ライフサイエンスコーパス: inositol monophosphatase

1 with that proposed previously for the human inositol monophosphatase.

2 beta-bulge that is conserved in related myo-inositol monophosphatases.

3 ial target of lithium action, in addition to inositol monophosphatases.

4 bundant transcript in axons was mRNA for myo-inositol monophosphatase-1 (Impa1), a key enzyme that re

5 of human inositol monophosphatase, exhibits inositol monophosphatase activity but with substrate spe

6 The purified protein has inositol monophosphatase activity that is inhibited by t

7 In the inm1Delta:URA3 null mutant, inositol monophosphatase activity was reduced but not el

8 likely related to its known ability to block inositol monophosphatase activity.

9 ich reduces InsP3 levels by interfering with inositol monophosphatase, also failed to alter I(CRAC).

10 id sequence significantly similar to that of inositol monophosphatase, an enzyme that is not involved

11 oM and 302 microM for the wild-type, [Gln217]inositol monophosphatase and [Phe219]inositol monophosph

12 .8 mM and 29.1 mM for the wild-type, [Gln217]inositol monophosphatase and [Phe219]inositol monophosph

13 is suppressed by an inhibitor of the enzyme inositol monophosphatase and hence of the phosphatidylin

14 report that the antioxidant ebselen inhibits inositol monophosphatase and induces lithium-like effect

15 es of lithium were mediated by inhibition of inositol monophosphatase and led to free inositol deplet

16 thium also inhibits other targets, including inositol monophosphatase and structurally related phosph

17 residues are required for activation of myo-inositol monophosphatase, and enzyme activation is enhan

18 Lithium inhibits inositol monophosphatase at therapeutically effective co

19 other Li(+)-sensitive phosphatases, such as inositol monophosphatase, but molecular modelling of I(1

20 e (ORF) YHR046c (termed INM1), which encodes inositol monophosphatase, characterized the protein Inm1

21 Inositol monophosphatase (EC 3.1.3.25) in hyperthermophi

22 [Gln217]inositol monophosphatase and [Phe219]inositol monophosphatase enzymes respectively.

23 [Gln217]inositol monophosphatase and [Phe219]inositol monophosphatase enzymes, respectively, each sho

24 is substantially homologous to that of human inositol monophosphatase, exhibits inositol monophosphat

25 Candidates include inositol monophosphatases, glycogen synthase kinase-3 (G

26 Myo-inositol (inositol) monophosphatase (IMP), an enzyme which catalyz

27 ed the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its r

28 We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-l

29 ces mTOR-independent autophagy by inhibiting inositol monophosphatase (IMPase) and reducing inositol

30 Inositol monophosphatase (IMPase) catalyzes the hydrolys

31 ntial biomolecule that is synthesized by myo-inositol monophosphatase (IMPase) from inositol monophos

32 Lithium sensitive myo-inositol monophosphatase (IMPase) is a pivotal enzyme wh

33 a coli product of the suhB gene, SuhB, is an inositol monophosphatase (IMPase) that is best known as

34 During the course of our analysis of myo-inositol monophosphatase (IMPase), a key enzyme of brain

35 In this context, we examined host inositol monophosphatase (IMPase), reduced levels of whi

36 first step in inositol biosynthesis, nor the inositol monophosphatase (IMPase), which generates myo-i

37 s is that lithium acts through inhibition of inositol monophosphatase (IMPase).

38 Li inhibits inositol-monophosphatase (IMPase)-1.

39 previously in prokaryotes and resembles myo-inositol monophosphatases (IMPases).

40 ion of inositol metabolism, we characterized inositol monophosphatase in this yeast.

41 tial for the catalytic activity of mammalian inositol monophosphatase, increase the ellipticity in th

42 mimetic with the potential both to validate inositol monophosphatase inhibition as a treatment for b

43 Inositol monophosphatase is a key enzyme in the de novo

44 Inositol monophosphatase is a possible target but no bio

45 oader than those of bacterial and eukaryotic inositol monophosphatases (it can also act as a fructose

46 y converted to the final product, DIP, by an inositol monophosphatase-like phosphatase.

47 Inositol monophosphatase plays a vital role in the de no

48 s are pretreated with Li(+), an inhibitor of inositol monophosphatases that prevents PIP2 resynthesis

49 d enzymes, inositol-1-phosphate synthase and inositol monophosphatase, were identified.