the parasite eukaryotic initiation factor-2alpha (eIF2alpha), leading to repress

132 utations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their isoforms.

133 s transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M.

134 d may represent a new group of transcription initiation factors.

135 was not observed before in other translation initiation factors.

136 After omalizumab initiation, FEV1 improved at 6 months in responder patie

137 ure and specifically represses transcription initiation from host RNAP-dependent promoters on the pha

138 In the human genome, translation initiation from non-AUG codons plays an important role i

139 Translation initiation generally occurs at AUG codons in eukaryotes,

140 manic episodes within 3 months of medication initiation (hazard ratio=6.7, 95% CI=2.0-22.4), with sim

141 Metabolic dysregulation drives tumor initiation in a subset of glioblastomas harboring isocit

142 nsolidation was blocked by the cap-dependent initiation inhibitor 4EGI-1.

143 unexpected and obligatory step early in the initiation involving a transient clamp closure as a prer

144 Translation initiation is a key step in the regulation of gene expre

145 ty to NAD+ and UDP-containing factors during initiation is much lower than their cellular concentrati

146 isk patients or according to setting of drug initiation is poorly characterized.

147 sitive diagnoses linked to ART per 1,000 ART initiations, life expectancy (LE, in years) and per-pers

148 sting that enhancers can influence the pause-initiation limit to regulate transcription.

149 Remarkably, dynactin can bias motility initiation locally from microtubule plus ends by autonom

150 These 2 predicted fracture initiation locations have some agreement with reported f

151 Structural comparisons demonstrate that the initiation mechanism in mitochondria is distinct from th

152 li, somatic EPSP normalization renders spike initiation more sensitive to synapse timing than dendrit

153 occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodel

154 During prostate cancer initiation, Nkx3.1 expression is frequently lost in both

155 e based on positive serologic findings found initiation of a gluten-free diet associated with small i

156 and Triplex in healthy adults motivated the initiation of a placebo-controlled multicenter trial of

157 gulating innate immune responses through the initiation of a type I IFN-dependent DDR.

158 he axon initial segment (AIS) is the site of initiation of action potentials and influences action po

159 We then simulated the initiation of an entirely LTACH-focused intervention in

160 reforestation practices have influenced the initiation of an episode of incision in the main channel

161 fore and at one, two, and three months after initiation of antiandrogen treatment are analysed using

162 only cancelled licking but also delayed the initiation of anticipatory licking for the next interval

163 itution inflammatory syndrome (C-IRIS), upon initiation of antiretroviral therapy (ART).

164 This disruption is independent of the initiation of apoptosis by the ion transporter.

165 e the effect of a POC diagnostic strategy on initiation of appropriate TB treatment.

166 Their increase after initiation of ART heralded a lack of virologic or clinic

167 er it is associated with the intiation or re-initiation of ART in people who have had previous exposu

168 expression increased over time despite early initiation of ART.

169 Notably, initiation of ASO treatment after disease onset restored

170 The reduction in the initiation of BCR signaling caused by actin alteration i

171 an be indicator molecular species signifying initiation of biofilms on membrane surfaces, demonstrate

172 other surrogate endpoints, and in some cases initiation of cardioprotective drug therapy in asymptoma

173 before, as well as 2 and 4 weeks after, the initiation of CCRT).

174 Initiation of CD79:GFP expression in Rag2:mCherry(+) cel

175 is and decreasing cell proliferation through initiation of cell cycle arrest.

176 singly, targeted degradation of HYLS-1 after initiation of ciliogenesis does not affect ciliary struc

177 ng activation of SFKs, which are crucial for initiation of CLEC-2 signaling.

178 inoculum sources may be responsible for the initiation of CLS epidemics in mixed-cropping farms, whe

179 L-1beta was a predominant feature during the initiation of colitis with miR-223 deficiency.

180 g of a key part of this sequence, namely the initiation of compression between Greenland and Svalbard

181 ver transplantation at 90 and 180 days after initiation of corticosteroid therapy.

182 translated region (UTR), is critical for the initiation of dengue virus replication, but quantitative

183 Initiation of differentiation required signals delivered

184 n inhibition abolishes nuclear transport and initiation of DNA replication, as well as general transc

185 On the tenth day following initiation of dosing, 10 patients underwent an intensive

186 t low myocardial (18)F-FDG uptake before the initiation of doxorubicin chemotherapy in HD patients ma

187 of constitutive CME is difficult because the initiation of endocytic events is unpredictable.

188 is a fundamental requirement for subsequent initiation of erythroid differentiation.

189 ind that common to all niches is the morning initiation of G1/S transition and daytime S-phase progre

190 pression of genes that are necessary for the initiation of gametocyte development in the subsequent c

191 that POT1 C terminus is essential to prevent initiation of genome instability permissive for tumorige

192 n chorionic gonadotropin >/= 1,000 mIU/mL at initiation of HDCT.

193 tion, which is the rate-limiting step in the initiation of HDR.

194 by mediating the fork cleavage that permits initiation of HR-mediated repair and restart of stressed

195 both the maintenance of lymphocytes and the initiation of immune responses.

196 The benefit of initiation of insulin pump therapy (continuous subcutane

197 h general theoretical models, predicting the initiation of intragranular cracks from grain boundaries

198 non-SHIFT-type patients became eligible for initiation of ivabradine.

199 f age-related diastolic dysfunction, and (2) initiation of late-life exercise training reverses age-r

200 to result in the opening of gaps before the initiation of leukocyte transmigration.

201 er 600 mg/kg dose of APAP, resulted in early initiation of liver regeneration in a dose-dependent man

202 ly, developing zebrafish come to control the initiation of locomotion, swimming preferentially when u

203 r management of decompensated heart failure, initiation of mechanical circulatory support, heart tran

204 Because mTOR signaling is required for initiation of messenger RNA translation, we hypothesized

205 The model analysis shows that initiation of motility critically depends on three dimen

206 Initiation of multiple micronutrient supplements before

207 d for its receptors CXCR4/CXCR7 on SC in the initiation of neural invasion in the cancer precursor st

208 and enamel tufts, crack deflections, and the initiation of new cracks within the enamel (internal cra

209 The proportion of those reporting initiation of nonmedical use of prescription opioids bef

210 Here, we show that initiation of ocular dominance plasticity was impaired w

211 ates metabolic intermediates reserved for re-initiation of peptidoglycan biosynthesis.

212 Initiation of prehospital transfusion and time from MEDE

213 ld increase occurred within 15 minutes after initiation of pulsed focused ultrasound tumor treatment,

214 Ser-346/7 plays in arrestin recruitment and initiation of receptor desensitization and provide insig

215 In conclusion the initiation of rivaroxaban and apixaban is increasing sig

216 ition requires nuclear reprogramming and the initiation of RNAPII at thousands of promoters.

217 lonoscopy as the preferred screening method, initiation of screening at age 40 years, 5-year re-scree

218 SIN3B has been implicated in the initiation of senescence in vitro Here we show that in a

219 Neurokinin-1 receptor treatment at the initiation of sepsis improved survival in cecal ligation

220 Although proteins that control transcription initiation of specialized metabolite gene clusters have

221 lecular basis for signal transduction in the initiation of sporulation in Bacillus subtilis and in ba

222 baseline and within the first year after the initiation of SRL therapy.

223 fast sensory encoding for rapid and precise initiation of startle responses.

224 STF recommendations would be associated with initiation of statin therapy in an additional 15.8% (95%

225 These findings support the value of early initiation of statin treatment for low-density lipoprote

226 brane potential fluctuations facilitated the initiation of synchronized spike activity.

227 elicit pathological processes leading to the initiation of T helper 1 (TH1) immunity against dietary

228 The initiation of the combs requires global or local anomalo

229 n the midline region of human embryos before initiation of the CXCL12/SDF1-guided chemotaxis.

230 ER and ERL1 also prevented premature initiation of the fiber differentiation process mediated

231 sis occur in infants <8 weeks of age, before initiation of the primary pertussis vaccine series.

232 t be instrumental in temporally aligning the initiation of the saccade with the visual suppression.SI

233 (OS) in the 145 specimens collected prior to initiation of the second or later lines of therapy.

234 hGHBp; and (iv) a hGHR bioassay demonstrated initiation of the signal transduction cascade, after bin

235 Recent studies demonstrate that initiation of the Vgamma9Vdelta2 T cell response begins

236 ent of Dvl-2 to the receptor complex and the initiation of the Wnt pathway.

237 ore initiating therapy); (2) 5/6 weeks after initiation of therapy (time 1 of therapy: T1) and at the

238 cal and histologic improvement 3 d after the initiation of therapy, at which time Ly6C(+) macrophages

239 diagnosis and may, at times, lead to prompt initiation of therapy.

240 the improvement of the impairment before the initiation of therapy.

241 rylation markedly suppresses AR activity and initiation of this positive feedback loop.

242 STA) and 13.6 (8.6) (VIVID) letters from the initiation of treatment with intravitreal aflibercept in

243 witching rules" at both 3 and 6 months after initiation of treatment.

244 y of 20/40 to 20/400 reexamined 6 days after initiation of treatment.

245 Since initiation of universal NBS for CF, significant improvem

246 This is a key factor in the initiation of vaso-occlusive episodes, the hallmark of S

247 an X-encoded ubiquitin ligase important for initiation of X-chromosome inactivation and XIST transcr

248 east 10 pg/mL above baseline after treatment initiation on 2 consecutive tests at least 2 weeks apart

249 lic pathways play an important role in tumor initiation or progression in smokers, representing novel

250 eostasis nor significantly accelerates tumor initiation or progression in the prostate-specific Pten

251 were randomly assigned (1:1) to standard ART initiation or same-day HIV testing and ART initiation.

252 IDH1/2 mutant cancers contributes to cancer initiation, our work demonstrates anti-tumor effects of

253 r with CtIP mediate an alternative resection initiation pathway where the nuclease activity of MRN ap

254 The initiation phase of angiogenesis was not associated with

255 hology and F-actin rearrangements during the initiation, progression, and completion of mouse and hum

256 rkov chain models that capture the multi-hit initiation-promotion-malignant-conversion hypothesis of

257 of Cdk2 to phosphorylate the key replication initiation protein treslin in vitro Furthermore, stimula

258 onic-like stemness and were capable of tumor initiation raised two important unanswered questions: ho

259 ut significant selection for maximization of initiation rate and, consequently, protein production.

260 tantial evidence suggests that breast cancer initiation, recurrence and drug resistance is supported

261 the cells of origin and mechanisms of tumor initiation remain unclear.

262 The molecular mechanism of eukaryotic TCR initiation remains unclear, with several long-standing u

263 easurable variables representing replication initiation, replication-division cycle, and the global b

264 embryonic vascular tissue formation and root initiation, respectively.

265 Global reductions in translation initiation resulting from mutations in the translational

266 el of translation based on Kozak translation initiation sequences alone does not adequately explain o

267 arno sequence towards a stronger translation initiation signal.

268 l II) pauses downstream of the transcription initiation site before beginning productive elongation.

269 elimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to t

270 ive elements act as autonomous transcription initiation sites.

271 o test if EGFR activity affects neurofibroma initiation, size, and/or number, we studied mice express

272 rted genes acting as activators of basal bud initiation, SPL4 acts as a suppressor for the formation

273 pression of cell cycle regulators during the initiation stage of reprogramming.

274 This monomeric 'initiation' state with the two domains 'locked' together

275 sis, which were revealed by studying the pre-initiation steps of promoter binding, bending and meltin

276 cess involving distinct phases of speciation initiation (structuring) and completion.

277 sual acuity (VA) is at the time of treatment initiation, the higher the likelihood that VA will be be

278 larity is a prerequisite in epithelial tumor initiation, the roles of CDC42 in tumorigenesis are stil

279 e time of intravitreal aflibercept injection initiation, these eyes had a mean (SD) loss of 11.0 (10.

280 ngs reveal a common core to pervasive Pol II initiation throughout the human genome.

281 The development of the translation initiation (TI) sequencing (TI-seq) technique has enable

282 ost of the mutations significantly decreased initiation-to-elongation transition by RNAP.

283 cits in fracture toughness, with lower crack-initiation toughness and less crack deflection at osteon

284 found differences in susceptibility to nevus initiation, transformation, tumorigenicity, and metastat

285 patients who would be recommended for statin initiation under full implementation of the 2013 ACC/AHA

286 ncy strains, which in turn may promote crack initiation under load.

287 ect to removal via alternative transcription initiation under normal growth conditions.

288 modeled repeated cycles of Okazaki fragment initiation using a collision with a completed Okazaki fr

289 t inhibits cap-dependent protein translation initiation via phosphorylation of eIF2alpha.

290 SGLT2i initiation was also associated with an approximately 2-f

291 Delayed initiation was also more frequent for higher OOP cost ca

292 Neuronal spiking activity at seizure initiation was highly heterogeneous and not hypersynchro

293 00 copies/mL or higher at 12 months post-ART initiation was significantly lower in the intervention g

294 Naltrexone initiation was voluntary and the percentage of participa

295 ssion, separate from its role in replication initiation, we analyzed changes in mRNA levels in Bacill

296 ission rates within 12 weeks after treatment initiation were significantly higher in the blinatumomab

297 e of shedding did not vary by time since ART initiation when plasma VL was detectable (P = .195), tho

298 FS transiently acts at the site of primordia initiation, where it provides a specific context to auxi

299 than their cellular concentrations, and that initiation with them stimulates promoter escape.

300 ew initiations (95% CI, 0.03-0.08), and 0.02 initiations without a recent test (95% CI, 0.01-0.03) pe