ライフサイエンスコーパス: inositol 1,4,5-trisphosphate

1 th an increase in the levels of its product, inositol 1,4,5-trisphosphate.

2 (PI(4,5)P(2) or PIP(2)) and the formation of inositol 1,4,5-trisphosphate.

3 nto the second messengers diacylglycerol and inositol 1,4,5-trisphosphate.

4 te also induces cytoplasmic concentration of inositol 1,4,5-trisphosphate.

5 Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a mo

6 ymes responsible for generating IP(5) reveal inositol 1,4,5-trisphosphate 3-kinase and inositol polyp

7 Inositol 1,4,5-trisphosphate 3-kinase B (or Itpkb) conve

8 iated proteins in human platelets identified inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB)

9 We used inositol 1,4,5-trisphosphate accumulation and radioligan

10 Inositol 1,4,5-trisphosphate alone did not affect reacti

11 -grown 5ptase11 mutants contain increases in inositol (1,4,5) trisphosphate and an inositol bisphosph

12 hippocampal-dependent memory in part through inositol 1,4,5-trisphosphate and brain-derived neurotrop

13 Increases in inositol 1,4,5-trisphosphate and cytoplasmic Ca(2+) leve

14 y of cellular pathways through production of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).

15 ts ability to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol, PLC, un

16 bsequent production of the second messengers inositol 1,4,5-trisphosphate and diacylglycerol.

17 ol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate and diacylglycerol.

18 eric G-protein coupling, and inhibits IP(3) (inositol-1,4,5-trisphosphate) and calcium mobilization,

19 hatidylinositol 4-phosphate, diacylglycerol, inositol 1,4,5-trisphosphate, and Ca(2+) upon muscarinic

20 ransient increases in intracellular calcium, inositol 1,4,5-trisphosphate, and G(q)-GTP in response t

21 (VSP), which depletes PIP2 without changing inositol 1,4,5-trisphosphate, and monitored NBCe1-mediat

22 , in particular via the second messenger myo-inositol 1,4,5-trisphosphate, and phosphoinositides comp

23 tensin II-induced cleavage is independent of inositol 1,4,5-trisphosphate- and Ca(2+)-mediated signal

24 but the downstream targets of Plc-generated inositol 1,4,5-trisphosphate are poorly described.

25 a receptor-independent method for producing inositol (1,4,5)-trisphosphate as the heart of the model

26 escent phosphatidylinositol 4,5-bisphosphate/inositol 1,4,5-trisphosphate biosensor GFP-PLCdelta1-PH

27 mechanism involving M1/M3 receptor-mediated inositol 1,4,5-trisphosphate/Ca(+2) signalling and downs

28 mechanism involving M1/M3 receptor-mediated inositol 1,4,5-trisphosphate/Ca(+2) signalling and downs

29 large cholangiocytes by activation of D-myo-inositol 1,4,5-trisphosphate/Ca(2+) /calmodulin-dependen

30 inhibit NBCe1, whereas hydrolysis of PIP2 to inositol 1,4,5-trisphosphate/Ca(2+) can stimulate the tr

31 nd -C in the intact oocyte primarily through inositol 1,4,5-trisphosphate/Ca(2+).

32 luble inositol phosphate headgroups, such as inositol 1,4,5-trisphosphate, can compete with PtdIns(4,

33 Instead, S1PR2 stimulated inositol 1,4,5-trisphosphate-dependent Ca(++) release an

34 ia L-type Ca(2+) channels and, on the other, inositol 1,4,5-trisphosphate-dependent Ca(2+) release.

35 increasing ROS production which facilitated inositol 1,4,5-trisphosphate-dependent Ca(2+) release.

36 inic acid-adenine dinucleotide phosphate- or inositol 1,4,5-trisphosphate-dependent calcium release a

37 R expression, (iii) persistent activation of inositol 1,4,5-trisphosphate-dependent cell signaling ca

38 idylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate-dependent intra-acrosomal c

39 receptor (GPCR) and tyrosine kinase-mediated inositol 1,4,5-trisphosphate-dependent mitochondrial Ca(

40 These data reveal the existence of an inositol 1,4,5-trisphosphate-dependent nuclear Ca(2+) to

41 Stimulation of endothelial inositol 1,4,5-trisphosphate-dependent signaling with su

42 )), which we show is mediated by SHP-2 in an inositol-1,4,5-trisphosphate-dependent manner.

43 ng concentrations for intracellular calcium, inositol 1,4,5-trisphosphate, diacylglycerol, phosphatid

44 n of phospholipase C at the plasma membrane, inositol 1,4,5-trisphosphate enters the cytosol and is i

45 Inositol 1,4,5-trisphosphate generated by the action of

46 Inositol 1,4,5-trisphosphate-generating agonist evoked c

47 signaling under these conditions depends on inositol-1,4,5-trisphosphate generation from phospholipa

48 onse to environmental cues that promote IP3 (inositol 1,4,5-trisphosphate) generation, IP3 receptors

49 l 4,5-bisphosphate (PIP(2)) and formation of inositol 1,4,5-trisphosphate in TRPV6-expressing cells.

50 ease from the sarcoplasmic reticulum through inositol 1,4,5-trisphosphate-induced Ca release and not

51 as inhibited by blocking phospholipase C and inositol 1,4,5-trisphosphate-induced Ca(2+) release, ind

52 Inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) 3-kinases

53 We investigated synergism between inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) and diacyl

54 belongs to a family of kinases that convert inositol 1,4,5-trisphosphate (Ins(1,4,5)P3 or IP3) to in

55 We investigated the contribution of inositol(1,4,5)-trisphosphate (Ins(1,4,5)P3 [IP3]) recep

56 butes to intracellular signaling through its inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) 3-kinase and

57 Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocyt

58 The inositol(1,4,5)trisphosphate [Ins(1,4,5)P3] binding assa

59 4,5)P(2) levels was accompanied by increased inositol 1,4,5 trisphosphate (InsP(3)) production, and w

60 asticity (ITDP) in cortical input depends on inositol 1,4,5-trisphosphate (InsP(3))-sensitive Ca(2+)

61 The phosphoinositide pathway and inositol-1,4,5-trisphosphate (InsP(3)) are implicated in

62 ss that is regulated, in mammalian cells, by inositol-1,4,5-trisphosphate (InsP(3)), cyclic ADP ribos

63 to the nucleus, as well as upon formation of inositol 1,4,5,-trisphosphate (InsP3) in the nucleus, wh

64 vated through depletion of ER Ca2+ stores by inositol 1,4,5-trisphosphate (InsP3) and store-independe

65 nd -C in the intact oocyte primarily through inositol 1,4,5-trisphosphate (InsP3)/Ca(2+).

66 2+) release and airway contraction evoked by inositol-1,4,5-trisphosphate (InsP3) uncaging in airway

67 For Ca2+ signals initiated by inositol-1,4,5-trisphosphate (InsP3), this requires loca

68 crystallographic studies have emphasized PH-inositol 1,4,5-trisphosphate (IP 3) interactions, biophy

69 hatidylinositol 4,5-bisphosphate (PIP(2)) to inositol 1,4,5-trisphosphate (IP(3)) and diacylglycerol

70 Inositol 1,4,5-trisphosphate (IP(3)) did not activate I(

71 y results from an increase in the potency of inositol 1,4,5-trisphosphate (IP(3)) in producing facili

72 Inositol 1,4,5-trisphosphate (IP(3)) is a crucial second

73 Inositol 1,4,5-trisphosphate (IP(3)) is a second messeng

74 gamma2 (PLCgamma2) accounts for LPS-induced inositol 1,4,5-trisphosphate (IP(3)) production and subs

75 phospholipase C-beta (PLC-beta) activation, inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) d

76 +)](i)) by increasing the sensitivity of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) t

77 ivation of TRPC3 channels is concurrent with inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-m

78 The inositol 1,4,5-trisphosphate (IP(3)) receptor is a Ca(2+

79 e that mir-240/786 functions upstream of the inositol 1,4,5-trisphosphate (IP(3)) receptor.

80 Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs)

81 Inositol 1,4,5-trisphosphate (IP(3)) receptors are endop

82 Inositol 1,4,5-trisphosphate (IP(3)) receptors are endop

83 Inositol 1,4,5-trisphosphate (IP(3)) receptors form tetr

84 In pancreatic acinar cells, inositol 1,4,5-trisphosphate (IP(3)) receptors populate

85 led receptors (GPCRs) through the binding of inositol 1,4,5-trisphosphate (IP(3)) to its receptor (IP

86 ssay in which binding of fluorescein-labeled inositol 1,4,5-trisphosphate (IP(3)) to N-terminal fragm

87 Physiologically, the production of inositol 1,4,5-trisphosphate (IP(3)) upon stimulation of

88 Inositol 1,4,5-trisphosphate (IP(3)), the product of PIP

89 , which encompasses dramatic potentiation of inositol 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) re

90 Inositol 1,4,5-trisphosphate (IP(3))-dependent Ca(2+) si

91 icoids inhibit downstream responses, such as inositol 1,4,5-trisphosphate (IP(3))-induced calcium sig

92 Inositol 1,4,5-trisphosphate (IP(3))-induced vasoconstri

93 Although inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

94 d knockout mice, we show that in addition to inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

95 osolic Ca(2+) rise is primarily initiated by inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) rel

96 lations are initiated by Ca(2+) release from inositol 1,4,5-trisphosphate (IP(3))-sensitive intracell

97 d trigger production of the second messenger inositol 1,4,5-trisphosphate (IP(3)).

98 it does not have a significant affinity for inositol 1,4,5-trisphosphate (IP(3)).

99 PLC activation results in production of inositol 1,4,5-trisphosphate (IP(3)).

100 h results in the lipid-derived production of inositol 1,4,5-trisphosphate (IP(3)).

101 h promotes the release of diacylglycerol and inositol 1,4,5-trisphosphate (IP(3)).

102 otein, adenylyl cyclase, Epac-1 protein, and inositol 1,4,5-trisphosphate (IP(3))/IP(3) receptor, wer

103 efficient chemical synthesis of an analog of inositol-1,4,5-trisphosphate (IP(3)) hexakis acetoxymeth

104 d by silencing of the NBCe1-B/CFTR activator inositol-1,4,5-trisphosphate (IP(3)) receptor-binding pr

105 We studied inositol-1,4,5-trisphosphate (IP(3)) receptor-dependent

106 splayed defective T cell receptor (TCR)- and inositol-1,4,5-trisphosphate (IP(3))-dependent Ca(2+) mo

107 to phospholipase C-coupled receptors elevate inositol-1,4,5-trisphosphate (IP(3)).

108 Hormone-induced inositol 1,4,5 trisphosphate (IP3 ) accumulation and pho

109 thway occurs at the level of hormone-induced inositol 1,4,5 trisphosphate (IP3 ) production and does

110 hate (IP), inositol 4,5-bisphosphate (IP2 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexaki

111 on is an increase in [Ca(2+) ]i triggered by inositol 1,4,5-trisphosphate (IP3 )-induced release of C

112 d CaMKII activation is probably initiated by inositol 1,4,5-trisphosphate (IP3 )-mobilized Ca(2+) : 8

113 ly to involve downstream Ca(2+) release from inositol 1,4,5-trisphosphate (IP3 )-triggered Ca(2+) -st

114 (PLC-gamma1), with the resultant increase in inositol 1,4,5-trisphosphate (IP3) and intracellular cal

115 on, nuclear mGlu5 receptors generate nuclear inositol 1,4,5-trisphosphate (IP3) in situ.

116 that phosphorylation of the second messenger inositol 1,4,5-trisphosphate (IP3) into inositol 1,3,4,5

117 oth mediated by an increase in intracellular inositol 1,4,5-trisphosphate (IP3) levels, because they

118 ausing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+

119 anisms, e.g., single channel kinetics of the inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ channel

120 findings indicate that Bcl-2 interacts with inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ channel

121 omain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor, an IP3-gate

122 a K+ channel, whereas mGluR5 operates via an inositol 1,4,5-trisphosphate (IP3) receptor-dependent me

123 ertebrate genomes code for three subtypes of inositol 1,4,5-trisphosphate (IP3) receptors (IP3R1, -2,

124 nic M3 receptors, or by direct activation of inositol 1,4,5-trisphosphate (IP3) receptors by photolys

125 ntributes to the ubiquitination of activated inositol 1,4,5-trisphosphate (IP3) receptors, and also,

126 hosphate kinase 2 (ip3k2), thereby affecting inositol 1,4,5-trisphosphate (IP3) signaling and calcium

127 holipase C-gamma (PLC-gamma) which increases inositol 1,4,5-trisphosphate (IP3) to release intracellu

128 a double-caged form of the second messenger inositol 1,4,5-trisphosphate (IP3) triggers focal calciu

129 The detection of the second messenger inositol 1,4,5-trisphosphate (IP3) was demonstrated with

130 CAS regulates concentrations of inositol 1,4,5-trisphosphate (IP3), which in turn direct

131 Genetically blocking inositol 1,4,5-trisphosphate (IP3)-dependent Ca(2+) incr

132 Sigma-1 receptor (sigma-1R) agonists enhance inositol 1,4,5-trisphosphate (IP3)-dependent calcium rel

133 opic glutamate receptors (mGluRs) generating inositol 1,4,5-trisphosphate (IP3).

134 neous Ca2+ transients were suppressed by the inositol-1,4,5-trisphosphate (IP3) receptor (IP3R) block

135 In addition, we identified the type 1 inositol-1,4,5-trisphosphate (IP3) receptor (ITPR1), an

136 Here we show that the cerebellar inositol-1,4,5-trisphosphate (IP3) receptor, whose activ

137 the cell and parallel fiber stimulus evoking inositol-1,4,5-trisphosphate (IP3)-meditated calcium rel

138 Here we report that the protein IRBIT (inositol-1,4,5-trisphosphate [IP3] receptors binding pro

139 ntext-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2), thereby a

140 C and to the formation of diacylglycerol and inositol 1,4,5-trisphosphate, leading to the release of

141 celerating Ca(2+) clearance and exaggerating inositol 1,4,5-trisphosphate-mediated Ca(2+) liberation.

142 rial function and to involve phospholipase C/inositol 1,4,5-trisphosphate-mediated Ca(2+) mobilizatio

143 steoclast (OC) differentiation by modulating inositol 1,4,5-trisphosphate-mediated calcium oscillatio

144 slocates to the nucleus to initiate nuclear, inositol 1,4,5-trisphosphate-mediated calcium signals in

145 lus secretion coupling and its regulation by inositol 1,4,5-trisphosphate, nicotinic acid adenine din

146 or the first time that the POCKET containing inositol 1,4,5-trisphosphate on crystal structure (the "

147 egranulation by thapsigargin, which bypasses inositol 1,4,5-trisphosphate production, is also substan

148 ysis of phosphatidylinositol 4,5-biphosphate inositol 1,4,5-trisphosphate production, nuclear Ca(2+)

149 PLCgamma1 phosphorylation and inhibition of inositol 1,4,5-trisphosphate production.

150 phospholipase C beta2 and the stimulation of inositol 1,4,5-trisphosphate production.

151 ome through phospholipase C, which catalyses inositol-1,4,5-trisphosphate production and thereby indu

152 discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and in

153 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and rya

154 Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated

155 The inositol 1,4,5 trisphosphate receptor (IP3R) is an intra

156 The potentiation is absent in conditional inositol 1,4,5 trisphosphate receptor type 2 KO mice, wh

157 tin A (AdA) is a potent agonist of the d-myo-inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P3R).

158 ut not wild-type Atx2 specifically binds the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and inc

159 The inositol 1,4,5-trisphosphate receptor (InsP(3)R), an int

160 o binds to and amplifies the activity of the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

161 protein that modulates Ca(2+) release by the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

162 The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a u

163 th the cytosolic C-terminal region of type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

164 ) specifically binds to and activates type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

165 exp) specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

166 -mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in car

167 Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP3R) and thus

168 PS1 (M146L)and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+ rele

169 2+ release from intracellular stores through inositol 1,4,5-trisphosphate receptor (InsP3R) channels

170 We examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R) in mediat

171 ves are polarized in hepatocytes because the inositol 1,4,5-trisphosphate receptor (InsP3R) is concen

172 ion of Ca(2+) waves, we examined the role of inositol 1,4,5-trisphosphate receptor (InsP3R) isoforms

173 , neuronal calcium sensor 1 (NCS-1), and the inositol 1,4,5-trisphosphate receptor (InsP3R) to preven

174 er intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor (InsP3R), is neces

175 known to increase the activity of the type-1 inositol 1,4,5-trisphosphate receptor (InsP3R1).

176 alicular membrane is mediated by the type II inositol 1,4,5-trisphosphate receptor (InsP3R2), so we i

177 mutation in ITPR2, which encodes the type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2), that wa

178 The type III isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R3) is apica

179 lobal Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activatio

180 poptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2)(+)

181 in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel f

182 t gating dynamics of a single, nonconducting inositol 1,4,5-trisphosphate receptor (IP(3)R) channel,

183 examethasone induces a striking elevation of inositol 1,4,5-trisphosphate receptor (IP(3)R) levels in

184 euronal Ca(2+) signaling by enhancing type-1 inositol 1,4,5-trisphosphate receptor (IP(3)R) steady-st

185 we demonstrated that PC2 interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) to modula

186 ) Ca2+ depletion and prolonged activation of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca2+ rele

187 During oocyte maturation, the inositol 1,4,5-trisphosphate receptor (IP(3)R1), the cha

188 In cardiac myocytes the type-2 inositol 1,4,5-trisphosphate receptor (IP(3)R2) is the p

189 is and the degradation of the Ca(2+) channel inositol 1,4,5-trisphosphate receptor (IP3R) affects pro

190 Inositol 1,4,5-trisphosphate receptor (IP3R) antagonists

191 Furthermore, inositol 1,4,5-trisphosphate receptor (IP3R) but not rya

192 sm involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channe

193 A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, wh

194 Ca2+ liberation through inositol 1,4,5-trisphosphate receptor (IP3R) channels ge

195 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

196 r ryanodine (400 microM), the antagonists of inositol 1,4,5-trisphosphate receptor (IP3R) or ryanodin

197 om apical Ca(2+) pools that are gated by the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and

198 of intracellular Ca2+ channels, such as the inositol 1,4,5-trisphosphate receptor (IP3R), have gener

199 o phospholipase C (PLC) isoforms, and (3) an inositol 1,4,5-trisphosphate receptor (IP3R).

200 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

201 The type 3 isoform of the inositol 1,4,5-trisphosphate receptor (ITPR3) is the mos

202 rypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(

203 sed phosphorylation of the ER Ca(2+) channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG c

204 ch is blunted by internal store depletion or inositol 1,4,5-trisphosphate receptor blockade.

205 parks arise from the cooperative activity of inositol 1,4,5-trisphosphate receptor Ca(2+) channels (I

206 tributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms i

207 ized releases of calcium through clusters of inositol 1,4,5-trisphosphate receptor channels constitut

208 phospholipase C inhibitor U73122 and by the inositol 1,4,5-trisphosphate receptor inhibitor Xestospo

209 Xestospongin C (an inositol 1,4,5-trisphosphate receptor inhibitor) had no

210 athway in which the expression of the type-1 inositol 1,4,5-trisphosphate receptor is regulated by th

211 Inositol 1,4,5-trisphosphate receptor isoforms are a fam

212 g gate structure is conserved in all RyR and inositol 1,4,5-trisphosphate receptor isoforms.

213 An increase in type-1 inositol 1,4,5-trisphosphate receptor mRNA and protein s

214 vation of cytosolic Ca(2+) by binding to the inositol 1,4,5-trisphosphate receptor on the endoplasmic

215 monitor conformational changes of the type I inositol 1,4,5-trisphosphate receptor protein in membran

216 563del] and c.7659T>G [p.Phe2553Leu]) in the inositol 1,4,5-trisphosphate receptor type 1 gene (ITPR1

217 TPase and ryanodine receptor type 2, but not inositol 1,4,5-trisphosphate receptor type 2, were requi

218 ty filter, and S6 transmembrane helix of the inositol 1,4,5-trisphosphate receptor were mutated in or

219 mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate receptor).

220 d upon activation of phospholipase C and the inositol 1,4,5-trisphosphate receptor, but not upon extr

221 Moreover, direct PC2 binding to inositol 1,4,5-trisphosphate receptor, KIF3A, and TRPC1

222 n immunoprecipitation assay, we found ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) as a dire

223 A variant (rs718314) in the inositol 1,4,5-trisphosphate receptor, type 2 gene (ITPR

224 espective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), a

225 Hg, ECs generated low-frequency (~2 min(-1)) inositol 1,4,5-trisphosphate receptor-based Ca(2+) event

226 onapoptotic necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor-dependent calcium

227 l melastatin subfamily 4 channels via type 2 inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) re

228 Additionally, inositol 1,4,5-trisphosphate receptor-mediated release o

229 ive to inhibitors of the phospholipase C and inositol 1,4,5-trisphosphate receptor.

230 ontext of a structural homology model of the inositol 1,4,5-trisphosphate receptor.

231 They arise from clustered inositol 1,4,5-trisphosphate receptor/channels (IP3Rs),

232 inds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulatin

233 transients (CaTs) are due to upregulation of inositol-1,4,5-trisphosphate receptor induced Ca(2+) rel

234 Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP(3)R) is t

235 ATP enhances Ca(2+) release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R).

236 to demonstrate that sensitization of type 1 inositol (1,4,5)-trisphosphate receptors by mHtt, which

237 lting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate receptors (IP3Rs).

238 Phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) by PKA

239 Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) can be

240 Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) repre

241 ositive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs).

242 regulates several Ca(2+) channels, including inositol 1,4,5-trisphosphate receptors (InsP3Rs).

243 family, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs).

244 Others, including the almost ubiquitous inositol 1,4,5-trisphosphate receptors (IP(3)R) and thei

245 The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspa

246 stimulates formation of cAMP and sensitizes inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3)

247 in A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thou

248 upling of sarcoplasmic reticulum (SR) type 1 inositol 1,4,5-trisphosphate receptors (IP(3)R1) to plas

249 es of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and rya

250 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) form te

251 A number of studies have demonstrated that inositol 1,4,5-trisphosphate receptors (IP(3)Rs) interac

252 Calcium (Ca(2+)) release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs) regulat

253 knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) stimula

254 etabotropic glutamate receptors (mGluRs) and inositol 1,4,5-trisphosphate receptors (IP(3)Rs), suppor

255 ) release through the ryanodine receptors or inositol 1,4,5-trisphosphate receptors (IP3 R) and upon

256 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a fa

257 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calc

258 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expr

259 d or refilled from one small site via either inositol 1,4,5-trisphosphate receptors (IP3R) or ryanodi

260 The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precise

261 ype 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-trisphosphate receptors (IP3R2s).

262 ms, like the endoplasmic reticulum-localized inositol 1,4,5-trisphosphate receptors (IP3Rs) and the v

263 supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close

264 Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the ad

265 hat Bok binds strongly and constitutively to inositol 1,4,5-trisphosphate receptors (IP3Rs), proteins

266 cell lines that Bok interacts strongly with inositol 1,4,5-trisphosphate receptors (IP3Rs), suggesti

267 otic cell death require calcium release from inositol 1,4,5-trisphosphate receptors (IP3Rs).

268 Such release occurs through a cluster of inositol 1,4,5-trisphosphate receptors (IP3Rs).

269 ly dependent on Ca2+ oscillation mediated by inositol 1,4,5-trisphosphate receptors 2 and 3 (ITPR2 an

270 ) release from the endoplasmic reticulum via inositol 1,4,5-trisphosphate receptors and by Ca(2+) ent

271 the cooperative activity of Ca(2+)-regulated inositol 1,4,5-trisphosphate receptors and ryanodine rec

272 uggests that it results from potentiation of inositol 1,4,5-trisphosphate receptors and/or phospholip

273 epletion of internal stores or inhibition of inositol 1,4,5-trisphosphate receptors but not by inhibi

274 2+) signals interact with both ryanodine and inositol 1,4,5-trisphosphate receptors during agonist st

275 nd blockade of either ryanodine receptors or inositol 1,4,5-trisphosphate receptors reduced [Ca(2+)](

276 astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2

277 neurons, cGKII-dependent phosphorylation of inositol 1,4,5-trisphosphate receptors was decreased, re

278 activity were also blunted by inhibition of inositol 1,4,5-trisphosphate receptors with 2-aminoethox

279 and endoplasmic reticulum Ca(2+) release via inositol 1,4,5-trisphosphate receptors.

280 through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP(3)Rs), whic

281 Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubi

282 d the detailed intracellular distribution of inositol-1,4,5-trisphosphate receptors (IP(3)Rs), and ry

283 s (RyRs), dihydropyridine receptors (DHPRs), inositol-1,4,5-trisphosphate receptors (IP(3)Rs), canoni

284 Inositol-1,4,5-trisphosphate receptors (IP3 Rs) modulate

285 ryanodine receptors, increased expression of inositol-1,4,5-trisphosphate receptors, and differential

286 gated Ca(2+) channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors.

287 IP(3) (inositol 1,4,5-trisphosphate) receptors (IP(3)Rs) regula

288 naptic stores (activated by spot-uncaging of inositol 1,4,5-trisphosphate) remain unaffected by GPR55

289 he lack of coupling between SP signaling and inositol 1,4,5-trisphosphate sensitive Ca(2+) stores, to

290 holipase C but is largely uncoupled from the inositol 1,4,5-trisphosphate sensitive Ca(2+) stores.

291 Interactions between ryanodine- and inositol 1,4,5-trisphosphate-sensitive intracellular Ca(

292 arise from regenerative Ca(2+) release from inositol 1,4,5-trisphosphate-sensitive stores followed b

293 Moreover, endogenous inositol-1,4,5-trisphosphate stimulation by the phosphol

294 C5a and UDP synergized in generating inositol 1,4,5-trisphosphate, suggesting synergy in acti

295 trisphosphate 3-kinase B (or Itpkb) converts inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetraki

296 IPMK phosphorylates inositol 1,4,5-trisphosphate to inositol tetrakisphospha

297 ulation of abscisic acid (ABA), proline, and inositol 1,4,5-trisphosphate under osmotic stress.

298 variety of inositol phosphates including myo-inositol 1,4,5-trisphosphate, which is a secondary messe

299 se C and the formation of diacylglycerol and inositol 1,4,5-trisphosphate, which results in the relea

300 ) to produce cAMP and via G(q/11) to produce inositol-1,4,5-trisphosphate, which is degraded to inosi