ライフサイエンスコーパス: inositol 1,4,5-trisphosphate receptor

1 mitochondrial calcium uniporter) and TcIP3R (inositol 1,4,5-trisphosphate receptor).

2 mily of intracellular Ca2+ release channels (inositol 1,4,5-trisphosphate receptors).

3 ontext of a structural homology model of the inositol 1,4,5-trisphosphate receptor.

4 Taxol increased binding of NCS-1 to the inositol 1,4,5-trisphosphate receptor.

5 ng protein), the ryanodine receptor, and the inositol 1,4,5-trisphosphate receptor.

6 e activity of the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor.

7 ive to inhibitors of the phospholipase C and inositol 1,4,5-trisphosphate receptor.

8 reased pool of Ca2+ for positive feedback on inositol 1,4,5-trisphosphate receptors.

9 efficiently activated in DT40 cells lacking inositol 1,4,5-trisphosphate receptors.

10 kinase A-mediated phosphorylation of type II inositol 1,4,5-trisphosphate receptors.

11 and endoplasmic reticulum Ca(2+) release via inositol 1,4,5-trisphosphate receptors.

12 gated Ca(2+) channels, the ryanodine and the inositol-1,4,5-trisphosphate receptors.

13 pase Cgamma to affect Ca(2+) release through inositol (1,4,5) trisphosphate receptors.

14 sed phosphorylation of the ER Ca(2+) channel inositol 1,4,5-trisphosphate receptor 1 (IP3R1) in CNG c

15 ly dependent on Ca2+ oscillation mediated by inositol 1,4,5-trisphosphate receptors 2 and 3 (ITPR2 an

16 Further, both inositol 1,4,5-trisphosphate receptor-3 and caveolin-1 w

17 Localization of Galpha(q/11), inositol 1,4,5-trisphosphate receptor-3, and phospholipa

18 s TRPC6, phospholipase Cbetas, Galpha(q/11), inositol 1,4,5-trisphosphate receptor-3, and syntaxin 3

19 lborate, a cell-permeant antagonist of D-myo-inositol 1,4,5-trisphosphate receptors, abrogates antige

20 attributed to changes in passive Ca2+ leak, inositol 1,4,5-trisphosphate receptor activity, or sensi

21 (8), two analogues of the superpotent 1D-myo-inositol 1,4,5-trisphosphate receptor agonist adenophost

22 dium pump, the sodium/calcium exchanger, and inositol-1,4,5-trisphosphate receptors (all ankyrin-B-bi

23 strate that TAT-PS2-LP can interact with the inositol 1,4,5-trisphosphate receptor and activate Ca(2+

24 itol 1,4,5-trisphosphate, which binds to the inositol 1,4,5-trisphosphate receptor and gates the open

25 of intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor and ryanodine rece

26 protein that is required for localization of inositol 1,4,5-trisphosphate receptor and ryanodine rece

27 ) release from the endoplasmic reticulum via inositol 1,4,5-trisphosphate receptors and by Ca(2+) ent

28 t from diacylglycerol, endoplasmic reticulum inositol 1,4,5-trisphosphate receptors and Ca2+ stores.

29 arcoplasmic reticulum Ca(2+) release through inositol 1,4,5-trisphosphate receptors and extracellular

30 demonstrate that RACK1 physiologically binds inositol 1,4,5-trisphosphate receptors and regulates Ca2

31 the cooperative activity of Ca(2+)-regulated inositol 1,4,5-trisphosphate receptors and ryanodine rec

32 rin-B (-/-) mice display mis-localization of inositol 1,4,5-trisphosphate receptors and ryanodine rec

33 uggests that it results from potentiation of inositol 1,4,5-trisphosphate receptors and/or phospholip

34 use morulae occurs predominantly through the inositol 1,4,5-trisphosphate receptor, and that alterati

35 ryanodine receptors, increased expression of inositol-1,4,5-trisphosphate receptors, and differential

36 g the phospholipase C antagonist U73122, the inositol 1,4,5-trisphosphate receptor antagonist 2-amino

37 oplasmic reticulum through small clusters of inositol 1,4,5-trisphosphate receptors, are the building

38 striated distribution of both ryanodine and inositol 1,4,5-trisphosphate receptors as well as normal

39 ral transcriptional regulator TFII-I and the inositol 1,4,5-trisphosphate receptor-associated PKG sub

40 Hg, ECs generated low-frequency (~2 min(-1)) inositol 1,4,5-trisphosphate receptor-based Ca(2+) event

41 tors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity f

42 ch is blunted by internal store depletion or inositol 1,4,5-trisphosphate receptor blockade.

43 0, p < 0.001), whereas pretreatment with the inositol 1,4,5-trisphosphate receptor blocker xestospong

44 glutamate receptors; (ii) membrane-permeable inositol 1,4,5-trisphosphate receptor blockers 2-APB and

45 epletion of internal stores or inhibition of inositol 1,4,5-trisphosphate receptors but not by inhibi

46 d upon activation of phospholipase C and the inositol 1,4,5-trisphosphate receptor, but not upon extr

47 to demonstrate that sensitization of type 1 inositol (1,4,5)-trisphosphate receptors by mHtt, which

48 parks arise from the cooperative activity of inositol 1,4,5-trisphosphate receptor Ca(2+) channels (I

49 as blocked by inhibiting the phospholipase C/inositol 1,4,5-trisphosphate receptor/Ca2+ signaling.

50 tributed to the differential distribution of inositol 1,4,5-trisphosphate receptor channel isoforms i

51 release events that arise from a cluster of inositol 1,4,5-trisphosphate receptor channels (IP(3)Rs)

52 ized releases of calcium through clusters of inositol 1,4,5-trisphosphate receptor channels constitut

53 They arise from clustered inositol 1,4,5-trisphosphate receptor/channels (IP3Rs),

54 estered in the endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors/channels (IP(3)Rs

55 physically with the N-terminal domain of the inositol 1,4,5-trisphosphate receptor, consistent with a

56 Importantly, ubiquitination of inositol 1,4,5-trisphosphate receptors correlates with s

57 onapoptotic necrotic cell death triggered by inositol 1,4,5-trisphosphate receptor-dependent calcium

58 have examined the distribution of the type 1 inositol 1,4,5-trisphosphate receptor during development

59 2+) signals interact with both ryanodine and inositol 1,4,5-trisphosphate receptors during agonist st

60 Glial cells do not express type 1 inositol 1,4,5-trisphosphate receptor, except for a tran

61 arked contrast with what is observed for the inositol 1,4,5-trisphosphate receptor for which the biph

62 (2+) binding protein that interacts with the inositol 1,4,5-trisphosphate receptor from a human brain

63 Adenophostin A, a potent activator of the inositol 1, 4,5-trisphosphate receptor, has been reporte

64 to a loss of function in the localization of inositol 1,4,5-trisphosphate receptors in ankyrin-B muta

65 Inositol 1,4,5-trisphosphate receptors in Caenorhabditis

66 many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation

67 transients (CaTs) are due to upregulation of inositol-1,4,5-trisphosphate receptor induced Ca(2+) rel

68 phospholipase C inhibitor U73122 and by the inositol 1,4,5-trisphosphate receptor inhibitor Xestospo

69 Xestospongin C (an inositol 1,4,5-trisphosphate receptor inhibitor) had no

70 crom concentrations of the membrane-permeant inositol 1,4,5-trisphosphate receptor inhibitor, 2-amino

71 However, xestospongin C, a specific inositol 1,4,5-trisphosphate receptor inhibitor, did not

72 tin A (AdA) is a potent agonist of the d-myo-inositol 1,4,5-trisphosphate receptor (Ins(1,4,5)P3R).

73 The inositol (1,4,5)-trisphosphate receptor (InsP(3)R) is an

74 Calcium release through inositol (1,4,5)-trisphosphate receptors (InsP(3)R) is t

75 ATP enhances Ca(2+) release from inositol (1,4,5)-trisphosphate receptors (InsP(3)R).

76 Modulation of the type 1 inositol (1,4,5)-trisphosphate receptors (InsP(3)R1) by

77 +)) by generating InsP(3) and activating the inositol 1,4, 5-trisphosphate receptor (InsP(3)R).

78 ut not wild-type Atx2 specifically binds the inositol 1,4,5-trisphosphate receptor (InsP(3)R) and inc

79 ng proteins (CaBPs) was shown to bind to the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+)

80 The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is a te

81 The inositol 1,4,5-trisphosphate receptor (InsP(3)R) is a te

82 The molecular mechanisms required for inositol 1,4,5-trisphosphate receptor (InsP(3)R) targeti

83 of SOCs and TRP channels is mediated by the inositol 1,4,5-trisphosphate receptor (InsP(3)R) was exa

84 The inositol 1,4,5-trisphosphate receptor (InsP(3)R), an int

85 protein that modulates Ca(2+) release by the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

86 o binds to and amplifies the activity of the inositol 1,4,5-trisphosphate receptor (InsP(3)R).

87 The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a u

88 exp) specifically associated with the type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

89 th the cytosolic C-terminal region of type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

90 ) specifically binds to and activates type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an in

91 -mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in car

92 The type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) was id

93 Phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) by PKA

94 Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) can be

95 Regulation of Ca(2+) release through inositol 1,4,5-trisphosphate receptors (InsP(3)R) has im

96 n kinase A (PKA)-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)R) in mou

97 Inositol 1,4,5-trisphosphate receptors (InsP(3)R) play a

98 calcium ([Ca(2+)](c)) through activation of inositol 1,4,5-trisphosphate receptors (InsP(3)R).

99 hannels interact directly with intracellular inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) and t

100 Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP(3)Rs) repre

101 ositive and negative [Ca(2+)](i) feedback on inositol 1,4,5-trisphosphate receptors (InsP(3)Rs).

102 through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP(3)Rs), whic

103 Bcl-2 interacts with the inositol 1,4,5-trisphosphate receptor (InsP3R) and thus

104 PS1 (M146L)and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+ rele

105 2+ release from intracellular stores through inositol 1,4,5-trisphosphate receptor (InsP3R) channels

106 The inositol 1,4,5-trisphosphate receptor (InsP3R) family of

107 tracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been

108 Both CGA and CGB associate with inositol 1,4,5-trisphosphate receptor (InsP3R) in a pH-d

109 We examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R) in mediat

110 The inositol 1,4,5-trisphosphate receptor (InsP3R) is an int

111 The inositol 1,4,5-trisphosphate receptor (InsP3R) is an int

112 ves are polarized in hepatocytes because the inositol 1,4,5-trisphosphate receptor (InsP3R) is concen

113 Wu et al. convincingly demonstrate that the inositol 1,4,5-trisphosphate receptor (InsP3R) is involv

114 The inositol 1,4,5-trisphosphate receptor (InsP3R) is the ma

115 ion of Ca(2+) waves, we examined the role of inositol 1,4,5-trisphosphate receptor (InsP3R) isoforms

116 xpression and function of the two rat type-1 inositol 1,4,5-trisphosphate receptor (InsP3R) ligand bi

117 The inositol 1,4,5-trisphosphate receptor (InsP3R) plays a k

118 , neuronal calcium sensor 1 (NCS-1), and the inositol 1,4,5-trisphosphate receptor (InsP3R) to preven

119 er intracellular Ca(2+) channels such as the inositol 1,4,5-trisphosphate receptor (InsP3R), is neces

120 Here we examined the role of the inositol 1,4,5-trisphosphate receptor (InsP3R)/Ca(2+) re

121 Inositol 1,4,5-trisphosphate receptors (InsP3R) are the

122 e- and splice variant-specific modulation of inositol 1,4,5-trisphosphate receptors (InsP3R) by inter

123 functional properties of the three mammalian inositol 1,4,5-trisphosphate receptors (InsP3R) isoforms

124 Inositol 1,4,5-trisphosphate receptors (InsP3R) play a k

125 discovered that mHtt protein binds to type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) and in

126 The type 1 inositol (1,4,5)-trisphosphate receptor (InsP3R1) plays

127 he three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor (InsP3R1) has been

128 known to increase the activity of the type-1 inositol 1,4,5-trisphosphate receptor (InsP3R1).

129 Type 1 inositol (1,4,5)-trisphosphate receptors (InsP3R1s) play

130 alicular membrane is mediated by the type II inositol 1,4,5-trisphosphate receptor (InsP3R2), so we i

131 mutation in ITPR2, which encodes the type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2), that wa

132 Antibodies against type 2 inositol 1,4,5-trisphosphate receptors (InsP3R2) and cal

133 The type III isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R3) is apica

134 lved in cardiac hypertrophic signaling, that inositol 1,4,5-trisphosphate receptors (InsP3Rs) in vent

135 nt isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using i

136 ctivation of certain cell surface receptors, inositol 1,4,5-trisphosphate receptors (InsP3Rs), which

137 family, modulates Ca2+-dependent activity of inositol 1,4,5-trisphosphate receptors (InsP3Rs).

138 regulates several Ca(2+) channels, including inositol 1,4,5-trisphosphate receptors (InsP3Rs).

139 Inositol-1,4,5-trisphosphate receptors (InsP3Rs) are ubi

140 we reported selective augmentation of type 3 inositol (1,4,5) trisphosphate receptors (IP(3)R3) in ly

141 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and rya

142 s) can be elicited from discrete clusters of inositol 1,4,5 trisphosphate receptors (IP(3)Rs) at low

143 lobal Ca(2+) concentration ([Ca(2+)](i)) via inositol 1,4,5-trisphosphate receptor (IP(3)R) activatio

144 ked by ryanodine (100 microM) but not by the inositol 1,4,5-trisphosphate receptor (IP(3)R) blocker,

145 poptotic activity of Bcl-2 by binding to the inositol 1,4,5-trisphosphate receptor (IP(3)R) Ca(2)(+)

146 in the channel domain that are critical for inositol 1,4,5-trisphosphate receptor (IP(3)R) channel f

147 t gating dynamics of a single, nonconducting inositol 1,4,5-trisphosphate receptor (IP(3)R) channel,

148 Inositol 1,4,5-trisphosphate receptor (IP(3)R) channels,

149 The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a calc

150 the regulatory domain of the neuronal type-I inositol 1,4,5-trisphosphate receptor (IP(3)R) isoform (

151 tly transfected with type I and type III myo-inositol 1,4,5-trisphosphate receptor (IP(3)R) isoforms

152 examethasone induces a striking elevation of inositol 1,4,5-trisphosphate receptor (IP(3)R) levels in

153 euronal Ca(2+) signaling by enhancing type-1 inositol 1,4,5-trisphosphate receptor (IP(3)R) steady-st

154 we demonstrated that PC2 interacts with the inositol 1,4,5-trisphosphate receptor (IP(3)R) to modula

155 nce tags (ESTs) demonstrated that the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R) was signi

156 tration-dependently and reversibly inhibited inositol 1,4,5-trisphosphate receptor (IP(3)R)-mediated

157 st three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor (IP(3)R).

158 ) Ca2+ depletion and prolonged activation of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca2+ rele

159 The inositol 1,4,5-trisphosphate receptor (IP(3)R-1), which

160 During oocyte maturation, the inositol 1,4,5-trisphosphate receptor (IP(3)R1), the cha

161 In cardiac myocytes the type-2 inositol 1,4,5-trisphosphate receptor (IP(3)R2) is the p

162 Inositol 1,4,5-trisphosphate receptors (IP(3)R) and ryan

163 Others, including the almost ubiquitous inositol 1,4,5-trisphosphate receptors (IP(3)R) and thei

164 The role of inositol 1,4,5-trisphosphate receptors (IP(3)R) in caspa

165 llular functions, including Ca(2+) efflux at inositol 1,4,5-trisphosphate receptors (IP(3)R) on the e

166 stimulates formation of cAMP and sensitizes inositol 1,4,5-trisphosphate receptors (IP(3)R) to IP(3)

167 in A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thou

168 novel protein which physiologically binds to inositol 1,4,5-trisphosphate receptors (IP(3)R).

169 upling of sarcoplasmic reticulum (SR) type 1 inositol 1,4,5-trisphosphate receptors (IP(3)R1) to plas

170 IP of Sec8 coimmunoprecipitates Sec6, type 3 inositol 1,4,5-trisphosphate receptors (IP(3)R3), and th

171 es of endoplasmic reticulum Ca(2+) channels, inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and rya

172 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a f

173 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are ubi

174 Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) form te

175 A number of studies have demonstrated that inositol 1,4,5-trisphosphate receptors (IP(3)Rs) interac

176 roximity of the C- and N-terminal domains of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) may be

177 Calcium (Ca(2+)) release through inositol 1,4,5-trisphosphate receptors (IP(3)Rs) regulat

178 knockdown and pharmacological inhibition of inositol 1,4,5-trisphosphate receptors (IP(3)Rs) stimula

179 gh the intracellular Ca(2+) release channel (inositol 1,4,5-trisphosphate receptors (IP(3)Rs)) that i

180 etabotropic glutamate receptors (mGluRs) and inositol 1,4,5-trisphosphate receptors (IP(3)Rs), suppor

181 IP(3) (inositol 1,4,5-trisphosphate) receptors (IP(3)Rs) regula

182 Inositol-1,4,5-trisphosphate receptors (IP(3)Rs) and rya

183 d the detailed intracellular distribution of inositol-1,4,5-trisphosphate receptors (IP(3)Rs), and ry

184 s (RyRs), dihydropyridine receptors (DHPRs), inositol-1,4,5-trisphosphate receptors (IP(3)Rs), canoni

185 ) release through the ryanodine receptors or inositol 1,4,5-trisphosphate receptors (IP3 R) and upon

186 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are a fa

187 Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3 Rs) are calc

188 Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expr

189 Inositol-1,4,5-trisphosphate receptors (IP3 Rs) modulate

190 Inositol 1, 4, 5-trisphosphate receptor (IP3R)-mediated

191 e of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanod

192 The inositol 1,4,5 trisphosphate receptor (IP3R) is an intra

193 is and the degradation of the Ca(2+) channel inositol 1,4,5-trisphosphate receptor (IP3R) affects pro

194 e increased amounts of messenger RNA for the inositol 1,4,5-trisphosphate receptor (IP3R) and increas

195 Inositol 1,4,5-trisphosphate receptor (IP3R) antagonists

196 Furthermore, inositol 1,4,5-trisphosphate receptor (IP3R) but not rya

197 t by evaluating the regulation of the type I inositol 1,4,5-trisphosphate receptor (IP3R) by TGF-beta

198 sm involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channe

199 A canonical example is the inositol 1,4,5-trisphosphate receptor (IP3R) channel, wh

200 Ca2+ liberation through inositol 1,4,5-trisphosphate receptor (IP3R) channels ge

201 PLC-gamma1) activation and Ca2+ release from inositol 1,4,5-trisphosphate receptor (IP3R) channels.

202 myo-Inositol 1,4,5-trisphosphate receptor (IP3R) degradation

203 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

204 The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiqui

205 The inositol 1,4,5-trisphosphate receptor (IP3R) is an intra

206 r ryanodine (400 microM), the antagonists of inositol 1,4,5-trisphosphate receptor (IP3R) or ryanodin

207 The inositol 1,4,5-trisphosphate receptor (IP3R) plays an es

208 cation channels that can be activated by the inositol 1,4,5-trisphosphate receptor (IP3R) protein.

209 ime and this is accompanied by a decrease in inositol 1,4,5-trisphosphate receptor (IP3R) responsiven

210 om apical Ca(2+) pools that are gated by the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and

211 beled cells provided the first evidence that inositol 1,4,5-trisphosphate receptor (IP3R) was phospho

212 of intracellular Ca2+ channels, such as the inositol 1,4,5-trisphosphate receptor (IP3R), have gener

213 strated to physiologically interact with the inositol 1,4,5-trisphosphate receptor (IP3R), the ryanod

214 The resistance of inositol 1,4,5-trisphosphate receptor (IP3R)-deficient c

215 o phospholipase C (PLC) isoforms, and (3) an inositol 1,4,5-trisphosphate receptor (IP3R).

216 not TRPC4, interacts with PLCgamma1 and the inositol 1,4,5-trisphosphate receptor (IP3R).

217 multiple intracellular targets including the inositol 1,4,5-trisphosphate receptor (IP3R).

218 Most inositol 1,4,5-trisphosphate receptors (IP3R) are expres

219 Inositol 1,4,5-trisphosphate receptors (IP3R) are mediat

220 intracellular calcium concentration through inositol 1,4,5-trisphosphate receptors (IP3R) on endopla

221 d or refilled from one small site via either inositol 1,4,5-trisphosphate receptors (IP3R) or ryanodi

222 The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precise

223 m the endoplasmic reticulum by modulation of inositol 1,4,5-trisphosphate receptors (IP3R), accountin

224 In DT40 B cells devoid of inositol 1,4,5-trisphosphate receptors (IP3R), the lack

225 hese channels: ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (IP3R).

226 Recent studies have suggested that inositol-1,4,5-trisphosphate-receptor (IP3R)-mediated Ca

227 The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) calcium re

228 a presented here demonstrate that the type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) protein, w

229 ype 2 ryanodine receptors (RyR2s) and type 2 inositol 1,4,5-trisphosphate receptors (IP3R2s).

230 inds, deubiquitylates, and stabilizes type 3 inositol-1,4,5-trisphosphate receptor (IP3R3), modulatin

231 Inositol (1,4,5)-trisphosphate receptors (IP3Rs) contrib

232 lting in reduced disulfide bond formation in inositol 1, 4, 5-trisphosphate receptors (IP3Rs).

233 ms, like the endoplasmic reticulum-localized inositol 1,4,5-trisphosphate receptors (IP3Rs) and the v

234 supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close

235 Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the ad

236 Ca2+ liberation through inositol 1,4,5-trisphosphate receptors (IP3Rs) plays a u

237 Inositol 1,4,5-trisphosphate receptors (IP3Rs) release c

238 hat Bok binds strongly and constitutively to inositol 1,4,5-trisphosphate receptors (IP3Rs), proteins

239 cell lines that Bok interacts strongly with inositol 1,4,5-trisphosphate receptors (IP3Rs), suggesti

240 otic cell death require calcium release from inositol 1,4,5-trisphosphate receptors (IP3Rs).

241 All three cell types express the three known inositol 1,4,5-trisphosphate receptors (IP3Rs).

242 n-regulation of both type I and type III myo-inositol 1,4,5-trisphosphate receptors (IP3Rs).

243 Such release occurs through a cluster of inositol 1,4,5-trisphosphate receptors (IP3Rs).

244 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shan

245 In brain, we find that type 1 inositol 1,4,5-trisphosphate receptor is expressed in ne

246 e also show, for the first time, that type 1 inositol 1,4,5-trisphosphate receptor is expressed in th

247 athway in which the expression of the type-1 inositol 1,4,5-trisphosphate receptor is regulated by th

248 Inositol 1,4,5-trisphosphate receptor isoforms are a fam

249 These data suggest separate roles for inositol 1,4,5-trisphosphate receptor isoforms in develo

250 g gate structure is conserved in all RyR and inositol 1,4,5-trisphosphate receptor isoforms.

251 ffects of NAFLD on expression of the type II inositol 1,4,5-trisphosphate receptor (ITPR2), the princ

252 The type 3 isoform of the inositol 1,4,5-trisphosphate receptor (ITPR3) is the mos

253 mutation in itr-1, which encodes the single inositol 1,4,5-trisphosphate receptor (ITR) in C. elegan

254 Moreover, direct PC2 binding to inositol 1,4,5-trisphosphate receptor, KIF3A, and TRPC1

255 of ankyrin-B are still capable of restoring inositol 1,4,5-trisphosphate receptor localization and n

256 l melastatin subfamily 4 channels via type 2 inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) re

257 Additionally, inositol 1,4,5-trisphosphate receptor-mediated release o

258 An increase in type-1 inositol 1,4,5-trisphosphate receptor mRNA and protein s

259 vation of cytosolic Ca(2+) by binding to the inositol 1,4,5-trisphosphate receptor on the endoplasmic

260 on of Mcl-1 did not affect expression of the inositol 1,4,5-trisphosphate receptor or the size of end

261 ta) stimulates phosphorylation of the type I inositol 1,4, 5-trisphosphate receptor, possibly via pro

262 monitor conformational changes of the type I inositol 1,4,5-trisphosphate receptor protein in membran

263 nd blockade of either ryanodine receptors or inositol 1,4,5-trisphosphate receptors reduced [Ca(2+)](

264 hrough L-type Ca2+ channels and release from inositol 1,4,5-trisphosphate receptor-sensitive intracel

265 athways (Ca(2+)/calmodulin-dependent kinase, inositol 1,4,5-trisphosphate receptor, SERCA).

266 uences in p53, CD44, neurofascin/L1, and the inositol 1,4,5-trisphosphate receptor suggests that the

267 ught to signal through the phospholipase and inositol (1,4,5)-trisphosphate receptor system, or throu

268 rypanosoma brucei acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (TbIP(3)R) for Ca(

269 astrocytes lack mGluR5, and knockout of the inositol 1,4,5-trisphosphate receptors that release Ca(2

270 ite matter of the spinal cord express type 1 inositol 1,4,5-trisphosphate receptor throughout develop

271 The inositol 1,4,5 trisphosphate receptor type 1 (IP3R1) in

272 The potentiation is absent in conditional inositol 1,4,5 trisphosphate receptor type 2 KO mice, wh

273 t processes: the intracellular Ca receptors, inositol 1,4,5-trisphosphate receptor type 1 (IP3R1) and

274 563del] and c.7659T>G [p.Phe2553Leu]) in the inositol 1,4,5-trisphosphate receptor type 1 gene (ITPR1

275 Furthermore, we show that induction of the inositol 1,4,5-trisphosphate receptor type 1 is controll

276 TPase and ryanodine receptor type 2, but not inositol 1,4,5-trisphosphate receptor type 2, were requi

277 mma13, phospholipase C-beta2 (PLC-beta2) and inositol 1,4,5-trisphosphate receptor type III (IP3R3).

278 n immunoprecipitation assay, we found ITPR1 (inositol 1,4,5-trisphosphate receptor, type 1) as a dire

279 A variant (rs718314) in the inositol 1,4,5-trisphosphate receptor, type 2 gene (ITPR

280 espective primary tumors, include C17orf104, inositol 1,4,5-trisphosphate receptor, type 3 (ITPR3), a

281 neurons, cGKII-dependent phosphorylation of inositol 1,4,5-trisphosphate receptors was decreased, re

282 tin A, two metabolically stable agonists for inositol 1,4,5-trisphosphate receptors, was investigated

283 ty filter, and S6 transmembrane helix of the inositol 1,4,5-trisphosphate receptor were mutated in or

284 activity were also blunted by inhibition of inositol 1,4,5-trisphosphate receptors with 2-aminoethox

285 y approximately 30% by the inhibition of the inositol 1,4,5-trisphosphate receptors with caffeine or