ライフサイエンスコーパス: inner cell mass

1 culture display abnormal expansion of their inner cell mass.

2 s but was undetectable in blastomeres of the inner cell mass.

3 iimplantational lethality and defects in the inner cell mass.

4 ells and governing the fate of the primitive inner cell mass.

5 expression became restricted to cells of the inner cell mass.

6 and cell death of both the trophectoderm and inner cell mass.

7 conceptus leads to the growth failure of the inner cell mass.

8 to Oct3/4 in mammals during formation of the inner cell mass.

9 for survival of the pluripotent cells of the inner cell mass.

10 vitro revealed impaired proliferation of the inner cell mass.

11 to two cell types, the trophectoderm and the inner cell mass.

12 ion of pluripotency and the formation of the inner cell mass.

13 of forming an epithelial layer covering, the inner cell mass.

14 omosome inactivation is then reversed in the inner cell mass.

15 rations, AMBMP caused disorganization of the inner cell mass.

16 In the embryonic tissues of the inner cell mass, a random form of XCI occurs in blastocy

17 and exhibited a cell proliferation defect in inner cell mass, accompanied by a slight decrease in Oct

18 4 h show no sign of "catch-up" growth of the inner-cell mass, although under these conditions, the tr

19 and capable of hatching and forming both an inner cell mass and a trophectoderm.

20 rsors for two cell lineages: the pluripotent inner cell mass and differentiating trophectoderm.

21 In mouse embryos, Gdf3 is expressed in the inner cell mass and epiblast, and null mutants frequentl

22 Oct4 expression becomes restricted to the inner cell mass and epiblast.

23 Initial cell lineages that presage the inner cell mass and extra-embryonic trophectoderm are es

24 therefore acts primarily in construction of inner cell mass and germ cell states rather than in the

25 Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has role

26 4 plays an essential role in maintaining the inner cell mass and pluripotence of embryonic stem (ES)

27 ereas laminin 10/11 is expressed only in the inner cell mass and polar trophectoderm.

28 wth, differentiation, and maintenance of the inner cell mass and raise the possibility that this acti

29 ows hES cell line derivation from blastocyst inner cell mass and single blastomere cells without a ne

30 ctor Sox-2 is first expressed throughout the inner cell mass and subsequently becomes localized to th

31 LRH-1 is colocalized with Oct4 in the inner cell mass and the epiblast of embryos at early dev

32 elopment is the segregation of the embryonic inner cell mass and the extra-embryonic trophectoderm.

33 n to be essential for differentiation of the inner cell mass and the formation of the primitive endod

34 nto a blastocyst with two cell lineages (the inner cell mass and the trophectoderm), migrates within

35 sion involves segregation of the pluripotent inner cell mass and the trophectoderm, a process regulat

36 nesis arise in the blastocyst, producing the inner cell mass and the trophectoderm.

37 tion mouse embryo gives rise to cells of the inner cell mass and the trophectoderm.

38 ages and further developed a 3D model of the inner cell mass and trophectoderm in which individual ce

39 Blastocyst volume and cell number (both inner cell mass and trophectoderm) were also increased w

40 (-/-) blastocysts are viable, hatch, form an inner cell mass and trophectoderm, and implant (roughly

41 blastocysts were viable, hatched, formed an inner cell mass and trophectoderm, and implanted (E4.5),

42 elopment, including the determination of the inner cell mass and trophectoderm.

43 ) blastocysts showed defective growth of the inner cell mass and, in contrast to the approximately 65

44 into basement membrane between endoderm and inner cell mass, and the ensuing differentiation of epib

45 conclude that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is

46 Cells of the inner cell mass are particularly dependent on Thoc1, as

47 fferentiation of ES cells and the blastocyst inner cell mass are poorly understood.

48 early-mid embryogenesis, particularly in the inner cell mass at E3.5, in epiblast at E6.5, and at lat

49 occurs between the pluripotent state of the inner cell mass at embryonic day 3.5 (E3.5) and the indu

50 round the time of implantation, cells of the inner cell mass cannot be maintained in vitro, and blast

51 source reduced blastocyst trophectoderm and inner cell mass cell number compared with that of embryo

52 blastocyst stage in vitro and a reduction in inner cell mass cell number in blastocysts.

53 giomotin-like 2, leads to differentiation of inner cell mass cells and compromised peri-implantation

54 g embryonic development, Cr1 is expressed in inner cell mass cells and the primitive streak, and late

55 g an enduring marker to trace the progeny of inner cell mass cells into the postimplantation visceral

56 ow the chromatin regulatory landscape in the inner cell mass cells is established from differentially

57 tem cells (hPSCs) have been derived from the inner cell mass cells of blastocysts (embryonic stem cel

58 Sin3a is essential for the maintenance of inner cell mass cells of mouse blastocysts, embryonic fi

59 lastocyst transition disrupts the ability of inner cell mass cells to adopt lineage-specific identity

60 Mammalian inner cell mass cells undergo lineage-specific different

61 A is present in both the trophectodermal and inner cell mass cells.

62 helial characteristics by the non-epithelial inner cell mass cells.

63 y 7 and reduced numbers of trophectoderm and inner cell mass cells.

64 pmt1(-/-) blastocysts failed to outgrow, and inner-cell-mass cells failed to thrive.

65 al uterus, the mouse blastocyst possesses an inner cell mass comprising two lineages: epiblast (Epi)

66 icating a trophectoderm defect, although the inner cell mass could grow in culture.

67 elop normally, but they subsequently exhibit inner cell mass death, diminished numbers of trophoblast

68 The primitive endoderm arises from the inner cell mass during mammalian pre-implantation develo

69 differentiation of pluripotent cells of the inner cell mass during the early stages of embryonic dev

70 Despite their origin from the inner cell mass, embryonic stem (ES) cells undergo diffe

71 Inner cell masses explanted from gp130(-/-) delayed blas

72 d than those from wild-type blastocysts, the inner cell mass fails to expand, and the outgrowth degen

73 3 signaling is also required to maintain the inner cell mass (from which stem cells are derived).

74 to the trophoblast of the placenta, and the inner cell mass, from which is derived the embryo proper

75 Reprogramming of genes expressed in the inner cell mass, from which ntESCs are derived, seems to

76 that resemble the cells seen in vivo in the inner cell mass has the potential to be an invaluable to

77 f geminin in the mouse prevents formation of inner cell mass (ICM) and causes premature endoreduplica

78 distinct pluripotent states representing the inner cell mass (ICM) and epiblast embryos.

79 is expressed in the pluripotent cells of the inner cell mass (ICM) and epiblast of the peri-implantat

80 cell blastomeres that will contribute to the inner cell mass (ICM) and polar trophectoderm and undert

81 cells are pluripotent cells derived from the inner cell mass (ICM) and the epiblast, and have been su

82 omeres that will generate both the embryonic inner cell mass (ICM) and the supportive trophectoderm (

83 Communication between the inner cell mass (ICM) and the trophoblast layer of the b

84 ent, genesis of the first two cell lineages, inner cell mass (ICM) and trophectoderm (TE), is depende

85 ormation of the blastocyst consisting of the inner cell mass (ICM) and trophectoderm (TE).

86 irections of differential expression between inner cell mass (ICM) and trophectoderm (TE).

87 the spatial organization and segregation of inner cell mass (ICM) and trophectoderm epithelium (TE)

88 IP in mouse embryonic stem (ES) cells and in inner cell mass (ICM) and trophectoderm of cultured blas

89 lantation development, the generation of the inner cell mass (ICM) and trophoblast lineages comprises

90 Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent

91 g early murine embryogenesis, cells from the inner cell mass (ICM) can be specified in epiblast (Epi)

92 This analysis revealed that inner cell mass (ICM) cells have unrestricted developmen

93 ells are generally derived by the culture of inner cell mass (ICM) cells, they are often assumed to b

94 ripotent human ES cells to those of isolated inner cell mass (ICM) cells.

95 expression is restricted to the pluripotent inner cell mass (ICM) cells.

96 The size of the inner cell mass (ICM) compartment is not reduced, howeve

97 In the mouse blastocyst, some cells of the inner cell mass (ICM) develop into primitive endoderm (P

98 f the mouse embryo distinguishes pluripotent inner cell mass (ICM) from differentiating trophectoderm

99 t-fertilization (dpf), and restricted to the inner cell mass (ICM) in 128-256 cell blastocysts (6dpf)

100 gregation of the trophectoderm (TE) from the inner cell mass (ICM) in the mouse blastocyst is determi

101 mation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events duri

102 traploid ESCs were able to contribute to the inner cell mass (ICM) just as diploid ESCs tagged with G

103 formation of the trophectoderm (TE) and the inner cell mass (ICM) lineages during preimplantation de

104 Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst c

105 Genesis of the trophectoderm and inner cell mass (ICM) lineages occurs in two stages.

106 ed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely e

107 r is activated in both the trophectoderm and inner cell mass (ICM) of embryos at embryonic day 3.5 vi

108 ine is distinct from both human PSCs and the inner cell mass (ICM) of human blastocysts.

109 Here we show that the inner cell mass (ICM) of Mbd3-deficient blastocysts fail

110 However, the inner cell mass (ICM) of mouse preimplantation blastocys

111 A subset of cells within the inner cell mass (ICM) of the blastocyst does not respond

112 le inner cells retain pluripotency to become inner cell mass (ICM) of the blastocyst.

113 ent epiblast precursors are specified in the inner cell mass (ICM) of the early blastocyst in a 'salt

114 The inner cell mass (ICM) of the implanting mammalian blasto

115 Cells of the inner cell mass (ICM) of the mouse blastocyst differenti

116 primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves i

117 (EPI), the two lineages specified within the inner cell mass (ICM) of the mouse blastocyst stage embr

118 versus pluripotent epiblast (EPI) within the inner cell mass (ICM) of the mouse blastocyst.

119 vel analysis of lineage specification in the inner cell mass (ICM) of the mouse blastocyst.

120 DNA methylation is first established in the inner cell mass (ICM) of the mouse blastocyst.

121 embryonic stem (ES) cells that resembles the inner cell mass (ICM) of the pre-implantation embryo.

122 lose contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of undiffer

123 ES cells are derived from mammalian inner cell mass (ICM) tissue that express the Class V PO

124 formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endo

125 X-chromosome inactivation (XCI) in the mouse inner cell mass (ICM), and reactivation of X-linked gene

126 ality is due to a defect in expansion of the inner cell mass (ICM), as Mtb(-/-) blastocysts failed to

127 ifferentiate to either trophectoderm (TE) or inner cell mass (ICM), followed by epiblast (EPI) or pri

128 contributes exclusively to the placenta, and inner cell mass (ICM), from which the embryo develops.

129 cells of the embryo proper, derived from the inner cell mass (ICM), undergo only random X inactivatio

130 egregation in the mouse embryo generates the inner cell mass (ICM), which gives rise to the pluripote

131 Here we show that inner cell mass (ICM)-generated cells expressing Blimp1,

132 be reverted to stable human preimplantation inner cell mass (ICM)-like naive states with only WNT, M

133 ablishment of the trophectoderm (TE) and the inner cell mass (ICM).

134 yonic stem (ES) cell lines, derived from the inner cell mass (ICM).

135 - blastocyst outgrowths revealed loss of the inner cell mass (ICM).

136 phectoderm (TE) and its segregation from the inner cell mass (ICM).

137 polarized trophectoderm cells from an apolar inner cell mass (ICM).

138 f primed PSCs and shares features with human inner cell mass (ICM).

139 iptional program and segregating TE from the inner cell mass (ICM).

140 antly reduced cell numbers, first within the inner cell mass (ICM; early blastocyst), and later withi

141 ll cells, the morphology appeared normal and inner cell masses (ICMs) formed, but resultant embryos h

142 Inner cell masses (ICMs) from Pdcd2(-/-) blastocysts fai

143 g labeled clones to the trophectoderm or the inner cell mass in a subset of embryos.

144 s showed greatly diminished expansion of the inner cell mass in culture, and this finding suggests th

145 s showed greatly diminished expansion of the inner cell mass in culture.

146 Sox2, and Fgf4, but when placed in vitro the inner cell mass initially proliferates and then fails to

147 lastocyst complementation, in which only the inner cell mass is formed from a few injected ES cells,

148 imitive endoderm layer on the surface of the inner cell mass is one of the earliest epithelial morpho

149 anog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeter

150 anisms through which FGF signaling regulates inner cell mass lineage restriction and cell commitment

151 establishment of trophoblast and pluriblast (inner cell mass) lineages and for subsequent development

152 trophectoderm and a subset of embryos showed inner cell mass localization.

153 outgrowth studies indicate that neither the inner cell mass nor trophectoderm survives.

154 Both embryonic stem cells (derived from the inner cell mass of a blastocyst) and adult stem cells (f

155 bryonic stem cells (HESC) generated from the inner cell mass of a human preimplantation embryo.

156 l lines are conventionally isolated from the inner cell mass of blastocysts and, in a few instances,

157 Pluripotent cells develop within the inner cell mass of blastocysts, a mosaic of cells surrou

158 lso leads to defects in the expansion of the inner cell mass of blastocysts, a transient pluripotent

159 Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in uni

160 ation of the primitive endoderm covering the inner cell mass of early mouse embryos can be simulated

161 This status is consistent with the inner cell mass of human blastocysts, where MYC transcri

162 are pluripotent cell types derived from the inner cell mass of human blastocysts.

163 pluripotent primitive ectoderm cells in the inner cell mass of mouse blastocysts.

164 hy does a totipotent state linger within the inner cell mass of mouse embryos?

165 ells co-exist and are convertible within the inner cell mass of murine blastocysts and embryonic stem

166 is significantly elevated in the presumptive inner cell mass of Oct4 null embryos, suggesting an unex

167 These cells derived from the inner cell mass of pig blastocysts are clearly distinct

168 naive type, pluripotent stem cells from the inner cell mass of porcine blastocysts by up-regulating

169 growth factor (FGF)-4 gene expression in the inner cell mass of the blastocyst and in EC cells requir

170 ence revealed that ZIP3 was expressed in the inner cell mass of the blastocyst and later during embry

171 specific developmental stages, including the inner cell mass of the blastocyst, the myotomes, and the

172 cells are clonal cell lines derived from the inner cell mass of the developing blastocyst that can pr

173 an apparently random distribution within the inner cell mass of the early blastocyst and then segrega

174 ting oogenesis and partitioning cells to the inner cell mass of the early embryo.

175 At E4.0 the inner cell mass of the mouse blastocyst consists of a co

176 The inner cell mass of the mouse blastocyst gives rise to th

177 The inner cell mass of the mouse pre-implantation blastocyst

178 Comparison to inner cell masses of marmoset primate blastocysts identi

179 ated human cells with ES properties from the inner cell mass or developing germ cells can provide a s

180 of ER was observed in cells derived from the inner cell mass or the trophoblast.

181 and of whether the blastomere is within the inner cell mass or the trophoectoderm.

182 2C-like ES cells and show that they lack the inner cell mass pluripotency proteins Oct4 (also known a

183 emergence of three distinct populations: the inner cell mass, primitive endoderm and trophectoderm.

184 mbryos, with higher expression levels in the inner cell mass progenitor cells.

185 eover, mTOR(-/-) embryos display a lesion in inner cell mass proliferation, consistent with the inabi

186 (ESC), which are derived from the blastocyst inner cell mass, retain properties of self-renewal and t

187 C phenotypes with simultaneous activation of inner cell mass-specific gene expression.

188 velopmental pluripotency state compared with inner cell mass stage murine embryonic stem cells (mESCs

189 t after prolonged culture, the growth of the inner cell mass stopped, no visceral endoderm formed, an

190 ian embryo development is construction of an inner cell mass surrounded by a trophoectoderm (a shell

191 se (UPR) and cell signaling, is required for inner cell mass survival during early embryonic developm

192 , around implantation, epiblast cells of the inner cell mass that give rise to the embryo reactivate

193 lastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis.

194 to the embryonic part (region containing the inner cell mass) that will give rise to the embryo prope

195 to the center of the embryo to establish the inner cell mass-the early precursor of the fetus.

196 onic from extra-embryonic tissues within the inner cell mass to generate the epiblast (EPI), which wi

197 did not progress much further even when the inner cell mass was 'rescued' from the abnormal placenta

198 racteristics of endoderm, trophectoderm, and inner cell mass were observed in the outgrowth of the ha

199 Inner cell masses were isolated by immunosurgery and pla

200 hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro.

201 genes have minimal epigenetic memory in the inner cell mass, whereas others may require active erasu

202 thought to be functionally equivalent to the inner cell mass, which lacks the ability to produce all

203 derm layer, but could not be detected in the inner cell mass without prior fixation and permeabilizat

204 expanded stage a 20% cellular deficit in the inner-cell mass without any change in trophectoderm cell