ライフサイエンスコーパス: innate immune system

1 associated with several abnormalities of the innate immune system.

2 ptors (TLR), which are key regulators of the innate immune system.

3 sed ragweed pollen (Ambrosia elatior) on the innate immune system.

4 which are crucial viral sensors in the host innate immune system.

5 is the interface between the fungus and the innate immune system.

6 Neutrophils are key effector cells of the innate immune system.

7 ul control of pathogenic viruses by the host innate immune system.

8 ltaT17) cells are critical components of the innate immune system.

9 ke receptors (TLRs) are major players of the innate immune system.

10 lecular patterns by sensory molecules of the innate immune system.

11 about whether and how it alters the brain's innate immune system.

12 s pathways are rapidly activated by the host innate immune system.

13 and due rather to an early activation of the innate immune system.

14 ch are potently chemotactic for cells of the innate immune system.

15 protect against AD by modulating the brain's innate immune system.

16 oss-seeding and also primes responses of the innate immune system.

17 cess was accompanied by an activation of the innate immune system.

18 riers, including low pH, bile acids, and the innate immune system.

19 associated molecular patterns (PAMPs) by the innate immune system.

20 e pathogens are able to evade or disable the innate immune system.

21 es of the TA polymers that interact with the innate immune system.

22 ytes are heterogeneous effector cells of the innate immune system.

23 due to its antagonistic activity against the innate immune system.

24 ical entities caused by dysregulation in the innate immune system.

25 ted in enhanced bacterial elimination by the innate immune system.

26 ial peptide and effector protein in the host innate immune system.

27 y T cells and a variety of cell types of the innate immune system.

28 LF5 levels drive metastasis by co-opting the innate immune system.

29 echanisms for signaling platform assembly in innate immune system.

30 phosphorylation protein, to subvert the host innate immune system.

31 ms of sensing the hyperosmotic stress by the innate immune system.

32 eutrophils are the main defense cells of the innate immune system.

33 mic dsRNA sensors belonging to the antiviral innate immune system.

34 ed here function as potent activators of the innate immune system.

35 on of their plasma membrane triggered by the innate immune system.

36 an essential defense mechanism of the human innate immune system.

37 ors (TLRs) is critical for activation of the innate immune system.

38 raction between cells of the cochlea and the innate immune system.

39 is not known but may involve a role for the innate immune system.

40 rent strategies to inhibit or avoid the host innate immune system.

41 ential bactericidal effector molecule of the innate immune system.

42 es the human immune system, particularly the innate immune system.

43 lting from the unregulated activation of the innate immune system.

44 sequenced belonged to the IgM isotype of the innate immune system.

45 ently emerged as important regulators of the innate immune system.

46 and inflammation-generating component of the innate immune system.

47 IL-1beta release is integral to the innate immune system.

48 process dictated by multiples cues from the innate immune system.

49 ovars, and several inhibit activation of the innate immune system.

50 ions for the therapeutic manipulation of the innate immune system.

51 entify a critical role for LPA in regulating innate immune system.

52 the inflammatory response of the peripheral innate immune system.

53 system, Inulin Acetate (InAc), activates the innate immune system.

54 e complement alternative pathway (AP) of the innate immune system.

55 pressing the cross talk between adaptive and innate immune systems.

56 on proteins that manipulate the adaptive and innate immune systems.

57 hat are tailored for co-option by eukaryotic innate immune systems.

58 of mPGES-1-dependent PGE2 may be crucial for innate immune system activation during various IL-33 dri

59 These data underscore the importance of innate immune system activation in the pathogenesis of p

60 Innate immune system activation via Toll-like receptor 4

61 e observed in Fat-1 mice modulated the brain innate immune system activity, leading to the protection

62 nstrated profound activation of cells of the innate immune system after food challenge, including mon

63 hylation as an identifier of self RNA in the innate immune system against foreign RNA has become clea

64 ce to antimicrobial peptides, weapons of the innate immune system against infections.

65 ne systems, revealed the significance of the innate immune system along with the complement protein C

66 Innate immune system alterations, including dendritic ce

67 t as vaccine adjuvants via activation of the innate immune system, although in many cases it is uncle

68 lement peptide C3a is a key component of the innate immune system and a major fragment produced follo

69 ELSs developed via cooperation between the innate immune system and adaptive immune system, an even

70 tant for blocking activation of the cellular innate immune system and allowing viral replication to o

71 is a key antibacterial component of the host innate immune system and almost all bacterial species po

72 d macrophages represent critical arms of the innate immune system and are considered regulators and e

73 a (CLL) and integrates its function with the innate immune system and B-cell receptor signaling.

74 hy controls were screened for markers of the innate immune system and bacterial infection.

75 inflammasome is a critical component of the innate immune system and can be activated in response to

76 AMPs are key components of the innate immune system and can protect the host from vario

77 ciprocal relationships between sleep and the innate immune system and considers the role of sleep in

78 Our findings suggest that EE alters the innate immune system and could serve as a therapeutic ap

79 (IFNs) are essential components of the host innate immune system and define first-line of defence ag

80 RIP2 kinase is a central component of the innate immune system and enables downstream signaling fo

81 attern (eDAMP) molecules, which activate the innate immune system and endothelium to an inflammatory,

82 cle vaccine (nanovaccine) that modulates the innate immune system and enhances adaptive immunity with

83 ller (NK) cells form an important arm of the innate immune system and function to combat a wide range

84 most recently identified constituents of the innate immune system and have been the focus of intense

85 eceptors (TLRs) are potent activators of the innate immune system and hold promise as vaccine adjuvan

86 nctional link between natural amines and the innate immune system and identifies CXCR4 as a potential

87 A critical role for the innate immune system and IFNL4 polymorphisms has been pr

88 ficiency in del(5q) MDS to activation of the innate immune system and induction of S100A8-S100A9 expr

89 Leukotrienes are mediators of the innate immune system and inflammatory processes, and the

90 oid-beta is accompanied by activation of the innate immune system and involves inflammasome-dependent

91 ng oligomerization domain 2), belongs to the innate immune system and is among others responsible for

92 We found that stimulation of the innate immune system and microglia/macrophage activation

93 Neutrophils are critical cells of the innate immune system and rapidly respond to tissue injur

94 ion in hepatocytes is restricted by the host innate immune system and related intracellular signaling

95 nition of potential microbial threats by the innate immune system and subsequent licensed adaptive im

96 findings highlight the interplay between the innate immune system and the viral genome in HCV control

97 rough licensing of cellular effectors of the innate immune system and via the canonical functions ass

98 eering that are successfully adopted by both innate immune systems and genome-editing technologies.

99 NK cells are part of the innate immune system, and are able to identify and kill

100 ride (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primar

101 es against CD46, a negative regulator of the innate immune system, and constructed antibody-drug conj

102 R4) is a pattern recognition molecule of the innate immune system, and evidence suggests that it modu

103 ociated molecular pattern recognition by the innate immune system, and how this may influence adaptiv

104 LYS is an important defence molecule of the innate immune system, and its overexpression can be a co

105 The relevance of the innate immune system, and monocytes in particular, has e

106 er (NK) cells are front-line soldiers of the innate immune system, and recent studies have revealed f

107 the receptor DC-SIGN (SIGN-R1) to affect the innate immune system, and that FcgammaR are not necessar

108 ough direct activation and engagement of the innate immune system, and thus might have clinical benef

109 sponsible for T. denticola activation of the innate immune system are currently not well defined.

110 responses involving the adaptive versus the innate immune system are observed at various stages of n

111 phase following tissue damage, cells of the innate immune system are rapidly recruited to sites of i

112 NK cells, lymphocytes of the innate immune system, are important for defense against

113 Macrophages, key cells of the innate immune system, are known to support angiogenesis

114 ndicate a crucial role for activation of the innate immune system as a disease-promoting factor.

115 recognition of viral invasion and an intact innate immune system as a first line of defense.

116 re best recognized for their role within the innate immune system as chemotactic cytokines, signaling

117 degradation and thus to escape from the host innate immune system but little is known about its physi

118 tern recognition molecules that regulate the innate immune system, but their chaperone activities rem

119 leased after tissue damage and activates the innate immune system by binding to toll-like receptor-9

120 omato DC3000 suppresses the two-tiered plant innate immune system by injecting a complex repertoire o

121 phocytes contribute to the regulation of the innate immune system by participating in the secretion o

122 rotein that primarily acts to antagonize the innate immune system by targeting STAT2 for proteasomal

123 lated, and that a primary disturbance of the innate immune system can "spill over" into autoimmunity

124 daptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection

125 The present results suggest that the CNS innate immune system can respond to an acute stressor as

126 ergetically efficient mechanism in which the innate immune system can simply alter leukocyte stiffnes

127 The cells and receptors of the innate immune system can therefore achieve different act

128 trations of procalcitonin, activation of the innate immune system (% CD16+CD14+ monocytes, interleuki

129 Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role i

130 toinflammatory diseases are disorders of the innate immune system, characterized by systemic inflamma

131 The plant innate immune system contains a limited NLR repertoire t

132 rent article, we tested whether the platelet innate immune system contributes to responses to oxPCCD3

133 The mosquito's innate immune system controls both Plasmodium and bacter

134 proinflammatory activation of the peripheral innate immune system, coupled with relative inactivation

135 oadenylate synthetase-1 (OAS1) is central in innate immune system detection of cytoplasmic double-str

136 The innate immune system detects diverse microbial species w

137 In vertebrate species, the innate immune system down-regulates protein translation

138 encoding components of the interferon lambda innate immune system drive viral polymorphism.

139 observations provide novel evidence that the innate immune system employs protective mechanisms aimed

140 In contrast to lymphocytes, cells of the innate immune system express adhesion and chemoattractan

141 ore complex microbial management role of the innate immune system for controlled accommodation of ben

142 can translocate to the spleen and prime the innate immune system for enhanced reactivity.

143 lectin on macrophages and other cells of the innate immune system, functions in response to pathogens

144 cyte necrosis, followed by activation of the innate immune system, further aggravating liver injury.

145 Persistent activation of the innate immune system greatly influences the risk for dev

146 The innate immune system has been implicated in both AKI and

147 Although activation of the innate immune system has been linked to the behavioral a

148 ng through Toll-like receptor (TLR) 9 of the innate immune system has been shown to further contribut

149 ed understanding about danger sensing by the innate immune system has led to the rational design of n

150 The functional relevance of the innate immune system has not yet been dissected in P0106

151 The innate immune system has recently been shown to promote

152 le and cell membrane-bound components of the innate immune system, has defined roles in the pathophys

153 Recently, however, cells of the innate immune system have been shown to be capable of di

154 es, especially their interplay with the host innate immune system, have not been well investigated.

155 ves increased expression of two genes of the innate immune system, IL1beta and CCL2, which enhance th

156 ngs suggest that T. denticola stimulates the innate immune system in a TLR2-dependent fashion and tha

157 ated fungus that can suppress the mosquito's innate immune system in a way that would favor Plasmodiu

158 creasing evidence implicating a role for the innate immune system in AD initiation and progression.

159 ureus survival and the ability to escape the innate immune system in blood.

160 ed upregulation of various components of the innate immune system in both diseases, including inflamm

161 ll populations and soluble components of the innate immune system in cancer, with a focus on compleme

162 sults add a new dimension to the role of the innate immune system in CNS regeneration, revealing how

163 of inflammatory signaling molecules and the innate immune system in directing brain masculinization,

164 ht a critical unappreciated role of the host innate immune system in exacerbating injury following ex

165 e novel insight into the broader role of the innate immune system in neurodegenerative disease.

166 data suggest compensatory regulation of the innate immune system in rag2(E450fs) mutant zebrafish.

167 Macrophages are a crucial component of the innate immune system in sensing pathogens and promoting

168 ophages) represent the main cell type of the innate immune system in the CNS; however, the mechanisms

169 Defects in the innate immune system in the lung with attendant bacteria

170 of family studies and the importance of the innate immune system in the pathogenesis of CD.

171 ich together suggest a dominant role for the innate immune system in the pathogenesis of TBM-IRIS.

172 Antimicrobial peptides are components of the innate immune systems in animals and plants as natural d

173 Innate immune systems in many taxa exhibit hallmarks of

174 corticosterone levels and activation of the innate immune system, including elevation of inflammator

175 ion of key regulators of inflammation by the innate immune system, including Toll-like receptor 4, nu

176 etween a pathogen and its host endocrine and innate immune system increases intestinal pathogen loads

177 The complement system, a part of the innate immune system, influences PGA formation, but the

178 suppression of the cellular response of the innate immune system inhibits motor neuron regeneration.

179 through which the enteric nervous system and innate immune system integrate to promote rapid type 2 c

180 an updated summary of the components of the innate immune system involved in NEC pathogenesis.

181 NA) and complement are key components of the innate immune system involved in the opsonization, phago

182 However, in a host plant with an innate immune system involving analogous resistance prot

183 The cerebral innate immune system is able to modulate brain functioni

184 The innate immune system is activated in a number of degener

185 abolic inflammation and oral infections, the innate immune system is activated through pattern recogn

186 The innate immune system is an ancient mode of immunity, and

187 The evolutionarily conserved innate immune system is considered to play a key role in

188 The innate immune system is critical for host defense agains

189 is apparent that adequate activation of the innate immune system is essential for pathogen clearance

190 ion of bacterial lipopolysaccharide (LPS) by innate immune system is mediated by the cluster of diffe

191 The vertebrate antiviral innate immune system is often considered to consist of t

192 The innate immune system is responsible for early defense ag

193 The innate immune system is strongly implicated in the patho

194 The innate immune system is the front line of host defense a

195 The interaction of Candida albicans with the innate immune system is the key determinant of the patho

196 The systemic innate immune system is thought to act as a modifier of

197 The innate immune system is tightly regulated, as excessive

198 hese features by recognition pathways of the innate immune system is translated into different classe

199 The innate immune system is vital to rapidly responding to p

200 receptor signaling is a key mediator of the innate immune system; its common genetic variant is asso

201 rstanding how dysregulation of this powerful innate immune system leads to these human diseases.

202 The defense machinery provided by the host innate immune system limits IAV replication; however, to

203 Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation.

204 t the crossroads between pathogen clearance, innate immune system, matrix deposition, female fertilit

205 g complement proteins that are active in the innate immune system may confer risk for schizophrenia b

206 Blockage of DNA recognition by the innate immune system may constitute a promising therapeu

207 y of certain drugs to directly stimulate the innate immune system may contribute to generate drug-spe

208 uanosine monophosphate (c-di-GMP) acts as an innate immune system modulator.

209 highly expressed in phagocytic cells of the innate immune system, most notably in myeloid cells capa

210 Several factors, including the innate immune system, mucus composition, and diet, have

211 As part of the innate immune system, myeloid cells have diverse roles i

212 The innate immune system needs to distinguish between harmfu

213 In contrast to other members of the innate immune system, neutrophils are classically consid

214 The innate immune system not only plays a critical role in p

215 Antimicrobial peptides, produced by innate immune system of hosts in response to invading pa

216 The innate immune system of humans and other mammals respond

217 The more primitive innate immune system of insects has also been shown to c

218 Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers int

219 oxidants is an important cornerstone in the innate immune system of mammals.

220 des (AMPs) are an important component of the innate immune system of most organisms.

221 The innate immune system of patients with Alzheimer's diseas

222 The innate immune system of plants recognizes microbial path

223 SBV, as it has lost the ability to block the innate immune system of the host.

224 Although NK cells are a component of the innate immune system, particular NK cell subsets express

225 A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The innate immune system plays a central role in the chronic

226 r signaling events, where the host cnidarian innate immune system plays a crucial role in recognition

227 The innate immune system plays diverse roles in health and d

228 -M) systems are often regarded as bacteria's innate immune systems, protecting cells from infection b

229 The innate immune system protects against infections by init

230 The innate immune system protects cells against viral pathog

231 ied a decade ago as a mechanism by which the innate immune system protects us from infections, especi

232 The innate immune system provides the first line of defense

233 The innate immune system provides the first response to infe

234 Although NK cells are considered part of the innate immune system, recent studies have demonstrated t

235 The inflammasomes are innate immune system receptors and sensors that regulate

236 Cells of the innate immune system recognize bacterial pathogens by de

237 The innate immune system recognizes microbial pathogens via

238 Adaptive and innate immune system related genes and pathways are part

239 Self/non-self-discrimination by the innate immune system relies on germline-encoded, non-rea

240 However, its role in macrophages and innate immune system remains unclear.

241 BACKGROUND & AIMS: The innate immune system responds not only to bacterial sign

242 mplex syndrome associated with a maladaptive innate immune system response that leads to deleterious

243 two other pathogen-binding receptors of the innate immune system, revealed why these two binding sit

244 nts utilizing mice with impaired adaptive or innate immune systems, revealed the significance of the

245 nisms that are not well understood, the host innate immune system's neutrophils select spontaneous M1

246 iscern virulent from innocuous microbes, the innate immune system senses events associated with bacte

247 The host innate immune system serves as the first line of defense

248 h the follicles: intradermal adipose tissue, innate immune system, sex hormones, aging, circadian rhy

249 antagonistic antimicrobial activities of the innate immune system should provide insight into how cel

250 nflammation resulting from activation of the innate immune system significantly contributes to ischem

251 pro- and antiinflammatory alterations of the innate immune system, similar to those reported in sever

252 ctivate pattern-recognition receptors of the innate immune system-specifically, high mobility group b

253 and provides new insight into how the human innate immune system starves microbes of essential metal

254 antibody-directed effector functions of the innate immune system such as antibody-dependent cell-med

255 SOCE has also been observed in cells of the innate immune system such as macrophages and dendritic c

256 it against enzymatic attack through the host innate immune system, such as the cell wall hydrolase ly

257 peptidases and recognition by the Drosophila innate immune system, suggesting relevant roles in the e

258 mary, our results show for the first time an innate immune-system-suppressive mechanism shared by the

259 The complement cascade is a part of the innate immune system that acts primarily to remove patho

260 l-like receptors (TLRs) are effectors of the innate immune system that are able to recognize hepatiti

261 emodeling, as well as being sentinels of the innate immune system that can contribute to protective i

262 alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory

263 An integrated, highly complex innate immune system that exhibits remarkable discrimina

264 is a potent proinflammatory cytokine of the innate immune system that is involved in host defense ag

265 le (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in re

266 NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and

267 Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and s

268 DCs), are integral components of the mucosal innate immune system that maintain co-existence with the

269 Complement is an innate immune system that most animal viruses must face

270 inase (PKR) is an important component of the innate immune system that presents a crucial first line

271 uced by pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic

272 ent of downstream signaling molecules in the innate immune system, the current study investigated the

273 that limited NS2's ability to antagonize the innate immune system, thereby attenuating rRSV growth an

274 e indicated that T. denticola stimulates the innate immune system through Toll-like receptor 2 (TLR2)

275 e molecular mechanism that allows the insect innate immune system to 'remember' a previous encounter

276 for TREM2 in regulating the response of the innate immune system to Abeta pathology.

277 Bacterial pathogens often subvert the innate immune system to establish a successful infection

278 ine axes are crucial for tolerization of the innate immune system to microbial endotoxin exposure thr

279 This is the first study to link the innate immune system to mitochondrial dynamics and morph

280 mportance of nucleic acid recognition by the innate immune system to mounting an appropriate immune r

281 Pattern recognition receptors allow the innate immune system to perceive the presence of microbi

282 peptides are short peptides secreted by the innate immune system to protect the host from pathogens.

283 for beta-(1,3)-glucan, is important for the innate immune system to recognize systemic fungal infect

284 l trials, SAP affects several aspects of the innate immune system to reduce fibrosis, whereas CRP app

285 The ability of the innate immune system to trigger an adaptive T cell respo

286 Detection of CMV by the innate immune system triggers production of type I IFNs

287 The mammalian innate immune system uses several sensors of double-stra

288 The vertebrate innate immune system uses several strategies to exploit

289 nals such as ATP are released and inform the innate immune system via activation of the purinergic re

290 tion of FcgammaRIIB on the regulation of the innate immune system, via inhibition of Toll-like recept

291 acroglobulin (A2M), a major component of the innate immune system, was associated with cerebrospinal

292 NA-155 (miR-155) regulates activation of the innate immune system, we aimed to determine its function

293 TLRs are central components of the innate immune system which, upon recognition of bacteria

294 The innate immune system, which includes antimicrobial pepti

295 mediated uptake of the ADCs by cells of the innate immune system, which may result in off-target tox

296 pattern recognition receptor of the humoral innate immune system with ancestral antibody-like proper

297 ta, and theta defensins are effectors of the innate immune system with potent antibacterial, antivira

298 OD2 are pattern recognition receptors of the innate immune system with well-established roles in sens

299 r cells (NKs) are important effectors of the innate immune system, with marked antitumor activity.

300 um is a source of alarmins that activate the innate immune system, yet their ability to activate fibr