ライフサイエンスコーパス: inositol polyphosphate 5-phosphatase

1 caused by mutation of the OCRL1 protein, an inositol polyphosphate 5-phosphatase.

2 Inpp5b is an ubiquitously expressed type II inositol polyphosphate 5-phosphatase.

3 ion; and INP53, encoding a synaptojanin-like inositol polyphosphate 5-phosphatase.

4 cerevisiae INP51 locus (YIL002c) encodes an inositol polyphosphate 5-phosphatase.

5 or oculocerebrorenal syndrome (OCRL), is an inositol polyphosphate 5-phosphatase.

6 DXNXR and PXWCDRXL, define a large family of inositol polyphosphate 5-phosphatases.

7 binding sites, and a domain with homology to inositol polyphosphate-5-phosphatases.

8 As the [IP3] was increased, inositol polyphosphate 5-phosphatase (5-phosphatase) deg

9 loning and characterization of a novel human inositol polyphosphate 5-phosphatase (5-phosphatase) tha

10 erase; a prenyl-binding protein) and INPP5E (inositol polyphosphate-5-phosphatase 5E).

11 loning strategy and found that it encodes an inositol polyphosphate 5' phosphatase (5PTase).

12 The myo-inositol polyphosphate 5-phosphatases (5PTases) (E.C. 3.

13 The inositol polyphosphate 5-phosphatases (5PTases) comprise

14 Type II inositol polyphosphate 5-phosphatases (5PTases) in yeast

15 D460A, in the 110 kDa form of the signaling inositol polyphosphate 5-phosphatase (5SIP110).

16 overlapped between MCF-7 and MCF-10A cells: inositol polyphosphate-5-phosphatase A, corticotropin ho

17 The SIP-130 and SIP-145 proteins and inositol polyphosphate 5-phosphatase activity associated

18 amino-terminal regions similar to mammalian inositol polyphosphate 5-phosphatases and to yeast SAC1.

19 tenin complexes), down-regulation of 51C (an inositol polyphosphate-5-phosphatase), and down-regulati

20 Inositol polyphosphate 5-phosphatases are central to int

21 Numerous inositol polyphosphate 5-phosphatases catalyze the degra

22 Mice deficient in inositol polyphosphate 5'-phosphatase D (INPP5D, also kn

23 The disease is caused by mutations in an inositol polyphosphate 5-phosphatase designated OCRL.

24 The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynapto

25 Here we show using the inositol polyphosphate 5'-phosphatase E (INPP5E) and the

26 phate (PtdIns(4)P) 5-kinase (PIPKIgamma) and inositol polyphosphate-5-phosphatase E (INPP5E), a Joube

27 ibe a protein-protein interaction network of inositol polyphosphate-5-phosphatase E (INPP5E), a preny

28 ified mutations in the INPP5E gene, encoding inositol polyphosphate-5-phosphatase E, which hydrolyzes

29 The inositol polyphosphate-5-phosphatase enzyme family now i

30 th increased expression of the gene encoding inositol polyphosphate-5-phosphatase f (Inpp5f) resultin

31 Here, we demonstrate that Inositol Polyphosphate-5-Phosphatase F (INPP5F), one of

32 tic vesicles and shown to be a member of the inositol polyphosphate 5-phosphatase family.

33 ducts of a single gene and as members of the inositol polyphosphate 5-phosphatase family.

34 pleckstrin in platelets is in a complex with inositol polyphosphate 5-phosphatase I (5-phosphatase I)

35 ited in cells microinjected with recombinant inositol polyphosphate 5-phosphatase I, which degrades i

36 ermed SIP-145 and SIP-130 (SIP for signaling inositol polyphosphate 5-phosphatase), identified them a

37 ating each to alanine in the platelet 75 kDa inositol polyphosphate 5-phosphatase II (5-phosphatase I

38 tal of 970 amino acids that is homologous to inositol polyphosphate 5-phosphatase II.

39 ms of two other 5-phosphatases designated as inositol polyphosphate-5- phosphatase II, and OCRL (the

40 These findings strongly implicate the inositol polyphosphate 5-phosphatases in Shc- and Grb2-m

41 tially suppressed by a mutation in IPP-5, an inositol polyphosphate 5-phosphatase, indicating that on

42 emically-induced dimerization to translocate inositol polyphosphate 5-phosphatase (Inp54p) to plasma

43 P(2) pool by plasma membrane targeting of an inositol polyphosphate-5-phosphatase (Inp54p) blocked PL

44 Ocrl1 deficiency is complemented in mice by inositol polyphosphate 5-phosphatase (Inpp5b), an autoso

45 ant functions of OCRL and its paralog type 2 inositol polyphosphate-5-phosphatase (INPP5B).

46 cible proapoptotic targets of p53, including inositol polyphosphate-5-phosphatase (INPP5D), pleckstri

47 The inositol polyphosphate 5-phosphatase INPP5E localizes to

48 s constitutively expressing the human type I inositol polyphosphate 5-phosphatase (InsP 5-ptase), an

49 cells were transformed with the human type I inositol polyphosphate 5-phosphatase (InsP 5-ptase), an

50 liana plants expressing the mammalian type I inositol polyphosphate 5-phosphatase (InsP 5-ptase), whi

51 Type II inositol polyphosphate 5-phosphatases (IPPs) act on both

52 OCRL, an inositol polyphosphate 5-phosphatase, is mutated in Lowe

53 bisphosphate even though at least four other inositol polyphosphate 5-phosphatase isozymes are presen

54 Phosphoinositide-specific inositol polyphosphate 5- phosphatase IV has the affinit

55 drolase 1 (Nceh1), adenylate kinase 1 (Ak1), inositol polyphosphate 5-phosphatase J (Inpp5j), ATP syn

56 INPP5K encodes the inositol polyphosphate-5-phosphatase K, also known as SK

57 ied bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K.

58 is also present at the amino termini of the inositol polyphosphate 5-phosphatases, mammalian synapto

59 tions and that substrates and/or products of inositol polyphosphate 5-phosphatases may have roles in

60 eans, by overexpression of the TGN-localized inositol polyphosphate 5-phosphatase Ocrl, or by blockad

61 Arabidopsis 5PTase13 gene, which encodes an inositol polyphosphate 5-phosphatase previously shown to

62 We have identified this protein as the novel inositol polyphosphate 5-phosphatase (SHIP).

63 Src homology-2 domain-containing inositol polyphosphate-5'-phosphatase (SHIP) also bound

64 tor activation by inhibitory coreceptors: an inositol polyphosphate 5'-phosphatase, SHIP, and a tyros

65 the recruitment of the SH2-domain-containing inositol polyphosphate 5-phosphatase, SHIP, to the tyros

66 The SH2 domain-containing inositol-polyphosphate 5-phosphatase, SHIP, associates w

67 of PI3,4,5P3 into PI3,4P2 with the signaling inositol polyphosphate 5' phosphatase SIP.

68 An inositol polyphosphate-5-phosphatase (SIP-110) that bind

69 although it hydrolyzes all four of the known inositol polyphosphate 5-phosphatase substrates: inosito

70 utations in both CVP2 and CVL1, which encode inositol polyphosphate 5'-phosphatases that generate the

71 nsive homology to the SH2 domain of SHIP, an inositol polyphosphate 5-phosphatase that functions as a

72 We found that VPA0450 is an inositol polyphosphate 5-phosphatase that hydrolyzed the

73 The subcellular localization of Ocrl, the inositol polyphosphate 5-phosphatase that is mutated in

74 Previous studies revealed that INPP5E, the inositol polyphosphate-5-phosphatase that is mutated in

75 Antibodies raised against the 51C/SHIP2 inositol polyphosphate 5'-phosphatase were used to exami

76 OCRL1 encodes an inositol polyphosphate 5-phosphatase which preferentiall

77 approximately 10-fold greater than the other inositol polyphosphate 5-phosphatases, which use this su

78 The association of inositol polyphosphate 5-phosphatase with FcgammaRIIB su

79 SIP is a phosphatidylinositol- and inositol-polyphosphate 5-phosphatase with specificity in