ライフサイエンスコーパス: initiation site

1 upstream of the presumptive transcriptional initiation site.

2 re 1.7 kb fragment 5' of the transcriptional initiation site.

3 between bp -158 and +30 of the transcription initiation site.

4 itiating upstream of the known transcription initiation site.

5 contributing factors in the selection of the initiation site.

6 inning 17 bp downstream of the transcription initiation site.

7 and definitively identify the authentic ORF3 initiation site.

8 mately 5 kb upstream of the flk1 translation initiation site.

9 tion -43.5 with respect to the transcription initiation site.

10 tivator to the GAL10 antisense transcription initiation site.

11 (EGFPapoE) immediately after the translation initiation site.

12 nding from the TATA box to the transcription initiation site.

13 on activity in the vicinity of transcription initiation site.

14 promoter, although not always at the correct initiation site.

15 nucleotides targeted to the Rx-L translation initiation site.

16 manner that exposes a potential replication initiation site.

17 ed just proximal to the alternative in-frame initiation site.

18 l peptide and putative alternate translation initiation sites.

19 t Z-lines, consistent with RyR2 and Ca spark initiation sites.

20 on by increasing discrimination against poor initiation sites.

21 cells identified multiple MRP2 transcription initiation sites.

22 rate prediction of single-peak transcription initiation sites.

23 ive elements act as autonomous transcription initiation sites.

24 ) protein that binds a subset of replication-initiation sites.

25 matic predictions of alternative translation initiation sites.

26 ased utilization of downstream transcription initiation sites.

27 omoter and mapped its multiple transcription initiation sites.

28 w mechanism for targeting ORC to replication initiation sites.

29 s to low-level transcription, at the correct initiation sites.

30 ere identified, including several downstream initiation sites.

31 e important for replicating regions far from initiation sites.

32 in a corresponding shift in DNA replication initiation sites.

33 marks characteristic of active transcription initiation sites.

34 nal modification and alternative translation initiation sites.

35 base pairs in width, fixed at RNA polymerase initiation sites.

36 possibly, the usage of multiple translation initiation sites.

37 and adopt perpendicular orientation at valve initiation sites.

38 nt DNA double-strand breaks act as silencing initiation sites.

39 ied between -118 and +178 flanking the major initiation site (+1) mapped in SK-N-SH cells.

40 A was isolated and found to contain a single initiation site 71 nt from the most 5' end, an open read

41 egion and identified the human transcription initiation site 86 bp upstream from the translation star

42 igh-resolution maps of meiotic recombination initiation sites across the genomes of budding yeast and

43 rved an enrichment of footprints at inferred initiation sites after drug-induced arrest of translatio

44 GABAergic synapses and the action potential initiation site along the AISs is not well defined.

45 endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogenesis.

46 ituitary hormone secretion possesses a spike initiation site and conducts action potentials while als

47 The initiation site and efficiency of Rad26-mediated repair

48 reporter gene replacing the Enam translation initiation site and gene sequences through exon 7.

49 study we identified a new RSK4 transcription initiation site and several alternative splice sites wit

50 f the HAS2 gene identified the transcription initiation site and showed that region F3, comprising th

51 mediately upstream of the HAS2 transcription initiation site and that mutation of the consensus recog

52 ethionine codons while leaving open the true initiation site and that the final recognition of the in

53 2,584 bp upstream of the TERT transcription initiation site and were all in the opposite transcripti

54 hibited abnormal voltage-Ca(2+) delay at the initiation site and were inhibited by either sarcoplasmi

55 ocated 90 kb downstream of the transcription initiation site and within the first intron.

56 CELSR1 regulating the direction of dendrite initiation sites and CELSR2/3 controlling radial migrati

57 ain structure abrogates the need for precise initiation sites and creates a scaffold for the evolutio

58 CGIs often include transcription initiation sites and display 'active' histone marks, not

59 gamma (iPLA2gamma) with multiple translation initiation sites and dual mitochondrial and peroxisomal

60 ene transcription from cryptic transcription initiation sites and in mitigating RNA polymerase II pro

61 nstability; therefore, we mapped replication initiation sites and prereplication complex protein bind

62 The finding that the subcellular location of initiation sites and protein microdomains was cell type

63 The initiation sites and restricted propagation of waves at

64 de important information about transcription initiation sites and the approximate locations of local

65 the free energy of formation of hydrophobic initiation sites and the parameter "average area buried

66 t are observed to fold first (termed folding initiation sites) and the "hydrophobicity" (as customari

67 roteasome has pronounced preferences for the initiation site, and its recognition represents a second

68 romoter region proximal to the transcription initiation site, and that suppression of Rab33A in melan

69 itiated upstream of the normal transcription initiation site, and was strongly regulated by both cisp

70 the number of assembly pathways and assembly initiation sites, and resulting in enhanced assembly eff

71 Multiple active translation initiation sites appear to operate in several plant gene

72 We mapped the transcription initiation site approximately 116 bp 5' to the translati

73 nhancer-like distal sequence element and the initiation site are protected during interphase whereas

74 We conclude that fracture initiation sites are controlled primarily by contact dam

75 RNA polymerase transcription initiation sites are largely unknown in Caenorhabditis e

76 es of the major splice donor and translation initiation sites are sequestered by long-range base pair

77 Alternative initiation sites are utilized for the synthesis of impor

78 models based on the hypothesis that folding initiation sites arise from hydrophobic interactions.

79 NFRs associated with transcription initiation sites as well as those not associated with pr

80 e protection assays mapped the transcription initiation site at 32 nucleotides upstream of the UXP ge

81 A polymerase II is targeted to the antisense initiation site at GAL10 by Reb1p activator as well as g

82 iates with the GAL10 antisense transcription initiation site at the 3' end of the coding sequence.

83 tion of RNA polymerase II with the antisense initiation site at the 3' end of the GAL10 coding sequen

84 ll or pause within tens of base pairs of its initiation site at the promoter, a state that may reflec

85 The initiation sites at oriC1 were determined by replication

86 Translation inhibitors were used to map initiation sites at single-nucleotide resolution at the

87 rmatic prediction of alternative translation initiation sites (aTIS).

88 l II) pauses downstream of the transcription initiation site before beginning productive elongation.

89 Pak1 to the plasma membrane at the dendrite initiation site before the activation of Cdc42.

90 binding site proximal to the transcriptional initiation site; both SRC-1 and c-Jun were recruited to

91 riction fragments that contained replication initiation sites (bubbles) in vivo.

92 els determine AP repolarization at the spike initiation site but not at more distal sites, limiting t

93 nsic cues guide sprouts after they leave the initiation site, but these cues are likely insufficient

94 and Mcm4 bound near each of the replication initiation sites, but a dramatic change in (CTG)(n) .

95 icate that Mcm10 is localized to replication initiation sites by directly binding MCM through the Mcm

96 e p19 promoter and defined its transcription initiation sites by the 5'-rapid amplification of cDNA e

97 lassification used, synthesized from varying initiation sites by the living anionic ring opening poly

98 at the subcellular scale (number of Ca wave initiation sites), cellular scale (sarcoplasmic reticulu

99 show that DNA sequences surrounding the IMD2 initiation site constitute a repressive element (RE) inv

100 entical junction upstream of the translation initiation site created CYP19 mRNA encoding functional a

101 he enzyme's ability to locate the downstream initiation site decreased exponentially as the start was

102 The centromeric and first euchromatic SC initiation sites depend on the cohesion protein ORD.

103 TREK-2 that has three potential translation initiation sites (designated M(1)M(2)M(3)) within the N-

104 The HIV-1 Dimerization Initiation Site (DIS) is an intriguing, yet underutilize

105 sing interaction formed via the dimerization initiation site (DIS) loop sequence, which has been prop

106 a a self-complementary sequence in the dimer initiation site (DIS) of the genomic RNA, but that dimer

107 Dimerization is initiated at the dimer initiation site (DIS) which encompasses stem-loop 1 (SL1

108 apical loop, which contains the dimerization initiation site (DIS), competes directly with the anneal

109 g frame (ORF) that may act as a dimerization initiation site (DIS), enabling the virus to package two

110 of stem-loop 1 (SL-1), also termed the dimer initiation site (DIS).

111 lel orientation by interactions at the dimer initiation site (DIS).

112 itiation of translation at a downstream M231 initiation site distinct from that of full-length mRNA.

113 lementary alpha and beta motifs in the dimer initiation site driven by long-range electrostatic inter

114 We investigate whether, at a given initiation site, DSBs occur independently among the four

115 frequencies only if AP onset was fast at the initiation site (e.g., attributable to cooperative gatin

116 ation was enabled by alternative translation initiation sites encoding distinct targeting signals.

117 s redirected towards unconventional upstream initiation sites, enhancing the translational efficiency

118 ream of the distal gene 50/RTA transcription initiation site exhibited promoter activity in both perm

119 both composition and structure to become the initiation site for de novo formation of a membrane call

120 ating its transcytosis to an apical membrane initiation site for lumen formation.

121 ns more than 1,000 bp from the transcription initiation site for most of these genes.

122 virus infection and is likely the authentic initiation site for ORF3.

123 The transcription initiation site for pri-miR-216a was delineated, and one

124 after the canonical 3'-GPyPy (Py is T or C) initiation site for primer synthesis showed that only UL

125 o other Drosophila non-LTR elements, a major initiation site for sense transcripts was mapped near th

126 cture, SL1, which serves as the dimerization initiation site for two identical copies of the genome a

127 nd identification of alternative translation initiation sites for a group of mRNA sequences that have

128 e N-terminal KTK(E/Q)GV repeats may serve as initiation sites for aggregation in mouse aS.

129 ys were used to identify two transcriptional initiation sites for algR within the algZ coding region,

130 Selection of initiation sites for DNA replication in eukaryotes is de

131 Utilization of alternative initiation sites for protein translation directed by non

132 res that allow identification of alternative initiation sites for protein translation.

133 demonstrated to utilize alternative non-AUG initiation sites for protein translation.

134 PrP(C)s to mechanical force to decipher the initiation sites for the transition from PrP(C) to an ag

135 Multiple putative transcriptional initiation sites for this gene were identified, includin

136 ity of these cells to Ag and shifts the wave initiation site from protrusions to the cell body.

137 Mutation of the second and third initiation sites from Met to Leu (M(1)L(2)L(3)) produced

138 Spatial accuracy for determining initiation sites from pacing was 6 mm.

139 or prolonged network activity may alter the initiation site geometry thus affecting cell excitabilit

140 The dimer initiation site has been characterized to some extent, b

141 is removed by trans-splicing, and noncoding initiation sites have not been investigated.

142 That is, initiation sites have the locally "best" initiator (INR)

143 b and -0.13 kb upstream of the transcription initiation site, HSIV and HSV within intron 1 and HSVII

144 the method consists of enhanced translation initiation site identification, ability to identify sequ

145 ces upstream of their probable transcription initiation sites, identified by primer extension.

146 Ribosome binding to the translation initiation site impedes degradation by both mechanisms.

147 as the only step necessary for selecting the initiation site in prokaryotes.

148 OC1, which is part of the daughter centriole initiation site in Tetrahymena.

149 w that the absence of a strong transcription initiation site in the G11 gene results in the productio

150 on sites was tissue-specific, with the major initiation site in the liver and kidney being -98 and -1

151 d from full-length viral mRNA at an upstream initiation site in the same reading frame as Pr65(gag),

152 cognition elements within cos, the packaging initiation site in viral DNA, to site-specifically assem

153 482 to 684 bp upstream of the transcription initiation site in vitro.

154 scQC, the product of an internal translation initiation site in yscQ, for their cooperative assembly.

155 sites, polyadenylation sites and translation initiation sites in both the native and fusion contexts.

156 s were common in ARVC patients with variable initiation sites in both ventricles.

157 red with 8-oxoguanine (G(O)) also act as MMR initiation sites in extracts of human cells or Xenopus l

158 and, particularly, in predicting translation initiation sites in modelled as well as in assembled tra

159 find that the vast majority of recombination initiation sites in mouse males are associated with test

160 ts that there are many potential replication initiation sites in permissive parts of the genome, most

161 he genome-wide distribution of recombination initiation sites in Prdm9 knockout mice and in two mouse

162 Rab27B and beta4 integrin to early adhesion initiation sites in spreading normal keratinocytes.

163 Mapping of replication initiation sites in the HAC revealed that replication pr

164 he genome-wide distribution of recombination initiation sites in the mouse genome.

165 ominated by the number of pre-existing crack-initiation sites in the sample.

166 Characterization of Ps1 transcription initiation sites in this allelic series revealed several

167 tate cancers, and share the same translation initiation site (in ERG exon 4) with the commonly observ

168 The initiation site, in other words, is a varied sequence of

169 sequences near and upstream of transcription initiation sites, in intronic regions, and within interg

170 ine pulses) increased, the number of Ca wave initiation sites increased, integrated Ca transients and

171 of a polycytosine track upstream of the HSP2 initiation site, influence transcriptional activity.

172 located 96-bp upstream of the transcription initiation site is critical for the activation of the pr

173 nthesis from a relatively weak translational initiation site is greatly influenced by the presence or

174 n the ICP4-binding site at its transcription initiation site is mutated, suggesting that ICP4 may pla

175 nd nuclease mapping revealed that the gene X initiation site is sequestered in an extended RNA second

176 b sequence upstream of the Nrl transcription initiation site is sufficient to drive reporter gene exp

177 TIE located at 401 bp from the transcription initiation site, is required for TGFbeta repression of t

178 around canonical and alternative translation initiation sites, is dynamic in response to physiologica

179 nduced dissociation of the MMLV dimerization initiation site kissing loop.

180 Two dimerization initiation site kissing sequences, Mal and Lai, have bee

181 Immediately distal to this initiation site, lamellae of increasing diameter are evi

182 of Rv1813c and direct transcription from an initiation site located several hundred base pairs upstr

183 n analysis identified two rpoS transcription initiation sites located 43 bp (P1) and 63 bp (P2) upstr

184 transcripts initiating from 2 transcription initiation sites located upstream of the currently defin

185 nthesis from the much weaker maturation gene initiation site, located 1300 nucleotides upstream.

186 icates that the ribosomal recognition of the initiation site may be the result of multiple interactio

187 ng on circuit 'choke points' remote from the initiation site might be as important as that of the ini

188 Folding initiation sites might therefore contain not only accept

189 onsistently assemble provided a small "dimer initiation" site near the actin binding domain is presen

190 reveal that pausing is not fixed relative to initiation sites, nor is it specified directly by the po

191 n site and that the final recognition of the initiation site occurs by cooperativity and cumulative s

192 ger complex, from the central spindle to the initiation site of cytokinesis.

193 This locus overlaps the transcription initiation site of RASGRF1, which is highly expressed in

194 ricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hs

195 nd the first heminode, which forms the spike initiation site of the auditory nerve.

196 n that utilizes TRPC channels to specify the initiation site of the Ca(2+) response.

197 n the 200 bp upstream from the transcription initiation site of the FcRgamma promoter.

198 n the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine

199 phism at -3081 upstream of the transcription initiation site of the human norepinephrine transporter

200 In this study, we show that the +3 initiation site of the Le is utilized with apparently hi

201 a flanking the 3-kb fragment upstream of the initiation site of the mouse NPC1L1 gene in mouse colon

202 We mapped the transcription initiation sites of all three primary miRNA transcripts

203 ICP4-binding sequences at the transcription initiation sites of both HSV-2 LAT (pri-miRNA for miR-I

204 Analysis of the initiation sites of Ca2+ sparks within the same junction

205 has an important function in determining the initiation sites of DNA replication.

206 t GABPalpha is associated with transcription initiation sites of genes encoding key molecules in TCR

207 one or two nucleotides of the transcription initiation sites of genes transcribed by RNA polymerase

208 re over-represented near the transcriptional initiation sites of immune response genes.

209 activation domain binds to the transcription initiation sites of these promoters and stimulates TFIIH

210 +66, and +186 relative to the transcription initiation site on the HIV long terminal repeat (LTR).

211 r region at the 3' end of the genome has two initiation sites, one at position +1, opposite the 3' te

212 erential targeting is effected by use of two initiation sites, one of which includes a mitochondrial

213 protein by utilizing alternative translation initiation sites: one (short form) with the nuclear loca

214 chromosomes requires thousands of potential initiation sites, only a small fraction of which are sel

215 c marks associated with active transcription initiation sites overlap with regions of reduced relativ

216 poE mRNA identified five new transcriptional initiation sites (P1 to P5) located distal to Esigma(E)-

217 nd SR Ca load, whereas the number of Ca wave initiation sites per myocyte is less important.

218 A kissing complex formed by the dimerization initiation site plays a critical role in the survival an

219 of a developmental regulation in translation initiation site preference for a T. gondii protein.

220 somes and subsequently targeted to preferred initiation sites prior to the next S phase.

221 n from the second (M(2)L(3)) or third (M(3)) initiation site produced the approximately 54 kDa isofor

222 uA4 KAT to the GAL10 antisense transcription initiation site promotes GAL10 antisense transcription.

223 ogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may b

224 ells and provides a quantitative estimate of initiation site redundancy.

225 ein interactions at subgroups of replication initiation sites (replication origins) modulate the ubiq

226 mRNA to an alternative, in-frame translation initiation site, resulting in the prevention of nonsense

227 roximal and distal gene 50/RTA transcription initiation sites revealed that the distal promoter is pa

228 combines weighted, signal-based translation initiation site scores and the contrast in coding potent

229 nct sites; however, the principles governing initiation site selection are unclear because proteins e

230 r, it displays a dichotomous requirement for initiation site selection between reading frames, with i

231 te data can be unified into a model in which initiation site selection is driven almost entirely by e

232 Ac transposase does not influence transcript initiation site selection.

233 elimbic cortex, which innervate PCs at spike initiation site, selectively control PCs projecting to t

234 In fact, comparison of a large number of initiation site sequences revealed that the sites are co

235 lution origin mapping technique that we call initiation site sequencing (ini-seq).

236 High-resolution mapping of replication initiation sites showed that replication initiation even

237 dingly, we conducted an analysis of synaptic initiation sites (SISs) and COs in human and mouse sperm

238 id hormone response element to transcription initiation site slide bi-directionally, with the third n

239 cZ inserted in frame at the Klk4 translation initiation site so that the endogenous Klk4 promoter dri

240 fied a handful of previously unknown non-AUG initiation sites, some of which serve as the exclusive s

241 mber of transcripts with novel transcription initiation sites, spliced variants and alternative polya

242 clustered but distinct M2 gene transcription initiation sites suggesting the presence of multiple pro

243 NCR) and one at the prominent lagging-strand initiation site termed Ori-L.

244 DNA replication starts at initiation sites termed replication origins.

245 d a region from -125 to -256 relative to the initiation site that mediated the inhibitory effect of L

246 x/pro-SCP-2 gene is a fusion gene having two initiation sites that generate a long (SCP-x; 58.9-kDa)

247 e also identified novel putative translation initiation sites that were mostly associated with short

248 e pairing of a unique leader sequence in the initiation site--the SD sequence--with the 3' end of the

249 eplication forks were stalled close to their initiation sites; therefore, copy number enrichment was

250 Data presented here identify replication initiation sites throughout the genome, providing a foun

251 Translation initiation site (TIS) identification is an important asp

252 Timely identification of the translation initiation site (TIS) is very important for conducting i

253 Proper selection of the translation initiation site (TIS) on mRNAs is crucial for the produc

254 nderstand how ribosomes choose a translation initiation site (TIS).

255 d comprehensive determination of translation initiation sites (TIS) across the entire transcriptome.

256 thm is able to predict genes and translation initiation sites (TIS) more accurately than Orphelia whi

257 ht transcripts by using four transcriptional initiation sites (TIS; resulting in three different init

258 urate detection of human mtDNA transcription initiation sites (TISs) in the heavy and light strands r

259 r, the evidence for noncanonical translation initiation sites (TISs) is largely indirect and based on

260 In addition to the annotated translation initiation sites (TISs), the translation process may als

261 ty of spike patterns propagated from a spike initiation site to a synaptic target, and that neuromodu

262 silencing did not spread from the silencing initiation site to adjacent cells.

263 er DNA and melts several base pairs near the initiation site to form an open complex.

264 )-induced gene silencing can spread from the initiation site to nearby cells.

265 ealed that the fast activation localized the initiation site to the proximal axon even upon strong sy

266 We assign transcription initiation sites to 7691 protein-coding genes and find t

267 ependent on sequence context at the multiple initiation sites to condition specific binding of at lea

268 mbined product yield as measures of relative initiation site usage and productive ribosome recruitmen

269 dium resolution structure of the heterodimer initiation site using homology modeling coupled with str

270 sful bioinformatic prediction of alternative initiation sites utilized in protein translation.

271 The presence of upstream translation initiation sites (uTISs) at the mRNA 5' untranslated reg

272 e-specifically upstream of the transcription initiation site via a DNA-binding domain (DBD).

273 Additionally, the calcium signal initiation site was altered upon C-CGB expression in neu

274 agu gene regulation, the aguB transcription initiation site was identified by primer extension and a

275 ound 240 bases upstream from the translation initiation site was of functional significance and inclu

276 ranscription of the Mrp2 gene at the various initiation sites was tissue-specific, with the major ini

277 the ZV motif located near the transcription initiation site, was abundant in HeLa cells, while it wa

278 on immediately upstream of the transcription initiation site we identified two closely associated Sp1

279 When we examined alternative transcription initiation sites, we determined that another CpG site in

280 ractionation) of the atrial signal at the AF initiation site were rate-dependent (both p = NS).

281 en -70 and +27 relative to the transcription initiation site were sufficient to confer a high level o

282 In the jejunum, the primary and secondary initiation sites were -98 and -132 nucleotides, respecti

283 ranscription start sites and the translation initiation sites were governed by the gamma distribution

284 Transcription initiation sites were highly supported by conserved arra

285 The transcription initiation sites were mapped by primer extension.

286 associated with these additional translation initiation sites were short, raising questions regarding

287 Transcription initiation sites were similar in Ac and Ds derivatives,

288 lyst 1), dendritic polymers bearing multiple initiation sites were synthesized and used as macroiniti

289 replication forks and the average density of initiation sites, were conserved among the cells analyze

290 Activated Akt was enhanced at branch initiation sites where its negative regulator, PTEN, was

291 asts revealed a novel upstream transcription initiation site, which was also utilized during wild-typ

292 Usage of this non-canonical initiation site with its weak translation initiation eff

293 Additional putative translational initiation sites with AUG or alternative codons occurred

294 his technique has revealed novel translation initiation sites with unprecedented scope and has furthe

295 4 gene sequence, starting at the translation initiation site, with a lacZ reporter gene.

296 otein syntheses were initiated at these uAUG initiation sites, with the third uAUG initiating the hig

297 anisms controlling the choice of translation initiation site within the AtLIG1 ORF.

298 urprisingly, TL-seq identified transcription initiation sites within 6% of protein-coding regions, an

299 ereby creating a database of all replication initiation sites within nonrepetitive DNA in two human c

300 rom +3 and that the RdRp could access the +3 initiation site without prior initiation at +1.