ライフサイエンスコーパス: innate immunity

1 ase SETDB1 as a novel, negative regulator of innate immunity.

2 s in the transcriptional regulation of plant innate immunity.

3 ysiological role in carcinogenesis and viral innate immunity.

4 this receptor in airway Ca(2+) signaling and innate immunity.

5 ession of genes, including those involved in innate immunity.

6 For decades, flies have been a model for innate immunity.

7 e phagocyte respiratory burst is crucial for innate immunity.

8 ved in energy metabolism, detoxification and innate immunity.

9 ation in mice ascites, both of which improve innate immunity.

10 ceptor signaling is an emerging principle in innate immunity.

11 icrobes are necessary for SDR-enhancement of innate immunity.

12 D51 is also implicated in the suppression of innate immunity.

13 eptors, that suggest universal principles of innate immunity.

14 reaction (AtHIR) proteins function in plant innate immunity.

15 cuses on nematode-bacterial interactions and innate immunity.

16 PRELP) is a novel antibacterial component of innate immunity.

17 P-1, which are transcriptional activators of innate immunity.

18 ty to oligoadenylate signalling in mammalian innate immunity.

19 S signaling to the actin cytoskeleton during innate immunity.

20 y which the fibrinolysis system may regulate innate immunity.

21 NLRP3 inflammasome is a critical player in innate immunity.

22 Tyro3, Axl, and Mer) have been implicated in innate immunity.

23 remission are involved in the regulation of innate immunity.

24 lved in protective or regulatory adaptive or innate immunity.

25 protozoa, providing autophagy with a role in innate immunity.

26 wherein granulocytes predominate to provide innate immunity.

27 own roles of PIAS proteins as suppressors of innate immunity.

28 ng host-specific mechanisms of resistance to innate immunity.

29 hroughout chordates, have been implicated in innate immunity.

30 latter of which provide barrier function and innate immunity.

31 ) as a possible mechanism for the effects on innate immunity.

32 ndent SA signaling, thereby subverting plant innate immunity.

33 fected tissues is a fundamental component of innate immunity.

34 ens have mastered the ability to evade plant innate immunity.

35 and then focus on their emerging function in innate immunity.

36 ent is well appreciated as a critical arm of innate immunity.

37 al role in HCV recognition and activation of innate immunity.

38 mplement cascade is a principal component of innate immunity.

39 R stress and represents a primordial form of innate immunity.

40 covered an apical role for PXR in regulating innate immunity.

41 s replication and interference with the host innate immunity.

42 role of intramembrane aspartyl proteases in innate immunity.

43 and hepatocytes is a key component in liver innate immunity.

44 aterial enhances gut microbial diversity and innate immunity.

45 ious trypanosomes, allowing evasion of human innate immunity.

46 etween autophagy and type I IFN signaling in innate immunity.

47 in digestion, development, reproduction and innate immunity.

48 aB) plays an essential role in regulation of innate immunity.

49 iseases are driven by abnormal activation of innate immunity.

50 tic studies may reveal the basis for the low innate immunity.

51 getable function for MARK4 in the control of innate immunity.

52 mite allergenicity through the activation of innate immunity.

53 s involved in bitter taste perception and/or innate immunity.

54 in) and characterized its functional role in innate immunity.

55 with key functions in PMN trafficking during innate immunity.

56 ing how they may impact multiple pathways of innate immunity.

57 surface that GAS employs to circumvent host innate immunity.

58 tion of NF-kappaB, an essential regulator of innate immunity.

59 ons we studied T stem cell memory (TSCM) and innate immunity.

60 alpha and an important regulator of pain and innate immunity.

61 ong been considered short-lived effectors of innate immunity.

62 ed kinase (IRAK)4 is a critical regulator of innate immunity.

63 Kagan studies how organelles control innate immunity.

64 hile mature RRCs express genes implicated in innate immunity.

65 Nucleic acids are potent triggers for innate immunity.

66 cells can regulate inflammatory responses in innate immunity.

67 polymerase as well as a potent antagonist of innate immunity.

68 y such as splicing, temperature sensing, and innate immunity.

69 Interferons play an important role in innate immunity.

70 anisms in the adaptive immune system but not innate immunity.

71 YAP deficiency resulted in enhanced innate immunity, a diminished viral load, and morbidity

72 Besides its well defined role in innate immunity, aberrant degranulation of neutrophils i

73 ly conserved Toll signaling pathway controls innate immunity across phyla and embryonic patterning in

74 ollow several distinct strategies, including innate immunity; adaptive immunity; and dormancy inducti

75 cells, degradation of tissue, suppression of innate immunity, adherence to host surfaces, biofilm for

76 for PXR as a critical negative regulator of innate immunity after infection.

77 genous structure (MARCO) promotes protective innate immunity against bacterial and parasitic infectio

78 suggest a novel antiviral mechanism in liver innate immunity against HCV infection and provide insigh

79 e HCV dsRNAs-induced intracellular antiviral innate immunity against HCV, suggesting the potential ap

80 an enhance hepatocyte-mediated intracellular innate immunity against HCV.

81 Cyclic GMP-AMP synthase is essential for innate immunity against infection and cellular damage, s

82 Taken together, PRELP enhances host innate immunity against M. catarrhalis through increasin

83 Moreover, APOBEC-3s are involved in host innate immunity against many viruses.

84 e of the SPL-IKKepsilon-IFN axis during host innate immunity against viral infection.

85 ized that cellular and humoral components of innate immunity alter fate and migration of human neural

86 rime human neutrophils, suggesting a role in innate immunity and acute inflammation.

87 ty of functions including dedifferentiation, innate immunity and adaptive immunity.

88 g oedema clearance), epithelial cell repair, innate immunity and airway function.

89 lian lipocalins highlights their function in innate immunity and allergy.

90 cytes and macrophages are important cells of innate immunity and also are targets of HIV/SIV infectio

91 In addition to being a component of innate immunity and an ancient defense mechanism against

92 posed to glucocorticoid (GC), a regulator of innate immunity and an important therapeutic agent.

93 st, MGN1703-could function as an enhancer of innate immunity and an LRA in vivo.

94 ave recently emerged as important players in innate immunity and antivirus.

95 re resulted in a more efficient detection by innate immunity and attenuation, proving the role of the

96 standing how microorganisms manipulate plant innate immunity and colonize host cells is a major goal

97 nting cells (APC) are critical components of innate immunity and consequently shape the adaptive resp

98 report that aberrant activation of the brain innate immunity and decreased serotonergic tonus in the

99 In contrast, early signatures of innate immunity and dendritic cell activation were highl

100 The RNAi pathway provides both innate immunity and efficient gene-knockdown tools in ma

101 PP1R11 plays an important role in regulating innate immunity and gram-positive bacterial clearance by

102 s review focuses on the evidence for trained innate immunity and highlights some insights into its re

103 , our findings show novel sex differences in innate immunity and identify a common neutrophil signatu

104 kout mice were linked to deregulated mucosal innate immunity and impaired myeloid-derived suppressor

105 In view of the emerging role of MCs in innate immunity and increased localization to the asthma

106 Neutrophils are essential for innate immunity and inflammation and many neutrophil fun

107 d after surgery; 248 (48%) were upregulated (innate immunity and inflammation) and 274 (52%) were dow

108 8 is a member of the IL-1 family involved in innate immunity and inflammation.

109 s within the signaling pathways that control innate immunity and inflammation.

110 gests a role of gut microbiota in regulating innate immunity and influencing brain function.

111 t activation by promoting cross-talk between innate immunity and integrin activation signaling pathwa

112 ranscription factor commonly associated with innate immunity and is activated by infection and inflam

113 arasite control, much less work has examined innate immunity and its connections to the adaptive resp

114 reasons for the PRRSV interference with the innate immunity and its poor elicitation of protective i

115 acute-phase plasma protein that functions in innate immunity and lipid homeostasis.

116 ggest an essential role for cGAMP in linking innate immunity and metabolic homeostasis, indicating po

117 stry, likely by modulating the activation of innate immunity and necroinflammation.

118 The oral epithelium contributes to innate immunity and oral mucosal homeostasis, which is c

119 e identified biological processes related to innate immunity and oxidative stress as prime response p

120 e infected with DNA viruses exhibit enhanced innate immunity and reduced viral load.

121 n of STING expression in these cells rescued innate immunity and suppressed DeltaICP0 virus infection

122 its non-classical actions in stimulation of innate immunity and suppression of inflammatory response

123 GAS]) has specifically adapted to evade host innate immunity and survive in multiple tissue niches, i

124 plant-parasitic nematodes to subjugate plant innate immunity and thereby promoting parasitism.

125 o seemingly disparate pathways that regulate innate immunity and tissue growth, respectively.

126 ction was characterized by overexpression of innate immunity and underexpression of adaptive immunity

127 n and unique interaction patterns regulating innate immunity and viral infection.

128 (DAPK-1) regulates epidermal morphogenesis, innate immunity and wound repair.

129 Our data highlight the relevance of innate immunity and, especially, the tight interaction b

130 This effect has been termed 'trained innate immunity', and is underwritten by stable epigenet

131 various transcriptional responses, including innate immunity, and (iii) repress apoptosis.

132 ng new mechanistic connections between FMRP, innate immunity, and abnormal development.

133 ssion, insulin-like growth factor signaling, innate immunity, and further metabolic re-programming.

134 f regulating IkappaB/Cactus transcription in innate immunity, and identify Gram-positive bacteria as

135 he gene coexpression network associated with innate immunity, and included clusters of genes with cor

136 ICP0 blocks innate immunity, and one mechanism is by degrading hosti

137 interferon (IFN) response, a major branch of innate immunity, and that lineage-specific ERVs have dis

138 teractions between the hemostatic system and innate immunity, and the coagulation and complement casc

139 We report that deletion of the innate immunity antibacterial gene Nod2 abolishes this r

140 Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanism

141 Importantly, the requirement of this innate immunity arm appears to be evolutionarily conserv

142 ice) and shows distinct rule choices for the innate immunity arm of the model between younger and agi

143 nctions including their role as effectors of innate immunity as macrophages (MACs) and bone remodelli

144 is an important factor in the initiation of innate immunity, as characterized by thrombotic microang

145 the colonic epithelium and implicate AQP3 in innate immunity at mucosal surfaces.

146 ound melanization i) is an important part of innate immunity because it was present in all major arth

147 s a ubiquitin-like protein that functions in innate immunity both as an intracellular protein modifie

148 A) cytosine deaminase has important roles in innate immunity but is also a major endogenous source of

149 virus displayed growth defects and activated innate immunity, but both effects were alleviated in STI

150 TLRs are critical for innate immunity, but excessive activation can lead to ti

151 red a profile with several genes involved in innate immunity, but with no recognised role in CSR.

152 ter a blood meal, which suppresses antiviral innate immunity by activating the GABAergic pathway.

153 ction, and provide evidence of regulation of innate immunity by cells of the adaptive immune system.

154 Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non

155 ge caused by pathogens or wounding to induce innate immunity by direct binding to the membrane-locali

156 the ability of P. gingivalis to dysregulate innate immunity by repressing gingipain-associated degra

157 These DNA-editing enzymes function in innate immunity by restricting the replication of viruse

158 That macrophages/innate immunity can be modulated to play a central role

159 el of persistent infection demonstrates that innate immunity can control both early and persistent vi

160 Plant innate immunity can effectively prevent the proliferatio

161 wever, little is known whether activation of innate immunity can lead to direct tumoricidal effect.

162 ophages-essential cell players of the pulpal innate immunity-can regulate pulpal inflammation and rep

163 reviously unknown defense systems, including innate immunity centered on Argonaute proteins, bacterio

164 in addition to two previously well-described innate immunity components and thus represents an additi

165 Innate immunity contributes to OA progression, mediated

166 how that cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS-STING (cyclic

167 Toll-like receptors (TLRs) play a role in innate immunity defending the organism against infection

168 and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING

169 Aspects of innate immunity derive from characteristics inherent to

170 ading did not affect other key components of innate immunity, did not indiscriminately promote intrac

171 Autophagy is an essential component of innate immunity, enabling the detection and elimination

172 rein, we explored the significance of type 2 innate immunity for restricting UGT tissue damage in Chl

173 s to understand evolutionary patterns of the innate immunity foundation on which complex immunologica

174 o mammalian cells led to potent induction of innate immunity genes and confers protection against vir

175 the 1000 Genomes Project, we first show that innate immunity genes have globally evolved under strong

176 and adaptations have driven the evolution of innate immunity genes is missing.

177 Finally, we show that innate immunity genes present higher Neandertal introgre

178 t, progressive upregulation of lysosomal and innate immunity genes, increased complement production,

179 igh-scoring signals of positive selection at innate immunity genes, variation in which has been assoc

180 se is influenced by three main factors: host innate immunity, host immune response, and viral strain.

181 In innate immunity, IL-33 and group 2 innate lymphoid cells

182 1 may act at the interface of metabolism and innate immunity in a model of oxidative stress.

183 c response and represent a tool for studying innate immunity in a mouse with a functional adaptive im

184 ellular kinase domain and induction of plant innate immunity in Arabidopsis.

185 he conclusion that SDE5 contributes to plant innate immunity in Arabidopsis.

186 MNV model, highlighting the role of IFNs and innate immunity in clearing persistent viral infection,

187 Complement is a key component of innate immunity in health and a powerful driver of infla

188 icient translation, and evasion of antiviral innate immunity in host cells.

189 rophil transcriptome and are associated with innate immunity in juvenile idiopathic arthritis (JIA).

190 ed protein-1 (LRP1), is reported to suppress innate immunity in macrophages and oppose microglial act

191 in assembly complex (LUBAC) is essential for innate immunity in mice and humans, yet its role in adap

192 of immune cells that play important roles in innate immunity in mucosal tissues, and in the maintenan

193 c antimicrobial peptides contributing to the innate immunity in plants.

194 f a social strategy, how the brain regulates innate immunity in response to stress, and how drugs imp

195 strate that MIF is essential for maintaining innate immunity in skin.

196 BKV specifically evades innate immunity in TEC and is not susceptible to an intr

197 h impairs TLR signaling, thereby suppressing innate immunity in the urinary tract and enhancing persi

198 LRP12 (which encodes a negative regulator of innate immunity) in human ulcerative colitis, by compari

199 ositive pathogen that resists many facets of innate immunity including nitric oxide (NO.).

200 was associated with increased intrinsic and innate immunity, including significantly higher inductio

201 direct impacts for the fields of chemotaxis, innate immunity, inflammation, carcinogenesis, and drug

202 indings firmly establish that alterations in innate immunity influence the course of autoimmune diabe

203 Inflammation induced by innate immunity influences the development of T cell-med

204 our understanding of the atopic march, with innate immunity initiating dermatitis and the adaptive i

205 n]) versus inflammation (eg, chemokines) and innate immunity (interferon) were upregulated versus mut

206 adaptor-like (MAL) is a critical protein in innate immunity, involved in signaling by several Toll-l

207 Altered innate immunity is a feature of certain skin inflammator

208 The data obtained suggest that innate immunity is a leading actor in the early developm

209 Here, we used IAV to investigate how host innate immunity is activated.

210 CircRNA activation of innate immunity is independent of a 5' triphosphate, dou

211 A major signaling molecule involved in innate immunity is inducible nitric oxide synthase (iNOS

212 The role of these nasal commensals in host innate immunity is largely unknown, although bacterial i

213 We have previously shown that innate immunity is necessary for transdifferentiation of

214 tion of self-components in the regulation of innate immunity is still unclear.

215 Here, we show that a mechanism for antiviral innate immunity is triggered after the ER stress pathway

216 Whether or not VISTA regulates innate immunity is unknown.

217 complement system, typically associated with innate immunity, is emerging as a key controller of noni

218 ded DNA viruses use TRIM29 to suppress local innate immunity, leading to the persistence of DNA virus

219 resting link between the coagulation system, innate immunity, LPS scavenging, and protein aggregation

220 in have so far been linked with acquired and innate immunity, lymphocyte development and genotoxic st

221 responses, including the gene-silencing and innate immunity machineries.

222 hile minimizing the detrimental roles of the innate immunity may aid functional recovery after SCI.

223 analysis corroborated previous findings that innate immunity may be involved in the progression of PT

224 ent and/or prophylaxis used for disorders of innate immunity may be successfully used for ASD patient

225 these findings, we hypothesize that humoral innate immunity may recognize senescent cells by the pre

226 obiota community diversity can regulate host innate immunity mechanisms that impact Abeta amyloidosis

227 Innate immunity, mediated by mononuclear phagocytes, inc

228 Thus, innate immunity-mediated recognition of viral nucleic ac

229 actin may serve as an important regulator of innate immunity, mediating AMP responses against both Gr

230 ense requires the orchestrated expression of innate immunity mediators, initiated by alveolar macroph

231 gnaling pathway is an essential component of innate immunity necessary for mediating proinflammatory

232 ors, but other inducers and sensors of viral innate immunity need to be identified and characterized.

233 stem, traditionally known as a controller of innate immunity, now stands as a multifaceted signaling

234 ity may provide opportunities to harness the innate immunity of epithelia against infection.

235 ion that explain how RD21 contributes to the innate immunity of mature plants and arthropod deterrenc

236 Modulation of innate immunity of patients with Alzheimer's disease by

237 Our results indicate that innate immunity of the CNS set in motion by B. abortus c

238 The innate immunity of the host, typified by interferon (IFN

239 ces in our understanding of the influence of innate immunity on neurodegenerative disorders such as A

240 canakinumab targeting the interleukin-1beta innate immunity pathway could significantly reduce incid

241 er, the disease genes that overlap these two innate immunity pathways can be used to classify the cas

242 The TSCM memory stem cell and innate immunity pathways have to be optimised to boost t

243 ing of the relative biological importance of innate immunity pathways in natural conditions.

244 The inhibition of host innate immunity pathways is essential for the persistenc

245 ion did not as strongly induce expression of innate immunity pathways, and significant differences we

246 e MRs driving the disease progression in the innate immunity pathways.

247 he TEMRA transcriptional program predicts an innate immunity phenotype associated with genes never re

248 udy has as yet been reported comparing their innate immunity phenotypes.

249 Adaptive and innate immunity play a key role controlling tumor growth

250 Human genes governing innate immunity provide a valuable tool for the study of

251 lation of p53 as a major player in antiviral innate immunity provides a long-sought explanation for d

252 Innate immunity provides an immediate defense against in

253 ions in neurovascular regulation through the innate immunity receptor CD36 (cluster of differentiatio

254 ow the complement system, a key component of innate immunity, regulates the development of pain hyper

255 IFN) lambda 3/4 (IFNL3/4) locus, influencing innate immunity regulation, has been associated with the

256 s, this study aims to evaluate levels of the innate immunity-related markers calprotectin, colony-sti

257 Although much of the plant innate immunity system provides highly specific resistan

258 uing relationship between lipid droplets and innate immunity that may represent a new paradigm for vi

259 , identifying it as an indirect regulator of innate immunity that mediates bidirectional cross-talk b

260 ignaling pathways are critical components of innate immunity that orchestrate appropriate immune resp

261 eta is a potent pro-inflammatory cytokine of innate immunity that plays pivotal roles in host defence

262 Natural killer (NK) cells mediate important innate immunity that provides a temporal bridge until th

263 ls are critical and short-lived mediators of innate immunity that require constant replenishment.

264 tes a novel mechanism underlying LPS-induced innate immunity; that is, a secondary upregulation of IL

265 5 conjugates in order to evade, or suppress, innate immunity, the impact of ISG15 biodiversity on deI

266 ularly well-characterized circuit regulating innate immunity, the inflammatory reflex, is dependent u

267 In innate immunity, the itchy E3 ubiquitin protein ligase (

268 Pattern recognition underpins innate immunity; the accurate identification of danger,

269 Thus, LUBAC components control TLR3-mediated innate immunity, thereby preventing development of immun

270 MIWI2 in airway cell identity and pulmonary innate immunity, these studies elucidate unanticipated p

271 d the complement system in the activation of innate immunity through engagement of TLR7 with papaya m

272 es, tilapia mince hydrolysate (TMH) enhanced innate immunity through induction of IL-1beta and COX-2

273 ndings provide new mechanistic insights into innate immunity through the activity of MMP-25, suggesti

274 g UL46, out of the context of the infection, innate immunity to a DeltaICP0 virus was largely comprom

275 e-tune lipid raft cholesterol that regulates innate immunity to adenovirus in endosomes.IMPORTANCE Ea

276 to determine how this interaction regulates innate immunity to adenovirus.

277 HBV uses multiple pathways to harness host innate immunity to enhance its replication.

278 protein that has been shown to control host innate immunity to Mtb infection.

279 Both NO and TLR9 are important elements of innate immunity to mycobacteria, and these features of b

280 Plants depend on innate immunity to prevent disease.

281 ated in response to cell stress and activate innate immunity to provide a pivotal mechanism by which

282 ng, antigen presentation, and stimulation of innate immunity, to achieve a robust T cell response for

283 ls; (iv) the DeltaUL46 virus failed to block innate immunity triggered by ligands of STING such as 2'

284 for mTORC1 downstream of TBK1 in control of innate immunity, tumorigenesis, and disorders linked to

285 irus (NDV), in addition to the activation of innate immunity, upregulates the expression of T-cell co

286 el mechanism of poxvirus inhibition of human innate immunity, validate current dynamic models of NEMO

287 ibitors (ATIs) are nutritional activators of innate immunity, via activation of the toll-like recepto

288 ibitors (ATIs) are nutritional activators of innate immunity, via activation of the toll-like recepto

289 Innate immunity, via the type I interferon (IFN) respons

290 Reduced innate immunity was dependent on fat body InR expression

291 n evolutionary old and critical component of innate immunity where it forms the first line of defense

292 ort an essential role for Hippo signaling in innate immunity whereby Yorkie directly regulates the tr

293 evation causes AT inflammation by activating innate immunity, which elicits an adaptive immune respon

294 Thus, site-specific cellular innate immunity, which is predominantly executed by resi

295 t from differentiated somatic cells in their innate immunity, which may have important implications i

296 or 5 (IRF5) is a key transcription factor of innate immunity, which plays an important role in host r

297 nt progress in circadian regulation of plant innate immunity with a focus on the molecular events lin

298 ur prior work, we showed that stimulation of innate immunity with Toll-like receptor 9 agonist, class

299 tion and characterizing the effects of SP on innate immunity, with the latter reflected in changes in

300 anipulating the mevalonate pathway regulates innate immunity within the endometrium, and that isopren