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1 ary chromosome replication requires the RctB initiator protein.
2 alone has all the activities expected of an initiator protein.
3 f organisms is multiple binding sites for an initiator protein.
4 , for binding a plasmid-specific replication initiator protein.
5 hich interacts specifically with a different initiator protein.
6 tor for inversion stimulation (Fis) and DnaA initiator protein.
7 ctivity consistent with the properties of an initiator protein.
8 the origin recognition complex, the putative initiator protein.
9 ion factors, including the Cdc18 replication initiator protein.
10 retained binding to the viral E1 replication initiator protein.
11 9 bp sequence that binds the P1-encoded RepA initiator protein.
12 adjacent to the binding site for the dimeric initiator protein.
13 wo residues in the helicase domain of the E1 initiator protein.
14 of the DNA molecule, allowing binding of the initiator protein.
15 g, while the repC gene encodes a replication initiator protein.
16 opic activity of the geminivirus replication initiator proteins.
17 helix topology with a unique structure among initiator proteins.
18 s common to rolling-circle replication (RCR) initiator proteins.
19 on in the theta mode and requires binding of initiator proteins.
20 nt in the helicase domain of all papovavirus initiator proteins.
21 eplication by limiting supply or activity of initiator proteins.
22 by limiting the synthesis or availability of initiator proteins.
23 low selectivity observed for DNA binding by initiator proteins.
24 a characteristic of other viral and cellular initiator proteins.
25 A unifying characteristic of DNA replication initiator proteins across the kingdoms of life is their
26 cognition complex (ORC) is a DNA replication initiator protein also known to be involved in diverse c
27 the origin recognition complex (ORC) is the initiator protein and replication protein A (RPA; ref.
31 the gamma origin for the plasmid-encoded pi initiator protein and three host-encoded proteins, DnaA,
32 action of structurally conserved ATP-binding initiator proteins and origin DNA to mediate assembly of
33 recise and reproducible interactions between initiator proteins and replication origins to assemble a
34 modest DNA-binding specificity exhibited by initiator proteins and the high specificity of initiatio
35 e-strand origin, the domain structure of the initiator proteins and the molecular basis for the funct
36 of the biochemical activities of the plasmid initiator proteins and their interaction with the double
37 origin recognition complex, the replication initiator protein, and one or more accessory sequences.
44 hat are required to recruit DNA polymerase - initiator proteins - are often used to regulate the timi
48 ding and hydrolysis in the papillomavirus E1 initiator protein based on the recent structural data.
49 t of replicative helicases via the action of initiator proteins belonging to the AAA+ superfamily of
54 ma of R6K, contains tandem iterons (iterated initiator protein binding sites), an AT-rich region that
56 antisense RNA that regulates the replication initiator protein by a translational attenuation mechani
60 Previous studies have demonstrated that the initiator proteins contain separate DNA binding and nick
61 n the surface of domain I of the replication initiator protein, corresponding to the binding site use
62 ne via a transesterification that leaves the initiator protein covalently bound on the 5'-end of the
63 hese results further link the actions of the initiator protein, Dbf4p, to the completion of mitosis a
64 eria must carefully regulate the activity of initiator protein DnaA and its interactions with the uni
65 gh regulation of the interaction between the initiator protein DnaA and specific DNA elements arrayed
66 F ori (oriV) and required both the bacterial initiator protein DnaA and the plasmid-encoded initiator
68 similar nucleoprotein complex comprising the initiator protein DnaA bound to three high-affinity reco
69 raction, two binding sites for the bacterial initiator protein DnaA, and a binding site for the DNA-b
80 structures independently of the replication initiator protein, DnaA, and thereby facilitates assembl
83 DNA replication requires the binding of the initiator protein, DnaA, to specific binding sites in th
85 ial chromosomes require only one replication initiator protein, e.g., DnaA, most plasmid replicons de
86 irus type 11 (HPV-11) origin recognition and initiator protein E1 and human polymerase alpha/primase
89 l transcription factor E2 recruits the viral initiator protein E1 to the origin of DNA replication (o
90 ght to determine whether the affinity of the initiator protein (EBNA1) for its binding sites in the o
93 The origin recognition complex (ORC) is an initiator protein for DNA replication, but also effects
94 isolated from Escherichia coli activates the initiator protein for replication in the purified system
97 ated in eukaryotic replicons is unknown, but initiator proteins from a handful of eukaryotic viruses
98 conserved among geminivirus AL1 proteins and initiator proteins from other rolling circle systems are
99 o function as origins of DNA replication, no initiator protein has yet been identified in the set of
101 cognition complex (ORC) is a DNA replication initiator protein in eukaryotes that defines the localiz
103 d to bind and modulate the viral replication-initiator protein in vitro and in Saccharomyces cerevisi
105 he superfamily of rolling-circle replication initiator proteins in general and the parvovirus replica
106 ructures may be applicable to the binding of initiator proteins in other single-stranded DNA priming
110 unctions characteristic of a DNA replication initiator protein, including origin-specific DNA binding
112 tead of a common surface of interaction with initiator proteins, interestingly, DnaB helicase appears
113 cognition of the replication origin (ori) by initiator protein is a recurring theme for the regulated
118 A unifying characteristic of DNA replication initiator proteins is their distinctive AAA+ nucleotide-
119 h cells show a specific defect in loading of initiator proteins Mcm4, Mcm7, and to a lesser degree, M
120 -positive bacteria requires the unwinding of initiator protein-nicked plasmid DNA by the PcrA helicas
121 replication in vitro, dependent on the viral initiator protein NS1, using plasmid forms of the 5' ori
128 -terminal domain IV of the host-encoded DnaA initiator protein of Escherichia coli interact physicall
129 monomeric and the dimeric forms of the RepE initiator protein of F factor together promote pairing o
131 ligation activities of RepC, the replication initiator protein of plasmid pT181, in plasmid sized and
132 monomeric biologically active form of the pi initiator protein of plasmid R6K as a complex with a sin
135 ing domain of SV40 T antigen (T-ag-obd), the initiator protein of the SV40 virus, and cognate and non
136 tructure of the catalytic domain of Rep, the initiator protein of tomato yellow leaf curl virus.
140 erichia coli that needs only one replication initiator protein (origin recognition protein) called Dn
141 as strictly dependent on the plasmid-encoded initiator protein pi and on the host-encoded initiator D
142 Individually, these sites do not bind to initiator protein pi but access it by DNA looping-mediat
143 t only near the primary binding sites of the initiator protein pi but also at a distance, caused by p
146 lements of the plasmid are a multifunctional initiator protein pi, and sequence-related DNA target si
151 orm of the Escherichia coli DnaA replication initiator protein remodels the chromosomal origin of rep
154 During replication of the plasmid pT181, the initiator protein RepC is modified by the addition of an
155 by controlling the synthesis of its dimeric initiator protein RepC/C and by inactivating the protein
159 ication of certain plasmids, acting with the initiator protein (RepD) that binds to and nicks the dou
161 pillomavirus E1 protein is a multifunctional initiator protein responsible for preparing the viral DN
163 ation via negative regulation of replication initiator proteins, such as CDC6, is key to maintenance
164 s 40 or bovine papilloma virus--in which the initiator protein, T antigen, or E1 protein alone, unwin
166 iochemical attributes of mutations in the pi initiator protein that caused loss of negative control o
167 a previously unrecognized candidate archaeal initiator protein that is distantly related to eukaryoti
168 Initiation of this replication occurs via an initiator protein that nicks one DNA strand at the doubl
170 adeno-associated virus (AAV) are replication initiator proteins that bind the viral replicative-form
171 poptotic members of the Bcl-2 family include initiator proteins that contain only BH3 domains and dow
172 s (BPV-1) and Simian virus 40 (SV40) are the initiator proteins that recognize and melt their respect
173 ed origins, which serve as binding sites for initiator proteins that recruit the replicative machiner
174 d because of the conserved structure of AAA+ initiator proteins these findings raise the possibility
175 This promptly recruits Sld3-Sld7 replication initiator proteins to pericentromeric replication origin
176 smid RK2 is dependent on the plasmid-encoded initiator protein, TrfA, and the RK2 origin of replicati
177 teraction of the herpes simplex virus type-1 initiator protein (UL9) with oriS, one of the viral orig
179 the 10 genes coding for Orc-Cdc6 replication initiator proteins were essential, while a third (orc7),
181 actors: a specific DNA sequence (origin), an initiator protein which binds to the origin, a helicase
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