ライフサイエンスコーパス: inner segment

1 of early redistribution of cone opsin to the inner segment.

2 hodopsin mislocalization in membranes of the inner segment.

3 Ca2+ conductance (gCa) in the photoreceptor inner segment.

4 orporation of molecules transported from the inner segment.

5 of post-Golgi rhodopsins retains them in the inner segment.

6 tors consist of an outer segment (OS) and an inner segment.

7 ceptors and the periciliary extension of the inner segment.

8 ty is present almost exclusively in the cone inner segment.

9 mtDNA damage, primarily in the photoreceptor inner segments.

10 nd inner plexiform layers, and photoreceptor inner segments.

11 The IR is predominately expressed in rod inner segments.

12 increase was localized to the photoreceptor inner segments.

13 tic terminals and became undetectable in the inner segments.

14 sorganization of the photoreceptor outer and inner segments.

15 in, but only in moving from the outer to the inner segments.

16 plexiform layer as well as to photoreceptor inner segments.

17 ssed constitutively on RPE and photoreceptor inner segments.

18 y on RPE and in high levels on photoreceptor inner segments.

19 ression in the photoreceptor cell bodies and inner segments.

20 e it appeared to be most concentrated in the inner segments.

21 Cone cells in the periphery had remnants of inner segments.

22 e ERG are truncated with shortened outer and inner segments.

23 ferentiation and was immediately targeted to inner segments.

24 xtracellular vesicles surrounding the distal inner segments.

25 toreceptors, localizing predominantly in the inner segments.

26 are retinal cells, especially photoreceptor inner segments.

27 t closely resembles rdgC is localized to rod inner segments.

28 iched in biochemical extracts of retinal rod inner segments.

29 tive stress was noted in their photoreceptor inner segments.

30 9-1 and Gbeta5L are primarily located in rod inner segments.

31 GS9-1 from R9AP and redistributing it to rod inner segments.

32 ary dendrites and HR2 mRNA was found in cone inner segments.

33 uperior central retina, within photoreceptor inner segments, 24 hours after light treatment, but decl

34 Of all adult cone inner segments, 88-90% contained L/M opsin mRNA, whereas

35 ctivity and, thus, is likely to regulate the inner segment actin cytoskeleton.

36 s a role in the assembly or stabilization of inner segment and calycal process actin filament bundles

37 actin filament bundles of the photoreceptor inner segment and calycal processes.

38 toresponse, mislocalization of ATP8A2 to the inner segment and cell body, and increased apoptosis in

39 ppears to affect the shape of the OS, as the inner segment and connecting cilium remain intact.

40 with GTP-locked mutants concentrated in the inner segment and GDP-locked mutants concentrated in the

41 remaining P23H-hRho-GFP mislocalizes to the inner segment and outer nuclear layer, with only approxi

42 In control mice REEP6 was localized to the inner segment and outer plexiform layer of rod photorece

43 horoid, retina pigment epithelium (RPE), and inner segment and outer segment (IS/OS) junction.

44 attachment of the ERM (P = .003), and foveal inner segment and outer segment junction disruption (P =

45 ed only in rod photoreceptors, mainly in the inner segment and perinuclear region.

46 ion of vacuole-like structures at the apical inner segment and reduction in selected rod phototransdu

47 It is localized to the inner segment and synapse in photoreceptor cells, and wh

48 ically, IMPDH1 is found predominately in the inner segment and synaptic terminals of retinal photorec

49 in and the ribbons in hair cells, and in the inner segment and the axon of the photoreceptor, consist

50 sed by protein transport defects between the inner segment and the outer segment of the photoreceptor

51 calization and aggregation of S-opsin in the inner segment and the synaptic region of rods, ER stress

52 identified that rhodopsin accumulates in the inner segments and around the nucleus of photoreceptors.

53 soform of Hmgb1 was present in photoreceptor inner segments and bound to a membrane fraction with cha

54 or cell death, rhodopsin was mislocalized in inner segments and cell bodies of Rp1(-/-) rods.

55 In the photoreceptor inner segments and cells expressing enhanced green fluor

56 ation of apical cell features: photoreceptor inner segments and cilia in renal and auditory systems.

57 affects retinoid metabolism in photoreceptor inner segments and delays the kinetics of dark adaptatio

58 ic terminals and, to a lesser degree, in rod inner segments and inner retinal neurons.

59 genes at the cell membranes of photoreceptor inner segments and Muller cell apical processes in the z

60 s retained cone nuclei, albeit with abnormal inner segments and OS.

61 erly, and some OS markers mislocalize to the inner segments and outer nuclear layer in the Nphp4(nmf1

62 enolase1 co-localized with arrestin1 in the inner segments and outer nuclear layer, but remained in

63 crystallin localization in the photoreceptor inner segments and outer plexiform layer in the WT contr

64 retina, where it was localized mostly in the inner segments and outer plexiform layer of photorecepto

65 Muller and RPE cells that extend between the inner segments and outer segments of photoreceptors, res

66 Arrestin localizes predominantly to the inner segments and perinuclear region of dark-adapted ro

67 r, mutant receptors were mislocalized to the inner segments and perinuclear region.

68 birth; in the adult, PMCA2 was expressed in inner segments and synaptic terminals of rod photorecept

69 imilarly in the outer retina, especially the inner segments and synaptic terminals of rod photorecept

70 ired to maintain baseline [Ca(2+)](i) in rod inner segments and synaptic terminals.

71 mas at birth but only later were targeted to inner segments and synaptic terminals.

72 a(2+)](i) to below prestimulus levels in rod inner segments and synaptic terminals.

73 gal staining was restricted to photoreceptor inner segments and synaptic termini.

74 sst(2A) immunostaining was seen in the inner segments and terminals of rod and cone photorecept

75 ow that RDH12 localizes to the photoreceptor inner segments and that deletion of this gene in mice sl

76 n, cGK I mRNA was localized to photoreceptor inner segments and the ganglion cell and inner nuclear l

77 MrdgB protein is localized to photoreceptor inner segments and the outer and inner plexiform layers.

78 s showed DRAM2 localization to photoreceptor inner segments and to the apical surface of retinal pigm

79 , it was localized to the connecting cilium, inner segment, and synapse.

80 that opsin accumulates initially within the inner segment, and then in the plasma membrane.

81 retinas, ZBED4 was localized to cone nuclei, inner segments, and pedicles, as well as to Muller cell

82 inner/outer plexiform layers, photoreceptor inner segments, and RPE.

83 d mitochondrial Ca2+ stores in photoreceptor inner segments, and suggest a role for CICR in the regul

84 amounts in ganglion cells and photoreceptor inner segments as well.

85 lecular disulfide bonding may be part of RDS inner-segment assembly in cones but not in rods.

86 ha-GTP complex capable of diffusing from the inner segment back to the outer segment after light-indu

87 or weakly positive before ED13, appeared in inner segments between ED13 and ED15, became subsequentl

88 In primates GCAP2-IR was intense in the rod inner segment but faint in the rod outer segment.

89 mb prevents targeting of Cng channels to the inner segment, by promoting their trafficking through th

90 In contrast, RDH12 in inner segments can protect vital cell organelles against

91 ural subdivisions include the outer segment, inner segment, cell body, and synaptic terminal.

92 psin immunolabeling was also observed in the inner segment, cell body, axon, and axon terminal of pho

93 tissue revealed that MAK is expressed in the inner segments, cell bodies, and axons of rod and cone p

94 85R protein accumulated in the photoreceptor inner segments, cellular bodies, or both.

95 y), outer nuclear layer (ONL) (nasally), and inner segment (centrally and temporally) were found in p

96 human retina showed intense labeling of cone inner segments compared to rods.

97 Prior homogenization of the rod outer-inner segment completely prevented the long-lasting inhi

98 us, sensitization of the photovoltage by rod inner segment conductances appears to extend the operati

99 ment could not be explained by modulation of inner segment conductances or the voltage sensitivity of

100 sin-II is a molecular motor localized to the inner segment, connecting cilium and axoneme of mammalia

101 tor cells, actin and TULP1 colocalize at the inner segment, connecting cilium, and outer limiting mem

102 Photoreceptor inner segments contain LGN, which can bind to the alpha

103 gments were short and disorganized and their inner segments contained stacks of rhodopsin-positive me

104 f free [3H]DHA from ROS to the photoreceptor inner segment contributed to an additional overall incre

105 Preserved inner segments could be identified, but outer segments w

106 discs by palmitoylation, whereas ARL3 is an inner segment cytoplasmic protein.

107 tochondria cluster at the apical side of the inner segment, directly below the outer segment.

108 inal during synaptic transmission and at the inner segment during protein translocation to the outer

109 nce from the fovea to the location where the inner segment ellipsoid (ISe) band became undetectable w

110 PURPOSE; The integrity of the inner segment ellipsoid (ISe) band, previously called th

111 d into 5 distinct categories: (1) continuous inner segment ellipsoid (ISe), (2) ISe disruption, (3) I

112 Inner segment ellipsoid and relative ellipsoid reflectiv

113 la demonstrated complete preservation of the inner segment ellipsoid band in 1 patient, with variable

114 onded closely with the lateral extent of the inner segment ellipsoid band in the OCT image.

115 One patient had mild disruption of the inner segment ellipsoid band on OCT and additional mild

116 ipsoid reflectivity (defined as the ratio of inner segment ellipsoid band reflectivity on overall ret

117 Inner segment ellipsoid band reflectivity, global retina

118 inner segment-outer segment junction or the inner segment ellipsoid band was disrupted within 1 degr

119 t in 6 subjects subtle irregularities at the inner segment ellipsoid band were seen.

120 ct outer retina; stage 2 (2 patients [12%]), inner segment ellipsoid line disruption; stage 3 (5 pati

121 Inner segment ellipsoid line loss generally correlated w

122 y, global retinal reflectivity, and relative inner segment ellipsoid reflectivity (defined as the rat

123 he annual rate of change in the width of the inner segment ellipsoid zone (EZ; ie, inner/outer segmen

124 igment epithelium (RPE) band, grading of the inner-segment ellipsoid (ISe) band integrity, and presen

125 TP1 showed specific labeling of rod and cone inner segments, especially in the mitochondria-rich elli

126 velopment leads to opsin accumulation in the inner segment even when the connecting cilium and outer

127 ers of mitochondria (hepatocytes and the rod inner segment) exhibited a punctate fluorescence.

128 e spine density reduction was significant in inner segments following 7 days of treatment.

129 Movement of the inner segments further from the choroid, which occurs in

130 Conversely, unphosphorylated Pd binds to inner segment G protein(s) in the light.

131 Photoreceptor inner segments have a high O(2) demand (QO(2)), and they

132 Photoreceptor inner segments have the highest concentration of Na,K-AT

133 s were immunopositive for TRPC1 whereas cone inner segments immunostained with TRPC6 channel antibodi

134 um regulation in the photoreceptor outer and inner segments implies that transduction and synaptic si

135 ated on large punctate structures within the inner segment in ARL3-Q71L retina.

136 analysis, Pd is found almost entirely in the inner segment in both light and dark, most abundantly ne

137 Mutant PRCD C2Y was found in the inner segment in contrast to normal localization of WT P

138 rding technique and recorded from single rod inner segments in isolated intact neural mouse retinae,

139 Ultrasturctural analysis revealed intact inner segments in light-treated retinas, whereas in untr

140 tet-ARR1), stored in the outer nuclear layer/inner segments in the dark, modulates photoreceptor syna

141 Electron microscopic observations of rat rod inner segments indicated generally excellent survival of

142 dies revealed a mosaic of cone photoreceptor inner segments indistinguishable from that of neonatal r

143 14 months, including improved rod outer and inner segment integrity, less photoreceptor cell loss, a

144 However, RDH12 function in the photoreceptor inner segments is also key, because loss of function mut

145 Transport of these proteins from the inner segments is regulated by the small GTPases Rab6 an

146 major retinal layers being visible, and both inner segment (IS) and outer segment (OS) length were wi

147 e outer segment (OS) in the light and to the inner segment (IS) in the dark.

148 ro-tetramers with Rom-1 in the photoreceptor inner segment (IS), while higher-order, disulfide-linked

149 her photoreceptor compartments including the inner segments (IS) and synaptic terminals (ST) is recog

150 al antibody showed staining localized to the inner segments (IS) of photoreceptor cells, as well as t

151 The inner segments (IS) of the photoreceptors in vertebrates

152 ion in length and broadening of rod and cone inner segments (IS) was next observed, followed by the f

153 outer plexiform (OPL) layers, photoreceptor inner segments (IS), and retinal pigment epithelium (RPE

154 GB1-P/rds interaction, were initiated within inner segments (ISs) before trafficking to OSs.

155 or disruption of the photoreceptor outer and inner segment junction was noted.

156 e ONL and that of the rod outer-segment plus inner-segment layer were measured at several points alon

157 In its absence, rod photoreceptor outer and inner segment length was reduced, and cone cell numbers

158 ause retention of ABCA4 in the photoreceptor inner segment, likely by impairing correct folding, resu

159 of stable rhodopsin/arrestin complex in the inner segment may be an important mechanism for triggeri

160 ization signal distributed to both outer and inner segment membranes.

161 Morphology of the inner segment mitochondria was examined by electron micr

162 Photoreceptor inner segment morphology was markedly affected in RS(-)(

163 EM revealed abnormal inner segment morphology, particularly in rods, and diso

164 Grb14 is localized predominantly to the inner segment, nuclear layer, and synapse in dark-adapte

165 f Phd isoforms with CRX predominantly in the inner segment of cone cells, with additional costaining

166 rences in the localization of RNA within the inner segment of cone photoreceptors, suggesting that mo

167 PDE6 present in the inner segment of Rce1-deficient photoreceptor cells was

168 ffective when applied either to the outer or inner segment of red-sensitive cones.

169 bonate exerted an effect when applied to the inner segment of rods but had little efficacy when appli

170 pted retina but was more concentrated in the inner segments of dark-adapted retina.

171 Within photoreceptors, only the inner segments of frog double cones are strongly labeled

172 l layer, inner and outer nuclear layers, and inner segments of photoreceptor cells in all 17 eyes.

173 the day and night was in the vicinity of the inner segments of photoreceptor cells, supporting the id

174 the outer plexiform layer (OPL), and in the inner segments of photoreceptor cells.

175 cein-conjugated PEDF stained exclusively the inner segments of photoreceptors and cells of the gangli

176 trans-retinaldehyde, which diffuses into the inner segments of photoreceptors from illuminated rhodop

177 and human retinas, NOS-1 is expressed in the inner segments of photoreceptors, cells in the inner nuc

178 ccumulation of intracellular vesicles in the inner segments of photoreceptors, whereas immunohistoche

179 s, C.O. and NOS levels were both high in the inner segments of retinal photoreceptor cells where ener

180 Intensity of the GCAP1-IR was strong in inner segments of rods in all species but weaker in oute

181 eadily discernible changes in [Ca2+]i in the inner segments of rods, but not cones.

182 that GFP was predominantly localized to the inner segments of the major rods; a smaller amount was i

183 immunoreactivity was observed in the OPL and inner segments of the photoreceptor cells.

184 ayers of the retina but in neither outer nor inner segments of the photoreceptor layers in mice beari

185 d expression pattern but is expressed in the inner segments of the photoreceptors whilst Cds2 shows a

186 els to the more hypoxic environment near the inner segments of the photoreceptors.

187 as restricted to the outer nuclear layer and inner segments of the retina.

188 etina, though it is clearly expressed in the inner segments of the rod photoreceptors.

189 of free Ca2+ concentration ([Ca2+]i) in the inner segments of vertebrate photoreceptors.

190 demonstrate that disruption of photoreceptor inner segment-outer segment (ellipsoid) layer on SD-OCT

191 fluid, size and location of cystoid changes, inner segment-outer segment (IS-OS) continuity, quantity

192 Retinal sensitivity over lesions with intact inner segment-outer segment (IS-OS) junction was 13.35 +

193 yer (ONL), external limiting membrane (ELM), inner segment-outer segment (IS-OS) junction, outer phot

194 E nodularity (8%), photoreceptor loss (43%), inner segment-outer segment junction (IS-OS) irregularit

195 The inner segment-outer segment junction or the inner segmen

196 The intensity of inner segment/outer segment (ellipsoid zone line) reflec

197 rence tomography (SD-OCT), disruption of the inner segment/outer segment (IS/OS) band, and thinning o

198 ellipsoid (ISe) band, previously called the inner segment/outer segment (IS/OS) border, seen on opti

199 (P < .001), regardless of the photoreceptor inner segment/outer segment (IS/OS) condition.

200 red autofluorescence patterns, the status of inner segment/outer segment (IS/OS) interface, and retin

201 ers evaluated the integrity of photoreceptor inner segment/outer segment (IS/OS) junction and externa

202 The SDOCT scans showed disruption of inner segment/outer segment (IS/OS) junction in 54.6% of

203 OCT data showed a loss of the photoreceptor inner segment/outer segment (IS/OS) junction in the cent

204 d on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measure

205 Disrupted inner segment/outer segment (IS/OS) junction was noted i

206 ild-type mice demonstrated visibility of the inner segment/outer segment (IS/OS) junction, external l

207 macular defects, including disruption of the inner segment/outer segment and outer segment/retinal pi

208 er (n = 4), outer nuclear layer (n = 12), or inner segment/outer segment junction (n = 1).

209 erence tomography showed preservation of the inner segment/outer segment junction at the fovea.

210 Generalized loss of the photoreceptor inner segment/outer segment junction was seen more frequ

211 Focal loss of the inner segment/outer segment junction was seen most commo

212 Evaluation of the photoreceptor inner segment/outer segment junction, using this approac

213 SD OCT results with preserved photoreceptor inner segment/outer segment junction, whereas this junct

214 e associated with concomitant defects of the inner segment/outer segment layer.

215 In all patients, a disrupted inner segment/outer segment line and the external limiti

216 In the midperipheral retina, the rod inner segment/outer segment line was disrupted and blurr

217 s most apparent for the foveal photoreceptor inner segment (p=0.001).

218 We recorded with patch electrodes the inner segment photovoltages and with suction electrodes

219 ted (Cng) channels, which accumulates on the inner segment plasma membrane in addition to its normal

220 PNPLA6 localizes mostly at the inner segment plasma membrane in photoreceptors and muta

221 ated primarily with the outer leaflet of the inner segment plasma membrane through anionic phospholip

222 ntaining the protocadherin, PCDH21, with the inner segment plasma membrane.

223 iles in the interphotoreceptor space and the inner segment plasma membranes are immunoreactive for rh

224 ic activity (EC 3.6.1.37) in a rat rod outer-inner segment preparation.

225 Photoreceptor inner segments produce the highest of these reflections

226 The rod inner segments projected through the cone mosaic in a pr

227 estricted membrane microdomain at the apical inner segment recess that wraps around the connecting ci

228 xpression occurred almost exclusively in the inner segment region of photoreceptors.

229 They developed inner segments rich in mitochondria.

230 t GCIP identified high levels of GCIP in the inner segments, somata and synaptic terminals of frog co

231 dult retinas, anti-TULP1 labels cone and rod inner segments, somata, and synapses; outer segments are

232 g with anti-GCAP2 antibodies was in the cone inner segments, somata, and synaptic terminals and, to a

233 ucin translocates from rod outer segments to inner segments/spherules in bright light, but the functi

234 e adhesion, in maintaining the photoreceptor inner segment stability and architecture.

235 nstitutive GITRL expression on photoreceptor inner segments suggests that photoreceptors participate

236 fter methanol intoxication, with evidence of inner segment swelling and mitochondrial disruption.

237 ium regulation in the outer segment (OS) and inner segment/synaptic terminal (IS/ST) regions of rods

238 kre oko photoreceptor cells, including their inner segments, the nuclear regions, and the synaptic te

239 is localized primarily in the photoreceptor inner segments, the site of mitochondrial oxidative stre

240 lace at or near the plasma membrane from the inner segment through the connecting cilium into the out

241 ransported from the site of synthesis in the inner segment through the connecting cilium, followed by

242 within the rod photoreceptor cells from the inner segments, through the rod nuclei to the rod photor

243 ed GFP immunoreactivity in rod photoreceptor inner segments throughout the retina, indicating the rod

244 tion mechanism of 11-cis-retinal in the cone inner segment to regenerate visual pigment.

245 ts of lipid and protein to be moved from the inner segment to the OS.

246 to regulate the export of proteins from the inner segment to the outer segment sensory axoneme.

247 extending from the outer segment through the inner segment to the synaptic terminals.

248 ng PDE6) from their site of synthesis in the inner segment to their final destination in the outer se

249 achment, severely reduces the ability of the inner segments to obtain O(2), even for detachment heigh

250 ique, nonredundant role in the photoreceptor inner segments to regulate the flow of retinoids in the

251 nts aberrant transport of rhodopsin from the inner segments to the nascent disc membranes of the oute

252 to light, a leak of retinoids from outer to inner segments was detected in rods from both wild-type

253 etina due to shortening of the rod outer and inner segments was observed when compared to control lit

254 hereas in untreated retinas only remnants of inner segments were observed.

255 However, the inner segments were significantly disrupted after incuba

256 Caffeine-evoked Ca2+ responses in cone inner segments were unmasked in the presence of inhibito

257 and outer nuclear layer, but remained in the inner segments when arrestin1 translocated in response t

258 nol is transported from Muller cells to cone inner segments, where it is oxidized to 11-cis-retinal.

259 rder neurons and, to a lesser extent, to the inner segments, where polarized protein translocation oc

260 e localized exclusively in the photoreceptor inner segments, which are known to be densely populated

261 ntral cones had 2-microm-wide outer (OS) and inner segments, which came straight off the cell body.

262 conditions require a large O(2) flux to the inner segments, which in turn requires high choroidal ox

263 of the plasma membrane of the photoreceptor inner segments, which synthesize and secrete it.

264 stin, and membranes within the photoreceptor inner segment, while the localization of alpha-transduci

265 scopy showed increased autophagosomes in rod inner segments with HDAC inhibitor (HDACi) treatment, po

266 EM showed abnormal cone inner segments with swollen mitochondria.

267 dentified as cones by dual labeling of their inner segments with the lectin peanut agglutinin or by c

268 s the majority of recoverin was found in rod inner segments, with approximately 12% present in the ou

269 e most intense immunolabeling was in the rod inner segments, with weaker labeling of cone myoids, som