ライフサイエンスコーパス: inositol phosphatase

1 SHIP-1 (Src homology [SH2] domain-containing inositol phosphatase).

2 e SopE-dependent activation of an endogenous inositol phosphatase.

3 vity, thus implicating the involvement of an inositol phosphatase.

4 2) domain-containing cytoplasmic tyrosine or inositol phosphatases.

5 (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1 (SHIP-1) and internalization of I

6 EAT-2 was mediated by SH2 domain-containing inositol phosphatase 1 (SHIP-1), which was recruited via

7 The SH2-containing inositol phosphatase-1 (SHIP-1) is a 5' inositol phospha

8 SH2 domain-containing inositol phosphatase-1 (SHIP-1) is phosphorylated on Y10

9 SHIP1 to be phosphorylated and stimulate its inositol phosphatase activity.

10 ding evidence that Src homology 2 containing inositol phosphatase, an inhibitor of NF-kappaB activati

11 kines and the upregulation of SH2-containing inositol phosphatase, an inhibitor of NF-kappaB signalin

12 and expression of Src homology 2-containing inositol phosphatase and Src homology 2-containing prote

13 ember function: first, several targets of an inositol-phosphatase-dependent inhibitory signaling path

14 ortance of the tyrosine phosphatases and the inositol phosphatase differs depending on the cell type.

15 int mutations of the signature motifs in the inositol phosphatase domain abolish SHIP's ability to in

16 atic mutagenesis approach, we identified the inositol phosphatase domain of SHIP between amino acids

17 is novel protein, p150(ship) (SH2-containing inositol phosphatase), identifies a component of a new g

18 nositol phosphatase) or SHIP (SH2-containing inositol phosphatase) is a recently identified SH2 domai

19 ning inositol phosphatase-1 (SHIP-1) is a 5' inositol phosphatase known to negatively regulate the pr

20 SHIP1 is a 5'-inositol phosphatase known to negatively regulate the si

21 SHIP2, a 5'-inositol phosphatase, localizes at the invadopodium core

22 usly identified as Src homology 2-containing inositol phosphatase, only under conditions of negative

23 SIP (signaling inositol phosphatase) or SHIP (SH2-containing inositol p

24 The inositol phosphatases phosphatase and tensin homologue (

25 me 10 or src homology 2 domain-containing 5' inositol phosphatase, phosphatases that negatively regul

26 the Dictyostelium genome called phospholipid-inositol phosphatase (PLIP), which defines a new subfami

27 ase (pBtk) and phosphorylated SH2-containing inositol phosphatase (pSHIP), are reduced and enhanced,

28 y, experiments identify up-regulation of the inositol phosphatase PTEN (phosphatase and tensin homolo

29 mmatory signaling by direct targeting of the inositol phosphatase PTEN, the signaling inhibitor SOCS1

30 CD19, as well as increased expression of the inositol phosphatase PTEN.

31 le signaling enzymes and is regulated by the inositol phosphatases PTEN (phosphatase and tensin homol

32 nts of protein-tyrosine phosphatase-like myo-inositol phosphatases (PTPLPs) from the non-pathogenic b

33 Disruption of the negative signaling inositol phosphatase, SH2-containing inositol-5-phosphat

34 The inositol phosphatase SHIP binds to the FcgammaRIIB1 rece

35 The inositol phosphatase SHIP has been implicated in signali

36 SHP-1 and -2 and the novel 5'-inositol phosphatase SHIP have recently been shown to fu

37 Activity of the inositol phosphatase SHIP is required for this negative

38 B cells results in the recruitment of the 5'-inositol phosphatase SHIP to the signaling complex.

39 resulted in enhanced phosphorylation of the inositol phosphatase SHIP, association of SHIP with Shc,

40 lving the tyrosine phosphatase SHP-1 and the inositol phosphatase SHIP-1 are required to maintain ane

41 Although the inositol phosphatase SHIP-1 is generally thought to inhi

42 y Fc gamma RIIa is tightly controlled by the inositol phosphatase SHIP-1, and the protein-tyrosine ph

43 cells by the expression and function of the inositol phosphatase SHIP-2.

44 tivation, and its intracellular effector the inositol phosphatase SHIP.

45 ein tyrosine phosphatase SHP-1 and SHP-2 and inositol phosphatase SHIP.

46 gate MPN-like disease in animals lacking the inositol phosphatase SHIP.

47 tion mediated by Fc gamma RIIb1 requires the inositol phosphatase SHIP.

48 ly identified as an SH2 domain containing 5'-inositol phosphatase (SHIP) and has been implicated in t

49 uggest that the receptor uses SH2-containing inositol phosphatase (SHIP) and SH2-containing phosphoty

50 current study, the effect of SH2-containing inositol phosphatase (SHIP) expression on these biologic

51 We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of

52 SH2-containing Inositol Phosphatase (SHIP) is a 145 kD protein expresse

53 ough the Src homology 2 domain-containing 5' inositol phosphatase (SHIP) is a well-known mediator of

54 atase Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP) is phosphorylated and associ

55 de, we have found that the SH2-containing 5'-inositol phosphatase (SHIP) is phosphorylated on tyrosin

56 (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP) negatively regulate phosphat

57 h IL-4R alpha signals Shc and SH2-containing inositol phosphatase (SHIP) phosphorylation, we could no

58 a the Src homology region 2 (SH2)-containing inositol phosphatase (SHIP) SH2 domain.

59 is pathway is blocked when an SH2-containing inositol phosphatase (SHIP)-dependent inhibitory recepto

60 rformed by the 145-kDa SH2 domain-containing inositol phosphatase (SHIP).

61 (PTEN) and Src homology 2 domain-containing inositol phosphatase (SHIP-1), which hydrolyze PI(3,4,5)

62 tyrosine phosphorylation or activity of the inositol phosphatase, SHIP, in Lyn(-/-) BMMCs.

63 and the binding of the SH2 domain-containing inositol phosphatase, SHIP, to Fc gamma RIIB1.

64 bition is mediated by the recruitment of the inositol phosphatase, SHIP, to the Fc gammaRIIB1 phospho

65 reduction of tyrosine phosphorylation of the inositol phosphatase, SHIP.

66 d, in part, via diminished expression of the inositol phosphatase SHIP1 and increased activation of E

67 is associated with phosphorylation of the 5-inositol phosphatase SHIP1 and requires SHIP1 expression

68 The Src homology 2-containing inositol phosphatase SHIP1 functions in hemopoietic cell

69 in part via miR-155's direct effects on the inositol phosphatase SHIP1.

70 Mena also interacts with the 5' inositol phosphatase SHIP2, which is important for the r

71 SH2 domain-containing 5-inositol phosphatase (SHIP2) is implicated in the develo

72 Here we investigate the role of the 5'-inositol phosphatase, SHIP2, and reveal an unexpected sc

73 Our recent studies revealed that the inositol phosphatase Src homology 2 (SH2) domain-contain

74 atase and tensin homolog), or SH2-containing inositol phosphatase suppressed the Btk(lo) phenotype in

75 In contrast, the 5'-inositol phosphatase synaptojanin 1 localizes to CCPs an

76 SHIP is an inositol phosphatase that can reverse the activation eve

77 SHIP1 is a 5' inositol phosphatase that dephosphorylates the phosphati

78 SHIP is an inositol phosphatase that downregulates PI3K-mediated ac

79 Among several inositol phosphatases that regulate the availability of

80 such as Fc epsilon RI, recruit tyrosine and inositol phosphatases that results in diminished calcium

81 The recruitment of inositol phosphatases to endocytic membranes mediates de

82 ing hemITAM can also couple to intracellular inositol phosphatases to modulate selected functional re

83 as SKIP (skeletal muscle and kidney enriched inositol phosphatase), which is highly expressed in the

84 t study we have demonstrated that SHIP-2, an inositol phosphatase with high-level homology to SHIP-1,