ライフサイエンスコーパス: initiation complex

1 iption bubble to stabilize the transcription initiation complex.

2 unwinding and the assembly of a replication initiation complex.

3 hways on the way to the formation of the pre-initiation complex.

4 es promoter melting and formation of an open initiation complex.

5 merase resulting in the formation of the pre-initiation complex.

6 nd these factors during formation of the pre-initiation complex.

7 of the entire mitochondrial transcriptional initiation complex.

8 scaffold that enables formation of the full initiation complex.

9 the binding of eIF4B to the eIF3 translation initiation complex.

10 itiator methionyl transfer RNA to form a 48S initiation complex.

11 n miRNAs impairing the function of the eIF4F initiation complex.

12 bilizing the overall conformation of the 80S initiation complex.

13 neighbouring AAA+ domains to form an active initiation complex.

14 kely impede subsequent assembly into the pre-initiation complex.

15 s, P7 may promote assembly by stabilizing an initiation complex.

16 selection before the formation of stable pre-initiation complex.

17 portant for the formation of the translation initiation complex.

18 e a structural model of the T4 late promoter initiation complex.

19 romoter is required to assemble a functional initiation complex.

20 ernary complex within the ribosome-bound pre-initiation complex.

21 factor TFIID, the major component of the pre-initiation complex.

22 n scanning beyond loading eIF4A onto the pre-initiation complex.

23 ar the predicted path of upstream DNA in the initiation complex.

24 sient component of the catalytic site of the initiation complex.

25 , the form in which it is present in the pre-initiation complex.

26 n interaction with RNA polymerase in the pre-initiation complex.

27 anization of the Spx-activated transcription initiation complex.

28 ter start codon recognition to the final 80S initiation complex.

29 ted in part through RPA in the DNA synthesis initiation complex.

30 the accurate formation of the transcription initiation complex.

31 in the ternary TF:VIIa:factor Xa coagulation initiation complex.

32 ript is extended to +2 and +3 in an abortive initiation complex.

33 at IRES motifs on mRNA by the translational initiation complex.

34 nd the Unc-51-like kinase 1 (ULK1) autophagy initiation complex.

35 lin and Atg14, constituents of the autophagy initiation complex.

36 ich then recruits EBNA2 to the transcription initiation complex.

37 n 1, an essential component of the autophagy initiation complex.

38 e RbpA-SID in the context of a transcription initiation complex.

39 dock and the TFIIB ribbon and stabilizes the initiation complex.

40 ent signaling through the ULK1 autophagy pre-initiation complex.

41 involvement in positioning components of the initiation complex.

42 cetylation and assembly of RNA Polymerase II initiation complexes.

43 d for 11 and 15 on corresponding replication initiation complexes.

44 and promote recruitment of ribosomal 43S pre-initiation complexes.

45 *PABP complexes competent to recruit 43S pre-initiation complexes.

46 echanistic sense for formation of functional initiation complexes.

47 ase active site to destabilize transcription initiation complexes.

48 ion of the solution structures of the intact initiation complexes.

49 rectly to the initiation codon, yielding 48S initiation complexes.

50 conservation of human Pol II and Pol III pre-initiation complexes.

51 imiting helicase-activation factors into pre-initiation complexes.

52 ly thus governing the formation of autophagy initiation complexes.

53 se-associated center (GAC) to an E. coli 30S initiation complex (30SIC(Cy3)) containing Cy3-labeled i

54 48S initiation complex (48S IC) formation is the first stage

55 of a FRET signal during formation of the 70S initiation complex (70SIC).

56 nsition from a closed to an open Pol III pre-initiation complex, a process dependent on the activity

57 identify approximately 160,000 transcription initiation complexes across the human K562 genome, and m

58 of the pathogen activates the host autophagy initiation complex (AIC) and the upstream regulatory com

59 n element (CRE) that stabilize transcription initiation complexes also occur in transcription elongat

60 ase in eIF4E associated with the translation initiation complex and a repression of global cap-depend

61 tivation, as the assembly of the translation initiation complex and cap-dependent translation are rap

62 y eIF5B alters the conformation of the final initiation complex and clears a path to promote rapid re

63 57 associates with components of the 48S pre-initiation complex and co-sediments with the 40S ribosom

64 modulate transcription by associating to the initiation complex and increasing the flux of transcript

65 TFS4 destabilises the TBP-TFB-RNAP pre-initiation complex and inhibits transcription initiation

66 n of a catalytically competent transcription initiation complex and remains closed during initial tra

67 to locate the initiation codon, form the 80S initiation complex and start protein synthesis.

68 ions the initiator tRNA on the 30S ribosomal initiation complex and stimulates its assembly to the 50

69 catalytically competent conformation of the initiation complex and that establishment of contacts be

70 romoter DNA to stabilize both the closed pre-initiation complex and the open-promoter complex, and to

71 hat interacts first with TFIID in the Pol II initiation complex and then exchanges TFIID for complexe

72 to the availability of the eIF2 translation initiation complex and to changes in the rate of transla

73 sts, Mer2 mediates assembly of recombination-initiation complexes and double-strand breaks (DSBs).

74 that are condensates of stalled translation initiation complexes and mRNAs.

75 olecular aggregates that contain translation initiation complexes and mRNAs.

76 A in front of the active site that stabilize initiation complexes and persist throughout elongation.

77 Loss of ELL destabilizes the pre-initiation complexes and results in disruption of early

78 03E polymerase (Pol) III alpha that can form initiation complexes and sequester primer termini but no

79 ted to 5S rRNA genes as a part of proficient initiation complexes and the activity persists at reinit

80 p closure accounts for the high stability of initiation complexes and the high stability and processi

81 he 40S subunit as a component of the 43S pre-initiation complex, and comparison of the ribosomal posi

82 directly links the mRNA cap with the 43S pre-initiation complex, and eIF4A, which is a helicase neces

83 olymerase recruitment, formation of the open initiation complex, and recycling of transcription.

84 4B), increased its assembly into translation initiation complex, and subsequently facilitated protein

85 ion in Eif3c, a component of the translation initiation complex, and that the phenotype is associated

86 granules, which contain stalled translation initiation complexes, and processing bodies (P bodies),

87 rk can promote remodeling of the translation initiation complexes, and the roles in the process playe

88 NA complex and in higher order transcription-initiation complexes, and we have mapped the crosslink t

89 Lectin pathway initiation complexes are composed of multimolecular carb

90 binding, hydrolysis, and the ability to form initiation complexes are not tightly coupled.

91 son of their ability to support formation of initiation complexes, as measured by processive replicat

92 onal pseudo-atomic model for a DNA-packaging initiation complex assembled from the terminase small su

93 regation of RNA polymerase II-containing pre-initiation complexes assembled next to each other in the

94 uctures of human mitochondrial transcription initiation complexes assembled on both light and heavy s

95 II genes, suggesting multiple rounds of pre-initiation complex assembly and disassembly before produ

96 n protein synthesis by enhancing translation initiation complex assembly at the 5' mRNA cap and an in

97 hibition of mTOR or Pim kinases, translation initiation complex assembly, or eIF4A function.

98 a loss of DNA packaging and an impairment of initiation complex assembly.

99 NA(f)(Met) was released from the translation initiation complex at 5.43 microM YafO in vitro.

100 nt role in the assembly of the transcription initiation complex at the late gene promoters.

101 Formation of initiation complexes at 5'-terminal AUGs was stimulated

102 chondrial 55 S ribosomes preferentially form initiation complexes at a 5'-terminal AUG codon over an

103 Biochemical analysis of ribosomal initiation complexes at CUG versus AUG initiation codons

104 rotein synthesis begins with assembly of 48S initiation complexes at the initiation codon of mRNA, wh

105 The eukaryotic 43S pre-initiation complex bearing tRNAi(Met) scans the mRNA lea

106 reaction: the ATP-dependent formation of an initiation complex between the Pol III HE and primed DNA

107 complex to the mRNA 5' end through the eIF4F initiation complex binding to the 5' m(7)G-mRNA cap.

108 w that the primosome in this stable helicase initiation complex binds the DNA of the fork primarily v

109 ompete with wild-type Pol III alpha and form initiation complexes, but cannot elongate.

110 active ATP binding site is required to form initiation complexes, but the two additional sites incre

111 Genetic blockade of the translation initiation complex by eIF4E knockdown or expression of a

112 ion of catalytically competent transcription initiation complex by measuring initiation activity of s

113 ockdown of RNase P abolishes the assembly of initiation complexes by preventing the formation of the

114 the extrinsic tissue factor (TF) coagulation initiation complex can selectively activate the antihemo

115 pen-promoter complex, and to regulate start--initiation complexes, combined with the localization of

116 es it interfere with eIF2 binding to 43S pre-initiation complex components.

117 or optimal translation of mRNAs may require initiation complexes composed of specific isoforms of in

118 an intact activator-dependent transcription initiation complex comprising the Escherichia coli catab

119 3.0 A resolution of functional transcription initiation complexes comprising Thermus thermophilus RNA

120 rmational rearrangement of the RepD-PcrA-ATP initiation complex confines it strictly within the bound

121 P system to probe the archaeal transcription initiation complex, consisting of promoter DNA, TBP, TFB

122 polymerase binds to promoter DNA to form an initiation complex containing a DNA bubble and enters in

123 ly controlled process that includes an early initiation complex containing eukaryotic initiation fact

124 rrent DNA replication, is accomplished by an initiation complex containing the host RNA polymerase as

125 ediate membranes and show that the autophagy-initiation complex containing ULK and FIP200 first assoc

126 crystal structures of E. coli transcription initiation complexes containing a complete transcription

127 crystal structures of Thermus transcription initiation complexes containing CarD.

128 In addition, very few initiation complexes could form on a hybrid mRNA constru

129 tants for the binding of 50S subunits to 30S initiation complexes during initiation and for their rel

130 E, an essential component of the translation initiation complex eIF4F, is downregulated by binding th

131 Initiation complexes exhibit a half-life of dissociation

132 It is likely that optimal multifactor initiation complexes exist that allow for optimal transl

133 N binds directly to the 43S pre-initiation complex facilitating loading of ribosomes ont

134 ymerase to the newly loaded clamp to form an initiation complex for processive replication.

135 located in similar positions to those of the initiation complex for the hepatitis C virus polymerase.

136 35, precluding the assembly of transcription initiation complexes for rDNA.

137 lex provides a molecular explanation for how initiation complexes form when supported by the nonhydro

138 ted in a nearly complete loss of activity in initiation complex formation and in the dissociation of

139 targeting at least two separate stages: 48S initiation complex formation and the steps involved in t

140 ATP analogue ATPgammaS was found to support initiation complex formation at 1/1000th the rate with A

141 , eIF3, eIF1 and eIF1A promote efficient 48S initiation complex formation at AUG828, which is reduced

142 -mediated polymerase chaperoning accelerates initiation complex formation by 100-fold.

143 osed ATPgammaS drives hydrolysis-independent initiation complex formation by tau-containing complexes

144 ntracellular signal transduction and dynamic initiation complex formation coordinated by flexible eIF

145 Interestingly, DHX29 impedes the 48S initiation complex formation in the absence of eIF1A per

146 articipation of i-tRNA in the first round of initiation complex formation licenses the final steps of

147 However, IF3(mt) stimulates initiation complex formation on leaderless mRNAs when te

148 effect on the ability of IF3(mt) to promote initiation complex formation on mitochondrial 55S riboso

149 lysis of three ATPs dramatically accelerates initiation complex formation to a rate constant (25-50 s

150 The kinetics of initiation complex formation were explored for DnaX comp

151 t although one ATPase site is sufficient for initiation complex formation, the combination of polymer

152 omoter that facilitate efficient de novo pre-initiation complex formation.

153 the core RNA polymerase and thereby promotes initiation complex formation.

154 the polymerase to promoter-bound SL1 in pre-initiation complex formation.

155 in the rDNA-promoter region and reduced pre-initiation complex formation.

156 -dependent, inhibitory effect on 48S and 80S initiation complex formation.

157 the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

158 ATPgammaS hydrolysis coincide with those for initiation complex formation.

159 advantages, including marked acceleration of initiation complex formation.

160 y single-stranded DNA binding protein during initiation complex formation.

161 nd by chromatin modifications to promote pre-initiation complex formation.

162 cell extracts, if this precedes the stage of initiation complex formation.

163 secondary mutations that were ineffective in initiation complex formation.

164 Transcription initiation complexes formed by bacterial RNA polymerases

165 Initiation complexes formed even at the very 5' end of m

166 riant topological analysis were performed on initiation complexes formed on the bacteriophage lambda

167 imolecular aggregates of stalled translation initiation complexes formed to aid cell recovery.

168 e steps involved in the formation of the 80S initiation complex from the 48S complex.

169 subunit to the small, 30S, ribosomal subunit initiation complex (IC) during bacterial translation ini

170 ation initiation factor 2 (IF2) promotes 30S initiation complex (IC) formation and 50S subunit joinin

171 actors (IFs) regulate association of the 30S initiation complex (IC) with the 50S subunit to control

172 romotes the 60S subunit joining with the 40S initiation complex (IC).

173 of interaction between the components of the initiation complex (IC).

174 ly released on conversion of 48S PICs to 80S initiation complexes (ICs) and this abnormality and rela

175 rate of 50S ribosomal subunit joining to 30S initiation complexes (ICs) that carry an N-formyl-methio

176 es, using the cap analog m7GTP to enrich for initiation complexes in glioma cells followed by mass sp

177 unteracts the formation of transcription pre-initiation complexes in vitro and represses abortive and

178 play key roles: in the assembly of the C5b-8 initiation complex; in driving and regulating the openin

179 facilitate the assembly of the transcription initiation complex including SL1 and Pol I.

180 embles a RNA polymerase II transcription pre-initiation complex including TFIIH.

181 c DNA replication is the assembly of the pre-initiation complex, including the formation of two head-

182 The coagulation initiation complex induced rapid and prolonged enhanceme

183 hat controls conversion of the transcription initiation complex into a transcription elongation compl

184 ation and aggregation of stalled translation initiation complexes into stress granules are severed, l

185 s (UAS), assembly of Mediator within the pre-initiation complex is accompanied by the release of CKM.

186 The ribosomal initiation complex is assembled on the mRNA via a cap-de

187 The periphery of the core initiation complex is decorated by additional polymerase

188 E-BP1 bound to the cap-dependent translation initiation complex is decreased when the expression of P

189 Once it is located, the 80S ribosome initiation complex is formed with the 60S subunit and in

190 nscription factor Mtf1, we show that the pre-initiation complex is highly dynamic and undergoes repet

191 pharmacological blockade of the translation initiation complex is highly effective against these tum

192 Our data indicate that the pre-initiation complex is likely to be an important target f

193 d to which membrane structures the autophagy-initiation complex is localized have not been fully char

194 the formation of the PL-rich apoB-containing initiation complex is mediated to a large extent by PLTP

195 y of the components of the transcription pre-initiation complex is proposed to control cell type-spec

196 anslation initiation, the 43 S ribosomal pre-initiation complex is recruited to the 5'-end of an mRNA

197 P2), a critical component of the translation initiation complex, is a calpain substrate.

198 form of the enzyme might constitute the pre-initiation complex leading to its unwinding activity.

199 nthetic enzymes and found that the autophagy-initiation complex localizes to phosphatidylinositol syn

200 between the upstream and downstream edges of initiation complexes making 4-7 nt RNA supports the DNA

201 llion dalton, Mediator-RNA polymerase II pre-initiation complex (Med-PIC) was assembled and analyzed

202 s of the pre- and postcatalytic forms of the initiation complex of bacteriophage N4 RNA polymerase th

203 ctive TF, assembly of the ternary TF-VIIa-Xa initiation complex of blood coagulation, and the EPCR-de

204 A paths included the proximity in eukaryotic initiation complexes of positions (+)7/(+)8 to the centr

205 n antibody that primarily recognizes the pre-initiation complexes of RNA polymerase II, we explore th

206 The initiation complexes of the lectin pathway consist of a

207 s detectable or functionally required at the initiation complexes of these promoters.

208 Analysis of the Pol II pre-initiation complex on immobilized chromatin templates re

209 emonstrate eIF2-independent assembly of 80 S initiation complex on the c-Src IRES.

210 ion of the human mitochondrial transcription initiation complex on the light-strand promoter (LSP) th

211 e assembly of the eIF4F-mediated translation initiation complex on the mRNA cap through directly bind

212 nd disrupted assembly of the transcriptional initiation complex on the SREBP-1c promoter.

213 scanning 43S complexes and formation of 48S initiation complexes on AUG codons immediately upstream

214 Our data suggest that assembly of the pre-initiation complexes on LSP and HSP brings these transcr

215 on complexes but were present in replication initiation complexes on ori-Lyt.

216 kinases (MAPKs), which it recruits into pre-initiation complexes on target gene promoters.

217 r abundance and recruitment into translation initiation complexes, or expressing viral translation fa

218 We analyzed initiation complexes paused on the HIV-2 gag IRES and re

219 led the position of TFE/TFIIE within the pre-initiation complex (PIC) and illuminated its role in OC

220 I)-dependent transcription by nucleating pre-initiation complex (PIC) assembly at the core promoter.

221 ocess involving multiple steps, from 43S pre-initiation complex (PIC) assembly, to ribosomal subunit

222 ne, and then stimulates the formation of pre-initiation complex (PIC) at several yeast promoters thro

223 nent of SAGA to promote the formation of pre-initiation complex (PIC) at the core promoter and, conse

224 The eukaryotic pre-initiation complex (PIC) bearing the eIF2.GTP.Met-tRNAi(

225 ukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal su

226 TAF4 promotes pre-initiation complex (PIC) formation at post-natal express

227 The translation pre-initiation complex (PIC) scans the mRNA for an AUG codon

228 iption initiation, a large multi-subunit pre-initiation complex (PIC) that assembles at the core prom

229 s a central player in recruitment of the pre-initiation complex (PIC) to mRNA.

230 RNA polymerase II (pol II) transcription pre-initiation complex (PIC) were determined by means of cry

231 sted the contributions of the RNA Pol II pre-initiation complex (PIC), mediator and cohesin to establ

232 ess a promoter architecture, including a pre-initiation complex (PIC), which mirrors that at the 5' r

233 ecruitment to the eukaryotic translation pre-initiation complex (PIC).

234 he upstream promoter and assemble into a Pre-Initiation Complex (PIC).

235 on of genes originate from transcription pre-initiation complexes (PICs).

236 The host eIF4F translation initiation complex plays a critical role the translation

237 Incorporation of repressive ncRNAs into pre-initiation complexes prevents transcription initiation,

238 the paths of the DNA strands in the complete initiation complexes provide insights into the mechanism

239 determination of the crystal structure of an initiation complex provided insight into the initiation

240 tive model that eIF5 and eIF5B cause 43S pre-initiation complex rearrangement favoring more efficient

241 r architecture of RNAP II-like transcription initiation complexes remains opaque due to its conformat

242 the fork and forms a stably bound helicase "initiation complex." Replacement of GTPgammaS with GTP p

243 ding formation of a stable transcription pre-initiation complex required for its activation.

244 comparison with the structure of the T7 RNAP initiation complex reveals that the pathway of the DNA t

245 tion initiation factor 4 gamma 1 translation initiation complex scaffolding protein that is mediated

246 with promoter DNA and inhibits formation of initiation complexes, sensitizing rRNA synthesis to chan

247 As aggregates of stalled initiation complexes, SGs are defined by the presence of

248 transcription machineries revealed that all initiation complexes share a conserved core.

249 wo factors can act on the same transcription initiation complex simultaneously.

250 DNA sequence and shape analysis of initiation complex sites suggest that both sequence and

251 condary channel, modifying the transcription initiation complex so that promoters with specific kinet

252 The conserved core initiation complex stabilizes the open DNA promoter comp

253 ts demonstrate a compact organization of the initiation complex, suggesting that protein-protein inte

254 ding bacteriophage T4-coded helicase hexamer initiation complex, suggesting that these motions may pl

255 t mechanism of regulation of the translation initiation complex that can be targeted with 4EGI-1, a s

256 of general transcription factors into a pre-initiation complex that ensures the accurate loading of

257 iption occurs upon sequential assembly of an initiation complex that includes mitochondrial RNA polym

258 tochondrial transcription intermediate-a pre-initiation complex that includes mtRNAP, TFAM and promot

259 This selection process occurs in a pre-initiation complex that includes multiple translation in

260 joining of the 60S subunit to produce an 80S initiation complex that is competent for elongation.

261 her the B-finger or another component of the initiation complex that is influenced by the B-finger.

262 quent recruitment of mtRNAP results in a pre-initiation complex that is remarkably similar in topolog

263 esent the structure of de novo transcription initiation complex that reveals unique contacts of the i

264 es display a highly stressed pretranslocated initiation complex that traps a pyrophosphate at the act

265 These findings suggest that the autophagy-initiation complex, the PIS-enriched ER subdomain, and A

266 n does not have a "blind spot." In assembled initiation complexes, the cap was no longer associated w

267 formation of the pre-catalytic transcription initiation complex-the decisive step in gene expression

268 e in arginine methylation of the translation initiation complex, thereby disrupting its assembly and

269 nscripts are released from the transcription initiation complex, thereby reducing the level of gene e

270 ring a unique phenomenon, the virus recruits initiation complexes through RNA structures located with

271 l structure of a mycobacterial transcription initiation complex (TIC) with RbpA as well as a CarD/Rbp

272 e crystal structures of E coli transcription initiation complexes (TICs) containing the stress-respon

273 yo-EM) to determine a structure of the eIF5B initiation complex to 6.6 angstrom resolution from <3% o

274 ring NMD that converts a pioneer translation initiation complex to a translationally compromised mRNP

275 CR interacts with the ternary TF coagulation initiation complex to enable PAR signaling and suggest t

276 hances translation by recruiting the 48S pre-initiation complex to newly exported mRNAs, through an i

277 -dependent trafficking of the ULK1 autophagy initiation complex to the phagophore.

278 mutually exclusive binding of transcription initiation complexes to closely opposed forward and reve

279 tionally competent 80S/Met-tRNA(i)(Met)/mRNA initiation complexes to repress continued translation in

280 that Brucella selectively co-opts autophagy-initiation complexes to subvert host clearance and promo

281 nteraction, for directing the binding of pre-initiation complexes to the 5'-ends of mRNAs and for bia

282 plex, similar to sigma2 in the transcription initiation complex, to stabilize the junction, and there

283 rase III subunits for the closed to open pre-initiation complex transition.Transcription initiation b

284 Then, the initiation complex translocates to the ATG9A-positive au

285 re of the HIV genomic RNA-human tRNA(Lys)(3) initiation complex using heteronuclear nuclear magnetic

286 athways regulate the assembly of translation initiation complexes, using the cap analog m7GTP to enri

287 icroscopic structure of cMed bound to a core initiation complex was determined at 9.7 A resolution.

288 mRNA on 40S ribosomal subunits in eukaryotic initiation complexes was determined by UV crosslinking u

289 phosphorylated rpS6 bound to the translation initiation complex were increased in PHLPP-knockdown cel

290 mon resonance, DNA polymerase III holoenzyme initiation complexes were formed on an immobilized gappe

291 lear vitamin D receptor (hVDR) transcription initiation complex, where the activation helix (i.e. hel

292 hat the transition of the closed to the open initiation complex, which occurs concomitant with DNA me

293 A to the small ribosomal subunit to form the initiation complex, which subsequently associates with t

294 on crystal structure of an Msm transcription initiation complex with a promoter DNA fragment.

295 R elicits association of the Vps34 autophagy initiation complex with JB12.

296 -dimensional reconstructions of yeast MtRNAP initiation complexes with and without the mitochondrial

297 hen scan to the initiation codon to form 48S initiation complexes with established codon-anticodon ba

298 hondrial DNA (mtDNA) transcription and forms initiation complexes with human mitochondrial transcript

299 increased association of pioneer translation initiation complexes with SF2/ASF, translationally activ

300 nables reconstituted eIF3 to assemble intact initiation complexes with the HCV IRES.