ライフサイエンスコーパス: inner leaflet

1 outer leaflet and phospholipids (PLs) at the inner leaflet.

2 leoyl-phosphatidylethanolamine (POPE) in the inner leaflet.

3 PSs are needed for lo phase induction in the inner leaflet.

4 eaflet, pyranine detects its movement to the inner leaflet.

5 d composition similar to the plasma membrane inner leaflet.

6 lipid mixture mimicking the plasma membrane inner leaflet.

7 1with the phospholipids of the cell membrane inner leaflet.

8 with phosphatidylserine (PS) confined to the inner leaflet.

9 ating the composition of the plasma membrane inner leaflet.

10 the lipid bilayer, which is confined to its inner leaflet.

11 phosphocholine alone has been imaged on the inner leaflet.

12 et packing but also on the properties of the inner leaflet.

13 atidylserine (PS) exclusively present in the inner leaflet.

14 stablishes a peripheral association with the inner leaflet.

15 ch was passively distributed with 80% in the inner leaflet.

16 ibrate across SV to approximately 20% in the inner leaflet.

17 n the outer leaflet and phospholipids in the inner leaflet.

18 n and oligomerization on the plasma membrane inner leaflet.

19 n and the negatively charged plasma membrane inner leaflet.

20 s, whereas PS is typically found only on the inner leaflet.

21 ositides show preferential clustering in the inner leaflet.

22 tidylinositol 4,5-bisphophate (PIP2), in the inner leaflet.

23 ral to the pore that faces the lipid bilayer inner leaflet.

24 n the outer leaflet and phospholipids in the inner leaflet.

25 drug pathway at the level of the membrane's inner leaflet.

26 eracts with negatively charged lipids in the inner leaflet.

27 ed different lipid mixtures in its outer and inner leaflets.

28 ) in their outer leaflets, and DOPC in their inner leaflets.

29 sphingomyelin (SM) with cholesterol and the inner leaflet a mixture of stearoyl-oleoyl-phosphatidyls

30 different number of lipids in the outer and inner leaflet, a difference in transmembrane headgroup h

31 ) sequential molecular interactions with the inner leaflet along with Tec kinase-dependent tyrosine p

32 cyte ghosts; membrane fusion is inhibited by inner-leaflet amphiphiles of positive intrinsic curvatur

33 ng sites were identified on UraA: two in the inner leaflet and a single site in the outer leaflet.

34 bacteria is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer

35 asymmetry, with phospholipids comprising the inner leaflet and lipopolysaccharides comprising the out

36 living cell membranes, communication between inner leaflet and outer leaflet, membrane adhesion, and

37 h a 5 A-wide lateral opening in the membrane inner leaflet and physically blocks ion passage.

38 s containing phosphatidylcholine (PC) in the inner leaflet and sphingomyelin (SM) in the outer leafle

39 o peptide bonds are hydrolyzed: one near the inner leaflet and the other in the middle of the transme

40 tidylserine (restricted to the cell membrane inner leaflet) and cardiolipin (present in the inner and

41 hosphatidylinositol-4,5-bisphosphate) in the inner leaflet, and GM3 (monosialodihexosylganglioside) i

42 rdinarily sequestered in the plasma membrane inner leaflet, appears in the outer leaflet during apopt

43 leaflets of the bilayers are mixed, but the inner leaflets are not.

44 and other lipids normally sequestered to the inner leaflet become exposed at the cell surface.

45 l chains capable of interdigitating into the inner leaflet, both outer- and inner-leaflet Lo domains

46 ne (P-C6-NBD-PC) to approximately 50% in the inner leaflet by a protein-mediated process.

47 , and RcsF was thought to be tethered to the inner leaflet by its lipidated N terminus, raising the q

48 Therefore, spontaneous curvature of inner leaflets can affect formation and enlargement of f

49 d by selective reacylation of lyso-PE in the inner leaflet, can account for the compositional and arc

50 OS is unique as it achieves nearly universal inner leaflet cellular activity to enable the exit of pa

51 phase domains are induced in all quaternary inner leaflet combinations composed of PCs, PEs, PSs, an

52 used to examine co-redistributions of these inner leaflet components with IgE-Fc(epsilon)RI and oute

53 do not detectably coredistribute with these inner leaflet components.

54 bilayer covering the cell surface, with its inner leaflet composed mainly of the aforementioned none

55 ymmetric vesicles was not destabilized by an inner leaflet composed of DOPE and POPS.

56 similar number of hydrocarbon chains as the inner leaflet composed of mycolic acids covalently linke

57 had little effect upon lateral diffusion in inner leaflets composed of dioleoyl PC (i.e., diffusion

58 cyl chains, also greatly reduce diffusion of inner leaflets composed of dioleoyl PC, indicative of st

59 but did greatly reduce lateral diffusion in inner leaflets composed of PC with one saturated and one

60 ions of PS that are representative of the PM inner leaflet content.

61 hemifusion of the outer leaflet followed by inner leaflet (core) fusion.

62 mount of galactosylceramide localized in the inner leaflet decreased from 70% in pure 1-palmitoyl-2-o

63 40A away, and suggest how lipids and bilayer inner leaflet deformations may gate the channel.

64 s unknown but may be due to the induction of inner leaflet domains by the outer leaflet.

65 ribution of total mass from the outer to the inner leaflet during the fusion process could be detecte

66 which the outer leaflets are fused while the inner leaflets engage in a hemifusion diaphragm (HD).

67 en the hardened outer leaflet and the softer inner leaflet generates bending stresses in the bilayer,

68 s PtdSer increases the charge density of the inner leaflet, generating foci of enhanced charge and cu

69 ot reflected in increased lipid order in the inner leaflet, i.e., there was no detectable coupling be

70 holipids were translocated from the outer to inner leaflet in a matter of minutes and reached an equi

71 between the physical states of the outer and inner leaflets in these asymmetric LUVs becomes very wea

72 dues are located either in the region of the inner leaflet, in the center, as well as in the periplas

73 The inner leaflet is composed predominantly of zwitterionic

74 Critical concentrations at which the inner leaflet is disrupted were determined for each olig

75 composed of lipopolysaccharide (LPS) and the inner leaflet is formed by glycerophospholipid (GPL).

76 cognize membrane rafts, if they exist in the inner leaflet, is unknown.

77 Specifically, inner leaflet lateral mobility of globular actin-support

78 However, inner leaflet lipid markers are able to diffuse through

79 rs with apposed leaflets composed of typical inner leaflet lipid mixtures.

80 xchange into the outer leaflet increased the inner leaflet lipid order, suggesting significant interl

81 hosphatydic acid (DOPA), was employed as the inner leaflet lipid to coat the nano-size CaP cores, whi

82 synaptobrevin C-terminus from the vesicle's inner-leaflet lipid headgroups and pulled it deeper into

83 ntent release and dequenching coincides with inner-leaflet lipid mixing within 10 ms.

84 ecific interaction between an amino acid and inner-leaflet lipid that governs the gating transformati

85 recovery after photobleaching indicated that inner leaflet lipids are able to move through DC-SIGN mi

86 that in vesicles containing either only the inner leaflet lipids from the asymmetric vesicles or onl

87 from those in the bulk membrane, whereas the inner leaflet lipids were quite similar to those found i

88 ting into the inner leaflet, both outer- and inner-leaflet Lo domains were depleted, to a similar ext

89 aturated fluorescent lipid (NBD-DPPE), while inner-leaflet Lo domains were not.

90 Simultaneously, at the inner leaflet, long acyl-chain-containing phosphatidylse

91 a fusion-committed second intermediate; (4) inner leaflet mixing on a time scale of ca. 150 s; and (

92 Inner leaflet mixing, which has never before been shown

93 ays that monitor both total lipid mixing and inner leaflet mixing.

94 Evidently, at the instant of inner-leaflet mixing, flattening of the vesicle increase

95 It appears that the phase behavior of the inner leaflet mixtures is dominated by the intrinsic cha

96 rol (Chol), which were selected to mimic the inner leaflet of a eukaryotic plasma membrane.

97 interactions of PIP(2) molecules within the inner leaflet of a lipid bilayer membrane with possible

98 ylethanolamine and phosphatidylserine in the inner leaflet of asymmetric vesicles stabilized the form

99 outer membrane leaflet and subsequently the inner leaflet of Bacillus vesicles.

100 hospholipid that is normally confined to the inner leaflet of cell membrane bilayer, gets exteriorize

101 of lipids characteristically present in the inner leaflet of cell membranes (phosphatidylserine, pho

102 hatidylserine (PS) normally localizes to the inner leaflet of cell membranes but becomes exposed in a

103 ontaining phosphatidylserine, a lipid of the inner leaflet of cell membranes that is exposed in damag

104 o engineer hybrid structures comprised of an inner leaflet of diblock copolymer and an independent li

105 e utilized photoaffinity probes to label the inner leaflet of erythrocytes.

106 -PIP(2) into cells, and we measured D on the inner leaflet of fibroblasts and epithelial cells by usi

107 omponent of lipopolysaccharide (LPS), and an inner leaflet of glycerophospholipids (GPLs).

108 plying Mn (2+) ions on the outer but not the inner leaflet of lipid bilayers, the sidedness of protei

109 6-(13)C]galactosylceramide prefers (70%) the inner leaflet of phosphatidylcholine vesicles.

110 er membrane is an asymmetric bilayer with an inner leaflet of phospholipids and an outer leaflet of l

111 ociate more strongly with the outer than the inner leaflet of plasma membrane bilayers based on the r

112 acilitates association of the protein to the inner leaflet of plasma membrane, enhances migratory phe

113 P1A1 is a recruitment factor for FGF2 at the inner leaflet of plasma membranes that may control phosp

114 hosphatidic acid commonly present within the inner leaflet of plasma membranes, and potently disrupts

115 ate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes.

116 GalCer and localizing preferentially to the inner leaflet of POPC vesicles, dimyristoylphosphatidyle

117 while the same species incorporated into the inner leaflet of stomatocytic erythrocytes was highly di

118 w how the dimeric protein interacts with the inner leaflet of the bacterial outer membrane and that t

119 0.8 microg/mL of 1 is found, above which the inner leaflet of the bilayer is significantly perturbed.

120 atively charged phospholipids located in the inner leaflet of the bilayer membrane.

121 Substrate binding from the inner leaflet of the bilayer releases the protons and tr

122 CADs are known to accumulate in the inner leaflet of the cell membrane where they bind to an

123 e membranes by interacting directly with the inner leaflet of the cell membrane.

124 ions where the PS content mimics that in the inner leaflet of the cell plasma membrane, the interacti

125 cteria, phospholipids are synthesized on the inner leaflet of the cytoplasmic membrane and must trans

126 diacylglycerol from the outer leaflet to the inner leaflet of the cytoplasmic membrane where DAGK's a

127 Injected CagA localizes to the inner leaflet of the host cell membrane, where it hijack

128 nantly localized in reticulate bodies on the inner leaflet of the inclusion membrane.

129 s have portals open to the cytoplasm and the inner leaflet of the lipid bilayer for drug entry.

130 the first nucleotide binding domain near the inner leaflet of the lipid bilayer.

131 rane phospholipid normally restricted to the inner leaflet of the lipid bilayer.

132 YidC.ribosome nascent chain complexes at the inner leaflet of the lipid bilayer.

133 a hydrophilic groove that is embedded in the inner leaflet of the lipid bilayer.

134 )P(2) can flip from the outer leaflet to the inner leaflet of the membrane.

135 /acyl-acyl carrier protein synthetase on the inner leaflet of the membrane.

136 rming a 20-A-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore

137 he inner membrane (IM) or transferred to the inner leaflet of the outer membrane (OM).

138 This requires Fe(3+) loading of Fbp at the inner leaflet of the outer membrane.

139 c domains of the T cell receptor bind to the inner leaflet of the plasma membrane (PM), and a previou

140 troviral structural protein Gag binds to the inner leaflet of the plasma membrane (PM), and many cell

141 Within infected cells VP40 localizes at the inner leaflet of the plasma membrane (PM), binds lipids,

142 hospholipid, is predominantly located in the inner leaflet of the plasma membrane and has been propos

143 VP40 interactions with lipid vesicles or the inner leaflet of the plasma membrane are electrostatic b

144 mally, phosphatidylserine is confined to the inner leaflet of the plasma membrane by an aminophosphol

145 ytosol, Ras proteins must be targeted to the inner leaflet of the plasma membrane for biological acti

146 own for targeting the Gag polyprotein to the inner leaflet of the plasma membrane for virus budding,

147 sion of proteins residing exclusively on the inner leaflet of the plasma membrane is regulated has be

148 Surface charges at the inner leaflet of the plasma membrane may contribute to r

149 Ebola virus assembles and buds from the inner leaflet of the plasma membrane of mammalian cells,

150 ns of Igalpha/Igbeta that is targeted to the inner leaflet of the plasma membrane of primary pro-B ce

151 phospholipid that resides exclusively on the inner leaflet of the plasma membrane of resting mammalia

152 yn kinase and other proteins anchored to the inner leaflet of the plasma membrane redistribute select

153 Ras proteins on the inner leaflet of the plasma membrane signal from transie

154 etrovirus assembly, Gag proteins bind to the inner leaflet of the plasma membrane to initiate the bud

155 nus of podocin/MEC-2 has to be placed at the inner leaflet of the plasma membrane to mediate choleste

156 (MARCKS) sequesters phosphoinositides at the inner leaflet of the plasma membrane until MARCKS dissoc

157 K-Ras attaches to the inner leaflet of the plasma membrane via a farnesylated

158 ues and acidic phospholipids enriched in the inner leaflet of the plasma membrane were required for b

159 3) (or PIP(3)) is generated primarily in the inner leaflet of the plasma membrane where it is believe

160 basic JMD also binds to acidic lipids in the inner leaflet of the plasma membrane, and this interacti

161 from the site of protein translation to the inner leaflet of the plasma membrane, are poorly underst

162 umerous but the organization of PIP 2 in the inner leaflet of the plasma membrane, as well as the fac

163 yotic cells, an actin-based cortex lines the inner leaflet of the plasma membrane, endowing the cells

164 ospholipids are critical constituents of the inner leaflet of the plasma membrane, ensuring appropria

165 Several proteins expressed at the inner leaflet of the plasma membrane, including alpha-ac

166 Ras, a small GTPase found primarily on the inner leaflet of the plasma membrane, is an important si

167 erine (PS), a lipid normally confined to the inner leaflet of the plasma membrane, is exported to the

168 lserine, which is normally restricted to the inner leaflet of the plasma membrane, is exposed on the

169 tidylserine (PS), normally restricted to the inner leaflet of the plasma membrane, is exposed on the

170 aM; this suggests that they also bind to the inner leaflet of the plasma membrane, reducing its negat

171 olipids that are normally sequestered to the inner leaflet of the plasma membrane, suggesting a role

172 osphate (PIP(3)) are normally located in the inner leaflet of the plasma membrane, where these anioni

173 noglycerophospholipids from the outer to the inner leaflet of the plasma membrane.

174 its major matrix protein to assemble at the inner leaflet of the plasma membrane.

175 re might be different pools of PIP(2) on the inner leaflet of the plasma membrane.

176 ading to net transport from the outer to the inner leaflet of the plasma membrane.

177 yrosine kinase Lyn, which is anchored to the inner leaflet of the plasma membrane.

178 tion occurs was found to be localized at the inner leaflet of the plasma membrane.

179 slocation of additional FA from the outer to inner leaflet of the plasma membrane.

180 re concentrated near the surface zone of the inner leaflet of the plasma membrane.

181 to simulate the presentation of cdE2 on the inner leaflet of the plasma membrane.

182 cells or anchored (via LynB protein) to the inner leaflet of the plasma membrane.

183 ids interact with the transporter within the inner leaflet of the plasma membrane.

184 e phospholipids, is normally confined to the inner leaflet of the plasma membrane.

185 tment of cytosolic signaling proteins to the inner leaflet of the plasma membrane.

186 f an endogenous actin cortex attached to the inner leaflet of the plasma membrane.

187 ylinositol 3,4,5-trisphosphate (PIP3) in the inner leaflet of the plasma membrane.

188 e charges facing the lipid phosphates of the inner leaflet of the plasma membrane.

189 well established that VP40 assembles on the inner leaflet of the plasma membrane; however, the mecha

190 well established that VP40 assembles on the inner leaflet of the plasma membrane; however, the mecha

191 ds electrostatically to acidic lipids on the inner leaflet of the plasma membrane; interaction with C

192 ipid is restricted almost exclusively to the inner leaflet of the plasmalemma.

193 ost abundant negatively charged lipid on the inner leaflet of the PM and makes a major contribution t

194 In a typical mammalian cell, the inner leaflet of the PM is enriched in phosphatidylserin

195 uses an increased cholesterol content on the inner leaflet of the PM, associated with increased Rac1

196 l and envelope proteins while binding to the inner leaflet of the PM.

197 sic Gag MA domain and the negatively charged inner leaflet of the PM.

198 53, the only lipoprotein associated with the inner leaflet of the Tp OM.

199 arcoplasmic reticulum (JSR) membrane and the inner leaflet of the transverse tubular ("T") sarcolemma

200 lindrical matrix protein layer linked to the inner leaflet of the viral envelope and with local order

201 wo interior layers of density apposed to the inner leaflet of the viral lipid bilayer were assigned a

202 he MA tyrosine kinase is associated with the inner leaflet of the viral membrane, while the tyrosine-

203 enhanced YFP that was incorporated into the inner leaflet of the viral membrane.

204 RV matrix protein VP40 (mVP40) underlies the inner leaflet of the virus and regulates budding from th

205 iffusion coefficient for other lipids on the inner leaflet of these cell membranes.

206 e show that PS is normally restricted to the inner leaflet of these cells.

207 at approximately two thirds of the PIP(2) on inner leaflet of these plasma membranes is bound reversi

208 The inner leaflet of this membrane likely is composed nearly

209 of fluorescent phospholipid in the outer and inner leaflets of Bacillus vesicles at the completion of

210 ms of domain induction between the outer and inner leaflets of cell plasma membranes do not necessari

211 nching of AOFA fluorescence in the outer and inner leaflets of the bilayer allows flip-flop to be sep

212 metrically distributed between the outer and inner leaflets of the plasma membrane in eukaryotic cell

213 ion by EM revealed immunoreactivity with the inner leaflets of the plasma membrane.

214 This suggests the inner-leaflet-ordered domains were depleted in unsaturat

215 acterize how outer-leaflet Lo domains induce inner-leaflet-ordered domains, i.e., interleaflet coupli

216 BD-DOPE) was depleted in both the outer- and inner-leaflet-ordered domains.

217 en SM-rich outer-leaflet-ordered domains and inner-leaflet-ordered domains.

218 This architecture prevents access of inner leaflet phospholipids to the pore, but allows oute

219 is dynamically regulated by multiple anionic inner leaflet phospholipids.

220 te plasma membrane and results in sorting of inner leaflet phospholipids.

221 In contrast, when incorporated into inner leaflets, positive curvature agents led to full fu

222 n to have merged outer leaflets and distinct inner leaflets prior to formation of fusion pores.

223 tion sites on Lyn, was compared with another inner leaflet probe, EGFP-GG, which contains a prenylati

224 sibility that PE and PS could participate in inner-leaflet raft formation or stabilization.

225 eaflets of two bilayers are combined and the inner leaflets remain intact; however, hemifusion has be

226 egative countercharges within the membrane's inner leaflet remains intact in the closed conformation.

227 tively charged fluorescent lipids, while the inner leaflet remains unaffected.

228 s may have on the lipids and proteins of the inner leaflet remains unknown.

229 eptor laden exterior membrane leaflet to the inner leaflet, representing a potential mechanism for li

230 Two long loops extend into the inner leaflet side of the cell membrane.

231 noglycerophospholipids from the outer to the inner leaflet, stimulated via phosphorylation by cortica

232 symmetric plasma membrane has a destabilized inner leaflet that facilitates membrane fusion upon bind

233 with net positive curvature is formed by the inner leaflets that compose a hemifusion diaphragm.

234 when the Arg(694) side chain snorkels to the inner leaflet, the MSD peptide assumes a metastable conf

235 events the translocation of tetramers to the inner leaflet, thereby forestalling the formation of com

236 vely unfolded, it could anchor gravin to the inner leaflet through hydrophobic insertion of its N-ter

237 addition of Mg2+ increased the amount on the inner leaflet to approximately 30% by an unknown mechani

238 The two pairs of helices converge at the inner leaflet to create an intramembrane pocket with add

239 s a matrix layer beneath the plasma membrane inner leaflet to facilitate budding from the host cell.

240 pers, which scan the plasma membrane and its inner leaflet to flip lipophilic substrates to the outer

241 r stroke for movement of drug substrate from inner leaflet to outer leaflet of lipid bilayer.

242 erine (PS) is moved from the plasma membrane inner leaflet to the outer leaflet where it triggers rec

243 creased, whereas that in the DOPC-containing inner leaflet was largely unchanged, confirming asymmetr

244 usion, lower concentrations of amphipaths in inner leaflets were required to promote transfer of aque

245 in specifically binds to the plasma membrane inner leaflet where it recognizes the target lipids phos

246 e majority of cholesterol was located on the inner leaflet, whereas on upregulation of transporters b