ライフサイエンスコーパス: inositol 1-phosphate

1 rmed from CDP-DAG and inositol (derived from inositol 1-phosphate).

2 enzyme to distinguish between HOLP and d-myo-inositol-1-phosphate).

3 ansporter and a kinase that generates 1L-myo-inositol 1-phosphate.

4 t the N-acetylglucosamine acceptor is 1L-myo-inositol 1-phosphate.

5 drolyzes PtdIns to form diacylglycerides and inositol 1-phosphate.

6 may inhibit the Ino1p-catalyzed synthesis of inositol 1-phosphate.

7 sphodiesterase activity that converts cIP to inositol 1-phosphate.

8 and generating the binding site for 1-L-myo-inositol-1-phosphate.

9 nding of UDP-N-acetylglucosamine and 1-L-myo-inositol-1-phosphate.

10 trates and in a complex with UDP and 1-L-myo-inositol-1-phosphate.

11 zes the first step in the synthesis of l-myo-inositol-1-phosphate.

12 conversion of glucose-6-phosphate (G-6-P) to inositol-1-phosphate.

13 of the product of the IPS reaction was L-myo-inositol-1-phosphate.

14 the conversion of glucose-6-phosphate to myo-inositol-1-phosphate.

15 t) induced a significant accumulation of [3H]inositol-1-phosphate ([3H]IP1).

16 atis and leads to production of radiolabeled inositol 1-phosphate and mycothiol.

17 The ability of IMPase to use both inositol 1-phosphates and galactose 1-phosphate equally

18 omplementary in producing enantiomeric D-myo-inositol-1-phosphate and D-myo-inositol-3-phosphate deri

19 ng occurred in two major orientations, while inositol 1-phosphate appeared primarily constrained to a

20 ons significantly decreased NE potency in an inositol 1-phosphate assay.

21 el insights into the architecture of the myo-inositol 1-phosphate binding site and the involvement of

22 hydrolysis of phosphatidylinositol (PI) into inositol 1-phosphate by a unique mechanism involving for

23 yclic)-phosphate (cIP) and cIP hydrolysis to inositol 1-phosphate by Bacillus thuringiensis phosphati

24 P NMR studies confirmed that the affinity of inositol 1-phosphate for the enzyme was indeed weak (K(D

25 proposed to occur with myo-inositol and myo-inositol 1-phosphate (I-1-P) used as precursors.

26 by cyclic phosphodiesterase activity to form inositol-1-phosphate (I-1-P)).

27 by cyclic phosphodiesterase activity to form inositol-1-phosphate (I-1-P)].

28 nitude greater than those determined for myo-inositol 1-phosphate (IMP) and fructose 1,6-bisphosphate

29 mine from UDP-N-acetylglucosamine to 1-L-myo-inositol-1-phosphate in the first committed step of myco

30 tol-containing compounds revealed that L-myo-inositol-1-phosphate is the principal inhibitory compone

31 1l-myo-inositol 1-phosphate (MIP) synthase catalyzes the conver

32 nversion of d-glucose 6-phosphate to 1-l-myo-inositol-1-phosphate (MIP), the first and rate-limiting

33 ivity was obtained with myo-inositol, 1D-myo-inositol 1-phosphate, or myo-inositol 2-phosphate as the

34 the human trimeric NCRD with myoinositol and inositol 1-phosphate showed binding of the equatorial OH

35 Combining mutational radioligand binding and inositol 1-phosphate signaling studies, together with mo

36 und to share similarities with that of a myo-inositol 1 phosphate synthase mutant that is also sensit

37 HO1/PSS), PI synthase (encoded by PIS1), and inositol 1-phosphate synthase (encoded by INO1) activiti

38 In this study, we focused on L-myo-inositol 1-phosphate synthase (INPS), which commits carb

39 nscripts for the enzyme, Inps1, encoding myo-inositol 1-phosphate synthase (INPS1), from the ice plan

40 l-myo-inositol 1-phosphate synthase (MIPS; EC 5.5.1.4) catalyz

41 specific activity of the seed-expressed myo-inositol 1-phosphate synthase by about 90%.

42 INO1, encoding inositol 1-phosphate synthase, is the most highly regula

43 anscription of INO1, the structural gene for inositol 1-phosphate synthase.

44 nstructed a mutant lacking the gene encoding inositol-1-phosphate synthase (ino1), which catalyses th

45 ely identified as the Archaeoglobus fulgidus inositol-1-phosphate synthase (IPS) gene was overexpress

46 ch as intestinal trefoil factor (ITF) or myo-inositol-1-phosphate synthase (IPS).

47 rized two distinct polypeptides with 1-L-myo-inositol-1-phosphate synthase (MI-1-P synthase) activity

48 myo-Inositol-1-phosphate synthase (mIPS) catalyzes the conve

49 Myo-inositol-1-phosphate synthase (MIPS) catalyzes the conve

50 myo-Inositol-1-phosphate synthase (mIPS) catalyzes the first

51 ccurrence in all eukaryotes, the role of myo-inositol-1-phosphate synthase and de novo inositol biosy

52 oding only two of the four required enzymes, inositol-1-phosphate synthase and inositol monophosphata

53 1-l-myo-Inositol-1-phosphate synthase catalyzes the conversion o

54 otated locus TM1418) form an operon with the inositol-1-phosphate synthase encoding gene (TM1419).

55 ion of tobacco Alternative oxidase1a and Myo-inositol-1-phosphate synthase in PsAP2 overexpressing to

56 myo-Inositol-1-phosphate synthase is a conserved enzyme that

57 rictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, lead

58 e enzyme required for inositol biosynthesis, inositol-1-phosphate synthase, encoded by INO1, is not r

59 s transcripts indicates that neither the myo-inositol-1-phosphate synthase, the first step in inosito

60 ct expression of INO1, a structural gene for inositol-1-phosphate synthase.

61 That same decrease in myo-inositol 1-phosphate synthetic capacity leads to a decre

62 onversion of d-glucose 6-phosphate to 1l-myo-inositol 1-phosphate, the first and rate-limiting step i

63 ganic phosphate from HOLP but not from d-myo-inositol-1-phosphate, the main substrate of IMPases.

64 ic attack of the 3-hydroxyl group of 1-L-myo-inositol-1-phosphate while at the same time promoting th