ライフサイエンスコーパス: inositol

1 transportation of food that contains the myo-inositol.

2 tryptophan, with nonsignificant results for inositol.

3 effects in animal models through lowering of inositol.

4 t can be rescued only partially by exogenous inositol.

5 nmental organic phosphates, and their parent inositols.

6 lting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate receptors (IP3Rs).

7 Inositol 1,3,4,5,6-pentakisphosphate 2-kinases (IP5 2-Ks

8 tiate the enantiotopic hydroxy groups of myo-inositol 1,3,5-orthoformate in the presence of a chiral

9 a Yb(OTf)3-catalyzed desymmetrization of myo-inositol 1,3,5-orthoformate using a proline-based chiral

10 onents required for these responses included inositol 1,3,5-triphosphate receptors, PKC, and enhancem

11 Hormone-induced inositol 1,4,5 trisphosphate (IP3 ) accumulation and pho

12 thway occurs at the level of hormone-induced inositol 1,4,5 trisphosphate (IP3 ) production and does

13 The inositol 1,4,5 trisphosphate receptor (IP3R) is an intra

14 An inositol 1,4,5-triphosphate (IP3) receptor inhibitor pre

15 an impaired thrombopoiesis and an abrogated inositol 1,4,5-triphosphate receptor-dependent intracell

16 inase A-dependent increase in the potency of inositol 1,4,5-triphosphate-induced Ca(2+) signaling und

17 ITPR1 encodes an inositol 1,4,5-triphosphate-responsive calcium channel.

18 hate (IP), inositol 4,5-bisphosphate (IP2 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexaki

19 on is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of C

20 d CaMKII activation is probably initiated by inositol 1,4,5-trisphosphate (IP3 )-mobilized Ca(2+) : 8

21 ly to involve downstream Ca(2+) release from inositol 1,4,5-trisphosphate (IP3 )-triggered Ca(2+) -st

22 nic M3 receptors, or by direct activation of inositol 1,4,5-trisphosphate (IP3) receptors by photolys

23 Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a mo

24 We used inositol 1,4,5-trisphosphate accumulation and radioligan

25 hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrop

26 y of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).

27 ol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate and diacylglycerol.

28 escent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-trisphosphate biosensor GFP-PLCdelta1-PH

29 phospholipase C beta2 and the stimulation of inositol 1,4,5-trisphosphate production.

30 is and the degradation of the Ca(2+) channel inositol 1,4,5-trisphosphate receptor (IP3R) affects pro

31 A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, wh

32 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

33 ch is blunted by internal store depletion or inositol 1,4,5-trisphosphate receptor blockade.

34 563del] and c.7659T>G [p.Phe2553Leu]) in the inositol 1,4,5-trisphosphate receptor type 1 gene (ITPR1

35 mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate receptor).

36 l melastatin subfamily 4 channels via type 2 inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) re

37 ) release through the ryanodine receptors or inositol 1,4,5-trisphosphate receptors (IP3 R) and upon

38 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a fa

39 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calc

40 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expr

41 epletion of internal stores or inhibition of inositol 1,4,5-trisphosphate receptors but not by inhibi

42 astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2

43 activity were also blunted by inhibition of inositol 1,4,5-trisphosphate receptors with 2-aminoethox

44 onse to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors

45 hatidylinositol 4-phosphate, diacylglycerol, inositol 1,4,5-trisphosphate, and Ca(2+) upon muscarinic

46 , in particular via the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comp

47 variety of inositol phosphates including myo-inositol 1,4,5-trisphosphate, which is a secondary messe

48 Stimulation of endothelial inositol 1,4,5-trisphosphate-dependent signaling with su

49 steoclast (OC) differentiation by modulating inositol 1,4,5-trisphosphate-mediated calcium oscillatio

50 mechanism involving M1/M3 receptor-mediated inositol 1,4,5-trisphosphate/Ca(+2) signalling and downs

51 discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and in

52 ned complex structure in the presence of myo-inositol-1,2,3,4,5,6-hexakisphosphate (InsP6 or phytate)

53 ndoplasmic reticulum Ca-ATPase (SERCA) pump, inositol-1,4,5-triphosphate receptor (IP3R), and Ryanodi

54 lucose-regulated protein 75), and the IP3R1 (inositol-1,4,5-triphosphate receptor 1), leading to mito

55 butes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and

56 inds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulatin

57 ogical inhibitors wortmannin, a phosphatidyl inositol 3-kinase inhibitor, and leupeptin plus E64 (inh

58 nd attenuate phosphorylation of phosphatidyl inositol 3-kinase, which is recruited by EGFR.

59 n receptor substrate-1 (IRS-1), phosphatidyl inositol-3 kinase (PI3K), Mammalian target of rapamycin

60 The phosphatidyl-inositol-3 kinases (PI3K) pathway regulates a variety of

61 evels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a r

62 no1), which encodes the rate-limiting enzyme inositol-3-phosphate synthase.

63 ly, we could detect inositol phosphate (IP), inositol 4,5-bisphosphate (IP2 ), inositol 1,4,5-trispho

64 mediated by SHIP (Src homology 2-containing inositol 5' phosphatase), in particular SHIP1, which act

65 Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase

66 s mediated through the SH2 domain-containing inositol 5-phosphatase 1 (SHIP1)/protein kinase B (Akt)

67 Mutation of the inositol 5-phosphatase OCRL1 causes Lowe syndrome and De

68 conditions that result from mutations of the inositol 5-phosphatase oculocerebrorenal syndrome of Low

69 SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-ph

70 introducing amino acids and other nutrients (inositol, adenine, or p-aminobenzoic acid) in the transf

71 hosphate (PIP2), which is generated from myo-inositol, an osmolyte transported into cells by sodium-d

72 fivefold increases in specific titers of myo-inositol and glucaric acid, respectively.

73 ges are associated with altered cortical myo-inositol and glycine levels, suggesting sleep loss-induc

74 Efflux of uncharged osmolytes (myo-inositol and taurine) was suppressed by deletion of LRRC

75 aturated aldehyde functionality on different inositols and derivatives by vinylogous elimination of t

76 ctive extraction of bioactive carbohydrates (inositols and inulin) from artichoke (Cynara scolymus L.

77 douridine, N-acetylalanine, erythronate, myo-inositol, and N-acetylcarnosine.

78 gs was related to sugars, organic acids, myo-inositol, and shikimate, gm showed a more complex patter

79 fects were more pronounced in medium lacking inositol, and were mirrored by inositol starvation of an

80 Some "other" inositols are medically relevant, for example, scyllo-in

81 , xylose, mannose, fructose and ribose) plus inositol as internal standard was obtained in 500mmol.L(

82 cid and phosphorylated forms of phosphatidyl inositol at least in part through the binding affinities

83 We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially b

84 action reduced INO1 expression and conferred inositol auxotrophy.

85 Inositol-based signaling molecules are central eukaryoti

86 here is allosteric communication between the inositol-binding site and the active site.

87 identify a new role for Ino1, independent of inositol biosynthesis, with broad effects on cell metabo

88 tabolic role for Ino1 that is independent of inositol biosynthesis.

89 ated with active disease, with the urine myo-inositol:citrate ratio being tightly correlated with act

90 (L-serine, L-leucine, glucose, fructose, myo-inositol, citric acid and 2, 3-hydroxypropanoic acid).Tw

91 e found that overexpression of the Na(+)/myo-inositol cotransporter (SMIT1) and myo-inositol suppleme

92 er concentrations of glutamate, taurine, myo-inositol, creatine and inosine were present in aqueous e

93 spartate (NAA)/Choline, NAA/Creatine and myo-inositol/Creatine ratios were measured.

94 Supplementation of choline to inositol-depleted growth medium led to decreased TAG syn

95 Inositol depletion also caused a dramatic generalized de

96 further support the therapeutic relevance of inositol depletion as a bipolar disorder treatment.

97 metabolic explanation as to how VPA-mediated inositol depletion causes increased synthesis of PHS and

98 Inositol depletion favors Opi1p interaction with both Sc

99 Moreover, inositol depletion in strains lacking this interaction r

100 These findings suggest that VPA-mediated inositol depletion induces the UPR by increasing the de

101 sed on the molecular and cellular effects of inositol depletion without considering Ino1 levels.

102 These drugs have been shown to cause inositol depletion, but translating this observation to

103 nstrate distinct effects of loss of Ino1 and inositol depletion.

104 to generate a suitably protected chiral myo-inositol derivatives is described here as a unified appr

105 and indirect regulatory mechanisms involving inositol-derived increases in PIP2, SMIT1, and likely ot

106 channel regulation by SMIT-transported, myo-inositol-derived phosphatidylinositol 4,5-bisphosphate (

107 ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations.

108 tol (neurodegenerative diseases) and d-chiro-inositol (diabetes).

109 After activation by inositol hexakisphosphate (InsP6), the autoprotease clea

110 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexakisphosphate (IP6 ) in T. brucei different

111 family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.

112 Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activa

113 Myo-inositol hexakisphosphate (IP6), is the main iron chelat

114 structure further reveals that Pds5 can bind inositol hexakisphosphate (IP6).

115 itol pentakisphosphate 2-kinase (TbIP5K) and inositol hexakisphosphate kinase (TbIP6K).

116 Inositol hexakisphosphate kinase 1 (IP6K1), which genera

117 1-1, that is predicted to encode a conserved inositol hexakisphosphate kinase from the VIP family tha

118 In this study, we report that IP6K1, an inositol hexakisphosphate kinase that catalyzes the synt

119 We found that cells lacking inositol hexakisphosphate kinase, which is responsible f

120 , 1 mM Km for ATP) of the 5-InsP7-generating inositol hexakisphosphate kinases (IP6Ks).

121 fy specific NMR signals like myo- and scyllo-inositol hexakisphosphate.

122 Eukaryotic inositol-hexakisphosphate (InsP6) binds an autoprocessin

123 isiae, extracellular [Pi] is "sensed" by the inositol-hexakisphosphate kinase (IP6K) that synthesizes

124 However, neo- and d-chiro-inositol hexakisphosphates were recently revealed in bot

125 ogen Ralstonia solanacearum, in complex with inositol hexaphosphate (InsP6), acetyl-coenzyme A (AcCoA

126 nd to a novel peptide-based inhibitor and to inositol hexaphosphate suggests a molecular basis of sub

127 of the mannose ring linked to 2-position of inositol in PIM1/PIM2.

128 llocatechin-3-gallate, myricetin, and scyllo-inositol, in cells expressing amyloid precursor protein

129 Escherichia coli, resulting in titers of myo-inositol increased 5.5-fold and titers of glucaric acid

130 The inositol is a natural compound widely used in the food i

131 Myo-inositol is an important cellular osmolyte in autoregula

132 Although the inositol kinases underlying inositol pyrophosphate biosy

133 g correlation between abnormal intracellular inositol levels and neurological disorders, very little

134 In contrast, high myo-inositol levels were observed prior to nodule formation

135 ao lower bound [CRLB], <20%) estimate scyllo-inositol levels with a CRLB of 14%.

136 Inositol levels, maintained by the biosynthetic enzyme i

137 mutant resulted in a rapid 56% reduction in inositol levels, triggering the induction of autophagy,

138 .5 +/- 0.2 vs 8.3 +/- 0.3; P < .01), and myo-inositol (m-Ins) (3.8 +/- 0.3 vs 5.6 +/- 0.4; P < .001)

139 the biosynthetic pathway of phosphatidyl-myo-inositol mannoside, lipomannan, and lipoarabinomannan, w

140 osynthesis of mycobacterial phosphatidyl-myo-inositol mannosides (PIMs).

141 Phosphatidyl-myo-inositol mannosyltransferase A (PimA) is an essential gl

142 w a new thermal event associated to beta myo-inositol melting at 221.43 degrees C, suggesting that th

143 he strongest sub-pathway association was for inositol metabolism (p = 2.0 x 10(-14)).

144 nds, creatine-containing compounds (Cr), myo-inositol (mI), and glutamate (Glu) levels in the anterio

145 with scaling and root planing (SRP) and myo-inositol (MI).

146 We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-l

147 In this context, we examined host inositol monophosphatase (IMPase), reduced levels of whi

148 previously in prokaryotes and resembles myo-inositol monophosphatases (IMPases).

149 concentrations of glutamate, glutamine, myo-inositol, NAA, creatine and choline.

150 are medically relevant, for example, scyllo-inositol (neurodegenerative diseases) and d-chiro-inosit

151 ression, in the absence of extracellular myo-inositol or other SMIT1 substrates, on fundamental funct

152 xpression of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitr

153 The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubul

154 ate multikinase (IPMK) and its major product inositol pentakisphosphate (IP5) regulate a variety of c

155 inositol polyphosphate multikinase (TbIPMK), inositol pentakisphosphate 2-kinase (TbIP5K) and inosito

156 ase (pBtk) and phosphorylated SH2-containing inositol phosphatase (pSHIP), are reduced and enhanced,

157 y, experiments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolo

158 lving the tyrosine phosphatase SHP-1 and the inositol phosphatase SHIP-1 are required to maintain ane

159 as SKIP (skeletal muscle and kidney enriched inositol phosphatase), which is highly expressed in the

160 Here we investigate the role of the 5'-inositol phosphatase, SHIP2, and reveal an unexpected sc

161 nts of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from the non-pathogenic b

162 radioligand-binding and functional assays of inositol phosphate (IP) accumulation and Ca(2+) mobiliza

163 Interestingly, we could detect inositol phosphate (IP), inositol 4,5-bisphosphate (IP2

164 alphaq/11 protein dissociation and increased inositol phosphate accumulation and GPCR-kinase interact

165 evelopment for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and des

166 Human inositol phosphate multikinase (HsIPMK) critically contr

167 tors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-

168 while failing to recruit arrestin, activate inositol phosphate signaling, or internalize CB2 recepto

169 Networks associated with inositol phosphate, glycerophospholipids, and sterol met

170 lical scaffold in the C-lobe constitutes the inositol phosphate-binding site, which, along with the p

171 Here we report that inositol phosphates (InsPs) and phosphatdidylinositol ph

172 traction and measurement of all six forms of inositol phosphates (InsPs) in almond meal and brown ski

173 myo-Inositol phosphates (IPs) are important bioactive molecu

174 A variety of inositol phosphates including myo-inositol 1,4,5-trispho

175 lyzed T. brucei extracts for the presence of inositol phosphates using polyacrylamide gel electrophor

176 f the yeast and plant enzymes, without bound inositol phosphates, do not structurally rationalize HsI

177 Cell signaling via inositol phosphates, in particular via the second messen

178 complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched b

179 scribed here as a unified approach to access inositol phosphates.

180 Study of the highly glycosylated glycosyl inositol phosphorylceramide (GIPC) sphingolipids has bee

181 an Arabidopsis GIPC glucuronosyltransferase, INOSITOL PHOSPHORYLCERAMIDE GLUCURONOSYLTRANSFERASE 1 (I

182 in fatty acids and dihydroxylated bases into inositol phosphorylceramides and GIPCs.

183 us, nearly all [PSI+] prion variants require inositol poly-/pyrophosphates for their propagation, and

184 s the thermal behavior of alpha and beta myo-inositol polymorphs.

185 Fungal inositol polyphosphate (IP) kinases catalyse phosphoryla

186 ressing wild-type, but not phosphatase dead, inositol polyphosphate 4-phosphatase show impaired SDF-i

187 Inositol polyphosphate 4-phosphatase type II (INPP4B) ne

188 Using the PI(3,4)P2-specific phosphatase inositol polyphosphate 4-phosphatase, we investigate the

189 Mice deficient in inositol polyphosphate 5'-phosphatase D (INPP5D, also kn

190 Here we show using the inositol polyphosphate 5'-phosphatase E (INPP5E) and the

191 emically-induced dimerization to translocate inositol polyphosphate 5-phosphatase (Inp54p) to plasma

192 The inositol polyphosphate 5-phosphatase INPP5E localizes to

193 OCRL1 encodes an inositol polyphosphate 5-phosphatase which preferentiall

194 that increased levels of this or some other inositol polyphosphate favors [PSI+] propagation.

195 RATIONALE: Inositol polyphosphate multikinase (IPMK) and its major

196 at damage sites requires phosphorylation by inositol polyphosphate multikinase (IPMK) and promotes n

197 biosynthetic pathway in Trypanosoma brucei: inositol polyphosphate multikinase (TbIPMK), inositol pe

198 were lost upon loss of ARG82, which encodes inositol polyphosphate multikinase.

199 merases--provide a basic binding surface for inositol polyphosphate signaling molecules (InsPs), the

200 er an interaction between the TOR kinase and inositol polyphosphate signaling systems that we propose

201 ant functions of OCRL and its paralog type 2 inositol polyphosphate-5-phosphatase (INPP5B).

202 erase; a prenyl-binding protein) and INPP5E (inositol polyphosphate-5-phosphatase 5E).

203 INPP5K encodes the inositol polyphosphate-5-phosphatase K, also known as SK

204 ied bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K.

205 Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in

206 nclude the highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol pyrophospha

207 red for potentiation of SMIT activity by myo-inositol preincubation.

208 inase), vip1Delta (IP6 1-kinase), ddp1Delta (inositol pyrophosphatase), or kcs1Delta vip1Delta mutant

209 se (IP6K) that synthesizes the intracellular inositol pyrophosphate 5-diphosphoinositol 1,2,3,4,6-pen

210 Although the inositol kinases underlying inositol pyrophosphate biosynthesis are well characteriz

211 racterization of the kinases involved in the inositol pyrophosphate biosynthetic pathway in Trypanoso

212 s a physiological phosphatase that modulates inositol pyrophosphate metabolism by dephosphorylating t

213 Our study links the inositol pyrophosphate pathway to the synthesis of polyp

214 anisms that can contribute to specificity in inositol pyrophosphate signaling, regulating InsP8 turno

215 However, a separate inositol pyrophosphate, 1,5-bisdiphosphoinositol 2,3,4,6

216 ) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential f

217 phate kinase that catalyzes the synthesis of inositol pyrophosphate, regulates inositol synthesis in

218 ffusible inositol polyphosphates (InsPs) and inositol pyrophosphates (PP-InsPs).

219 The inositol pyrophosphates 5-InsP7 (diphosphoinositol penta

220 Inositol pyrophosphates are high energy signaling molecu

221 Inositol pyrophosphates are novel signaling molecules po

222 hich is responsible for the synthesis of the inositol pyrophosphates IP7 and IP8, reach abnormally hi

223 hich there is a functional interplay between inositol pyrophosphates, ATP, and polyP.

224 Bloodstream forms unable to produce inositol pyrophosphates, due to downregulation of TbIPMK

225 tially offset by an increase of both ATP and inositol pyrophosphates, evidence for a model in which t

226 og Ddp1 prefers inorganic polyphosphate over inositol pyrophosphates.

227 ly have been demonstrated to dephosphorylate inositol pyrophosphates; however, theSaccharomyces cerev

228 Hypocitraturia and elevated urinary myo-inositol remained associated with active disease, with t

229 During ER stress, the inositol requiring enzyme 1alpha (IRE1alpha) endoribonuc

230 Inositol Requiring Enzyme-1 (IRE1) is the most conserved

231 y of the unfolded protein response activator inositol-requiring enzyme (IRE-1) via modulation of the

232 amazonensisactivates the inositol-requiring enzyme (IRE1)/ X-box binding protein

233 The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream ta

234 does not temper the ribonuclease activity of inositol-requiring enzyme 1 (IRE1) under temporary ER st

235 t UPR regulator, the kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1), is activated in lipi

236 y unfolded protein response (UPR) transducer inositol-requiring enzyme 1 (IRE1alpha) in diabetic woun

237 Here, we identified inositol-requiring enzyme 1alpha (IRE1alpha) as a critic

238 endoplasmic reticulum stress, activation of inositol-requiring enzyme 1alpha (IRE1alpha), and suppre

239 autophosphorylation of the ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha), while acti

240 renal epithelial cells on activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-active spli

241 ng protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bo

242 nin secretion under the selective control of inositol-requiring enzyme 1alpha, a key activator of the

243 e RNA-activated (PKR)-like ER kinase (PERK), inositol-requiring enzyme-1alpha (IRE1alpha), and activa

244 branches of unfolded protein responses, the inositol-requiring enzyme-1alpha pathway.

245 lum (ER) stress and activated the protective inositol-requiring kinase (IRE)-1alpha pathway.

246 Here, we report that the inositol-requiring kinase 1 (Ire1p)-mediated unfolded pr

247 eover, CAMTA3-dependent activation of IRE1a (inositol-requiring protein-1) and bZIP60 (basic leucine

248 Inositol-requiring transmembrane kinase/endonuclease 1al

249 orylated IP binding differed in both the myo-inositol ring position and orientation when compared wit

250 e with the number of phosphate groups on the inositol ring, with phosphate positional effects observe

251 the pah1Delta mutant is induced through the inositol-sensitive upstream activation sequence (UASINO)

252 scyllo-Inositol (SI) is a potential therapeutic for AD by direc

253 edium lacking inositol, and were mirrored by inositol starvation of an ino1Delta mutant.

254 To date, most inositol studies have focused on the molecular and cellu

255 binds to negatively charged phosphatidyl-myo-inositol substrate and non-substrate membrane model syst

256 )/myo-inositol cotransporter (SMIT1) and myo-inositol supplementation enlarged intracellular PI(4,5)P

257 Removal of inositol supplementation from the ino1(-) mutant resulte

258 Inositol supplementation, however, favors the translocat

259 of a catabolic state that was not rescued by inositol supplementation.

260 phosphoinositide levels that was rescued by inositol supplementation.

261 very little is known about the regulation of inositol synthesis in mammalian cells.

262 on of IP6K1 as a novel negative regulator of inositol synthesis in mammalian cells.

263 nthesis of inositol pyrophosphate, regulates inositol synthesis in mammalian cells.

264 raction of slightly higher concentrations of inositol than PLE at 75 degrees C for 26.7 min (11.6 mg/

265 to determine the transition lifetime of myo-inositol to occur 5% of solid-solid transition at 20 deg

266 In contrast, myo-inositol (transported through SMIT1) reproduced the toxi

267 ncluding vacuole cation/proton exchanger and inositol transporter, were considered to play important

268 ansported into cells by sodium-dependent myo-inositol transporters (SMITs).

269 Inositol transporters and catabolism genes, which proces

270 We conclude that in Arabidopsis, inositol transporters are responsible for arsenite loadi

271 dependent solute transporters, including myo-inositol transporters SMIT1 and SMIT2, potentially facil

272 omain activity that occurs in the absence of inositol triphosphate (IP3)-dependent release from endop

273 Ca(2+) -ATPase (SERCA) pump and blockers of inositol triphosphate receptor (InsP3 R) and ryanodine r

274 effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP3R-1).

275 lcium elevations during PIDs are mediated by inositol triphosphate receptor type 2-dependent (IP3R2-d

276 They act nonredundantly to produce inositol triphosphate-mediated intracellular Ca(2+) flux

277 gs, where we found that specific infusion of inositol trisphosphate (InsP3) into either distal or pro

278 activation of phospholipase C and opening of inositol trisphosphate (InsP3) receptors.

279 rt mediated by TGFbeta-induced inhibition of inositol trisphosphate (IP3) production, leading to a de

280 We previously reported decreased inositol trisphosphate (IP3)-mediated Ca(2+) release fro

281 hand, the induction of the second messenger inositol trisphosphate and the mobilization of calcium a

282 pholipase C to generate the second messenger inositol trisphosphate often evokes repetitive oscillati

283 purinergic P2Y receptors and stimulated the inositol trisphosphate receptor to provoke transient rel

284 The initial Ca(2+) rise in PSCs was due to inositol trisphosphate receptor-mediated release from in

285 lar calcium levels via signaling through the inositol trisphosphate receptor.

286 Tightly clustered inositol trisphosphate receptors (IP3Rs) control localiz

287 (TRPV4) channels in the plasma membrane and inositol trisphosphate receptors in the endoplasmic reti

288 Thus, inositol trisphosphate, and not calcium, diffused intere

289 ted CRAC channels in the plasma membrane and inositol trisphosphate-gated channels in the endoplasmic

290 This increase was abrogated by inhibiting inositol trisphosphate-mediated calcium release with Xes

291 nals were due to initial Ca(2+) release from inositol trisphosphate-sensitive stores followed by Ca(2

292 e second messengers diacylglycerol and 1,4,5-inositol trisphosphate.

293 or, phosphoinositide 3-kinase (PI3K), and by inositol-trisphosphate 3-kinase B (Itpkb).

294 after hepatectomy, mice were pretreated with inositol trispyrophosphate (ITPP), an allosteric effecto

295 e, we show that transporters responsible for inositol uptake in the phloem in Arabidopsis also transp

296 on of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter ju

297 Myo-inositol was also moderately predictive.

298 , i.e. phosphatidyl-choline and phosphatidyl-inositol, were differentially affected by the high gluco

299 and sphingomyelin with inflammation and myo-inositol with cellular proliferation.

300 rged osmolytes [(3) H]taurine and myo-[(3) H]inositol, without major impact on the simultaneously mea