ライフサイエンスコーパス: inositol 5-phosphatase

1 demonstrating the function of an additional inositol 5-phosphatase.

2 inhibitory Lyn target SH2 domain-containing inositol 5' phosphatase.

3 g tyrosine phosphatase-2, and SH2-containing inositol 5'-phosphatase.

4 y enhancing Src homology 2 domain-containing inositol 5' phosphatase 1 activity or by blocking sphing

5 The Src homology 2 domain-containing inositol 5'-phosphatase 1 (SHIP1) dephosphorylates phosp

6 The phosphatase Src homology 2-containing inositol 5'-phosphatase 1 (SHIP1) is known to exert inhi

7 if phosphorylation and SH2 domain-containing inositol 5'-phosphatase 1 activation were Src-dependent,

8 s restored the reduced SH2 domain-containing inositol 5'-phosphatase 1 to normal levels.

9 the presence of SHIP1 (SH2 domain-containing inositol 5'-phosphatase 1) and involves inhibition of Mn

10 ess SHIP-1 (Src homology 2 domain-containing inositol 5'-phosphatase 1), that CRP induces SHIP-1 stim

11 esulting activation of SH2 domain-containing inositol 5'-phosphatase 1, and consistent with this mech

12 trolling the levels of SH2 domain-containing inositol 5'-phosphatase 1, miR-155 in part maintains an

13 inhibitory motif, and SH2 domain-containing inositol 5'-phosphatase 1.

14 we identify Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1) as a direct target of m

15 s mediated through the SH2 domain-containing inositol 5-phosphatase 1 (SHIP1)/protein kinase B (Akt)

16 r levels of Src homology-2 domain-containing inositol 5-phosphatase 1 and were more responsive to B-c

17 SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are stru

18 SH2-containing inositol-5'-phosphatase 1 (SHIP1) is an endogenous inhib

19 gnaling inositol phosphatase, SH2-containing inositol-5-phosphatase 1 (SHIP), results in the loss of

20 SH2-domain-containing inositol 5'-phosphatase-1 (SHIP) deficiency significantl

21 The SH2 domain-containing inositol 5'-phosphatase-1 (SHIP) has the potential to mo

22 we show that a deficiency of SH2-containing inositol-5'-phosphatase-1 (SHIP) in a nonhematopoietic h

23 nositide phosphatases, SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) and phosphatase and te

24 , which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to in

25 Shc homology 2-containing inositol 5' phosphatase-2 (SHIP2) is a lipid phosphatase

26 Inositol 5' phosphatases (5PTases) are enzymes that remo

27 We previously have identified 15 putative inositol 5-phosphatases (5PTases) from Arabidopsis and s

28 Cdk5 phosphorylation inhibited the inositol 5-phosphatase activity of synaptojanin 1, where

29 n COS7 cells produced a 140-kDa protein with inositol 5'-phosphatase actvity.

30 Thus, inositol 5-phosphatases are important contributors to th

31 Inositol-5-phosphatases are important enzymes involved i

32 t by the synaptojanin 2A mutants lacking the inositol 5'-phosphatase domain.

33 re two similar proteins comprising a central inositol 5-phosphatase domain followed by an ASH and a R

34 The inositol 5-phosphatase domain of OCRL (5-ptase(OCRL)), w

35 s strongly inhibited by coclustering with an inositol 5-phosphatase domain to decrease local PI(4,5)P

36 Moreover, in vivo recruitment of Synj1's inositol 5-phosphatase domain to endophilin-induced memb

37 f synaptojanin defines it as a member of the inositol-5-phosphatase family, which includes the produc

38 Synaptojanin 1 is an inositol 5'-phosphatase highly enriched in nerve termina

39 ino-terminal SacI homology region, a central inositol 5'-phosphatase homology region, and a carboxyl-

40 mediated by SHIP (Src homology 2-containing inositol 5' phosphatase), in particular SHIP1, which act

41 Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an impor

42 ble recruitment to the plasma membrane of an inositol 5-phosphatase module through the rapamycin/FRB/

43 Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syn

44 Mutations in the inositol 5-phosphatase OCRL cause Lowe syndrome and Dent

45 We found that two inositol 5-phosphatases, OCRL and Inpp5B, become associa

46 Mutation of the inositol 5-phosphatase OCRL1 causes Lowe syndrome and De

47 Mutations of the inositol 5' phosphatase oculocerebrorenal syndrome of Lo

48 conditions that result from mutations of the inositol 5-phosphatase oculocerebrorenal syndrome of Low

49 ns, including SHC, Src homology 2-containing inositol-5-phosphatase, protein kinase C-delta, and Erk2

50 be a comparative study of two representative inositol-5-phosphatases, Schizosaccharomyces pombe synap

51 SHIP-2, a recently identified inositol 5'-phosphatase, shares high level homology with

52 RI on mast cells leads to recruitment of the inositol 5' phosphatase SHIP and to inhibition of mast c

53 The inositol 5' phosphatase SHIP is recruited to tyrosyl-pho

54 phosphorylated, recruits the SH2-containing inositol 5'- phosphatase SHIP and the SH2-containing tyr

55 Because the inositol 5'-phosphatase SHIP-1 is an important regulator

56 f the FcR, the adapter protein, Shc, and the inositol 5'-phosphatase Ship.

57 ported here, Src homology-2 (SH2)-containing inositol 5-phosphatase SHIP-1 and its adaptor Dok-1 were

58 e protein tyrosine phosphatase SHP-1 and the inositol 5-phosphatase SHIP.

59 The SH2-containing inositol-5-phosphatase SHIP is a 145-kDa protein which h

60 vels of the Src homology 2 domain-containing inositol 5' phosphatase (SHIP) in basophils.

61 ermine the role of src-homology 2-containing inositol 5' phosphatase (SHIP) in regulating the PI3K/Ak

62 The Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) is recruited to immunorec

63 The SH2-containing inositol 5'-phosphatase (SHIP) is tyrosine-phosphorylate

64 SH2-containing inositol 5'-phosphatase (SHIP) modulates the activation

65 The SH2 domain containing inositol 5'-phosphatase (SHIP) was initially described a

66 t anti-Ig and that the SH2 domain-containing inositol 5'-phosphatase (SHIP) was recruited to the same

67 his pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility

68 hatases SHP-1, SHP-2, and the SH2 containing inositol 5'phosphatase (SHIP) to the phosphorylated Fc g

69 Src homology 2 domain-containing inositol 5-phosphatase (SHIP(-/-)) animals display an ag

70 er germline or induced SH2 domain-containing inositol 5-phosphatase (SHIP) deficiency in the host abr

71 als lacking Src homology 2 domain-containing inositol 5-phosphatase (SHIP) display a reduction in lym

72 role of the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) has been invoked in a vari

73 an important role for SH2-domain-containing inositol 5-phosphatase (SHIP) in negative signaling.

74 The Src homology (SH)2-containing inositol 5-phosphatase (SHIP) negatively regulates a var

75 y which the Src homology 2 domain-containing inositol 5-phosphatase (SHIP) negatively regulates phago

76 hosphatase, Src homology domain 2-containing inositol 5-phosphatase (SHIP), for FcgammaRIIB-mediated

77 mice deficient in the SH2 domain-containing inositol 5-phosphatase (SHIP), in response to collagen r

78 itol-5-phosphatase Src homology 2-containing inositol 5-phosphatase (SHIP), which has been shown by u

79 ine phosphatase SHP-2 and the SH2 containing inositol 5-phosphatase (SHIP).

80 protein 2 (Grb2), and SH2 domain containing inositol 5-phosphatase (SHIP).

81 osine and recruits the SH2 domain-containing inositol 5-phosphatase (SHIP).

82 ermine that Src homology 2 domain-containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding

83 restricted protein Src homology 2-containing inositol-5-phosphatase (SHIP) blunts phosphatidylinosito

84 A SH2-domain containing inositol-5-phosphatase (SHIP) is a regulator of PI3K sig

85 The inositol 5'-phosphatase, SHIP (also referred to as SHIP-

86 yrosine phosphatases, SHP1 and SHP2, and the inositol 5'-phosphatase, SHIP.

87 l blasts also express the recently described inositol 5-phosphatase, SHIP-2.

88 In this study, we show that the inositol 5' phosphatases SHIP1 and SHIP2 interact prefer

89 Inpp5d (Src homology 2 domain-containing inositol-5-phosphatase [Ship1])-deficient mice experienc

90 The SH2 domain-containing inositol 5' phosphatase, SHIP1, regulates hematopoietic

91 kDa isoform of the Src homology 2-containing inositol 5-phosphatase, SHIP1.

92 In this study, we show that the inositol 5-phosphatase SHIP2, a negative regulator of PI

93 ynaptojanin) and human SH2 domain-containing inositol-5-phosphatase SHIP2.

94 de lipids, the type II SH2-domain-containing inositol 5-phosphatase (SHIP2; approved gene symbol Inpp

95 SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-ph

96 om the consumption of PtdIns 3,4,5-P3 by the inositol-5-phosphatase Src homology 2-containing inosito

97 e indicates that ex vivo B cells require the inositol 5-phosphatase, Src homology domain 2-containing

98 ) is an integral membrane protein related to inositol-5-phosphatases such as synaptojanin, a protein

99 The GTPase dynamin I and the inositol 5-phosphatase synaptojanin are nerve terminal p

100 H3) domain with the GTPase dynamin I and the inositol-5-phosphatase synaptojanin.

101 d by the activation of SH2 domain-containing inositol 5-phosphatase that inhibits WASP activation.

102 SHIP1 is an SH2 domain containing inositol-5-phosphatase that appears to be a negative reg

103 ietic progenitor kinase 1 and SH2-containing inositol 5-phosphatase to BCR signalosomes.

104 sphatase-1 (SHP-1) and SH2 domain-containing inositol 5 phosphatase were hyperphosphorylated in GC ce

105 in (synaptojanin 1) is a recently identified inositol 5'-phosphatase, which is highly enriched in ner

106 The in vivo association of SH2-containing inositol 5'-phosphatase with IL-4Ralpha was verified by

107 he presence of a family of synaptojanin-type inositol 5'-phosphatases with different tissue and subce