ライフサイエンスコーパス: inner cell

1 TE derives from outer cells whereas ICM from inner cells.

2 een previously classified as either outer or inner cells.

3 ve curvature of the membrane surrounding the inner cell and the negative curvature of the cytoplasmic

4 ve Rac1 additionally blocks the apoptosis of inner cells and cavitation, indicating that the spatiall

5 eral ring of primarily viable cells, whereas inner cells are mostly necrotic.

6 it embeds in the membrane that surrounds the inner cell but not in the cytoplasmic membrane of the ou

7 to as intermediate cells, share features of inner cells but exhibit different dynamic behaviors and

8 All inner cells coexpress lineage markers such as Nanog and

9 Caulobacter crescentus and localizes to the inner cell curvature.

10 helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.

11 A transient inner cell death phenotype was detected in their develop

12 es show replacement of outer cell fates with inner cell fates.

13 ypodermal cell divides periclinally with the inner cell giving rise to the sporogenous archesporial c

14 (pre-LC) and PB external lateral-inner (PBel-inner) cell groups of the dorsolateral pons.

15 is unknown how biomechanical forces allocate inner cells in vivo.

16 Our results indicate that inner cells intercalate by first wedging between the bas

17 projections of phase-locking neurons in the inner cell layer (ICL) of the ELL.

18 All but one neuron in the inner cell layer of the medial zone responded exclusivel

19 The inner cell layer of the outer integument also produces a

20 ncluding its reserve HFSCs and SC-inhibitory inner cell layer, is lost.

21 the free diffusion of molecules between the inner cell layers of the root and the outer environment.

22 al that is transmitted from the outer to the inner cell layers of the root.

23 tor and, in the retina, is released from the inner cell layers.

24 3 signaling is also required to maintain the inner cell mass (from which stem cells are derived).

25 f geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplica

26 distinct pluripotent states representing the inner cell mass (ICM) and epiblast embryos.

27 is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantat

28 cell blastomeres that will contribute to the inner cell mass (ICM) and polar trophectoderm and undert

29 cells are pluripotent cells derived from the inner cell mass (ICM) and the epiblast, and have been su

30 omeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (

31 Communication between the inner cell mass (ICM) and the trophoblast layer of the b

32 ent, genesis of the first two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is depende

33 ormation of the blastocyst consisting of the inner cell mass (ICM) and trophectoderm (TE).

34 irections of differential expression between inner cell mass (ICM) and trophectoderm (TE).

35 the spatial organization and segregation of inner cell mass (ICM) and trophectoderm epithelium (TE)

36 IP in mouse embryonic stem (ES) cells and in inner cell mass (ICM) and trophectoderm of cultured blas

37 lantation development, the generation of the inner cell mass (ICM) and trophoblast lineages comprises

38 Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent

39 g early murine embryogenesis, cells from the inner cell mass (ICM) can be specified in epiblast (Epi)

40 This analysis revealed that inner cell mass (ICM) cells have unrestricted developmen

41 ells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to b

42 ripotent human ES cells to those of isolated inner cell mass (ICM) cells.

43 expression is restricted to the pluripotent inner cell mass (ICM) cells.

44 The size of the inner cell mass (ICM) compartment is not reduced, howeve

45 In the mouse blastocyst, some cells of the inner cell mass (ICM) develop into primitive endoderm (P

46 f the mouse embryo distinguishes pluripotent inner cell mass (ICM) from differentiating trophectoderm

47 t-fertilization (dpf), and restricted to the inner cell mass (ICM) in 128-256 cell blastocysts (6dpf)

48 gregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determi

49 mation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events duri

50 traploid ESCs were able to contribute to the inner cell mass (ICM) just as diploid ESCs tagged with G

51 formation of the trophectoderm (TE) and the inner cell mass (ICM) lineages during preimplantation de

52 Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst c

53 Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages.

54 ed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely e

55 r is activated in both the trophectoderm and inner cell mass (ICM) of embryos at embryonic day 3.5 vi

56 ine is distinct from both human PSCs and the inner cell mass (ICM) of human blastocysts.

57 Here we show that the inner cell mass (ICM) of Mbd3-deficient blastocysts fail

58 However, the inner cell mass (ICM) of mouse preimplantation blastocys

59 A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond

60 le inner cells retain pluripotency to become inner cell mass (ICM) of the blastocyst.

61 ent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a 'salt

62 The inner cell mass (ICM) of the implanting mammalian blasto

63 Cells of the inner cell mass (ICM) of the mouse blastocyst differenti

64 primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves i

65 (EPI), the two lineages specified within the inner cell mass (ICM) of the mouse blastocyst stage embr

66 versus pluripotent epiblast (EPI) within the inner cell mass (ICM) of the mouse blastocyst.

67 vel analysis of lineage specification in the inner cell mass (ICM) of the mouse blastocyst.

68 DNA methylation is first established in the inner cell mass (ICM) of the mouse blastocyst.

69 embryonic stem (ES) cells that resembles the inner cell mass (ICM) of the pre-implantation embryo.

70 lose contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of undiffer

71 ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V PO

72 formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endo

73 X-chromosome inactivation (XCI) in the mouse inner cell mass (ICM), and reactivation of X-linked gene

74 ality is due to a defect in expansion of the inner cell mass (ICM), as Mtb(-/-) blastocysts failed to

75 ifferentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or pri

76 contributes exclusively to the placenta, and inner cell mass (ICM), from which the embryo develops.

77 cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivatio

78 egregation in the mouse embryo generates the inner cell mass (ICM), which gives rise to the pluripote

79 Here we show that inner cell mass (ICM)-generated cells expressing Blimp1,

80 be reverted to stable human preimplantation inner cell mass (ICM)-like naive states with only WNT, M

81 ablishment of the trophectoderm (TE) and the inner cell mass (ICM).

82 yonic stem (ES) cell lines, derived from the inner cell mass (ICM).

83 - blastocyst outgrowths revealed loss of the inner cell mass (ICM).

84 phectoderm (TE) and its segregation from the inner cell mass (ICM).

85 polarized trophectoderm cells from an apolar inner cell mass (ICM).

86 f primed PSCs and shares features with human inner cell mass (ICM).

87 iptional program and segregating TE from the inner cell mass (ICM).

88 antly reduced cell numbers, first within the inner cell mass (ICM; early blastocyst), and later withi

89 and capable of hatching and forming both an inner cell mass and a trophectoderm.

90 rsors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm.

91 In mouse embryos, Gdf3 is expressed in the inner cell mass and epiblast, and null mutants frequentl

92 Oct4 expression becomes restricted to the inner cell mass and epiblast.

93 Initial cell lineages that presage the inner cell mass and extra-embryonic trophectoderm are es

94 therefore acts primarily in construction of inner cell mass and germ cell states rather than in the

95 Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has role

96 4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES)

97 ereas laminin 10/11 is expressed only in the inner cell mass and polar trophectoderm.

98 wth, differentiation, and maintenance of the inner cell mass and raise the possibility that this acti

99 ows hES cell line derivation from blastocyst inner cell mass and single blastomere cells without a ne

100 ctor Sox-2 is first expressed throughout the inner cell mass and subsequently becomes localized to th

101 LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early dev

102 elopment is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm.

103 n to be essential for differentiation of the inner cell mass and the formation of the primitive endod

104 nto a blastocyst with two cell lineages (the inner cell mass and the trophectoderm), migrates within

105 sion involves segregation of the pluripotent inner cell mass and the trophectoderm, a process regulat

106 tion mouse embryo gives rise to cells of the inner cell mass and the trophectoderm.

107 nesis arise in the blastocyst, producing the inner cell mass and the trophectoderm.

108 ages and further developed a 3D model of the inner cell mass and trophectoderm in which individual ce

109 Blastocyst volume and cell number (both inner cell mass and trophectoderm) were also increased w

110 (-/-) blastocysts are viable, hatch, form an inner cell mass and trophectoderm, and implant (roughly

111 blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5),

112 elopment, including the determination of the inner cell mass and trophectoderm.

113 ) blastocysts showed defective growth of the inner cell mass and, in contrast to the approximately 65

114 conclude that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is

115 Cells of the inner cell mass are particularly dependent on Thoc1, as

116 fferentiation of ES cells and the blastocyst inner cell mass are poorly understood.

117 early-mid embryogenesis, particularly in the inner cell mass at E3.5, in epiblast at E6.5, and at lat

118 occurs between the pluripotent state of the inner cell mass at embryonic day 3.5 (E3.5) and the indu

119 round the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blast

120 source reduced blastocyst trophectoderm and inner cell mass cell number compared with that of embryo

121 blastocyst stage in vitro and a reduction in inner cell mass cell number in blastocysts.

122 giomotin-like 2, leads to differentiation of inner cell mass cells and compromised peri-implantation

123 g embryonic development, Cr1 is expressed in inner cell mass cells and the primitive streak, and late

124 g an enduring marker to trace the progeny of inner cell mass cells into the postimplantation visceral

125 ow the chromatin regulatory landscape in the inner cell mass cells is established from differentially

126 tem cells (hPSCs) have been derived from the inner cell mass cells of blastocysts (embryonic stem cel

127 Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fi

128 lastocyst transition disrupts the ability of inner cell mass cells to adopt lineage-specific identity

129 Mammalian inner cell mass cells undergo lineage-specific different

130 A is present in both the trophectodermal and inner cell mass cells.

131 helial characteristics by the non-epithelial inner cell mass cells.

132 y 7 and reduced numbers of trophectoderm and inner cell mass cells.

133 al uterus, the mouse blastocyst possesses an inner cell mass comprising two lineages: epiblast (Epi)

134 icating a trophectoderm defect, although the inner cell mass could grow in culture.

135 elop normally, but they subsequently exhibit inner cell mass death, diminished numbers of trophoblast

136 The primitive endoderm arises from the inner cell mass during mammalian pre-implantation develo

137 differentiation of pluripotent cells of the inner cell mass during the early stages of embryonic dev

138 d than those from wild-type blastocysts, the inner cell mass fails to expand, and the outgrowth degen

139 that resemble the cells seen in vivo in the inner cell mass has the potential to be an invaluable to

140 g labeled clones to the trophectoderm or the inner cell mass in a subset of embryos.

141 s showed greatly diminished expansion of the inner cell mass in culture, and this finding suggests th

142 s showed greatly diminished expansion of the inner cell mass in culture.

143 Sox2, and Fgf4, but when placed in vitro the inner cell mass initially proliferates and then fails to

144 lastocyst complementation, in which only the inner cell mass is formed from a few injected ES cells,

145 imitive endoderm layer on the surface of the inner cell mass is one of the earliest epithelial morpho

146 anog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeter

147 anisms through which FGF signaling regulates inner cell mass lineage restriction and cell commitment

148 trophectoderm and a subset of embryos showed inner cell mass localization.

149 outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives.

150 Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (f

151 bryonic stem cells (HESC) generated from the inner cell mass of a human preimplantation embryo.

152 l lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances,

153 Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrou

154 lso leads to defects in the expansion of the inner cell mass of blastocysts, a transient pluripotent

155 Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in uni

156 ation of the primitive endoderm covering the inner cell mass of early mouse embryos can be simulated

157 This status is consistent with the inner cell mass of human blastocysts, where MYC transcri

158 are pluripotent cell types derived from the inner cell mass of human blastocysts.

159 pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts.

160 hy does a totipotent state linger within the inner cell mass of mouse embryos?

161 ells co-exist and are convertible within the inner cell mass of murine blastocysts and embryonic stem

162 is significantly elevated in the presumptive inner cell mass of Oct4 null embryos, suggesting an unex

163 These cells derived from the inner cell mass of pig blastocysts are clearly distinct

164 naive type, pluripotent stem cells from the inner cell mass of porcine blastocysts by up-regulating

165 growth factor (FGF)-4 gene expression in the inner cell mass of the blastocyst and in EC cells requir

166 ence revealed that ZIP3 was expressed in the inner cell mass of the blastocyst and later during embry

167 specific developmental stages, including the inner cell mass of the blastocyst, the myotomes, and the

168 cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can pr

169 an apparently random distribution within the inner cell mass of the early blastocyst and then segrega

170 ting oogenesis and partitioning cells to the inner cell mass of the early embryo.

171 At E4.0 the inner cell mass of the mouse blastocyst consists of a co

172 The inner cell mass of the mouse blastocyst gives rise to th

173 The inner cell mass of the mouse pre-implantation blastocyst

174 ated human cells with ES properties from the inner cell mass or developing germ cells can provide a s

175 of ER was observed in cells derived from the inner cell mass or the trophoblast.

176 and of whether the blastomere is within the inner cell mass or the trophoectoderm.

177 2C-like ES cells and show that they lack the inner cell mass pluripotency proteins Oct4 (also known a

178 mbryos, with higher expression levels in the inner cell mass progenitor cells.

179 eover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inabi

180 velopmental pluripotency state compared with inner cell mass stage murine embryonic stem cells (mESCs

181 t after prolonged culture, the growth of the inner cell mass stopped, no visceral endoderm formed, an

182 ian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell

183 se (UPR) and cell signaling, is required for inner cell mass survival during early embryonic developm

184 , around implantation, epiblast cells of the inner cell mass that give rise to the embryo reactivate

185 lastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis.

186 onic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which wi

187 did not progress much further even when the inner cell mass was 'rescued' from the abnormal placenta

188 racteristics of endoderm, trophectoderm, and inner cell mass were observed in the outgrowth of the ha

189 hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro.

190 derm layer, but could not be detected in the inner cell mass without prior fixation and permeabilizat

191 establishment of trophoblast and pluriblast (inner cell mass) lineages and for subsequent development

192 to the embryonic part (region containing the inner cell mass) that will give rise to the embryo prope

193 In the embryonic tissues of the inner cell mass, a random form of XCI occurs in blastocy

194 and exhibited a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct

195 into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epib

196 Despite their origin from the inner cell mass, embryonic stem (ES) cells undergo diffe

197 to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper

198 Reprogramming of genes expressed in the inner cell mass, from which ntESCs are derived, seems to

199 emergence of three distinct populations: the inner cell mass, primitive endoderm and trophectoderm.

200 (ESC), which are derived from the blastocyst inner cell mass, retain properties of self-renewal and t

201 genes have minimal epigenetic memory in the inner cell mass, whereas others may require active erasu

202 thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all

203 C phenotypes with simultaneous activation of inner cell mass-specific gene expression.

204 to the center of the embryo to establish the inner cell mass-the early precursor of the fetus.

205 culture display abnormal expansion of their inner cell mass.

206 s but was undetectable in blastomeres of the inner cell mass.

207 iimplantational lethality and defects in the inner cell mass.

208 ells and governing the fate of the primitive inner cell mass.

209 expression became restricted to cells of the inner cell mass.

210 and cell death of both the trophectoderm and inner cell mass.

211 conceptus leads to the growth failure of the inner cell mass.

212 to Oct3/4 in mammals during formation of the inner cell mass.

213 for survival of the pluripotent cells of the inner cell mass.

214 vitro revealed impaired proliferation of the inner cell mass.

215 ion of pluripotency and the formation of the inner cell mass.

216 to two cell types, the trophectoderm and the inner cell mass.

217 omosome inactivation is then reversed in the inner cell mass.

218 of forming an epithelial layer covering, the inner cell mass.

219 rations, AMBMP caused disorganization of the inner cell mass.

220 expanded stage a 20% cellular deficit in the inner-cell mass without any change in trophectoderm cell

221 4 h show no sign of "catch-up" growth of the inner-cell mass, although under these conditions, the tr

222 pmt1(-/-) blastocysts failed to outgrow, and inner-cell-mass cells failed to thrive.

223 ll cells, the morphology appeared normal and inner cell masses (ICMs) formed, but resultant embryos h

224 Inner cell masses (ICMs) from Pdcd2(-/-) blastocysts fai

225 Inner cell masses explanted from gp130(-/-) delayed blas

226 Comparison to inner cell masses of marmoset primate blastocysts identi

227 Inner cell masses were isolated by immunosurgery and pla

228 Sporulation involves an inner cell maturing into a spore and an outer cell nurtu

229 mbrane and the cell wall before reaching the inner cell membrane for subsequent viral DNA injection.

230 al toxins that spontaneously insert into the inner cell membrane of sensitive bacteria to form voltag

231 ent within the processes and adjacent to the inner cell membrane of the differentiated astrocytes.

232 the movement of the T4 endolysin though the inner cell membrane to its target, the cell wall.

233 not kill the host cells) associates with the inner cell membrane, suggesting a possible correlation b

234 s, and thus the kinase, are clustered on the inner cell membrane.

235 ttributed to the mitochondria as well as the inner cell membrane.

236 Second, cAMP promotes the death of inner cells occupying the lumen.

237 acellular matrix (ECM), and the apoptosis of inner cells of acini lacking contact with the ECM.

238 mitive endoderm differentiation, even in the inner cells of ES cell aggregates.

239 ve apical constriction to position the first inner cells of living mouse embryos.

240 polarization of outer cells and apoptosis of inner cells of the acinus.

241 ers likely contributed to reduction of Na in inner cells of the tips.

242 yo, but the continuous cell-cell contact of ;inner' cells of the morulae seemingly precludes formatio

243 y more of these organelles located along the inner cell periphery.

244 th rate, the termini usually remain near the inner cell pole and migrate to the cell centre in the mi

245 one arrestin from cone outer segments to the inner cell regions was disrupted in the absence of GC1,

246 cells differentiate into trophectoderm while inner cells retain pluripotency to become inner cell mas

247 The MUC1 CT was detected at the inner cell surface, in the cytosol, and in the nucleus o

248 solid cell mass by the apoptotic removal of inner cells that do not contact the basement membrane (B

249 en placenta or asymmetric that gives rise to inner cells that generate the embryo proper.

250 bles the tumor to minimize the distance from inner cells to external nutrients, contributing to cance

251 mally enlarged vacuoles and a poorly defined inner cell wall layer, which consequently results in dis

252 0 residues were assigned to positions at the inner, cell-wall-facing lattice surface, while 5 residue