ライフサイエンスコーパス: inositol hexakisphosphate

1 cPho5, is not able to hydrolyze phytic acid (inositol hexakisphosphate).

2 biomolecules of low molecular weight (e.g., inositol hexakisphosphates).

3 t metabolites inositol pentakisphosphate and inositol hexakisphosphate.

4 that measured the displacement of D-myo-[3H]inositol hexakisphosphate.

5 on heparin-agarose and affinity elution with inositol hexakisphosphate.

6 tion identified the bioactive molecule as an inositol hexakisphosphate.

7 ty is stimulated by Gle1 and its coactivator inositol hexakisphosphate.

8 fy specific NMR signals like myo- and scyllo-inositol hexakisphosphate.

9 akisphosphate 2-kinase (Ipk1) that generates inositol hexakisphosphate.

10 Inositol hexakisphosphate-1 (IP6K1) generates the inosit

11 Inositol hexakisphosphate accounted for 46-54% of the so

12 Inositol hexakisphosphate and other inositol high polyph

13 AP3 binds both inositol hexakisphosphate and preassembled clathrin cage

14 finity (Km = 0.7 microM) and selectivity for inositol hexakisphosphate as substrate.

15 However, neither inositol hexakisphosphate binding nor clathrin cage bind

16 Inositol hexakisphosphate, but not inositol tetrakisphos

17 repeat domain of TIR1 contains an unexpected inositol hexakisphosphate co-factor and recognizes auxin

18 However, with the addition of inositol hexakisphosphate, Gag adopts a linear conformat

19 tended conformation required the presence of inositol hexakisphosphate in addition to nucleic acid.

20 was only 7.5-fold weaker a ligand than D-myo-inositol hexakisphosphate in assays that measured the di

21 Both [3H]inositol trisphosphate and [3H]inositol hexakisphosphate increased 3-and 1.5-fold, resp

22 upted, although the presence of 10% residual inositol hexakisphosphate indicates the existence of a m

23 cellular interactions between arrestin-2 and inositol hexakisphosphate (inositol 1,2,3,4,5,6-hexakisp

24 al toxin TcdB and recent studies showed that inositol hexakisphosphate (Ins(1,2,3,4,5,6)P(6) or InsP(

25 proteolytically processed in the presence of inositol hexakisphosphate (InsP(6)) by an intrinsic cyst

26 ophila pathways leading to the production of inositol hexakisphosphate (InsP(6)) have been elucidated

27 enzyme(s) responsible for the production of inositol hexakisphosphate (InsP(6)) in vertebrate cells

28 Inositol hexakisphosphate (InsP(6)) levels rise and fall

29 ol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) levels were depleted

30 mammals (types 1 and 2), which phosphorylate inositol hexakisphosphate (InsP(6)) to diphosphoinositol

31 ol 1,3,4,5,6-pentakisphosphate (InsP(5)) and inositol hexakisphosphate (InsP(6)) with high affinity i

32 * Myo-inositol hexakisphosphate (InsP(6)), abundant in animals

33 ere by Gle1 together with the small-molecule inositol hexakisphosphate (InsP(6)).

34 which is promoted by the allosteric cofactor inositol hexakisphosphate (InsP(6)).

35 The CPD is activated upon binding inositol hexakisphosphate (InsP(6)).

36 roduce large amounts of their precursor, myo-inositol hexakisphosphate (InsP6 ).

37 Interestingly, Gle1 binds directly to inositol hexakisphosphate (InsP6) and InsP6 potentiates

38 myces cerevisiae defined an in vivo role for inositol hexakisphosphate (InsP6) and NPC-associated Gle

39 InsP7 is formed from inositol hexakisphosphate (InsP6) by a family of three i

40 InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified

41 Cellular inositol hexakisphosphate (InsP6) induces an autocatalyt

42 Recent studies have shown inositol hexakisphosphate (InsP6) is a potent cofactor f

43 myo-Inositol hexakisphosphate (InsP6) is the most abundant i

44 akisphosphate kinases (InsP6Ks) that convert inositol hexakisphosphate (InsP6) to InsP7, conferred en

45 ted by the eukaryote-specific small molecule inositol hexakisphosphate (InsP6), and we present the 2.

46 After activation by inositol hexakisphosphate (InsP6), the autoprotease clea

47 r InsP6 kinase (InsP6K/IP6K), which converts inositol hexakisphosphate (InsP6/IP6) to InsP7, causes r

48 Eukaryotic inositol-hexakisphosphate (InsP6) binds an autoprocessin

49 Phytic acid (myo-inositol hexakisphosphate, InsP6) is an important phosph

50 uring messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facil

51 Four stereoisomers of inositol hexakisphosphate (IP(6)) occur, although for th

52 , the conserved mRNA export factors Gle1 and inositol hexakisphosphate (IP(6)) play an essential role

53 It was recently shown that myo-inositol hexakisphosphate (IP(6)) stimulates the joining

54 inositol pyrophosphate synthesis, converting inositol hexakisphosphate (IP(6)) to IP(7).

55 Inositol hexakisphosphate (IP(6)) was previously found t

56 Despite the high deposition of inositol hexakisphosphate (IP(6)), also known as phytate

57 yme at the branch point for the synthesis of inositol hexakisphosphate (IP(6)), an intracellular sign

58 ity of DEAD-box protein Dbp5 is activated by inositol hexakisphosphate (IP(6))-bound Gle1 to mediate

59 itol 1,3,4,5,6-pentakisphosphate (IP(5)) and inositol hexakisphosphate (IP(6)).

60 n of Dbp5's ATPase activity by Gle1 bound to inositol hexakisphosphate (IP(6)).

61 pJ and identify this activating factor to be inositol hexakisphosphate (IP(6)).

62 function is dependent on the small molecule inositol hexakisphosphate (IP(6)).

63 ), inositol 1,4,5-trisphosphate (IP3 ), and inositol hexakisphosphate (IP6 ) in T. brucei different

64 re we report the characterization of a human inositol hexakisphosphate (IP6) and diphosphoinositol pe

65 Vip1 and Asp1 acted as enzymes that encode inositol hexakisphosphate (IP6) and inositol heptakispho

66 sphate, is synthesized on phosphorylation of inositol hexakisphosphate (IP6) by IP6 kinases, of which

67 Production of inositol hexakisphosphate (IP6) by Ipk1, the inositol-1,

68 family of enzymes in charge of synthesizing inositol hexakisphosphate (IP6) in eukaryotic cells.

69 Inositol hexakisphosphate (IP6) inhibits nucleosome mobi

70 Here, we show that inositol hexakisphosphate (IP6) is a non-receptor activa

71 Unexpectedly, inositol hexakisphosphate (IP6) is buried within the enz

72 his question, we have previously purified an inositol hexakisphosphate (IP6) kinase from rat brain su

73 We have purified an inositol hexakisphosphate (IP6) kinase from rat brain su

74 nd are formed primarily by a family of three inositol hexakisphosphate (IP6) kinases (IP6K1-3).

75 We have now explored the binding of inositol hexakisphosphate (IP6) to Gag and its effects u

76 Previously, inositol hexakisphosphate (IP6) was shown to be bound by

77 phate, inositol pentakisphosphate (IP5), and inositol hexakisphosphate (IP6)) in rat cells.

78 However, inositol hexakisphosphate (IP6), a fairly abundant form

79 linositol triphosphate (PIP3), we found that inositol hexakisphosphate (IP6), a soluble signaling mol

80 Myo-inositol hexakisphosphate (IP6), is the main iron chelat

81 mational change of HopZ1a in the presence of inositol hexakisphosphate (IP6), which acts as a eukaryo

82 r messenger RNA export through production of inositol hexakisphosphate (IP6).

83 om phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6).

84 structure further reveals that Pds5 can bind inositol hexakisphosphate (IP6).

85 inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6).

86 inositol 1,3,4,5-tetrakisphosphate (IP4) and inositol hexakisphosphate (IP6).

87 Phytate (inositol hexakisphosphate, IP6) is a regulator of intrac

88 ates from inositol pentakisphosphate but not inositol hexakisphosphate is indispensable for optimal I

89 g-Zipper protein also assembles correctly if inositol hexakisphosphate is supplemented with other pol

90 Phytic acid (myo-inositol hexakisphosphate) is the major storage form of

91 isphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axi

92 itol pentakisphosphate 2-kinase (TbIP5K) and inositol hexakisphosphate kinase (TbIP6K).

93 Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the

94 Inositol hexakisphosphate kinase 1 (IP6K1) participates

95 Here, we demonstrate that inositol hexakisphosphate kinase 1 (IP6K1), the enzyme r

96 Inositol hexakisphosphate kinase 1 (IP6K1), which genera

97 We previously showed that inositol hexakisphosphate kinase 2 (IHPK2) functions as

98 We recently identified inositol hexakisphosphate kinase 2 (IP6K2) as a positive

99 A new target gene, coding for inositol hexakisphosphate kinase 2 (IP6K2) was identifie

100 Inositol hexakisphosphate kinase 2 (IP6K2), a member of

101 s revealed that RID-2 was identical to human inositol hexakisphosphate kinase 2 (IP6K2).

102 sphosphate kinase 2 (IP6K2), a member of the inositol hexakisphosphate kinase family, functions as a

103 1-1, that is predicted to encode a conserved inositol hexakisphosphate kinase from the VIP family tha

104 In this study, we report that IP6K1, an inositol hexakisphosphate kinase that catalyzes the synt

105 We found that cells lacking inositol hexakisphosphate kinase, which is responsible f

106 (Hh) signaling for the IP kinase designated inositol hexakisphosphate kinase-2 (IP6K2) that produces

107 Inositol hexakisphosphate kinase-2 (IP6K2), one of a fam

108 Inositol hexakisphosphate kinase-2 (IP6K2), one of the m

109 Inositol hexakisphosphate kinase-2 (IP6K2), which genera

110 isiae, extracellular [Pi] is "sensed" by the inositol-hexakisphosphate kinase (IP6K) that synthesizes

111 e synthesized by a recently cloned family of inositol hexakisphosphate kinases (InsP(6)Ks).

112 exakisphosphate (InsP6) by a family of three inositol hexakisphosphate kinases (InsP6K).

113 nase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert

114 The inositol hexakisphosphate kinases (IP6Ks) are the princi

115 Inositol trisphosphate kinases (IP3Ks) and inositol hexakisphosphate kinases (IP6Ks) each regulate

116 We identified and cloned a family of three inositol hexakisphosphate kinases (IP6Ks) that generate

117 takisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates div

118 hosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks), of which IP6K

119 are generated primarily by a family of three inositol hexakisphosphate kinases (IP6Ks), the principal

120 They are formed by a family of inositol hexakisphosphate kinases (IP6Ks).

121 , 1 mM Km for ATP) of the 5-InsP7-generating inositol hexakisphosphate kinases (IP6Ks).

122 inases, inositol phosphate multikinases, and inositol hexakisphosphate kinases.

123 myl-Met-Leu-Phe, platelet-activating factor, inositol hexakisphosphate, lipopolysaccharide, leukotrie

124 levels of either inositol pentakisphosphate, inositol hexakisphosphate or other diphosphorylated inos

125 is Bifidobacterium strain contributed to myo-inositol hexakisphosphate (phytate) hydrolysis, resultin

126 In these habitats, myo-inositol hexakisphosphate (phytate) is prevalent and use

127 Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator

128 Soluble -myo-inositol hexakisphosphate shows converse behavior.

129 cells, albeit at low levels as compared with inositol hexakisphosphate synthesis.

130 However, neo- and d-chiro-inositol hexakisphosphates were recently revealed in bot