ライフサイエンスコーパス: innate

1 ities and (2) a sense of number might not be innate.

2 Further understanding of innate allorecognition and its consequences would provid

3 play a pivotal role at the interface between innate and acquired immunities following their recruitme

4 cells by HDMs that ultimately mediates said innate and adaptive allergic responses is poorly underst

5 plus free OX or OX/IND-MSNP induce effective innate and adaptive anti-PDAC immunity when used in a va

6 control the differentiation and function of innate and adaptive cell types.

7 Innate and adaptive immune cells modulate heart failure

8 us agents involves a coordinated response of innate and adaptive immune cells working in concert, wit

9 odel revealed wide-ranging effects of AES on innate and adaptive immune compartments.

10 ial of combination therapies recruiting both innate and adaptive immune effectors to eradicate establ

11 nificantly expanded our understanding of the innate and adaptive immune mechanisms that protect again

12 rce antibacterial responses by reprogramming innate and adaptive immune mechanisms.

13 icacy; rather, this therapy recruits both an innate and adaptive immune response, as deficiencies in

14 istically, global knockout of PLD4 modulated innate and adaptive immune responses and attenuated the

15 In patients with CHB, both innate and adaptive immune responses are weak and thus r

16 al cells, IL-33 plays critical roles in both innate and adaptive immune responses in mucosal organs.

17 ism, HO-1 is also capable of modulating host innate and adaptive immune responses in response to seps

18 y significant changes to the microbiome, and innate and adaptive immune responses that are critical t

19 ered gut microbiota, leading to dysregulated innate and adaptive immune responses.

20 r that is also involved in the regulation of innate and adaptive immune responses.

21 ssion of genes associated with inflammatory, innate and adaptive immune responses.

22 The enteric microbiota and the innate and adaptive immune system represent prime candid

23 here we perform in-depth systems analysis of innate and adaptive immune system responses to implanted

24 ponents and metabolites interacting with the innate and adaptive immune system, which would set the b

25 Both innate and adaptive immunities are involved.

26 PDAC that the coordinated activation of both innate and adaptive immunity can effectively reduce the

27 y pathways of B cell activation, as it links innate and adaptive immunity, promoting potent B cell re

28 tor-modifying enzymes, and a wide variety of innate and adaptive immunity-related proteins.

29 n stimulates neuronal circuits that regulate innate and adaptive immunity.

30 ch hematopoietic cells initiate and maintain innate and adaptive immunity.

31 onal circuits operating reflexively regulate innate and adaptive immunity.

32 tions and genomic reprogramming underlie the innate and adaptive resistance of RISC cells, and both n

33 ) interneurons depends on the interaction of innate and experience-dependent factors.

34 PLZF directs the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 its

35 theory, suggesting that a sense of number is innate and non-symbolic numerosity is being processed in

36 components comprising the maternal brain are innate and sex specific.

37 the changes in expression of proinflammatory innate and T-cell-derived cytokines during ustekinumab t

38 n MDA5 deficiency is a novel inborn error of innate and/or intrinsic immunity that causes impaired (d

39 IS treatment alters innate antimicrobial defenses and disrupts the gut micro

40 e burst was augmented, suggesting that their innate antimicrobial functions were preserved.

41 est that viral glycoproteins induce a strong innate antiviral response through activating the ER stre

42 Human CD40L(+) ILC3s provide innate B-cell help and are involved in an innate immunor

43 ory detection to higher brain that influence innate behavior and are essential for learned responses

44 ive effects of miRNA regulation on a complex innate behavior in Drosophila and suggests that miRNAs m

45 While innate behaviors are conserved throughout the animal kin

46 understanding neuromodulation of Drosophila innate behaviors, with a special focus on feeding, court

47 rs not to assume that number sense is simply innate, but to put this hypothesis to the test and consi

48 anti-inflammatory cytokines, and evidence of innate cell activation that included neutrophil extracel

49 established, it is not fully understood how innate cells integrate qualitative pathogenic informatio

50 Although the fundamental principles of innate control of adaptive immunity are well established

51 Our results reveal that an innate cortical mechanism contributes to the emergence o

52 the known dependence of this response on the innate cytokine TSLP.

53 that the Western lifestyle and diet promote innate danger signals and immune responses through produ

54 piratory epithelium is crucial in the host's innate defence against primary alphaherpesvirus infectio

55 udomonas aeruginosa adhesion if it lacks the innate defense protein MyD88 (myeloid differentiation pr

56 -inducible immunity and comprises primordial innate defense.

57 e, with dependence on atypical intrinsic and innate defenses.

58 iatum and promote a shift from expression of innate defensive responses toward more adaptive behavior

59 Moreover, dissociating innate differences in cognitive function from cannabis-i

60 This study highlights the importance of innate effector cells in establishing a broad-spectrum a

61 actions for optimal protection; however, the innate effector cells responsible for mediating this pro

62 m by which antigen presentation controls the innate effector function of Th2 cells at the site of inf

63 New work on innate escape behavior shows that mice spontaneously for

64 Activation of TPNs influences innate feeding behavior, whereas inhibition has little e

65 The innate flexibility of a DNA sequence is quantified by th

66 Due to environmental insult or innate genetic deficiency, protein folding environments

67 adaptive immune responses can contribute to innate IEL activation during mucosal inflammation.

68 ammadelta T cells provide an early source of innate IL-17, which promotes antimicrobial peptide produ

69 This study establishes novel mechanisms of innate IL-17A/IL-22 production via PGE2 and regulation o

70 In this study, we asked whether combining innate immune activation in the brain with concurrent Ab

71 mechanism for TREX1-mediated suppression of innate immune activation through maintaining genome inte

72 ing axis, with broad implications in linking innate immune activation to mucosal wound repair.

73 tterns by host cells is an important step in innate immune activation.

74 their sputum cells that may reflect ongoing innate immune activation.

75 th eosinophil-deficient mice identified this innate immune cell as essential for endometrial repair d

76 4 T cell function but result from defects in innate immune cell recruitment and function.

77 TH 2 inflammation, we have demonstrated that innate immune cells (notably, airway macrophages) play e

78 ing of the inflammatory gene networks in the innate immune cells are poorly understood.

79 onses to pathogens by transducing signals in innate immune cells in response to microbial products.

80 n inflammatory responses and mobilization of innate immune cells into the tumors including neutrophil

81 ckpoint acting to potentiate the activity of innate immune cells towards cancer.

82 and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.

83 Here we review antitumor activities of innate immune cells, mechanisms of their synergy with ad

84 mammals, where it stimulates the activity of innate immune cells, mesenchymal and hematopoietic stem

85 are a family of proteins widely expressed on innate immune cells.

86 ly type I BL, stimulates strong responses of innate immune cells.

87 s to produce CXCL8, a prototypic cytokine of innate immune cells.

88 ced levels of pro-inflammatory cytokines and innate immune cells.

89 This innate immune checkpoint is composed of what has become

90 in vivo implicated macrophages as a critical innate immune contributor to IL-10-induced wound closure

91 thereby leading to evasion of this important innate immune defense mechanism.

92 monstrate its new role in producing AMPs for innate immune defense.

93 s lymphomas in individuals with acquired and innate immune disorders and is strongly associated with

94 Here we investigate auto-regulation of the innate immune effector protein kinase R, which phosphory

95 1 expression is required for the sterilizing innate immune effects of IFN-lambda by extending these f

96 Vaccinia virus (VACV) encodes an innate immune evasion protein, E3, which contains an N-t

97 HD domain-containing protein 1 (SAMHD1), an innate immune factor that suppresses HIV replication, wa

98 These studies reveal distinctive innate immune features that may underlie a unique virus-

99 onnection between neonicotinoid exposure and innate immune function in the bumblebee Bombus impatiens

100 virus construct reported that caused a muted innate immune gene expression profile and decreased immu

101 and postulates that CS therapy, by reducing innate immune mechanisms, may promote C. albicans coloni

102 esting that these MRs may correlate with the innate immune module identified by Breen et al.

103 irect inhibition of downstream components of innate immune pathways is particularly well documented b

104 mechanism through which MZB cells use their innate immune properties to limit an exaggerated adaptiv

105 egulated by the alpha4beta1 integrin and the innate immune receptor toll-like receptor 4.

106 Toll-like receptors (TLRs) are innate immune receptors for sensing microbial molecules

107 atory responses to GBS mediated through host innate immune receptors play a critical role in the dise

108 As these cells express many innate immune receptors with the potential to directly r

109 n nucleic acids is an important strategy for innate immune recognition of pathogens.

110 The extent of NK cell activity during the innate immune response affects downstream immune functio

111 role of IL-1 ligands in epidermal repair and innate immune response after damaging UVB exposure.

112 thesized that NSG mice, which have a reduced innate immune response and lack adaptive immunity, would

113 antibody producing cells, participate in the innate immune response by secreting inflammatory cytokin

114 itional evidence that the microglia-mediated innate immune response contributes directly to the devel

115 preciated role for miR-223 in regulating the innate immune response during intestinal inflammation.

116 on patterns, including a strong induction of innate immune response genes at early times post-exposur

117 Despite this, the mechanism of the innate immune response has been less well studied, altho

118 domain containing 4 (BRD4) in mediating this innate immune response in human small airway epithelial

119 Moreover, the outcome of innate immune response is also affected by the cross-tal

120 The innate immune response is regulated at various stages, f

121 ng of the role factors such as an overactive innate immune response play in the pathogenesis of this

122 9 and TLR3) leading to a type-I IFN mediated innate immune response that is modulated by IRF7 and IRF

123 Enhanced innate immune response to B. pertussis was characterized

124 well as broadening our understanding of the innate immune response to dengue virus infection.

125 The inducible innate immune response to infection requires a concerted

126 ns Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes, but mount

127 tial antibiotic-free strategy for tuning the innate immune response to treat methicillin-resistant S.

128 N activity is required for resistance to the innate immune response, and antiviral mechanisms affecti

129 d by TNFAIP3, TRAFD1 and PML are involved in innate immune response, suggesting that these MRs may co

130 ce of bacterial neutralization of the host's innate immune response, which permits uncontrolled growt

131 organelles of spirochetes, in stimulating an innate immune response.

132 6 d postsonication, as is consistent with an innate immune response.

133 on modulates miRNA expression to subvert any innate immune response.

134 ty in the induction of and resistance to the innate immune response.

135 y which P. aeruginosa ExoY inhibits the host innate immune response.

136 cross vessel walls is a critical step in the innate immune response.

137 gonists that prevent or disrupt an efficient innate immune response.

138 ncluding dopamine neuron differentiation and innate immune response.

139 d cytokine release, which mediate protective innate immune response.

140 nases that play critical roles in initiating innate immune responses against foreign pathogens and ot

141 This assigns platelets a central role in innate immune responses and identifies them as potential

142 y and suggest potential interactions between innate immune responses and STAT3-driven oncogenic pathw

143 Our aim was to define the nature of innate immune responses associated with 12-week mortalit

144 To examine the role of PRMT1 in innate immune responses in vivo, we created a cell type-

145 ermediates in murine macrophages, regulating innate immune responses through the initiation of a type

146 role for gestational maternal infection and innate immune responses to infection in the pathogenesis

147 ors is important not only for instigation of innate immune responses to invading pathogens but also f

148 molecular patterns and play crucial roles in innate immune responses to invading pathogens.

149 mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides.

150 Innate immune responses triggered by cGAMP contribute to

151 Despite these diminished innate immune responses, vDeltaK1L vaccination induced a

152 ntegral components of local inflammatory and innate immune responses.

153 the ability of H3N8 CIV NS1 to inhibit host innate immune responses.

154 triggering a signaling cascade that leads to innate immune responses.

155 Macrophages become activated initiating innate immune responses.

156 rity of EBOV infection is its suppression of innate immune responses.

157 impact that viral infection had on human FM innate immune responses.

158 ase and potentially suppresses host cellular innate immune responses.

159 ituents of pathogens and activate the host's innate immune responses.

160 O-methyl modifications in RNA stability and innate immune sensing, and functions of adenosine to ino

161 RAGE can also act as an innate immune sensor of microbial pathogen-associated mo

162 -like receptor 4 (TLR4) is a key mediator of innate immune signaling and has been implicated in alcoh

163 how intracellular bacterial pathogens target innate immune signaling, the unfolded protein response,

164 Our study highlights an important innate immune signalling pathway that functions in intes

165 with persistent egg allergy exhibit a unique innate immune signature, characterized by increased numb

166 (IFNs) are essential components of the host innate immune system and define first-line of defence ag

167 The plant innate immune system contains a limited NLR repertoire t

168 rent article, we tested whether the platelet innate immune system contributes to responses to oxPCCD3

169 ore complex microbial management role of the innate immune system for controlled accommodation of ben

170 The functional relevance of the innate immune system has not yet been dissected in P0106

171 The innate immune system has recently been shown to promote

172 creasing evidence implicating a role for the innate immune system in AD initiation and progression.

173 ureus survival and the ability to escape the innate immune system in blood.

174 ed upregulation of various components of the innate immune system in both diseases, including inflamm

175 of inflammatory signaling molecules and the innate immune system in directing brain masculinization,

176 NA) and complement are key components of the innate immune system involved in the opsonization, phago

177 The innate immune system is activated in a number of degener

178 Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation.

179 BACKGROUND & AIMS: The innate immune system responds not only to bacterial sign

180 mplex syndrome associated with a maladaptive innate immune system response that leads to deleterious

181 le (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in re

182 NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and

183 uced by pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic

184 R4) is a pattern recognition molecule of the innate immune system, and evidence suggests that it modu

185 ociated molecular pattern recognition by the innate immune system, and how this may influence adaptiv

186 es, especially their interplay with the host innate immune system, have not been well investigated.

187 process dictated by multiples cues from the innate immune system.

188 which are crucial viral sensors in the host innate immune system.

189 ke receptors (TLRs) are major players of the innate immune system.

190 es of the TA polymers that interact with the innate immune system.

191 ical entities caused by dysregulation in the innate immune system.

192 ently emerged as important regulators of the innate immune system.

193 associated with several abnormalities of the innate immune system.

194 Antimicrobial peptides are components of the innate immune systems in animals and plants as natural d

195 Taken together, PRELP enhances host innate immunity against M. catarrhalis through increasin

196 n and unique interaction patterns regulating innate immunity and viral infection.

197 el of persistent infection demonstrates that innate immunity can control both early and persistent vi

198 Plant innate immunity can effectively prevent the proliferatio

199 how that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-STING (cyclic

200 c antimicrobial peptides contributing to the innate immunity in plants.

201 Here, we used IAV to investigate how host innate immunity is activated.

202 responses, including the gene-silencing and innate immunity machineries.

203 analysis corroborated previous findings that innate immunity may be involved in the progression of PT

204 e MRs driving the disease progression in the innate immunity pathways.

205 ions in neurovascular regulation through the innate immunity receptor CD36 (cluster of differentiatio

206 IFN) lambda 3/4 (IFNL3/4) locus, influencing innate immunity regulation, has been associated with the

207 es, tilapia mince hydrolysate (TMH) enhanced innate immunity through induction of IL-1beta and COX-2

208 g UL46, out of the context of the infection, innate immunity to a DeltaICP0 virus was largely comprom

209 HBV uses multiple pathways to harness host innate immunity to enhance its replication.

210 This effect has been termed 'trained innate immunity', and is underwritten by stable epigenet

211 In innate immunity, the itchy E3 ubiquitin protein ligase (

212 for mTORC1 downstream of TBK1 in control of innate immunity, tumorigenesis, and disorders linked to

213 hile mature RRCs express genes implicated in innate immunity.

214 s in the transcriptional regulation of plant innate immunity.

215 e phagocyte respiratory burst is crucial for innate immunity.

216 ndent SA signaling, thereby subverting plant innate immunity.

217 ase SETDB1 as a novel, negative regulator of innate immunity.

218 surface that GAS employs to circumvent host innate immunity.

219 alpha and an important regulator of pain and innate immunity.

220 de innate B-cell help and are involved in an innate immunoregulatory mechanism through induction of i

221 This triggers production of innate inflammatory mediators that stimulate the product

222 t cellular glucose metabolism as well as the innate inflammatory response.

223 suggests that glycosylation of Env modulates innate/inflammatory responses elicited by cells of monoc

224 les, the results highlight critical roles of innate/inflammatory responses in SIVmac239 infection.

225 presence of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classi

226 on, HEV gt1 and gt3 infections do not elicit innate intrahepatic immune responses and remain highly s

227 (NK) cells have been defined by nonspecific innate killing of virus-infected and tumor cells.

228 w "B-1," has received renewed interest as an innate-like B cell population of fetal-derived hematopoi

229 riant NKT (iNKT) cells or a unique subset of innate-like CD1d-independent T cells.

230 s the differentiation of multiple innate and innate-like cell lineages, but how Zbtb16 itself is regu

231 strate that a population of Thy1.2(+) non-NK innate-like cells present in the liver expresses IFN-gam

232 resulting in an altered composition of this innate-like lymphocyte compartment.

233 iant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection,

234 gammadelta T cells are considered to be innate-like lymphocytes that respond rapidly to stress w

235 Collectively, these data reveal an innate-like mode of epitope recognition with potential i

236 ral Th17 and Th1 cells (nTh17 and nTh1) with innate-like phenotype have been identified in the thymus

237 nt T (MAIT) cells are a recently discovered, innate-like subset of T cells with cytotoxic function, t

238 ng of germinal center cells and serves as an innate link between viral infection and B cell immunity.

239 Here, we describe type 2 innate lymphocytes (ILC2s) as a novel cell type resident

240 promoted the development of tissue-resident innate lymphoid cell (ILC) subsets.

241 , recombinant HpARI abrogated IL-33, group 2 innate lymphoid cell (ILC2) and eosinophilic responses t

242 aluated whether AHR antagonism could promote innate lymphoid cell differentiation from hESCs.

243 L233 increased the proportion of ST2-bearing innate lymphoid cells (ILC2) in blood and kidneys, and a

244 Type 2 innate lymphoid cells (ILC2) share cytokine and transcri

245 6.C3(Cg)-Rorasg/sg mice deficient in group 2 innate lymphoid cells (ILC2), and C57BL/6 wild-type mice

246 ell established, the newly identified type 2 innate lymphoid cells (ILC2s) can also contribute to orc

247 Group 2 innate lymphoid cells (ILC2s) expand in the lungs of mic

248 Ts induced eosinophilia and expanded group 2 innate lymphoid cells (ILC2s) in aspirin-exacerbated res

249 murine models of allogeneic BMT, that type 2 innate lymphoid cells (ILC2s) in the lower GI tract are

250 Group 2 innate lymphoid cells (ILC2s) produce type 2 cytokines,

251 Type 2 innate lymphoid cells (ILC2s) resemble TH2 cells and pro

252 cytokine (IL-5, IL-13) production by type 2 innate lymphoid cells (ILC2s).

253 Innate lymphoid cells (ILCs) are rapidly-responding cell

254 In particular, the discovery of innate lymphoid cells (ILCs) has opened entirely new ave

255 Innate lymphoid cells (ILCs) have an important role in t

256 Innate lymphoid cells (ILCs) have been classified into "

257 Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell re

258 ng the GR is selectively deleted in NKp46(+) innate lymphoid cells (ILCs), we demonstrated a major ro

259 Type 2 innate lymphoid cells and basophils were scarce in BAL f

260 Finally, we provide evidence that group 2 innate lymphoid cells are a source of IL-13, which promo

261 l sources of alloantigens, the cross talk of innate lymphoid cells with damaged epithelia and with th

262 airway epithelial cells, macrophages, type 2 innate lymphoid cells, and TH2 cells along with increase

263 NK cell developmental intermediates, non-NK innate lymphoid cells, and the capacity for NK cells to

264 ng tissue injury in sepsis, activates type 2 innate lymphoid cells, which promote polarization of M2

265 rete components of commitment, resolving how innate lymphoid, myeloid, and dendritic, and B-cell fate

266 for proper development of adaptive, but not innate, lymphoid cells.

267 It exploits the change in innate milk properties, such as electrical conductivity

268 nt of the approximations, discerning between innate, model-free, heuristic, and model-based controlle

269 LysM-PTP1B(-/-) mice lacking PTP1B in the innate myeloid cell lineage displayed a dysregulation of

270 nes (Rag2(-/-)gammac(-/-)), indicating their innate nature and their gammac cytokine independence.

271 roglia are essential for CNS homeostasis and innate neuroimmune function, and play important roles in

272 immunotherapies include activation of either innate or adaptive immune responses.

273 While an innate program of myelin development proceeds independen

274 Thus, unlike other POPs thought to diminish innate protection, POP2 reduces detrimental inflammation

275 However, the contribution of innate receptor engagement on epithelial or dendritic ce

276 tion, approximately half of patients exhibit innate resistance and suffer from disease progression.

277 es are fully supportive of FeLV replication, innate resistance of blood cells could be critical in pr

278 APOL1 is a trypanolytic protein that confers innate resistance to most African trypanosomes, but not

279 Vocalization in young mice is an innate response to isolation or mechanical stimulation.

280 A549 cells, a human cell line with a robust innate response, were infected with the Makona variant o

281 atory and inhibitory engrams, the release of innate responses and recall of associative memories can

282 dies provide insights into the complexity of innate responses and regional differences in the epithel

283 m, as critical cellular components governing innate responses to non-self RNA species.

284 This work suggests that sex-specific skin innate responsiveness to Hla and neutrophil bactericidal

285 r activation, HIV coreceptor expression, and innate restriction factor expression.

286 ssessment, based on the observation that the innate restriction factor MxA represents an effective sp

287 Innate sensing of influenza virus infection induces acti

288 MCs) and dendritic cells (DCs) are essential innate sentinels populating host-environment interfaces.

289 nt macrophages and the localized delivery of innate signals to antigen-experienced B cells.

290 within the mouse hypothalamus, that underlie innate social behaviours, are shaped by social experienc

291 around the proline catalyst can override its innate stereochemical preference to dictate the preferre

292 fic or activated T cells whereas exposure to innate stimuli such as Toll-like receptor ligands was no

293 stem occur in B cells, T cells, cells of the innate system, as well as hematopoietic stem and progeni

294 ls and propose that sulfatide recognition by innate T cells may be an important pathologic feature of

295 osal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitam

296 c microenvironment via type 2 cytokines from innate T cells.

297 ller T (iNKT) cells, a specialized subset of innate T lymphocytes.

298 from the immune microenvironment to promote innate type 2 immunity, and also to integrate systemic m

299 e the idea that preferences are driven by an innate, universal, and stable sense of number or value.

300 impact of coinfection with T. gondii on the innate virus-directed responses of human pDCs.