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1 , like the CrPV IRES, eliminate the need for initiation factors.
2 ble to initiate translation without any host initiation factors.
3 V mutant could not interact with translation initiation factors.
4 ganization, and the abundance of translation initiation factors.
5 teracts genetically with Pol I transcription initiation factors.
6 d may represent a new group of transcription initiation factors.
7 ous protein complexes such as the eukaryotic initiation factors.
8 have historically been regarded as dedicated initiation factors.
9 hesis of complete proteins in the absence of initiation factors.
10 p and some/all of the associated translation initiation factors.
11 onal rearrangements that may be modulated by initiation factors.
12 get mRNAs and interacting with translational initiation factors.
13 was not observed before in other translation initiation factors.
14 cation origins compete for a limited pool of initiation factors.
15 ay composed of polo-like kinase, cytokinesis initiation factor 1 (CIF1), and aurora B kinase that act
16 During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary complex (TC)
23 se R (PKR), which inactivates the eukaryotic initiation factor 2 (eIF2) translation initiation factor
24 Activated GCN2 phosphorylates eukaryotic initiation factor 2 (eIF2), altering gene-specific trans
25 ly GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translational contro
28 s regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2-P) that causes decreased globa
29 fically phosphorylate eukaryotic translation initiation factor 2 (eIF2alpha) on Ser51 to regulate glo
30 iver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylation, activat
31 es phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in inhibition
33 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) to activate the integrat
34 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), is an important protect
37 tional control by the eukaryotic translation initiation factor 2 alpha (eIF2alpha) bidirectionally re
38 llular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2alpha) or other signal tr
40 (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called
41 elic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are de
42 dent of source of infection, with eukaryotic initiation factor 2 signaling being the most enriched ca
43 hosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), whi
45 ent increased phosphorylation of translation initiation factor 2, IkappaBalpha, and JNK, indicating i
46 al control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and
47 ed" translation despite inhibited eukaryotic initiation factor 2-guanosine triphosphate-initiator met
48 in kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in translational con
49 Dephosphorylation of eukaryotic translation initiation factor 2a (eIF2a) restores protein synthesis
50 nd phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) are associated with
53 s exhibit increased levels of phosphorylated initiation factor 2alpha (eIF2alpha) dependent on the pr
55 ) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse embryonic fib
56 regulatory subunit of eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphatase, is a R
58 arm stimulates phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), resulting in rapid
59 to prevent granule formation in a eukaryotic initiation factor 2alpha (eIF2alpha)-independent manner.
61 hosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced translation of bet
63 KR-like, ER-localized eukaryotic translation initiation factor 2alpha kinase branch of the UPR is req
64 trol nonderepressible 2-dependent eukaryotic initiation factor 2alpha phosphorylation and activating
65 P2 cannot form SGs in response to eukaryotic initiation factor 2alpha phosphorylation or eIF4A inhibi
66 d within a few days, resulting in eukaryotic initiation factor 2alpha phosphorylation, TCRzeta-chain
68 inase R, which phosphorylates the eukaryotic initiation factor 2alpha to inhibit global protein trans
70 orylate its substrate, eIF2alpha (eukaryotic initiation factor 2alpha), halting cellular translation.
71 l of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and the downstre
72 n phosphorylation of the parasite eukaryotic initiation factor-2alpha (eIF2alpha), leading to repress
76 omes and diminishes dependence on eukaryotic initiation factor 3 (eIF3) of reinitiation by recycled 4
77 The 13-subunit, 800-kilodalton eukaryotic initiation factor 3 (eIF3) organizes initiation factor a
78 ingle 5' UTR m(6)A directly binds eukaryotic initiation factor 3 (eIF3), which is sufficient to recru
79 process that involved eukaryotic translation initiation factor 3 subunit b as a P311 binding partner.
80 TOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the cell membra
82 lieves the inhibitory function of eukaryotic initiation factor 3f, a repressive component in the 43S
83 EAD-box RNA helicases eukaryotic translation initiation factor 4A (eIF4A) and Ded1 promote translatio
85 ubstrates, reminiscent of that of eukaryotic initiation factor 4A (eIF4A) on double-stranded substrat
88 a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently inhibited Sin
89 d gamma-subunits) and eukaryotic translation initiation factor 4A (three isoforms), although the asso
90 depleted of CDK12 or eukaryotic translation initiation factor 4A3 (eIF4A3) from the EJC, EGF induced
91 ng, we identified the eukaryotic translation initiation factor 4B (eIF4B) as a MELK-interacting prote
96 d on mutations in the eukaryotic translation initiation factor 4E (eIF4E) and its isoform, eIF(iso)4E
97 Here, we show that eukaryotic translation initiation factor 4E (eIF4E) binding proteins (4E-BPs),
98 s enhanced polysome occupancy and eukaryotic initiation factor 4E (eIF4E) binding to the 5' 7mG cap o
99 ow that mice in which eukaryotic translation initiation factor 4E (eIF4E) cannot be phosphorylated ar
100 Elevated levels of phosphorylated eukaryotic initiation factor 4E (eIF4E) have been implicated in man
101 and indicate that activation of translation initiation factor 4E (eIF4E) is involved in the mechanis
105 e cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a key control
106 Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic protein hig
107 d an orthosteric inhibitor of the eukaryotic initiation factor 4E (eIF4E), an enzyme involved in mRNA
108 is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-bi
109 imally phosphorylated form binds translation initiation factor 4E (eIF4E), preventing binding of eIF4
110 or for translation is eukaryotic translation initiation factor 4E (eIF4E), which is negatively regula
111 were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-substituted anal
112 1) to directly hyperphosphorylate eukaryotic initiation factor 4E (eIF4E)-binding protein (4E-BP1) at
113 hosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1),
114 n of the translational repressor translation initiation factor 4E (eIF4E)-binding protein 1 (4EBP1).
116 n of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs).
118 estigated the role of eukaryotic translation initiation factor 4E (eIF4E)-eIF4G interactions and p70
119 mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of int
120 required to activate eukaryotic translation initiation factor 4E (eIF4E)-initiated cap-dependent tra
122 closely related to the canonical translation initiation factor 4E (eIF4E1a), cap-binding protein is h
123 s downstream effector eukaryotic translation initiation factor 4E activity equally reduced FBP1/2 con
124 rtance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production downstream o
125 on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP) under the c
127 mycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein
128 ing kinase (MNK), and eukaryotic translation initiation factor 4E, which is a critical regulator of t
129 al protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding (eIF4E-binding) protein 1 (
130 tructure (kl-TSS) and eukaryotic translation initiation factor 4E-binding Panicum mosaic virus-like t
131 aling through p70S6Ks (S6K1/2) or eukaryotic initiation factor 4E-binding protein (4E-BP1/2), which b
132 HSCs had more hypophosphorylated eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and 4E-B
133 perphosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and incr
134 al level via co-operative regulation of both initiation factor 4E-binding protein 1 (4E-BP1) and ribo
136 mycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphor
137 nt of the translational repressor eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) prevents
138 Here we show that deletion of the eukaryotic initiation factor 4E-binding protein 1 (4E-BP1), a major
139 referentially targets eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), and sec
140 tein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 during postexerci
141 protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ eukaryotic trans
142 mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we dete
143 mRNA translation initiation, the eukaryotic initiation factor 4E-binding protein 2, leads to ASD-lik
146 blocking the interaction between eukaryotic initiation factors 4E (eIF4E) and 4G (eIF4G) reduces the
148 e scaffold subunit of eukaryotic translation initiation factor 4F (eIF4F), preferentially impacts sho
149 eased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F), the key regulator of the m
150 for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and initiation of m
153 Remarkably, depleting eukaryotic translation initiation factor 4G (eIF4G), the scaffold subunit of eu
154 n by interaction with eukaryotic translation initiation factor 4G (eIF4G), we investigated whether Un
155 poly(A) tail of mRNA, as well as translation initiation factor 4G and eukaryotic release factor 3a (e
158 Hypusine modification of the eukaryotic initiation factor 5A (eIF-5A) is emerging as a crucial r
164 f these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is involved in cell
168 in kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2alpha) phosphorylation earl
169 ticulum kinase (PERK)-eukaryotic translation initiation factor alpha (eIF2alpha)-CEBP homologous prot
170 elevated phosphorylation of the translation initiation factor alpha subunit of eukaryotic initiation
171 ication stress in S phase, Dbf4 and Sld3, an initiation factor and essential target of Cyclin-Depende
172 oteins identified, Cdc6 is a DNA replication initiation factor and exhibits oncogenic activities when
173 aryotic initiation factor 3 (eIF3) organizes initiation factor and ribosome interactions required for
176 present recent structural investigations of initiation factors and their interactions with other fac
177 ng proteins, ribosomal proteins, translation initiation factors and translation elongation factors.
178 5' upstream open reading frames, translation initiation factors, and primary and secondary structures
179 WDHD1 may also function as a DNA replication initiation factor as well as a G1 checkpoint regulator.
180 selection is regulated by many trans-acting initiation factors as well as sequence/structural elemen
181 of mTORC1 in translation are the eukaryotic initiation factor-binding protein 1 (4E-BP1) and ribosom
182 (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key roles in mRNA
183 anslation by targeting ribosomal proteins or initiation factors, but whether this involves modificati
184 t that the reduced activity of a translation initiation factor called eIF2alpha might be partly respo
185 the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer.
187 These models allow us to locate PTMs within initiation factor complexes and to highlight possible ro
191 o signals specifically targeting translation initiation factors during mitosis have been identified.
193 h as ribosomal protein RPS-1 and translation initiation factor EIF-3.J to reduce infection-triggered
194 is triggered by both eukaryotic translation initiation factor (eIF) 2alpha phosphorylation and eIF4F
195 tivation increased stress-induced eukaryotic initiation factor (eIF) 2alpha phosphorylation and reduc
198 rgently signal to the eukaryotic translation initiation factor (eIF) 4F complex to regulate the sensi
199 r ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the eIF4F cap-bi
202 horylate the alpha subunit of the eukaryotic initiation factor (eIF)-2 complex, resulting in a shut-o
203 t) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for a
204 ibosomal subunit, initiator transfer RNA and initiation factors (eIF) 2, 3, 1 and 1A, attach to the 5
206 tion of the alpha subunit of the translation initiation factor eIF2 (eIF2alpha) can promote apoptosis
207 hich respectively inactivate the translation initiation factor eIF2 and stimulate RNA cleavage by RNa
210 alpha subunit of the eukaryotic translation initiation factor eIF2, leading to global downregulation
211 during the ISR required both the alternative initiation factor eIF2A and non-AUG-initiated uORFs.
213 ontrol by phosphorylation of the translation initiation factor eIF2alpha (p-eIF2alpha) accounts for a
214 t, phosphorylates the eukaryotic translation initiation factor eIF2alpha and causes translational shu
216 tion leads to phosphorylation of translation initiation factor eIF2alpha inhibition of protein synthe
217 und that reduced activity of the translation initiation factor eIF2alpha underlies the hypersensitivi
219 e an increased phosphorylation of eukaryotic initiation factor eIF2alpha, a hallmark of stress pathwa
220 , different kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the translation of
221 ction induces phosphorylation of translation initiation factor eIF2alpha, which promotes the formatio
223 ty, dephosphorylating eukaryotic translation initiation factor (eIF2alpha), and derepressing GM-CSF m
225 Moreover, overexpression of translation initiation factor eIF4A, a helicase, enhances production
226 ted with increased expression of translation initiation factors eIF4A and eIF4GI, and reduced express
227 bition of eIF4F complex, an amalgam of three initiation factors, eIF4A, eIF4G, and eIF4E, by the chem
228 the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN
230 f mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well as elevated
234 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, drives HA biosy
235 eurin regulator Rcn2, the 4E-BP (translation initiation factor eIF4E-binding protein) translation rep
241 utations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their isoforms.
242 its ability to compete with the translation initiation factor eIF4F to specifically recognize foreig
243 cing, interacts with the general translation initiation factor eIF4G and promotes translation of a su
246 DAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesi
248 s, 48S complex formation requires eukaryotic initiation factors (eIFs) 1, 1A, 2, 3, 4A, 4B and 4G, an
249 ing of the 40S ribosomal subunit, eukaryotic initiation factors (eIFs) and initiator tRNA scans mRNA
251 o latency are sequestration of transcription initiation factors, establishment of epigenetic barriers
252 n-mediated inactivation of a key translation initiation factor, eukaryotic initiation factor 2 (eIF2)
253 ion homologous to the yeast Sld2 replication initiation factor, followed by a cysteine-rich region, p
254 e Rps5 beta-hairpin is as crucial as soluble initiation factors for efficient and accurate start codo
255 which inhibits the function of transcription initiation factor I (TIF-IA) and impacts the interaction
256 hesis in T cells by inhibiting transcription initiation factor I (TIF-IA), a GTP-binding protein that
260 oorly characterized domain II of translation initiation factor IF2 and prevented the binding of lamot
261 In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of ini
263 translation initiation pathway during which initiation factors (IFs) regulate association of the 30S
264 ore, our results define eIF4A as a universal initiation factor in cap-dependent translation initiatio
267 on, the small ribosomal subunit, assisted by initiation factors, locates the messenger RNA start codo
268 itochondrial RNA polymerase (mtRNAP) and the initiation factors mitochondrial transcription factor A
269 rkable RNA-based mechanism involving neither initiation factor nor initiator tRNA, the CrPV IRES jump
270 manner, fully encircling 40S to position key initiation factors on opposite ends of the mRNA channel,
271 m falciparum eIF2alpha factor, an eukaryotic initiation factor phosphorylated by eIF2alpha kinases un
272 itates RRM2 expression through transcription initiation factor recruitment; second, WEE1 inhibition d
273 wever, the precise molecular details for how initiation factors regulate mRNA accommodation into the
274 2016) show that P-eIF2alpha, a translational initiation factor, reinforces the quiescent state of mus
276 the RNA polymerase I-specific transcription initiation factor RRN3, were up-regulated after SIRT1 in
277 te that protein levels of an essential Pol I initiation factor, Rrn3, are reduced when Spt6 is inacti
278 gh sigma factors are generally classified as initiation factors, sigma can also remain associated wit
279 We identified a mutation of the replication initiation factor Sld3, Sld3-m16, that is specifically d
280 LH1, SOHLH2 and DMRT1 as well as the meiotic initiation factor STRA8, and causing most late spermatog
281 encodes an RNA polymerase III transcription initiation factor subunit for further analysis, based on
282 HYDRATION14, AUXIN RESISTANT1, a translation initiation factor SUI1 family protein, and two genes of
283 ents facilitate recruitment of the essential initiation factors TATA-binding protein and transcriptio
285 en recently suggested that the transcription initiation factor TFAM binds to HSP and LSP in opposite
286 the binding sites of the core transcription initiation factors TFAM and TFB2M on human mitochondrial
289 down1 quantitatively displaces the essential initiation factor TFIIF from free pol II and elongating
291 equences is a binding site for the sigma(70) initiation factor that induces pausing at a site near la
292 er of an expanding subset of DNA replication initiation factors that are not strictly required for en
293 ryotes requires the interplay of at least 10 initiation factors that interact at the different steps
294 Here we define the critical sequence and initiation factors that mediate CGG repeat RAN translati
295 ated by the phosphorylation of a translation initiation factor, the alpha subunit of eukaryotic initi
297 d chromatin immunoprecipitation (PIP-seq) of initiation factors to identify the precise location of m
299 yotic initiation factor 2 (eIF2) translation initiation factor upon binding to viral double-stranded
300 on factor eIF5A, originally identified as an initiation factor, was later shown to promote translatio
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