ライフサイエンスコーパス: inner medullary

1 in-regulated urea transporter protein in the inner medullary base, and Northern analysis showed no ch

2 In summary, AC6 expression determines inner medullary cAMP formation and AQP2 phosphorylation

3 re, AC6-deficient mice lacked dDAVP-promoted inner medullary cAMP formation and phosphorylation of se

4 reover, mice lacking AC6 had lower levels of inner medullary cAMP, reduced abundance of phosphorylate

5 tagonist PSB-0739 in primary cultures of rat inner medullary CD cells potentiated the expression of A

6 GPC protects inner medullary cells against the perturbing effects of

7 We demonstrate that renal inner medullary cells are able to efficiently repair hyp

8 As with adapted cells in culture, inner medullary cells in normal mice exhibit numerous DN

9 g organic osmolyte that accumulates in renal inner medullary cells in response to high NaCl and urea.

10 Renal inner medullary cells in vivo are normally exposed to a

11 ylates proteins in mIMCD3 cells and in renal inner medullary cells in vivo.

12 the hyperosmotic stress resistance of renal inner medullary cells is based not only on adaptations t

13 in the interstitial fluid surrounding renal inner medullary cells varies with operation of the renal

14 s (mediating salt and water absorption), and inner medullary cells, which mediate all three types of

15 ndant and relatively nonabundant proteins in inner medullary collecting duct (IMCD) altered in abunda

16 Mineralocorticoid receptors in the inner medullary collecting duct (IMCD) are protected fro

17 ssin increases the water permeability of the inner medullary collecting duct (IMCD) by inducing traff

18 Immunoblots using membrane fractions from inner medullary collecting duct (IMCD) cell suspensions

19 c phosphodiesterase (PDE5) activity in renal inner medullary collecting duct (IMCD) cells contributes

20 ANP-dependent cGMP accumulation by isolated inner medullary collecting duct (IMCD) cells from both S

21 ted protein (NRP) is found on the surface of inner medullary collecting duct (IMCD) cells in culture

22 Intercalated and inner medullary collecting duct (IMCD) cells of the kidn

23 the responsiveness of isolated glomeruil and inner medullary collecting duct (IMCD) cells to ANP and

24 ble contribution of COX-2 to the survival of inner medullary collecting duct (IMCD) cells under hyper

25 In inner medullary collecting duct (IMCD) cells, acid secre

26 ers branching morphogenesis and migration of inner medullary collecting duct (IMCD) cells, and suppor

27 Absorption of urea in the renal inner medullary collecting duct (IMCD) contributes to hy

28 ndance of the apical urea transporter of the inner medullary collecting duct (IMCD) is regulated in v

29 ated urea transporter (UT-A) in the terminal inner medullary collecting duct (IMCD) permits very high

30 Although the inner medullary collecting duct (IMCD) plays a major rol

31 is was investigated in isolated perfused rat inner medullary collecting duct (IMCD) segments using co

32 Urea permeability was measured in perfused inner medullary collecting duct (IMCD) subsegments from

33 lated phosphorylation events in isolated rat inner medullary collecting duct (IMCD) suspensions.

34 P regulates water reabsorption by the kidney inner medullary collecting duct (IMCD) through the inser

35 Mice lacking the inner medullary collecting duct (IMCD) urea transporter

36 To investigate the role of inner medullary collecting duct (IMCD) urea transporters

37 insulin regulates NO production in the renal inner medullary collecting duct (IMCD), the segment with

38 We have reported the presence of an inner medullary collecting duct (IMCD)-specific enhancer

39 in (AVP) and hyperosmolality in rat terminal inner medullary collecting duct (IMCD).

40 of Henle and a less well defined role in the inner medullary collecting duct (IMCD).

41 id transepithelial urea transport across the inner medullary collecting duct (IMCD).

42 in transepithelial anion secretion by renal inner medullary collecting duct (IMCD, mIMCD-K2 cell lin

43 Proteomic analysis of Inner Medullary Collecting Duct (IMCD3) cells adapted to

44 other claudins, was initially identified in inner medullary collecting duct (IMCD3) cells by gene ar

45 to detect differentially expressed genes in inner medullary collecting duct (IMCD3) cells grown unde

46 ted protein in response to osmotic stress in inner medullary collecting duct (IMCD3) cells.

47 Murine kidney cells of the inner medullary collecting duct (mIMCD) were exposed to

48 We used a cultured murine cell model of the inner medullary collecting duct (mIMCD-3 cells) to exami

49 ation of a cultured murine cell model of the inner medullary collecting duct (mIMCD-3 cells) via tran

50 es Pax2 mRNA and protein expression in mouse inner medullary collecting duct (mIMCD3) cells, and its

51 In mouse inner medullary collecting duct (mIMCD3) cells, Dragon g

52 Vipar- and Vps33b-deficient mouse inner medullary collecting duct (mIMDC-3) cells expresse

53 d osmotic water permeability in the terminal inner medullary collecting duct (tIMCD) raise luminal ca

54 detect differentially expressed proteins in inner medullary collecting duct 3 (IMCD3) cells grown un

55 gic inhibition of p38MAPK activity in murine inner medullary collecting duct 3 (mIMCD3) cells decreas

56 transition zone of cilia in cultured murine inner medullary collecting duct 3 (mIMCD3) renal cells.

57 alpha (PI3K-C2alpha) in renal tubule-derived inner medullary collecting duct 3 cells and show that PI

58 id transepithelial urea transport across the inner medullary collecting duct and plays a major role i

59 criptional targets of aldosterone in a mouse inner medullary collecting duct cell line and found that

60 311, Leu-322, and Leu-323, or Phe-340 in the inner medullary collecting duct cell line IMCD.

61 s of cystin expression are low, we generated inner medullary collecting duct cell lines that stably e

62 transiently overexpressed the constructs in inner medullary collecting duct cells (IMCD-3 cell line)

63 itutively in long term cultures of polarized inner medullary collecting duct cells (mIMCD-3).

64 70 superfamily that is up-regulated in renal inner medullary collecting duct cells (mIMCD3 cells) dur

65 ell cycle delay and apoptosis in mouse renal inner medullary collecting duct cells (mIMCD3) and incre

66 ugs individually and in combination on mouse inner medullary collecting duct cells (mIMCD3).

67 collecting ducts, and in cultured outer and inner medullary collecting duct cells (mOMCD1 and mIMCD3

68 carried out phosphoproteomic analysis of rat inner medullary collecting duct cells by using a combina

69 inally, patch-clamp studies in primary mouse inner medullary collecting duct cells did not detect ENa

70 ype intercalated cells, principal cells, and inner medullary collecting duct cells do not.

71 stimulated edn1 mRNA in acutely isolated rat inner medullary collecting duct cells ex vivo and ET-1 p

72 similar to cells lacking PC2, NEK8-depleted inner medullary collecting duct cells exhibited a defect

73 AngII-treated inner medullary collecting duct cells exhibited augmente

74 e call Thm1 and which encodes THM1) in mouse inner medullary collecting duct cells expressing an IFT8

75 Madin-Darby canine kidney cells and in mouse inner medullary collecting duct cells in isotonic medium

76 r, and genetic knockdown of TRIP13 in murine inner medullary collecting duct cells in the presence of

77 A occurred in cortical, outer medullary, and inner medullary collecting duct cells in vitro.

78 In vivo, inner medullary collecting duct cells may regulate urea

79 escribed for the bradykinin B(2) receptor in inner medullary collecting duct cells of the kidney.

80 Furthermore, ptip null inner medullary collecting duct cells were sensitive to

81 by hypertonicity is isoform-specific, renal inner medullary collecting duct cells were stably transf

82 ngII induced BdkrB2 mRNA expression in mouse inner medullary collecting duct cells, and this effect w

83 We find that in mouse inner medullary collecting duct cells, high NaCl increas

84 In cultured inner medullary collecting duct cells, HSP expression wa

85 lized retinal pigmented epithelial and mouse inner medullary collecting duct cells-3.

86 a plasma membrane Cl(-) conductance in renal inner medullary collecting duct cells.

87 expression of this receptor in cultured rat inner medullary collecting duct cells.

88 expression through a p38 MAPKbeta pathway in inner medullary collecting duct cells.

89 Immunoblotting of proteins from rat kidney inner medullary collecting duct endosomes with CaR-speci

90 ubunit of Na/K-ATPase in cells of the murine inner medullary collecting duct line (IMCD3) by activati

91 lex regulatory circuitry in the cells of the inner medullary collecting duct linking two independent

92 nel subunit alpha (alpha-ENaC) gene in mouse inner medullary collecting duct mIMCD3 cells and mouse k

93 d represses the alpha-ENaC promoter in mouse inner medullary collecting duct mIMCD3 cells, and that a

94 n isolated renal collecting ducts, and in an inner medullary collecting duct mouse cell line.

95 egments from the proximal tubule through the inner medullary collecting duct of rat kidneys.

96 In the inner medullary collecting duct of the terminal nephron,

97 unique phosphoproteins were identified from inner medullary collecting duct samples treated short-te

98 Rat inner medullary collecting duct suspensions were incubat

99 Cells derived from the inner medullary collecting duct undergo in vitro branchi

100 tachment, apical membranes of cultured renal inner medullary collecting duct were biotinylated, the c

101 his study, we established stable IMCD (mouse inner medullary collecting duct) cell lines, in which FP

102 g and uniform in the epithelial cells of the inner medullary collecting duct, and in epithelial cells

103 NA knockdown of GDPD5 increases GPC in mouse inner medullary collecting duct-3 cells, and over expres

104 s and mislocalization of E-cadherin in mouse inner medullary collecting duct-3 renal tubular cells.

105 sm in the medullary thick ascending limb and inner medullary collecting duct.

106 segments with the highest expression in the inner medullary collecting duct.

107 of 25 TRs that are also expressed in native inner medullary collecting duct.

108 lates adenylyl cyclase activity in the renal inner medullary collecting duct.

109 ated adenylyl cyclase activity in the intact inner medullary collecting duct.

110 essin increases UT-A1 phosphorylation in rat inner medullary collecting duct; (3) UT-A protein abunda

111 ncreases the phosphorylation of UT-A1 in rat inner medullary collecting duct; (b) UT-A1 protein abund

112 timulates urea transport across rat terminal inner medullary collecting ducts (IMCD) by increasing th

113 We employed proteomic analysis of inner medullary collecting ducts (IMCD) from rats fed wi

114 dly increases urea transport in rat terminal inner medullary collecting ducts (IMCD).

115 Rat inner medullary collecting ducts (IMCD3s) possess a lumi

116 nduces a change in urea transport in initial inner medullary collecting ducts (IMCDs) which could con

117 In isolated inner medullary collecting ducts (IMCDs), vasopressin (0

118 hannel and may shed light on the function of inner medullary collecting ducts and polycystins.

119 staining of glomeruli, proximal tubules, or inner medullary collecting ducts was found.

120 the apical region of the principal cells of inner medullary collecting ducts.

121 We made use of primarily cultured rat renal inner medullary collecting-duct cells and microarray ana

122 ing ability of AQP3 null mice was due to the inner medullary collecting-duct water channel AQP4, AQP3

123 novel 3D cell culture model that uses mouse inner-medullary collecting duct (mIMCD3) cells to genera

124 -ATPase are up-regulated by hypertonicity in inner-medullary collecting duct cells adapted to survive

125 Although cultured inner-medullary collecting duct cells lacked the gamma s

126 Previous studies showed that renal inner medullary epithelial (IME) cells respond to hypert

127 that Pax2 expression in second-passage mouse inner-medullary epithelial cells is increased by a high

128 eins are induced by hyperosmolality in renal inner medullary (IM) cells, but their role for cell adap

129 Hypertonic stress induced in inner medullary (IMCD3) cells by addition of NaCl to the

130 Similarly, 24 h of dehydration increased inner medullary inositol, sorbitol, and betaine concentr

131 Further, the lower renal inner medullary interstitial NaCl concentration that occ

132 of urea transport from the IMCD lumen to the inner medullary interstitium, resulting in osmotic diure

133 th altered water balance, immunoblots of rat inner medullary membrane fractions were probed with rabb

134 reactive oxygen species (ROS) in mouse renal inner medullary (mIMCD3) cells in culture.

135 here were no significant differences in mean inner medullary Na(+) or Cl(-) concentrations between UT

136 o-Cys-1,d-Arg-8 vasopressin, which increases inner-medullary NaCl concentration, causes a 4-fold incr

137 Treatment with furosemide, which decreases inner-medullary NaCl, reduces inner-medullary Pax2 mRNA

138 Moreover, inner medullary Osp94 expression was increased during wa

139 hich decreases inner-medullary NaCl, reduces inner-medullary Pax2 mRNA and protein.

140 l concentration, causes a 4-fold increase in inner-medullary Pax2 protein.

141 lization of both AQP2 and pAQP2 in the renal inner medullary principal cells appeared more dispersed,

142 in urea transporter mRNA abundance in either inner medullary region.

143 significantly increased UT-A1 protein in the inner medullary tip after 7 d, whereas aldosterone reple

144 both membrane and vesicle fractions from the inner medullary tip of adrenalectomized rats.

145 rsed UT-A1 protein abundance increase in the inner medullary tip of adrenalectomized rats.

146 vesicle fraction proteins were isolated from inner medullary tip or base and Western analysis was per

147 s from the cortico-medullary boundary to the inner medullary tip.

148 Analysis of inner medullary tissue after water restriction revealed