ライフサイエンスコーパス: inositol phosphate

1 binan of LAM is not capped or is capped with inositol phosphate.

2 ed a significantly decreased accumulation of inositol phosphate.

3 yze the conversion of glucose 6-phosphate to inositol phosphate.

4 pairment of signal generation of cAMP and/or inositol phosphate.

5 2)-InsP(4) synthesis without affecting other inositol phosphates.

6 scribed here as a unified approach to access inositol phosphates.

7 (AT(1)) receptor-stimulated accumulation of inositol phosphates.

8 iciently modulate intercellular signaling by inositol phosphates.

9 CH(3) and were accompanied by an increase in inositol phosphates.

10 nd the synthesis and functions of the higher inositol phosphates.

11 yme that generates a series of water-soluble inositol phosphates.

12 interference decreases the amounts of these inositol phosphates.

13 tive activity allowing for its regulation by inositol phosphates.

14 udies into the cellular activities of higher inositol phosphates.

15 e and utilized as affinity ligands to entrap inositol phosphates.

16 ponsive to hCG with respect to production of inositol phosphates.

17 icity for the phosphate at the 3 position of inositol phosphates.

18 , including bilayers containing phosphatidyl inositol phosphates.

19 ly generates PIP(3) as well as water soluble inositol phosphates.

20 ls by determining the accumulation of [(3)H]-inositol phosphates ([(3)H]-IPs) by anion-exchange chrom

21 Rab1 significantly attenuated AT1R-mediated inositol phosphate accumulation and ERK1/2 activation an

22 alphaq/11 protein dissociation and increased inositol phosphate accumulation and GPCR-kinase interact

23 ) receptor agonist, decreased DOI-stimulated inositol phosphate accumulation and increased the phosph

24 Studies of inositol phosphate accumulation and of protein kinase C

25 kinase, and epidermal growth factor-induced inositol phosphate accumulation and phosphorylation/dese

26 increases such agonist signaling pathways as inositol phosphate accumulation as assessed by either cl

27 LPC does not further enhance inositol phosphate accumulation but dose-dependently aug

28 reover, PLC-epsilon-dependent stimulation of inositol phosphate accumulation by activation of the epi

29 Inositol phosphate accumulation by Gq-coupled M3-muscari

30 TPDase1 fusion protein, we quantitated basal inositol phosphate accumulation in cells stably expressi

31 ll GTPases activate PLC-epsilon, we measured inositol phosphate accumulation in COS-7 cells expressin

32 RhoA, RhoB, and RhoC all markedly stimulated inositol phosphate accumulation in PLC-epsilon-expressin

33 ty of either carbachol or AC-42 to stimulate inositol phosphate accumulation or intracellular calcium

34 ned previously in studies of P2Y1-R-promoted inositol phosphate accumulation or platelet aggregation.

35 n COS-7 cells resulted in G protein-promoted inositol phosphate accumulation that was partially rever

36 onhydrolyzable agonist ADPbetaS to stimulate inositol phosphate accumulation was similar, and the EC(

37 ximately 82% impairment) from stimulation of inositol phosphate accumulation while the capacity to in

38 tely 67% desensitization of agonist-promoted inositol phosphate accumulation without significantly af

39 s-encoded US28 GPCR in its ability to induce inositol phosphate accumulation, activate NF-kappaB, and

40 apidly induces signaling events resulting in inositol phosphate accumulation, Ca(2+) mobilization, in

41 ers, in COS-7 cells resulted in increases in inositol phosphate accumulation.

42 indicated by decreased bradykinin-stimulated inositol phosphate accumulation.

43 hosphorylation mimic, reduced DOI-stimulated inositol phosphate accumulation.

44 vented the PLC-epsilon-dependent increase in inositol phosphate accumulation.

45 strong pH-dependent responses as measured by inositol phosphate accumulation.

46 desensitized subsequent glutamate-stimulated inositol phosphate accumulation.

47 lation of US28 that results in a decrease of inositol phosphate accumulation.

48 inositol 1,4,5-triphosphate release, and [3H]inositol phosphate accumulation.

49 ceptor antagonism blocked DOR stimulation of inositol phosphate accumulation.

50 es also showed that agonist-stimulated [(3)H]inositol phosphate accumulations were more sustained in

51 sensitive to pH fluctuations as measured by inositol phosphate and cAMP accumulation.

52 corresponding diphosphates in promoting both inositol phosphate and cyclic AMP accumulation.

53 ation-dependent increase on both total [(3)H]inositol phosphate and intracellular calcium, and to ind

54 te 5-phosphatases (IPPs) act on both soluble inositol phosphate and phosphoinositide substrates.

55 at hydrolyzes 5-phosphates from a variety of inositol phosphate and phosphoinositide substrates.

56 G alpha(16) does interact with RGS2, in both inositol phosphate and PM recruitment assays.

57 endently stimulates the accumulation of both inositol phosphates and cAMP.

58 an essential precursor for the production of inositol phosphates and inositol phospholipids in all eu

59 flected by a lower accumulation of total [3H]inositol phosphates and Ins(1,4,5)P3 mass.

60 ms involving receptor-mediated generation of inositol phosphates and phosphorylated phosphatidylinosi

61 tase), which specifically hydrolyzes soluble inositol phosphates and terminates the signal.

62 t as a regulator--potentially explaining why inositol phosphates and their kinases have been found to

63 hexose residue, one hexuronic acid residue, inositol phosphate, and a ceramide moiety with a C18 tri

64 The inositol phosphates are an abundant but poorly understoo

65 Inositol phosphates are key signaling molecules affectin

66 Inositol phosphates are well-known signaling molecules,

67 Inositol phosphates are widely produced throughout anima

68 eophile, generating the five-membered cyclic inositol phosphate as an intermediate or product.

69 mutation or phosphorylation at this site on inositol phosphate as compared to cAMP signaling was fou

70 The mutants also accumulate myo-inositol and inositol phosphates as in the lpa2 mutant.

71 yme also accepts a variety of alkyl and aryl inositol phosphates as substrates, making it a suitable

72 ubstrates and monomeric water-soluble cyclic inositol phosphates as well as long-chain PI in bilayer

73 orpromazine significantly lowered all higher inositol phosphates, as well as DIPs, whereas the calmod

74 ic cleavage of aryl and nonhydrophobic alkyl inositol phosphates (beta(lg) = -0.58) indicates that th

75 -fold decrease in the K(m) of the IMPase for inositol phosphates between 75 and 85 degrees C (for l-I

76 lical scaffold in the C-lobe constitutes the inositol phosphate-binding site, which, along with the p

77 Thus, it is widely accepted that inositol phosphate biosynthesis is largely restricted to

78 ine genetic controls that spatially regulate inositol phosphate biosynthesis.

79 ikinase (IPMK) is a central component of the inositol phosphate biosynthetic routes, playing essentia

80 [3H]Inositol phosphates bound to IMAC-SPA beads through the

81 he kindlin-1 PH domain is most likely not an inositol phosphate but another phosphorylated species.

82 ely charged yttrium silicate beads that bind inositol phosphates, but not inositol.

83 ane-bound alpha(q/11) subunits and increased inositol phosphate/Ca(2+) signaling.

84 These results confirm that the inositol phosphates can constitute a considerable fracti

85 , the minerals, total alpha-galactosides and inositol phosphates contents were reduced (>25%) in both

86 l requirements for binding and activation by inositol phosphates, demonstrating that activation requi

87 C (PI-PLC) is an important component of the inositol phosphate/diacylglycerol signaling pathway.

88 Our work indicates that inositol phosphates do not regulate arginine-dependent g

89 acid binding affinity of the RSV MA domain, inositol phosphates do not regulate RSV Gag-facilitated

90 f the yeast and plant enzymes, without bound inositol phosphates, do not structurally rationalize HsI

91 2-monophosphate (Ins(2)P1), a member of the inositol phosphate family of compounds, which are import

92 Two novel water-soluble fluorescein myo-inositol phosphate (FLIP) substrates, butyl-FLIP and met

93 We show that the SopB-independent inositol phosphate fluxes are the consequence of the Sop

94 Surprisingly, the inositol phosphate fluxes induced by Salmonella were not

95 Rab8 expression attenuates mGluR1a-mediated inositol phosphate formation and calcium release from mo

96 the maximum efficacy for 5-HT2AR-stimulated inositol phosphate formation and that the deletion of th

97 rho-TIA reduced maximal NE-stimulated [(3)H]inositol phosphate formation in HEK293 cells expressing

98 for inhibition of norepinephrine-stimulated inositol phosphate formation showed a single low-affinit

99 Studies of norepinephrine-stimulated inositol phosphate formation showed that maximal respons

100 the alpha1D-AR C terminus markedly decreased inositol phosphate formation stimulated by norepinephrin

101 Ang II-stimulated inositol phosphate formation was decreased by preincubat

102 DNA increased thrombin-promoted ATP release, inositol phosphate formation, and RhoA activation.

103 ile having no effect on PGF2alpha-stimulated inositol phosphates formation.

104 chromatography step to separate radiolabeled inositol phosphates from radiolabeled inositol, making t

105 with Galpha(q), vav2 impaired G(q)-mediated inositol phosphate generation but not G(s)-mediated cAMP

106 Moreover, the benefit for PTHR-mediated inositol phosphate generation in the absence of vav2 req

107 Inositol phosphate generation was evident only with the

108 IP-induced cAMP and TP-induced inositol phosphate generation were unaltered when the re

109 differences in receptor levels, magnitude of inositol phosphate generation, and dynamics of inositol

110 F-2 in LPA-induced cell migration, invasion, inositol phosphate generation, and nuclear factor-kappaB

111 220R) effectively relieved the inhibition of inositol phosphate generation.

112 DesArg(10)-kallidin enhances inositol-phosphate generation and elevates [Ca(2+)](i) b

113 Networks associated with inositol phosphate, glycerophospholipids, and sterol met

114 Non-acylated inositol phosphates had no effect up to 100 muM.

115 These data indicate that binding to the inositol phosphate head group is necessary but may not b

116 Soluble inositol phosphate headgroups, such as inositol 1,4,5-tr

117 62, on M1-muscarinic receptor stimulation of inositol phosphate hydrolysis, consistent with a direct

118 exakisphosphate (InsP6) is the most abundant inositol phosphate in cells, yet it remains the most eni

119 hosphate or Ins P6, is the most abundant myo-inositol phosphate in plant cells, but its biosynthesis

120 action, and either inositol in eukaryotes or inositol phosphate in prokaryotes as the acceptor alcoho

121 aling pathway to induce high levels of total inositol phosphates in an agonist-independent manner.

122 stigations aimed at elucidating the roles of inositol phosphates in cellular growth and development i

123 The binding brought [3H]inositol phosphates in close proximity to the scintillan

124 activation but lower levels of generation of inositol phosphates in comparison to thrombin.

125 AGS4/G18.1b did not alter the generation of inositol phosphates in COS7 cells cotransfected with the

126 ) domains to bind inositol lipids or soluble inositol phosphates in vitro and to localize to cellular

127 Cell signaling via inositol phosphates, in particular via the second messen

128 A variety of inositol phosphates including myo-inositol 1,4,5-trispho

129 Depletion of inositol phosphates, including InsP(5) and InsP(6) metab

130 and many recent studies point to a role for inositol phosphates, including InsP(5), InsP(6), and ino

131 Myo-inositol phosphates, including phytic acid, play diverse

132 Remarkably, high concentrations of soluble inositol phosphates induce dissociation of myo1c(IQ-tail

133 As inositol phosphates inhibit Akt signaling, IPMK appears

134 Inositol phosphate (InsP) 4, 5 and 6 were noted in all t

135 A method for the detection and speciation of inositol phosphates (InsP(n)) in sediment samples was te

136 e for phytase) and appearance of lower-order inositol phosphates (InsP5 -InsP1 ), the hydrolysis prod

137 we have investigated the interaction between inositol phosphates (InsPs) and OAG on Icat.

138 Here we report that inositol phosphates (InsPs) and phosphatdidylinositol ph

139 traction and measurement of all six forms of inositol phosphates (InsPs) in almond meal and brown ski

140 nositol and lacks significant amounts of myo-inositol phosphate intermediates in seeds.

141 nserved protein that initiates production of inositol phosphate intracellular messengers (IPs), which

142 Unexpectedly, increases in inositol phosphates, intracellular calcium and phosphory

143 radioligand-binding and functional assays of inositol phosphate (IP) accumulation and Ca(2+) mobiliza

144 T2A receptors, we found that IL-6 attenuates inositol phosphate (IP) accumulation in response to the

145 Eukaryotes possess numerous inositol phosphate (IP) and diphosphoinositol phosphate

146 t in stimulating 5-HT2C-receptor-coupled [3H]inositol phosphate (IP) formation and calcium mobilizati

147 decreased cell surface expression and basal inositol phosphate (IP) formation.

148 tution, assays for hormone binding, cAMP and inositol phosphate (IP) induction, and photoaffinity lab

149 Inositol phosphate (IP) kinases constitute an emerging c

150 The effects of some of these drugs on the inositol phosphate (IP) levels in ciliary processes were

151 erved when pilocarpine was used to stimulate inositol phosphate (IP) metabolism, but not when acetylc

152 We show that the inositol phosphate (IP) pathway controls transcription o

153 d-type (WT) NK3R, with near complete loss of inositol phosphate (IP) signaling, implicating these dom

154 r incapable of binding ligand or stimulating inositol phosphate (IP) signaling.

155 erine myometrial smooth muscle cells induced inositol phosphate (IP) turnover, which was abolished by

156 Interestingly, we could detect inositol phosphate (IP), inositol 4,5-bisphosphate (IP2

157 ing assembly, MA specifically interacts with inositol phosphate (IP)-containing lipids in the plasma

158 N-lobe of IPK1 is unstable in the absence of inositol phosphate (IP).

159 CS1, which are involved in the generation of inositol phosphates (IP4, IP5, and inositol pyrophosphat

160 ablished that IP(3) is converted to numerous inositol phosphates (IPs) and pyrophosphates (PP-IPs) th

161 myo-Inositol phosphates (IPs) are important bioactive molecu

162 cofactors are added; either nucleic acid or inositol phosphates (IPs) can promote particle assembly.

163 Inositol phosphates (IPs) regulate vital processes in eu

164 te kinases (IPKs) sequentially phosphorylate inositol phosphates (IPs) to yield a group of small sign

165 mpetition assays confirmed that RSV MA binds inositol phosphates (IPs), but in contrast to HIV-1 GagD

166 g, but the apparent affinity for the soluble inositol phosphate is substantially lower than that for

167 inositol is blocked, and the mass of soluble inositol phosphates is a quantitative readout of recepto

168 Because inositol phosphate isomers elicit different biological a

169 The maize inositol phosphate kinase (ZmIpk) gene was identified th

170 Inositol phosphate kinase 2 (Ipk2), also known as IP mul

171 acid lpa2 mutant is caused by mutation in an inositol phosphate kinase gene.

172 witch, inhibiting or stimulating Akt via its inositol phosphate kinase or PI3-kinase activities, resp

173 Most of these enzymes belong to the inositol phosphate kinase superfamily, which consists of

174 inase (ITPK1) is a reversible, poly-specific inositol phosphate kinase that has been implicated as a

175 uction of PI(4,5)P(2) by type 1 phosphatidyl inositol phosphate kinase type 1gamma (PIPK1gamma) is th

176 Inositol phosphate kinases (IPKs) sequentially phosphory

177 ) through the action of up to six classes of inositol phosphate kinases (IPKs), it is not clear that

178 n mammals and fungi, two distinct classes of inositol phosphate kinases mediate biosynthesis of inosi

179 several classes of evolutionarily conserved inositol phosphate kinases.

180 , and their cellular levels are regulated by inositol phosphate kinases.

181 Plc inhibitor U73122 prevented increases in inositol phosphate levels and blocked progression of cel

182 n this study, we investigated the changes in inositol phosphate levels in alpha-factor-treated S. cer

183 Although marked elevation of inositol phosphate levels occurred with wild-type P2Y(1)

184 ceptors results in marked increases in basal inositol phosphate levels.

185 LCbeta2 suppresses elevated basal [Ca2+] and inositol phosphates levels and the sustained agonist-ind

186 tillation proximity assay to measure soluble inositol phosphate mass in cell extracts, thus obviating

187 anonical Galphaq signaling via production of inositol phosphates mediated by each receptor was also r

188 The possible relationship between inositol phosphate metabolism and DNA repair is discusse

189 These results contribute to our knowledge of inositol phosphate metabolism and will lay a foundation

190 evelopment for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and des

191 ella to stimulate Rho GTPases signalling and inositol phosphate metabolism through alternative mechan

192 Using several yeast mutants with defects in inositol phosphate metabolism, we identify dramatic memb

193 5PTases, which also hydrolyze tris- and bis inositol phosphate molecules.

194 Human inositol phosphate multikinase (HsIPMK) critically contr

195 Inositol phosphate multikinase (IPMK, also called Ipk2 a

196 etermined the crystal structure of the yeast inositol phosphate multikinase Ipk2 in the apoform and i

197 monstrated that the human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-te

198 ists of three subgroups, inositol 3-kinases, inositol phosphate multikinases, and inositol hexakispho

199 ly or completely lost the ability to produce inositol phosphate or diacylglycerol messengers after st

200 irions were obtained in vitro by addition of inositol phosphates or phosphatidylinsitol phosphates to

201 ven polyphosphoinositol lipids, more than 30 inositol phosphates), or by the number of functions for

202 naling to the traditional Galphaq-stimulated inositol phosphate pathway.

203 tabolism, proteins of the diacylglycerol and inositol phosphate pathways, mitochondrial proteins, his

204 SopB is an inositol phosphate phosphatase that is a virulence facto

205 ORF74 activates the inositol phosphate/phospholipase C pathway and the downs

206 pathway requires Akt binding to phosphatidyl-inositol phosphates (PIP) on the cell membrane.

207 ne proteins which interact with phosphatidyl-inositol phosphates (PIPs) in cell membranes.

208 plant seeds store a little over 1% of their inositol phosphate pool as InsP7 and InsP8 .

209 Diphospho-myo-inositol phosphates (PP-InsP(y)) are an important class

210 kinase-2 (IP6K2) that produces diphosphoryl inositol phosphates (PP-IPs).

211 We used radioligand binding and inositol phosphate production (a measure of G-protein co

212 yrotropin-releasing hormone (TRH)-stimulated inositol phosphate production and accelerated internaliz

213 1)gamma(2) inhibits Gbeta(1)gamma(2)-induced inositol phosphate production and Akt activation in COS-

214 e observations, PAR1 and PAR2 stimulation of inositol phosphate production and RhoA activation was bl

215 hat basal and agonist-induced AA release and inositol phosphate production as well as expression of P

216 iased agonist exhibiting partial agonism for inositol phosphate production but essentially full agoni

217 genous beta-arrestins reduced TRH-stimulated inositol phosphate production by 48% (beta-arrestin-1),

218 five-fold higher levels of Ang II-stimulated inositol phosphate production compared to E1,2,3 express

219 urenic acid elicits calcium mobilization and inositol phosphate production in a GPR35-dependent manne

220 in an activation-dependent manner, stimulate inositol phosphate production in a receptor-independent

221 Quantification of [3H]inositol phosphate production in cells preincubated with

222 Agonist-induced inositol phosphate production in g-HCM cells was conside

223 RH) receptor (GnRHR) progressively decreases inositol phosphate production in response to agonist, va

224 or did not elevate cytosolic free calcium or inositol phosphate production in response to angiotensin

225 ion of the LPA(1) or PAR1 receptor increased inositol phosphate production in response to LPA or SFLL

226 t increases in intracellular free Ca(2+) and inositol phosphate production in these cells but did not

227 dent constitutive activity, assessed through inositol phosphate production in transiently or stably t

228 ositide-specific phospholipase C pathway but inositol phosphate production is stimulated by growth-re

229 intact HEK293 cells and completely inhibited inositol phosphate production stimulated by H1HR, wherea

230 fold higher levels of angiotensin II-induced inositol phosphate production than wild type (WT).

231 Direct assessment of inositol phosphate production using a PIP2/IP3 "biosenso

232 was measured by radioimmunoassay, [(3)H]myo-inositol phosphate production was measured by ion-exchan

233 F(2alpha) > CCh > ET-1; and their effects on inositol phosphate production were in the following orde

234 also significantly attenuated H1HR-mediated inositol phosphate production, as did an N-terminal frag

235 q)4Q failed to couple activated receptors to inositol phosphate production, it was able to bind betag

236 binding and internalization, stimulation of inositol phosphate production, or activation of Pyk2 and

237 ssed in hepatic C9 cells markedly stimulated inositol phosphate production, phosphorylation of the pr

238 ion did not reduce global agonist-stimulated inositol phosphate production, suggesting a requirement

239 more robustly stimulated G protein-mediated inositol phosphate production.

240 receptors with a maximal 12-fold increase in inositol phosphate production.

241 LPA did not stimulate inositol phosphate production.

242 -coupled receptors (GPCRs) to stimulation of inositol phosphate production.

243 These results provide evidence that inositol phosphate productions may be required for effic

244 tolerance and the expected alteration of the inositol phosphate profile in developing seeds.

245 gents used to antagonize PLC (U73122) or the inositol phosphate receptor (Xestospongin C) inhibited F

246 this substrate in an assay, we purified the inositol phosphate-regulated protein kinase and determin

247 The substrate for the inositol phosphate-regulated protein kinase was identifi

248 hibition of Galpha(q)-Q152A-R183C-stimulated inositol phosphate release is reduced in comparison to G

249 GS5 ribozyme enhanced angiotensin-stimulated inositol phosphate release.

250 or but had no effect on the agonist-promoted inositol phosphate response of the M1 or P2Y(2) receptor

251 runcated AT1a-(1--309), where Ang II-induced inositol phosphate response was preserved.

252 ubtypes, despite the unequal efficacy of the inositol phosphate response.

253 s bearing a 5-phosphate and 54 water-soluble inositol phosphates reveals that SP-synaptojanin and SHI

254 native PAR1 and PAR2 receptors that activate inositol phosphate, RhoA, and ERK1/2 signaling.

255 Both isoforms activate inositol phosphate second messenger signaling pathways b

256 n also enhances the increase in the level of inositol phosphates seen upon G protein stimulation, sug

257 localisation studies that suggest that these inositol phosphates serve to anchor a portion of cellula

258 the enzymatic cleavage of hydrophobic alkyl inositol phosphates showed low negative Bronsted coeffic

259 e relative coupling to G(s) (cAMP) and G(q) (inositol phosphates) signal transduction pathways during

260 nisms involving Shp2, desensitizes PDGFRbeta inositol phosphate signaling and enhances PDGFRbeta-trig

261 osphates") are a specialized subgroup of the inositol phosphate signaling family.

262 Human alpha(1a)AR-mediated inositol phosphate signaling is acutely desensitized in

263 alterations in its coupling to both cAMP and inositol phosphate signaling pathways relative to the wi

264 We now report a link between the TNF-R1 and inositol phosphate signaling pathways.

265 a synthetic biological approach to redesign inositol phosphate signaling pathways.

266 sion, although no specific ligand-binding or inositol phosphate signaling was detected.

267 GRK5-mediated desensitization of PDGFRbeta inositol phosphate signaling was diminished by Shp2 knoc

268 nt impairs G protein-dependent activation of inositol phosphate signaling while enhancing beta-arrest

269 tors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-

270 while failing to recruit arrestin, activate inositol phosphate signaling, or internalize CB2 recepto

271 Finally, in contrast to the results with inositol phosphate signaling, we provide evidence that t

272 uirement for intracellular Ca(2+) stores and inositol phosphate signaling, whereas Pep/PEPR signaling

273 estin and accordingly demonstrates increased inositol phosphate signaling.

274 cribed for other 5ptase mutants defective in inositol phosphate-specific 5PTase enzymes.

275 r of effector coupling of the alpha(2A)AR to inositol phosphate stimulation.

276 ariety of phosphatidylinositol phosphate and inositol phosphate substrates.

277 been shown to hydrolyze the 5-phosphate from inositol phosphate substrates.

278 e InoEFGK (TM0418-TM0421) transporter to myo-inositol-phosphate suggests that the novel pathway in Th

279 1-L-myo-inositol-phosphate synthase (mIPS) catalyzes the first s

280 Surprisingly, myoinositol and all inositol phosphates tested were permeable through homome

281 pentakisphosphate (IP(7)), are water-soluble inositol phosphates that contain high energy diphosphate

282 The ability of the higher inositol phosphates to directly stimulate CK2 catalytic

283 corrected to varying degrees by addition of inositol phosphates to the assembly reaction.

284 cell rounding and stimulate the formation of inositol phosphates to the same extent as PGF2alpha in c

285 ayed high-affinity MCH binding, resulting in inositol phosphate turnover and release of intracellular

286 id not prevent the receptor from stimulating inositol phosphate turnover but almost completely preven

287 lular PLC with an inhibitor (U73122) reduced inositol phosphate turnover in all of the HNSCC cell lin

288 onstrates that BQCA requires M(1) to promote inositol phosphate turnover in primary neurons and to in

289 ositol phosphate generation, and dynamics of inositol phosphate turnover occurred in the different ce

290 g system involving calcium ions, calmodulin, inositol phosphates, ubiquitin, cyclin, and GTP-binding

291 lyzed T. brucei extracts for the presence of inositol phosphates using polyacrylamide gel electrophor

292 howing that phosphate is transferred between inositol phosphates via ITPK1-bound nucleotide.

293 Permeability to inositol phosphates was assessed by flux through reconst

294 This was a selective effect; levels of other inositol phosphates were unaffected by AICAR.

295 ric channels are selectively permeable among inositol phosphates, whereas the corresponding homomeric

296 complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched b

297 array of kinases and phosphatases into other inositol phosphates with diverse and critical cellular a

298 ail that binds phosphoinositides and soluble inositol phosphates with high affinity.

299 tion on the selectivity, the permeability of inositol phosphates with one to four phosphate groups th

300 d striking differences in permeability among inositol phosphates with three or four phosphate groups