ライフサイエンスコーパス: initiation factor-2

1 anslation initiation factor eIF2 (eukaryotic initiation factor 2).

2 es by phosphorylating eukaryotic translation initiation factor 2.

3 the alpha subunit of eukaryotic translation initiation factor 2.

4 orylation of the alpha subunit of eukaryotic initiation factor 2.

5 starved cells by phosphorylating translation initiation factor 2.

6 nding site overlaps with the binding site of initiation factor 2.

7 inding domain of the prokaryotic translation initiation factor 2.

8 phorylating the alpha-subunit of translation initiation factor 2.

9 r amino acids by phosphorylating translation initiation factor 2.

10 orylation of the alpha-subunit of eukaryotic initiation factor 2.

11 erine 51 on the alpha subunit of translation initiation factor 2.

12 n of PKR and the alpha subunit of eukaryotic initiation factor 2.

13 orylation of the alpha-subunit of eukaryotic initiation factor 2.

14 sphorylating the alpha subunit of eukaryotic initiation factor-2.

15 quitin-conjugating enzyme (15%); translation-initiation factor 2 (6%); and GTP-binding protein, Rab38

16 Tat competes with eukaryotic initiation factor 2, a well-characterized substrate of P

17 The beta subunit of archaeal translation initiation factor 2 (aIF2beta) is a representative of a

18 Phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha) is typically ass

19 ic heme-regulated inhibitor (HRI)-eukaryotic initiation factor 2 alpha (eIF2 alpha) kinase is activat

20 tional control by the eukaryotic translation initiation factor 2 alpha (eIF2alpha) bidirectionally re

21 bitor kinase (HRI), a eukaryotic translation initiation factor 2 alpha (eIF2alpha) kinase, plays crit

22 llular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2alpha) or other signal tr

23 PKR's pro-apoptotic role through eukaryotic initiation factor 2 alpha (eIF2alpha) phosphorylation is

24 ating protein translation through eukaryotic initiation factor 2 alpha (eIF2alpha) phosphorylation.

25 hosphorylation of the eukaryotic translation initiation factor 2 alpha (eIF2alpha), an important comp

26 KR) and its substrate eukaryotic translation initiation factor 2 alpha (eIF2alpha).

27 Active PKR phosphorylates eukaryotic initiation factor 2 alpha and leads to inhibition of tra

28 capsid-induced phosphorylation of eukaryotic initiation factor 2 alpha and with capsid-mediated inhib

29 (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called

30 cientists discovered mutations in eukaryotic initiation factor 2 alpha kinase 4 (EIF2AK4) that cause

31 elic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are de

32 polysomes likewise depends on the eukaryotic initiation factor 2 alpha kinase 4, which associates wit

33 ment protein C1qB and eukaryotic translation initiation factor 2 alpha kinase 4-an orchestrator of th

34 nd phosphorylates the eukaryotic translation initiation factor 2 alpha subunit (cIF-2 alpha) to inhib

35 ication of S. mansoni eukaryotic translation initiation factor 2 alpha subunit (eIF2 alpha), through

36 R, we observed a reduced level of eukaryotic initiation factor 2 alpha subunit (eIF2alpha) phosphoryl

37 ct characterized by deficiency of eukaryotic initiation factor 2 alpha subunit phosphorylation, delay

38 ation (phosphorylated eukaryotic translation initiation factor 2 alpha), and cell death [terminal deo

39 e repressed by phosphorylation of eukaryotic initiation factor 2 alpha-subunit (eIF2alpha).

40 that UV light-induced eukaryotic translation initiation factor 2 alpha-subunit phosphorylation transl

41 n site, Ser-51 in the eukaryotic translation initiation factor 2 alpha-subunit, is replaced with a no

42 aspase-12, and phosphorylation of eukaryotic initiation factor-2 alpha in a human dopaminergic neuron

43 (PKR), which then phosphorylates translation initiation factor 2-alpha (eIF-2alpha), and inhibits tra

44 protein synthesis by inactivating eukaryotic initiation factor 2-alpha (eIF2-alpha), to examine the m

45 ithin the promoter of eukaryotic translation initiation factor 2-alpha (eIF2-alpha).

46 s demonstrated phosphorylation of eukaryotic initiation factor 2-alpha (eIF2alpha), a 'collapsed' pol

47 dependent on the presence of the eukaryotic initiation factor 2-alpha homology region, mapping to th

48 , small molecule inhibitor of the eukaryotic initiation factor 2-alpha kinase 3 (EIF2AK3) or PERK, on

49 ation of eIF2alpha (eukaryotic translational initiation factor 2-alpha) and ensuing activation of p38

50 orylation of the alpha subunit of eukaryotic initiation factor 2 and NF-kappaB activity at 72 h posti

51 epressible 2), phosphorylation of eukaryotic initiation factor 2, and increased synthesis of activati

52 Eukaryotic initiation factor 2-associated glycoprotein, p67, plays

53 peptidase 2, which is the same as eukaryotic initiation factor 2-associated glycoprotein, p67.

54 at phosphorylation of eukaryotic translation initiation factor 2 at Ser-51 on the alpha subunit was n

55 , fMet-tRNA(fMet), and the GTP bound form of initiation factor 2 bound to the 30S subunit.

56 orylation of the alpha subunit of eukaryotic initiation factor 2 causes translating mRNAs to accumula

57 ns, OmpA and OmpB, we identified translation initiation factor 2, cell division protein FtsZ, and cys

58 complex (30SIC(Cy3)) containing Cy3-labeled initiation factor 2 complexed with GTP leads to rapid de

59 nase)-eIF2alpha (alpha subunit of eukaryotic initiation factor 2)-dependent pathway by SubAB-mediated

60 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha), the primary physiolog

61 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2) and total shutoff of protein

62 Eukaryotic translation initiation factor 2 (eIF-2) comprises three non-identica

63 A eukaryotic translation initiation factor 2 (eIF-2)-associated 67 kDa glycoprote

64 the alpha-subunit of eukaryotic translation initiation factor 2 (eIF-2).

65 hosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) and inhibit translation

66 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha) and the induction of ap

67 alpha-subunit of the eukaryotic translation initiation factor 2 (eIF-2alpha) and to apoptotic cell d

68 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) by activated PKR, and,

69 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) is a well-characterized

70 ated increase in alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) phosphorylation and ini

71 d suppresses the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha) phosphorylation.

72 R and the alpha subunit of protein synthesis initiation factor 2 (eIF-2alpha) was elevated severalfol

73 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha) was enhanced approximat

74 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha), a process that prevent

75 e (PERK) and the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha), as well as induce robu

76 rate of PKR, the alpha subunit of eukaryotic initiation factor 2 (eIF-2alpha), was equally phosphoryl

77 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha).

78 lpha subunit of protein synthesis eukaryotic initiation factor 2 (eIF-2alpha).

79 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha).

80 the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2alpha).

81 -starved cells phosphorylated the eukaryotic initiation factor-2 (eIF-2) alpha-subunit.

82 orylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2) is a well characterized mech

83 ar stresses by phosphorylation of eukaryotic initiation factor-2 (eIF-2).

84 orylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2).

85 orylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2alpha) and inhibition of prote

86 orylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2alpha).

87 the alpha subunit of eukaryotic translation initiation factor 2, (eIF-2 alpha).

88 Stress-induced eukaryotic translation initiation factor 2 (eIF2) alpha phosphorylation paradox

89 the translation initiation factor eukaryotic initiation factor 2 (eIF2) and thereby inhibits protein

90 Translation initiation factor 2 (eIF2) binds Met-tRNA(i)(Met) to the

91 Translation initiation factor 2 (eIF2) bound to GTP transfers the in

92 e to phosphorylation of the alpha-subunit of initiation factor 2 (eIF2) by its specific kinase, GCN2,

93 Phosphorylation of the alpha-subunit of initiation factor 2 (eIF2) controls protein synthesis by

94 During translation initiation the eukaryotic initiation factor 2 (eIF2) forms a ternary complex (TC)

95 hange factor that converts protein synthesis initiation factor 2 (eIF2) from a GDP-bound form to the

96 rotein kinases that phosphorylate eukaryotic initiation factor 2 (eIF2) in coordinating stress gene r

97 tRNA(Met) binding to eukaryotic translation initiation factor 2 (eIF2) in response to eIF2 phosphory

98 Eukaryotic initiation factor 2 (eIF2) is a central regulator of tra

99 Eukaryotic translation initiation factor 2 (eIF2) is a G protein heterotrimer r

100 Eukaryotic translation initiation factor 2 (eIF2) is a G-protein that functions

101 Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, w

102 Translation initiation factor 2 (eIF2) is a heterotrimeric protein t

103 Eukaryotic initiation factor 2 (eIF2) is a key integrator of cellul

104 Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important mechanism reg

105 The eukaryotic translation initiation factor 2 (eIF2) is central to the onset of pr

106 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2) is fundamental to the process

107 nsing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

108 In eukaryotes, initiation factor 2 (eIF2) plays an important role in tr

109 of the p53 protein by the CUGBP1-eukaryotic initiation factor 2 (eIF2) repressor complex.

110 Protein translation through eukaryotic initiation factor 2 (EIF2) signaling, a pathway previous

111 se R (PKR), which inactivates the eukaryotic initiation factor 2 (eIF2) translation initiation factor

112 er RNA induces phosphorylation of eukaryotic initiation factor 2 (eIF2) via the GC nonderepressing 2

113 that can regulate the activity of eukaryotic initiation factor 2 (eIF2), a critical translation initi

114 Activated GCN2 phosphorylates eukaryotic initiation factor 2 (eIF2), altering gene-specific trans

115 Eukaryotic initiation factor 2 (eIF2), eIF3, and eIF4F were require

116 al complexes on the IRES requires eukaryotic initiation factor 2 (eIF2), eIF3, eIF4A, and the central

117 rly initiation complex containing eukaryotic initiation factor 2 (eIF2), GTP, and methionine-charged

118 he translation initiation complex eukaryotic initiation factor 2 (eIF2), have a profound impact on is

119 tes-initiation factor 2 (IF2) and eukaryotic initiation factor 2 (eIF2), respectively.

120 specific ternary complex between eukaryotic initiation factor 2 (eIF2), the initiator methionyl-tRNA

121 osphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF2), thus rendering eIF2 inactive

122 Recruitment of the eukaryotic translation initiation factor 2 (eIF2)-GTP-Met-tRNAiMet ternary comp

123 ly GTPase, has been implicated in eukaryotic initiation factor 2 (eIF2)-mediated translational contro

124 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

125 nd its substrate, the eukaryotic translation initiation factor 2 (eIF2).

126 e nucleotide exchange factor for translation initiation factor 2 (eIF2).

127 ey translation initiation factor, eukaryotic initiation factor 2 (eIF2).

128 1A stimulates 40S-binding of the eukaryotic initiation factor 2 (eIF2)/GTP/Met-tRNA(iMet) ternary co

129 s regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2-P) that causes decreased globa

130 activate Gcn2p phosphorylation of eukaryotic initiation factor-2 (eIF2) and the general amino acid co

131 Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PE

132 ular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene expression desig

133 in kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in translational con

134 Phosphorylation of eukaryotic initiation factor-2 (eIF2) is an important mechanism mit

135 ntal stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) rapidly reduces protein synth

136 Phosphorylation of eukaryotic initiation factor-2 (eIF2) regulates general and gene-sp

137 sphorylation of the alpha-subunit eukaryotic initiation factor-2 (eIF2), and its attendant regulation

138 nism involving phosphorylation of eukaryotic initiation factor-2 (eIF2).

139 Eukaryotic initiation factor 2- (eIF2-) associated glycoprotein p67

140 ation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits global prot

141 orylates the alpha-subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits translation

142 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) and the consequent shuto

143 hosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stresse

144 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) at Ser51.

145 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) by the endoplasmic retic

146 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) by the interferon-induce

147 elective inhibitor of eukaryotic translation initiation factor 2 (eIF2alpha) dephosphorylation.

148 tion of the alpha subunit of the translation initiation factor 2 (eIF2alpha) in an AR-dependent manne

149 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in MEFs in an IFN-depend

150 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) in response to different

151 o-Ser 51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha) in stressed cells.

152 lation through phosphorylation of eukaryotic initiation factor 2 (eIF2alpha) is essential to preserve

153 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) is known to be an import

154 nitiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) is known to occur in res

155 The alpha subunit of translation initiation factor 2 (eIF2alpha) is the target of specifi

156 tivation of the alpha subunit of translation initiation factor 2 (eIF2alpha) kinase GCN2 and conseque

157 fically phosphorylate eukaryotic translation initiation factor 2 (eIF2alpha) on Ser51 to regulate glo

158 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) on serine 51 integrates

159 iver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylation, activat

160 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) protein via phosphorylat

161 rylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation an

162 rylation of the alpha-subunit of translation initiation factor 2 (eIF2alpha) represses translation in

163 es phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in inhibition

164 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates signalling in

165 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) to activate the integrat

166 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) translation initiation f

167 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), attenuating translation

168 osphorylates the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha), inhibiting the function

169 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), is an important protect

170 -subunit of wild-type eukaryotic translation initiation factor 2 (eIF2alpha), one of the known substr

171 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting in decreased

172 the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting in inhibition

173 the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2alpha), resulting in the inhibi

174 ation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha), the cellular substrate

175 osphorylate the alpha subunit of translation initiation factor 2 (eIF2alpha), thus attenuating mRNA t

176 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha).

177 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

178 he alpha-subunit of eukaryotic translational initiation factor 2 (eIF2alpha).

179 phorylating the alpha subunit of translation initiation factor 2 (eIF2alpha).

180 tion factor, the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

181 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

182 nitiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

183 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

184 rylation of the alpha subunit of translation initiation factor 2 (eIF2alpha).

185 osphorylate the alpha subunit of translation initiation factor 2 (eIF2alpha).

186 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

187 phorylating the alpha subunit of translation initiation factor 2 (eIF2alpha).

188 Phosphorylation of the translation initiation factor 2 (eIF2alpha)atSer(51) is a molecular

189 ated alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha-P), a regulator of genera

190 the alpha-subunit of eukaryotic translation initiation factor-2 (eIF2alpha) leading to inhibition of

191 e the beta subunit of eukaryotic translation initiation factor 2 (eIF2beta) and the N-terminal domain

192 eukaryotic translation initiation factor 5B/initiation factor 2 (eIF5B/IF2) impair yeast cell growth

193 The absence of eukaryotic initiation factor 2 from these complexes suggests that t

194 ed" translation despite inhibited eukaryotic initiation factor 2-guanosine triphosphate-initiator met

195 ed kinase of the alpha subunit of eukaryotic initiation factor 2 (HRI) is activated in rabbit reticul

196 ationships among the components of bacterial initiation factor 2 (IF-2) and eukaryotic IF-2 (eIF-2)/e

197 n in initiation through its interaction with initiation factor 2 (IF-2).

198 encoding bovine mitochondrial translational initiation factor 2 (IF-2mt) has been obtained.

199 S ribosomes in the presence of mitochondrial initiation factor 2 (IF2(mt)), [(35)S]fMet-tRNA, and eit

200 Initiation factor 2 (IF2) and elongation factor G (EF-G)

201 lation factors in prokaryotes and eukaryotes-initiation factor 2 (IF2) and eukaryotic initiation fact

202 The initiation of protein synthesis uses initiation factor 2 (IF2) in prokaryotes and a related p

203 ecycling factor (RRF) activity or increasing initiation factor 2 (IF2) levels enhanced initiation wit

204 Translation initiation factor 2 (IF2) promotes 30S initiation comple

205 ukaryotic initiation and elongation factors, initiation factor 2 (IF2), eukaryotic initiation factor

206 -tRNA (fMet-tRNAfMet) in a process involving initiation factor 2 (IF2).

207 s binding of Met-tRNA(f)(Met) to translation initiation factor 2 (IF2).

208 sence of the full-length form of Translation Initiation Factor 2 (IF2-1) or deficiency in helicase ac

209 cule tracking, the timing of initiator tRNA, initiation factor 2 (IF2; encoded by infB) and 50S subun

210 ent increased phosphorylation of translation initiation factor 2, IkappaBalpha, and JNK, indicating i

211 nase, and its downstream effector eukaryotic initiation factor 2 in human leukemia (HL60) and ovarian

212 Evn inhibits activity of initiation factor 2 in vitro, suggesting that the drug i

213 n of PKR and the alpha subunit of eukaryotic initiation factor 2, indicating that K1L and C7L functio

214 the eIF-2alpha (alpha subunit of eukaryotic initiation factor 2) kinase PERK to transiently arrest p

215 The ZPR1 domain consists of an elongation initiation factor 2-like zinc finger and a double-strand

216 ifm1 mutants, lacking the mitochondrial initiation factor 2 (mIF2), are unable to respire, indic

217 in kinase R, which phosphorylates eukaryotic initiation factor 2, nor oligoadenylate synthetase, whic

218 orylation of the alpha subunit of eukaryotic initiation factor 2 on serine 51 was not detectably incr

219 es phosphorylation of eukaryotic translation initiation factor 2 on the alpha-subunit (eIF2alpha) and

220 f both protein kinase R (PKR) and eukaryotic initiation factor 2 on the alpha-subunit in skeletal mus

221 initiation via phosphorylation of eukaryotic initiation factor 2 on the alpha-subunit.

222 (AADR) such as phosphorylation of eukaryotic initiation factor 2 (p-eIF2) leading to increased mRNA l

223 orylation of the alpha subunit of eukaryotic initiation factor 2, requiring PKR-like endoplasmic reti

224 dent of source of infection, with eukaryotic initiation factor 2 signaling being the most enriched ca

225 impaired autophosphorylation and eukaryotic initiation factor 2 subunit alpha (eIF2alpha) phosphoryl

226 that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).

227 hosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), whi

228 nae, increased phosphorylation of eukaryotic initiation factor 2 subunit alpha (P-eIF2alpha), reduced

229 arrest through phosphorylation of eukaryotic initiation factor 2 subunit alpha.

230 osphorylates the alpha subunit of eukaryotic initiation factor 2, thereby inhibiting protein synthesi

231 osphorylates the alpha-subunit of eukaryotic initiation factor 2, thereby inhibiting protein synthesi

232 ate group on the alpha subunit of elongation initiation factor 2, thereby reversing the shutoff of pr

233 the alpha subunit of eukaryotic translation initiation factor 2 was defective after virus infection

234 ion of the alpha-subunit of eIF2 (eukaryotic initiation factor 2), which inhibits its guanine nucleot

235 al control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and

236 ange factor (GEF) for eukaryotic translation initiation factor 2, which stimulates formation of the e