ライフサイエンスコーパス: initiator caspase

1 proposed, which suggests caspase-2 to be an initiator caspase.

2 strating its capacity to affect a vertebrate initiator caspase.

3 polyubiquitination and aggregation of a key initiator caspase.

4 domains is required for their processing by initiator caspases.

5 tive suppression than inhibitors of upstream initiator caspases.

6 daptor protein bridging death receptors with initiator caspases.

7 ause it induces apoptosis independent of the initiator caspases.

8 le of selectively binding to large prodomain initiator caspases.

9 are sufficient to cleave and activate other initiator caspases.

10 activity that resides in the zymogens of the initiator caspases.

11 requires a novel pathway in addition to the initiator caspases.

12 be achieved through restricted activation of initiator caspases.

13 d by mature executioner caspases rather than initiator caspases.

14 sts diverse mechanisms for the activation of initiator caspases.

15 d near complete loss of the p10 subunit from initiator caspases 1 and 8 but not from the executioner

16 damaging agent camptothecin to activate the initiator caspase 2.

17 death was associated with activation of both initiator (caspases-2, -8 and -10) and effector (caspase

18 death is partly controlled by the apoptotic initiator caspase-2 (C2).

19 The apoptotic initiator caspase-2 has been implicated in oocyte death,

20 Here, we show that the initiator caspase-2 is required for robust death of ovar

21 ced apoptosis and affinity-labeled activated initiator caspase-2, -8, and -9.

22 a BH3-only protein that is processed by the initiator caspase-2.

23 These bile acids differentially activate initiator caspases-2 and -8 and induce cleavage of full-

24 duced c-Jun N-terminal kinase activation and initiator caspase 8 cleavage.

25 the effector caspases 3 and 7, although the initiator caspase 8 had been activated.

26 pase cascade, antagonizing the activation of initiator caspase 8.

27 eolytic cascade by recruiting and activating initiator caspases 8 and 10.

28 Activation of both initiator caspases 8 and 9 and effector caspase 3 was no

29 bisphosphate (PIP2) is a direct inhibitor of initiator caspases 8 and 9, and their common effector ca

30 (i) rapid formation of covalent complex with initiator caspases 8 or 1, (ii) very slow deacylation, a

31 y monitor executioner (caspase-3 and -7) and initiator (caspase-8 and -9) caspase activity.

32 erexpression of TIMP-3 induced activation of initiator caspase-8 and -9 and promoted caspase-mediated

33 gnals from death receptors to the downstream initiator caspase-8 and connects to the mitochondrial in

34 aspases and, surprisingly, activation of the initiator caspase-8 and processing of its substrate Bid.

35 ken together these data demonstrate that the initiator caspase-8 can directly activate pro-caspase-3

36 rigger apoptosis by recruiting the apoptosis initiator caspase-8 through the adaptor FADD.

37 lustering with subsequent recruitment of the initiator caspase-8, and ultimately cellular demise.

38 We show here that in a purified system, the initiator caspases-8 and -10 directly process the execut

39 only modulated by either VES or MSA included initiator caspases-8 and -10, as well as executioner cas

40 rinsic apoptotic pathways with activation of initiator caspases-8 and -9 and downstream effector casp

41 ation of the effector caspase-3 but also the initiators caspase-8 and caspase-9, mitochondrial cytoch

42 apoptosis is the activation of the apoptotic initiator caspase 9.

43 d (1.5- and 1.4-fold, respectively), whereas initiator caspase-9 and death caspase-3 transcripts were

44 mac antagonizes several IAPs and assists the initiator caspase-9 and effector caspases (caspase-3, ca

45 cytochrome c release; and (iv) activation of initiator caspase-9 and executioner caspase-3.

46 High glucose also induces loss of the initiator caspase-9 and increases caspase-3 cleavage, ef

47 sis largely through direct inhibition of the initiator caspase-9 and the effector caspase-3 and -7.

48 the executioner caspase-3 and the intrinsic initiator caspase-9 in primary cerebellar granule neuron

49 During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosom

50 Activation of the initiator caspase-9 is essential for induction of apopto

51 ed in recent years, the mechanism of how the initiator caspase-9 is regulated by IAPs remains enigmat

52 D specifically cleaved caspase-8 but not the initiator caspase-9 or -10 and significantly increased c

53 inhibiting the effectors caspase-3/-7 and an initiator caspase-9 through its BIR2 and BIR3 domains, r

54 are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and

55 data suggest that caspase-9 is the critical initiator caspase activated during heat-induced apoptosi

56 Caspase-2 is an initiator caspase activated in response to heat shock an

57 ctive caspase, we identified caspase-2 as an initiator caspase activated in rotenone-treated primary

58 Although widely regarded as an inhibitor of initiator caspase activation and cell death, c-FLIP(L) i

59 nducing signaling complex (DISC) to regulate initiator caspase activation and launch the apoptotic pr

60 evaluated and other possible mechanisms for initiator caspase activation are discussed.

61 at TNF death signals are blocked proximal to initiator caspase activation, at the level of TNF recept

62 ss, which could be explained by a failure of initiator caspase activation.

63 mitochondrial dysfunction, we determined the initiator caspase and its role in cell death in primary

64 Caspase-9 (casp-9) is an initiator caspase and plays a central role in activating

65 9 has the potential to inhibit both upstream initiator caspases and downstream effector caspases, we

66 ins assemble into the DISC to fully activate initiator caspases and execute cell death, and finally w

67 The activated form of caspase-8, an initiator caspase, and amyloid-beta, a product of APP pr

68 Caspase-9 is the initiator caspase, and its loss blocks effector caspase

69 reted to be proximity-driven dimerization of initiator caspases, and consequently their activation.

70 Initiator caspases are activated in response to death st

71 The molecular mechanisms by which initiator caspases are activated remain poorly understoo

72 According to dogma, initiator caspases are activated through proximity-induc

73 cytometry, and immunoblotting, we find that initiator caspases are active during the long and variab

74 It is widely believed that 'initiator' caspases are recruited to and activated withi

75 Caspase 8, the initiator caspase associated with Fas-mediated apoptosis

76 activated by the cleavage of caspase-8, the initiator caspase associated with the death receptor pat

77 Caspase-2 is considered an initiator caspase because its long prodomain contains a

78 and execution phases of cell death, with the initiator caspases being recruited to multicomponent sig

79 the decline in SK1 occurs downstream of the initiator caspase but upstream of the effector caspase.

80 mechanistic insights into the activation of initiator caspase by the apoptosome.

81 o that any free p20 formed by deacylation of initiator caspases cannot reassociate to active heterote

82 tor caspases (caspase 3, 6, 7, or 12) or the initiator caspases (caspase 8 or 9) could be detected in

83 de biochemical evidence that other apoptosis initiator caspases (caspase-2 and -10) as well as a proc

84 related activities of caspases, including an initiator caspase, caspase 8, and effector caspases, suc

85 he activity of the death receptor-associated initiator caspase, caspase 8, and is inhibited by the pe

86 Activity of the DR-associated initiator caspase, caspase 8, was also increased in the

87 ing to the recruitment and activation of the initiator caspase, caspase-9.

88 Therefore, like other initiator caspases, Caspase-1 activation by inflammasome

89 ved to have a low potency for inhibiting the initiator caspases, caspase-1 and caspase-8, and caspase

90 DP-ribose) polymerase, and activation of the initiator caspases, caspase-8 and -9, earlier in infecti

91 stern blots, indicated that each of the main initiator caspases, caspase-8, caspase-9, and caspase-12

92 ccompanied by activation of a combination of initiator caspases (caspases-2, -8, and -9) and executed

93 DR-proximal initiator caspases cleaved the clathrin adaptor subunit

94 provide evidence that ceramide generation is initiator caspase-dependent and occurs prior to commitme

95 Ceramide generation induced by FADD was initiator caspase-dependent, being blocked by crmA.

96 es DIAP2-dependent polyubiquitylation of the initiator caspase DREDD.

97 CRINKLED (CK) selectively interacts with the initiator caspase DRONC and regulates some of its non-ap

98 It was found that the initiator caspase Dronc and the proapoptotic gene head i

99 This set includes the Drosophila initiator caspase Dronc and, surprisingly, several metab

100 The initiator caspase Dronc does not cleave dSREBP, but anim

101 The initiator caspase Dronc is the only Drosophila caspase t

102 phila effector caspase DrICE or its upstream initiator caspase DRONC prevented FHV-induced apoptosis

103 wing that cellular NADPH levels modulate the initiator caspase Dronc through its phosphorylation at S

104 In living glands, activation of the initiator caspase dronc triggers cortical F-actin disman

105 This process is under control of the initiator caspase Dronc, but not effector caspases.

106 nfirming that P49 targeted DrICE and not the initiator caspase DRONC, depletion of DrICE by RNA silen

107 bitor p35 or a dominant-negative form of the initiator caspase Dronc, is sufficient to inhibit saliva

108 in Drosophila IAP1 (DIAP1) and displaces the initiator caspase DRONC.

109 of DNA-damage sensing but that requires the initiator caspase Dronc.

110 x, which culminates in the activation of the initiator caspase, either caspase-8 or caspase-10.

111 as distal to activation of several different initiator caspases, evidence for a further downstream pr

112 The autocatalytic activation of an initiator caspase, exemplified by caspase-9 in mammals o

113 ctivation is started by trans-cleavage by an initiator caspase followed by autocleavage of effector c

114 Caspase 8, the initiator caspase for death receptor-induced apoptosis,

115 Here, we show that the initiator caspase for the intrinsic pathway is activated

116 e a downstream caspase that depends on other initiator caspases for activation.

117 Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage

118 ap1 silencing was rescued by cosilencing the initiator caspase gene Aedronc, indicating that the mort

119 inally proposed to explain the activation of initiator caspases, has recently been reinterpreted to b

120 lly, b-VAD-fmk failed to label any activated initiator caspase in Apaf-1-deficient cells exposed to h

121 rthermore, we determined that caspase-10, an initiator caspase in death receptor signaling, is the mo

122 In response to TRAIL, caspase-8, an initiator caspase in death receptor-mediated apoptosis,

123 utocatalytic cleavage of Dronc, an important initiator caspase in Drosophila, results in a drastic en

124 ase inhibitor, we identified caspase-2 as an initiator caspase in EtOH-treated corneal fibroblasts.

125 previously unknown role for caspase-2 as an initiator caspase in lipoapoptosis and suggest that casp

126 We investigated whether the initiator caspase in the extrinsic pathway, caspase-8, o

127 and reduced activations of both effector and initiator caspases in high cell density, postconfluent C

128 n neuronal injury, direct evidence of active initiator caspases in stroke and the functional relevanc

129 evidence for the differential involvement of initiator caspases in the apoptotic volume decrease duri

130 Activation of initiator caspases in the dying cells stimulates the pro

131 To define the potential role of initiator caspases in vivo, we tested the effect of cell

132 ignificantly reduced the expression level of initiator caspases, increased the ratio of XIAP to Smac/

133 ion motif is required but not sufficient for initiator caspase inhibition by P49.

134 Caspase-8, an initiator caspase involved in lymphocyte apoptosis, is p

135 Activation of an initiator caspase is essential to the execution of apopt

136 This role in regulating initiator caspases is an entirely novel role for the PAK

137 Enzymatic activation of initiator caspases leads to proteolytic activation of do

138 Thus we demonstrate a direct role for initiator caspase-mediated proteolysis in promoting gene

139 In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and acti

140 etected in dying cells, and neither of these initiator caspases nor the endoplasmic reticulum stress-

141 so detected the activation of caspase 8, the initiator caspase of the death receptor pathway.

142 Caspase-8 is the initiator caspase of the extrinsic apoptosis pathway and

143 e examine the role of caspase-9 (Casp9), the initiator caspase of the intrinsic apoptotic cascade, in

144 quitous IAP, can inhibit both caspase-9, the initiator caspase of the mitochondrial apoptotic pathway

145 heat shock does not require any of the known initiator caspases or their activating complexes to prom

146 Binding of initiator caspase precursors to activator molecules appe

147 lammatory signaling is the activation of the initiator caspase, procaspase-1.

148 NOS) inhibitors regulate S-nitrosation of an initiator caspase, procaspase-9, in a human colon adenoc

149 eptors include the adaptor protein FADD, the initiator caspases procaspases-8 and -10 and the regulat

150 These data indicate that activated initiator caspases provide another effective target for

151 Procaspase-8, an initiator caspase recruited to death receptors, is activ

152 esults suggest that caspase-11 is a critical initiator caspase responsible for the activation of casp

153 Examination of initiator caspases revealed the cleavage of caspase 9 bu

154 uring apoptosis occurs in a cascade from the initiator caspase(s) (e.g. caspase-8) to the effector ca

155 other basal deuterostomes, signal-responsive initiator caspase subfamilies (caspases-8/10 and 9, whic

156 as caspase-7 via a linker_BIR2 fragment and initiator caspases such as caspase-9 via the BIR3 domain

157 Caspase-8 is an initiator caspase that becomes activated when Fas death

158 otif, P49 was impaired for inhibition of the initiator caspase that cleaves and activates pro-Sf-casp

159 el in vivo specificity for a P35-insensitive initiator caspase that functions at an evolutionarily co

160 apoptosis in invertebrates by inhibiting an initiator caspase that is P35 insensitive.

161 e consistent with the involvement of a novel initiator caspase that is resistant to P35, but directly

162 sulted in isolation of caspase-8 (Casp8), an initiator caspase that mediates death-receptor-induced a

163 These results indicate that levels of initiator caspases vary widely among different leukemia

164 No evidence of TcapQ647 cleavage by initiator caspases was observed.

165 To define the roles of specific initiator caspases, we utilized Jurkat cells genetically

166 e to TRAIL or TNF requires the activation of initiator caspases, which then activate the effector cas

167 nc mutation, indicating that dronc is a main initiator caspase, while strica plays a minor role that

168 roduced after adapter-mediated clustering of initiator caspase zymogens.