ライフサイエンスコーパス: innate immune response

1 gonists that prevent or disrupt an efficient innate immune response.

2 ation of autophagy mechanisms as part of the innate immune response.

3 stance to CAMPs and prevent clearance by the innate immune response.

4 ncluding dopamine neuron differentiation and innate immune response.

5 hypothesized that miR-718 helps regulate the innate immune response.

6 line with our inspiration from the mammalian innate immune response.

7 d cytokine release, which mediate protective innate immune response.

8 (RORgammat) and a nicotinic proinflammatory innate immune response.

9 ted pathogen clearance and resolution of the innate immune response.

10 nserved basal defense mechanism in the plant innate immune response.

11 at CoV ExoN also functions to antagonize the innate immune response.

12 organelles of spirochetes, in stimulating an innate immune response.

13 cell-signalling to initiate the cellular and innate immune response.

14 tion in T lymphocytes but fails to induce an innate immune response.

15 N activity is required for resistance to the innate immune response.

16 cell nucleus into the cytosol, engaging this innate immune response.

17 tate RNA replication and antagonize the host innate immune response.

18 ction, suggesting that an HSD potentiates an innate immune response.

19 intracellular components that can trigger an innate immune response.

20 s for three OAS enzymes (OAS1-3) involved in innate immune response.

21 bute to the inhibition of activation of this innate immune response.

22 s substantial resources to avoiding the host innate immune response.

23 6 d postsonication, as is consistent with an innate immune response.

24 on that prevents the damaging effects of the innate immune response.

25 first organ with full capacities to mount an innate immune response.

26 ar mechanism controlling NF-kappaB-dependent innate immune response.

27 the host organism, and evasion of the host's innate immune response.

28 tability is central to mounting an effective innate immune response.

29 s imply that tumor growth elicits a specific innate immune response.

30 on modulates miRNA expression to subvert any innate immune response.

31 ammatory challenge and is a component of the innate immune response.

32 ty in the induction of and resistance to the innate immune response.

33 y which P. aeruginosa ExoY inhibits the host innate immune response.

34 e of defense against viral infections is the innate immune response.

35 d spread efficiently in the face of a potent innate immune response.

36 m of intracellular bacteria to modulate host innate immune response.

37 NA accumulates in the cytosol, initiating an innate immune response.

38 lators and effectors of inflammation and the innate immune response.

39 cross vessel walls is a critical step in the innate immune response.

40 lence factor essential for counteracting the innate immune response.

41 novel mechanism by which WNV evades the host innate immune response.

42 protein chaperone, and an antagonist of the innate immune response.

43 inoculation, consistent with differences in innate immune responses.

44 olysis, an important determinant of effector innate immune responses.

45 ntegral components of local inflammatory and innate immune responses.

46 ion expansion and provide camouflage against innate immune responses.

47 ew, we discuss the benefits of each of these innate immune responses.

48 initiating behavioral adaptations along with innate immune responses.

49 in these two age groups, particularly in the innate immune responses.

50 of programmed cell death and their impact on innate immune responses.

51 and quantitative defects in the adaptive and innate immune responses.

52 tion and tissue effects are abrogated by RLH innate immune responses.

53 the ability of H3N8 CIV NS1 to inhibit host innate immune responses.

54 in fundamental biological processes, such as innate immune responses.

55 e transcription role for Pol in evading host innate immune responses.

56 can be subverted by viral proteins to evade innate immune responses.

57 of PRR signaling and activation of antiviral innate immune responses.

58 triggering a signaling cascade that leads to innate immune responses.

59 immune detection and to suppress the host's innate immune responses.

60 Macrophages become activated initiating innate immune responses.

61 and has been proposed to act as a trigger of innate immune responses.

62 mitochondrial signaling adaptor in mediating innate immune responses.

63 t the level of transcriptional regulation of innate immune responses.

64 in mice and studied CPS I in the context of innate immune responses.

65 rity of EBOV infection is its suppression of innate immune responses.

66 impact that viral infection had on human FM innate immune responses.

67 ase and potentially suppresses host cellular innate immune responses.

68 ortant small molecules that trigger powerful innate immune responses.

69 is removed from membranes to avoid sustained innate immune responses.

70 AS) is a cytosolic DNA sensor that activates innate immune responses.

71 IFN and inflammatory gene expression during innate immune responses.

72 ituents of pathogens and activate the host's innate immune responses.

73 t temporal desynchrony of food intake alters innate immune responses.

74 al interferon-inhibiting domains in the host innate immune responses.

75 The extent of NK cell activity during the innate immune response affects downstream immune functio

76 role of IL-1 ligands in epidermal repair and innate immune response after damaging UVB exposure.

77 n the cytoplasm, triggering a STING-mediated innate immune response after replication stress and DNA

78 This mutation led to increased innate immune responses after viral infection, augmented

79 ity factor 30 (CPSF30), leading to increased innate immune responses after viral infection.

80 xpressed by myeloid cells contributes to the innate immune response against Leishmania major parasite

81 ry cytokines that are essential for a potent innate immune response against pathogens.

82 e immune-suppressive properties and suppress innate immune responses against B. pertussis infection.

83 ial wounds in the colon and impaired mucosal innate immune responses against C. rodentium infection,

84 nases that play critical roles in initiating innate immune responses against foreign pathogens and ot

85 myelopoiesis under steady state and dampened innate immune responses against Listeria monocytogenes i

86 Plants have complex and adaptive innate immune responses against pathogen infections.

87 of IKKepsilon to propel type I IFN-mediated innate immune responses against viral infection.

88 is the main viral protein counteracting host innate immune responses, allowing the virus to efficient

89 at EVs from P. brasiliensis can modulate the innate immune response and affect the relationship betwe

90 Lipopeptides promote innate immune response and are related to disease pathol

91 o the caudate-putamen (CP) and scored for an innate immune response and inhibition of virus spread.

92 in early infection as it does not induce the innate immune response and is known to be the cause of s

93 thesized that NSG mice, which have a reduced innate immune response and lack adaptive immunity, would

94 n lung, and the relative contribution of the innate immune response and NiV to acute lung injury (ALI

95 CFAs, effector memory T cells, and the acute innate immune response and no effect on other markers of

96 the interplay between the virus and the host innate immune response and provides an important data se

97 CD71(+) cell ablation unleashed innate immune response and restored resistance to B. per

98 RNA virus infection consists of an intrinsic innate immune response and the induction of apoptosis as

99 nts such as cell cycle control, development, innate immune response and the occurrence of genetic dis

100 have identified important roles for IL-6 in innate immune responses and adaptive immunity.

101 host reactive oxygen species suppressed rice innate immune responses and allowed the Deltanmo2 mutant

102 ic complexes with host proteins that repress innate immune responses and force host cells into S-phas

103 the ability of H3N8 CIV NS1 to inhibit host innate immune responses and gene expression.

104 This assigns platelets a central role in innate immune responses and identifies them as potential

105 ription factors that play a critical role in innate immune responses and inflammation, yet the molecu

106 me adaptor protein, ASC, contributes to both innate immune responses and inflammatory diseases via se

107 used by some IAV strains to escape the host innate immune responses and modulate virus pathogenicity

108 y and suggest potential interactions between innate immune responses and STAT3-driven oncogenic pathw

109 usly that PRMT1 is an important regulator of innate immune responses and that it is required for M2 m

110 clude that RSV induced strong and persistent innate immune responses and that RSV severity may be rel

111 l viruses and the effect of the mutations in innate immune responses and virus pathogenesis.

112 l viruses and the effect of the mutations on innate immune responses and virus pathogenesis.

113 This was associated with the activation of innate immune responses and with the up-regulation of se

114 y new mutations in the NS1 protein affecting innate immune responses and, as a consequence, the patho

115 N activity is required for resistance to the innate immune response, and antiviral mechanisms affecti

116 cell proliferation, cytokine production, the innate immune response, and apoptosis.

117 l factor responsible for the control of host innate immune responses, and changes in NS1 can play an

118 ses both basal and hypersensitive cell death innate immune responses, and immunosuppression requires

119 hanisms regarding cockroach allergen-induced innate immune responses, and the genetic basis for cockr

120 ompromised barrier likely leads to increased innate immune responses, antigen-presenting cell stimula

121 Innate immune responses are critical in stroke pathophys

122 Innate immune responses are crucial for host resistance

123 Mast cells, central to the innate immune response, are one of the earliest sensors

124 r understand how to stimulate and/or enhance innate immune responses as a therapeutic modality to tre

125 s the stabilities of these key activators of innate immune responses, as shown directly for IRF3.

126 ood to phenotype and quantify the functional innate immune response associated with clinical phenotyp

127 Our aim was to define the nature of innate immune responses associated with 12-week mortalit

128 more potent than DV230 for the induction of innate immune responses at the injection site and draini

129 Inflammation is a crucial part of innate immune responses but, if imbalanced, can lead to

130 The function of the innate immune response by CD14 is crucial during biliary

131 antibody producing cells, participate in the innate immune response by secreting inflammatory cytokin

132 ic pathogen Porphyromonas gingivalis dampens innate immune responses by disruption of kinase signalin

133 Inflammasomes regulate innate immune responses by facilitating maturation of in

134 cGAMP enhances innate immune responses by inducing production of cytoki

135 , have developed a mechanism to subvert host innate immune responses by simultaneously targeting key

136 ll-like receptor 2 (TLR2)- and TLR4-mediated innate immune responses by targeted degradation of the T

137 e developed novel mechanisms to subvert host innate immune responses by targeting key factors in the

138 Inappropriate activation of the innate immune response can engender pathological inflamm

139 s show that noninvasive molecular imaging of innate immune responses can serve as an imaging biomarke

140 s the host epithelium while evading the host innate immune response, causing little if any inflammati

141 itional evidence that the microglia-mediated innate immune response contributes directly to the devel

142 T cells, and that the induction of a robust innate immune response correlates with cessation of viru

143 emory CD8(+) T cells in the orchestration of innate immune responses critical to host defense upon mi

144 ated molecular patterns and trigger first an innate immune response, dominated by monocyte-macrophage

145 sis but also acts as a critical regulator in innate immune responses due to its antiviral activity an

146 ces a timely and efficient activation of the innate immune response during acute infection.

147 preciated role for miR-223 in regulating the innate immune response during intestinal inflammation.

148 -intrinsic manner and modulates adaptive and innate immune responses during sepsis.

149 somes that could be important players in the innate immune response following certain infections of t

150 pe I IFN and uninfected microglia induced an innate immune response following virus injection.

151 in inflammation and early activation of host innate immune responses following virus infection.

152 ism that was used by HCV to disrupt the host innate immune responses for viral replication and persis

153 But differences in the neonatal innate immune response, for example, to Toll-like recept

154 on patterns, including a strong induction of innate immune response genes at early times post-exposur

155 Despite this, the mechanism of the innate immune response has been less well studied, altho

156 Most global analyses of the innate immune response have focused on transcription ind

157 domain containing 4 (BRD4) in mediating this innate immune response in human small airway epithelial

158 additional mechanism for alterations to the innate immune response in individuals with CD.

159 muscle catabolism as well as stimulating an innate immune response in mice bearing Lewis lung carcin

160 observed (ie, elevated neutrophil-dominated innate immune response in Peyer's patches, limited dendr

161 critically review the significance of human innate immune response in preventing oral candidiasis.

162 VP35 and VP24 IID were found to suppress the innate immune response in rousette cells, but only VP35

163 viruses, particularly MARV, induced a potent innate immune response in rousette cells, which was gene

164 Timothy Billiar summarizes the role of the innate immune response in the clinical course following

165 ration and disease progression driven by the innate immune response in the CNS.

166 tion 7 dpi coincides with a robust antiviral innate immune response in the ganglia.

167 These results support involvement of innate immune response in the pathogenesis of AgP.

168 gest that LJ001-inactivated IHNV elicited an innate immune response in the rainbow trout host, making

169 We studied innate immune responses in Cmah(-/-) mice, emulating hum

170 hile supporting differentiation and limiting innate immune responses in human keratinocytes.

171 Yop effectors inhibit innate immune responses in infected macrophages to promo

172 ed at elucidating the mechanisms of improved innate immune responses in mTBI mice.

173 the sensory neurons ASH and ASI to suppress innate immune responses in non-neural tissues against Ps

174 mplies that HBV replication may trigger host innate immune responses in the absence of HBsAg.

175 -receptor for Toll-like receptors to mediate innate immune responses in the adult brain, but developm

176 addition, arthritis, once induced, triggers innate immune responses in the brain, leading to resolut

177 To examine the role of PRMT1 in innate immune responses in vivo, we created a cell type-

178 irus infection induced strong and persistent innate immune responses including interferon signaling a

179 eutrophils without affecting other important innate immune responses, including phagocytosis and neut

180 after immunization and are critical for the innate immune responses, including rapid IL-18 productio

181 eptide (MDP), triggers a distinct network of innate immune responses, including the production of int

182 s a ubiquitin-binding protein that regulates innate immune responses, including Toll-like receptor si

183 y of the two NS1 proteins to counteract host innate immune responses, indicating that another factor

184 ersinia pestis, is favored by a robust early innate immune response initiated by IL-1beta and IL-18.

185 These enzymes regulate the innate immune response, intracellular trafficking, autop

186 Innate immune responses involving KC represent the first

187 The innate immune response is a central element of the initi

188 Moreover, the outcome of innate immune response is also affected by the cross-tal

189 The innate immune response is known to be critical for prote

190 The innate immune response is regulated at various stages, f

191 and permeability, its functional role in the innate immune response is still poorly understood.

192 Coordinated regulation of innate immune responses is necessary in all metazoans.

193 LTB4, a product of the innate immune response, is a constituent of the eicosano

194 These viral products could then elicit an innate immune response, leading to activation of the Tol

195 the mechanisms by which hemocyanins trigger innate immune responses, leading to beneficial adaptive

196 s have addressed the role of NOD proteins in innate immune responses, little attention has been given

197 e, together suggesting that the local airway innate immune response may be relatively preserved from

198 The host innate immune response mediated by type I interferon (IF

199 products in clinical usage, contain residual innate immune response modulating impurities (IIRMIs) ca

200 ultifunctional protein that counteracts host innate immune responses, modulating virus pathogenesis.

201 oxicity in infected cells and activated host innate immune responses more robustly.

202 ctors, elevation of cytokines as part of the innate immune response, myelin clearance by activation o

203 Following spinal cord injury (SCI), the innate immune response of microglia and infiltrating mac

204 n of BTV (NS4) is critical to counteract the innate immune response of the host.

205 However, the role of astrocytes in innate immune responses of the BBB during viral infectio

206 roblasts, acting as a feedback suppressor of innate immune responses otherwise triggered by self-RNAs

207 lthough abnormal mitochondria metabolism and innate immune responses participate in the pathogenesis

208 ged that foreign DNA potently stimulates the innate immune response, particularly type 1 interferon (

209 ated the presence of previously unrecognized innate immune response pathways in addition to the TLR9

210 nent microglial reactivity and activation of innate immune response pathways, commonly referred to as

211 ng of the role factors such as an overactive innate immune response play in the pathogenesis of this

212 to bronchopulmonary dysplasia, modulates the innate immune response, producing an exaggerated proinfl

213 irect induced toxicity as a component of the innate immune response, reactive oxygen species (ROS) ca

214 ings demonstrate that subversion of the host innate immune response requires ExoS-mediated ADP-ribosy

215 We identified a novel role for RAD51 in innate immune response signaling.

216 d by TNFAIP3, TRAFD1 and PML are involved in innate immune response, suggesting that these MRs may co

217 parasite population by a potent multifaceted innate immune response that engages resident and homing

218 9 and TLR3) leading to a type-I IFN mediated innate immune response that is modulated by IRF7 and IRF

219 at autophagy-deficient flies have a systemic innate immune response that promotes a hyperplasia pheno

220 Plants resist infection and herbivory with innate immune responses that are often associated with r

221 vivo synthesis of c-di-GMP stimulates strong innate immune responses that correlate with enhanced ada

222 res have multifaceted effects on homeostatic innate immune responses that have critical impact on the

223 s are known to be fundamental in controlling innate immune responses, their role in regulating adapti

224 PV also induced differential patterns of the innate immune responses, thereby possibly shaping the sp

225 es (MKP)-1 acts as an important regulator of innate immune response through a mechanism of control an

226 These "non-metastatic" exosomes stimulate an innate immune response through the expansion of Ly6C(low

227 found that HCV infection suppressed the host innate immune response through the induction of autophag

228 te IL-33, an IL-1 family member that induces innate immune responses through ST2 signaling.

229 ermediates in murine macrophages, regulating innate immune responses through the initiation of a type

230 gene duplex results in a defective perinatal innate immune response, tissue damage, and progressive d

231 sted the ability of the brain to initiate an innate immune response to a virus, which was directly in

232 ) cells into adult recipients impaired their innate immune response to B. pertussis infection.

233 Enhanced innate immune response to B. pertussis was characterized

234 earance in the lung or on the intrapulmonary innate immune response to bacteria or lipopolysaccharide

235 vide a novel platform for studying the human innate immune response to C. burnetii.

236 well as broadening our understanding of the innate immune response to dengue virus infection.

237 on specific cell surfaces, thus allowing the innate immune response to discriminate between self and

238 the human population points to both forms of innate immune response to EBV having benefit for human s

239 study is a comparative analysis of the host innate immune response to either MARV or EBOV infection

240 6 are required for the full activation of an innate immune response to exogenous DNA and DNA viruses.

241 immune antagonists that counteract the host innate immune response to facilitate efficient viral rep

242 omplement system is an important part of the innate immune response to infection but may also cause s

243 The inducible innate immune response to infection requires a concerted

244 membrane-associated syndecan-1 regulates the innate immune response to influenza infection by facilit

245 ity in diabetic mice results from a delay in innate immune response to inhaled Mycobacterium tubercul

246 l effects of IFN-alpha/beta signaling on the innate immune response to L. monocytogenes may be an art

247 stimulation, in conscious rats, controls the innate immune response to lipopolysaccharide attenuating

248 ecules and thus plays a critical role in the innate immune response to malignant transformation.

249 eprosy and implicate mucosal factors and the innate immune response to microbial exposure in Behcet's

250 ction of IL-1beta, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis.

251 P functions as a checkpoint regulator of the innate immune response to pathogen challenge.

252 ns Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes, but mount

253 The role of CD47-SIRPalpha in the innate immune response to Plasmodium falciparum infectio

254 uggest that inflammation be redefined as the innate immune response to potentially harmful stimuli su

255 terized the cat flea (Ctenocephalides felis) innate immune response to R. typhi Initially, we determi

256 d MDA5, is critical to the initiation of the innate immune response to RNA virus infection.

257 ly-recruited monocytes to regulate a maximal innate immune response to Salmonella infection, allowing

258 ional changes in salamander cells suggest an innate immune response to the alga, with potential atten

259 strong host immune response triggered by the innate immune response to the bite to promote disseminat

260 lectin complement pathway and directing the innate immune response to the distressed renal tubule.

261 and molecular mechanisms that coordinate the innate immune response to tissue damage and cell death i

262 tial antibiotic-free strategy for tuning the innate immune response to treat methicillin-resistant S.

263 ritical for normal effector function and the innate immune response to tumors and pathogens.

264 ocalization of host proteins involved in the innate immune response to viral infection.

265 ion-associated protein 5 (MDA5) mediates the innate immune response to viral infection.

266 ng, which is a central component of the host innate immune response to viral infection.

267 PLSCR1 as a potent target through which the innate immune response to viral vectors, and potentially

268 SGs are emerging as a component of the innate immune response to virus infection, and modulatio

269 yet poorly understood, players in the host's innate immune response to virus infection.

270 Our work highlights the importance of innate immune responses to control M. ulcerans infection

271 Our study was aimed at characterization of innate immune responses to filoviruses and the role of f

272 role for gestational maternal infection and innate immune responses to infection in the pathogenesis

273 ors is important not only for instigation of innate immune responses to invading pathogens but also f

274 molecular patterns and play crucial roles in innate immune responses to invading pathogens.

275 To investigate the protective mechanisms of innate immune responses to KyA, KyA-immunized mice were

276 th acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and

277 crophages (M2) have an important function in innate immune responses to parasitic helminths, and emer

278 he airways leads to persistent activation of innate immune responses to resident lung microbiota, dri

279 noparticles enables noninvasive detection of innate immune responses to stem cell transplants with ma

280 ferumoxytol enables noninvasive detection of innate immune responses to stem cell transplants with MR

281 stromal reaction, it concomitantly activates innate immune responses to tumor expansion.

282 mucosa as a consequence of both adaptive and innate immune responses to undigested gliadin peptides.

283 s, including the regulation of apoptosis and innate immune responses to viral infection, have been pr

284 reveals a previously undefined link between innate immune responses to virus infection and acute liv

285 Innate immune responses triggered by cGAMP contribute to

286 th of the DeltaICP0 virus failed to activate innate immune responses upon treatment with 2'3'-cyclic

287 Despite these diminished innate immune responses, vDeltaK1L vaccination induced a

288 s, which elicit a broad range of PMo-reliant innate immune responses via trigger(s) of immune surveil

289 that T2S acts to dampen the triggering of an innate immune response, we observed that the mitogen-act

290 ls is suggested to be associated with strong innate immune responses, we verified whether TIZ and RM-

291 After 24 h, innate immune responses were assessed by RT-qPCR and IFN

292 Innate immune responses were restored in these cells by

293 liver on day 8 after viral challenge, while innate immune responses were waning.

294 interleukin-6 (IL-6), suggesting an enhanced innate immune response, whereas animals infected with P.

295 gated whether HRV infection of MCs generated innate immune responses which were protective against in

296 infection is detected and restrained by the innate immune response, which is followed by a strong an

297 ce of bacterial neutralization of the host's innate immune response, which permits uncontrolled growt

298 Membrane lipids affect the innate immune response, which requires domains that infl

299 and NK T cells, which partially enhances the innate immune response, while the later treatment suppre

300 ed by pathogens and processes that stimulate innate immune responses within the cochlea.