ライフサイエンスコーパス: innexin

1 structure-function analyses of invertebrate innexins.

2 xin genes into the large family of planarian innexins.

3 tify genes (e.g. Tomosyn, Chitinase 5, Adar, Innexin 2, Transferrin 1, Sick, Oatp26F) and Gene Ontolo

4 es a germline-specific gap junction protein, Innexin 4, that is required for survival of differentiat

5 ortholog of the Drosophila gap junction gene Innexin 7, leads to failure of cellularization.

6 These data demonstrate a critical role for innexin AGAP001476 in mediating innate immune responses

7 Innexin AGAP001476 mRNA levels in midguts were induced d

8 ty and 39-66% similarity to other Drosophila innexins and share a similar hydrophobicity profile.

9 Invertebrate innexins and their mammalian homologues, the pannexins,

10 s with connexins and evolutionarily distinct innexins and their vertebrate pannexin homologs.

11 pharynx, providing supporting evidence that innexins are components of gap junctions.

12 Thus, CALHMs, connexins, and pannexins and innexins are structurally related protein families with

13 Innexins are the proposed structural components of gap j

14 Innexins are the subunits of invertebrate gap junctions.

15 provide a relatively detailed description of innexin-based gap junctions in a native tissue and sugge

16 ed fate by GJC loss-of-function suggest that innexin-based GJC mediates instructive signaling during

17 unctions in a native tissue and suggest that innexin-based small conductance gap junctions can play a

18 Transgenic expression of the appropriate innexins during pupal development (but not later) rescue

19 Innexin expression was detected throughout the animal, a

20 Planarian innexins fall into 3 groups according to both sequence a

21 he recent identification of the invertebrate innexin family opens up powerful genetic systems to stud

22 ation and characterization of smedinx-11--an innexin gap junction channel gene expressed in the adult

23 here that a transient network formed by the innexin gap-junction protein NSY-5 coordinates left-righ

24 This study examined whether innexins, gap junction proteins in insects, are involved

25 oned and characterized the expression of the Innexin gene family during planarian regeneration.

26 The Innexin gene family forms gap junctions in invertebrates

27 ystem are assembled from two products of the innexin gene shaking-B.

28 aryngeal pumping via a pathway involving the innexin gene unc-7 and components of the glutamatergic p

29 We show here that the innexin gene unc-9 is required in RMG hub neurons to dri

30 ping suggests diversification of 3 ancestral innexin genes into the large family of planarian innexin

31 Here we investigate two Drosophila innexin genes, Dm-inx2 and Dm-inx3 and show that they ar

32 e maturation, we performed an RNAi screen of innexin genes, which encode channel-forming proteins.

33 Here we show that the innexin INX-14 promotes sperm guidance to the fertilizat

34 This wave is propagated via the innexin INX-16, likely by calcium influx.

35 Fifteen of the 21 innexin (Inx) genes (Hve-inx) found in the genome of the

36 se results reveal that expression of certain innexins is sufficient to couple individual neurons to p

37 may connect with hemichannels made of other innexin isoforms on adjacent somatic cells.

38 Connexins are unique to chordates; innexins/pannexins encode gap-junction proteins in prech

39 exins, which are exclusive to chordates, and innexins/pannexins, which are found throughout the anima

40 Members of the innexin protein family are structural components of inve

41 fically recognize the Caenorhabditis elegans innexin protein INX-3 were generated and used to examine

42 sh among gap junctions composed of different Innexin proteins (is not subject to compensation or redu

43 mediated by the central nervous system and 3 innexin proteins, which determine the fate and axial pol

44 sing targeting of the gap junctional protein innexin shaking-B to gap junctions (GJs).

45 transmembrane domain (M1) of the Drosophila innexin Shaking-B(Lethal), which is a component of recti

46 es with mutations in the gap junction genes (innexins), shakingB, and ogre have normal photoreceptor

47 our homologues of insect gap junction genes (innexins) termed vinnexins, which are expressed in multi

48 Pannexins are homologous to innexins, the invertebrate gap junction family.

49 proteins that exhibits sequence homology to innexins, the invertebrate gap junction proteins, and wh

50 ins in mammals, and 3 pannexins, homologs of innexins, the main gap junction forming proteins in inve

51 nctions with antibodies to Shaking-B (ShakB) Innexin, they were significantly decreased or absent in

52 The innexin UNC-9 appeared to be a key component of the gap