ライフサイエンスコーパス: inotropic

1 Given that IL-1beta has a negative inotropic action on the heart, and that both its natural

2 However, precise mechanisms for its in vivo inotropic action remain unclear.

3 olinergic (NANC) peptide with vasodilatative/inotropic action that may benefit the failing heart.

4 es to enhanced myocyte calcium transient and inotropic action.

5 ucleotide phosphodiesterase (PDE) PDE3A have inotropic actions in human myocardium, but their long-te

6 meningococci in vitro abolished the negative inotropic activity.

7 normalities and repletion doses, duration of inotropic administration, and mortality.

8 lation period, absence of any vasopressor or inotropic agent (dopamine, epinephrine) use, higher lowe

9 serve as an alternative to dobutamine as an inotropic agent for management of postresuscitation myoc

10 Apelin may have use as an acute inotropic agent in patients with ischemic heart failure.

11 Levosimendan is an inotropic agent that has been shown in small studies to

12 Omecamtiv mecarbil (OM) is a novel inotropic agent that prolongs systolic ejection time and

13 ough digoxin has been used for decades as an inotropic agent to treat heart failure, it does not impr

14 TE shortening corresponded to a reduction in inotropic agent use and improvement in cardiac function.

15 Overall, an inotropic agent was administered in 7691 of 126 564 (6.1

16 Before implantation, 100% were on > or =1 inotropic agent, and 77% had an intra-aortic balloon pum

17 n, P=0.005), to receive intravenous positive inotropic agents (31% risk reduction, P<0.001), and to h

18 ated from the maximum dose of the individual inotropic agents administered in the first 3 days after

19 cur without hypertrophic cardiomyopathy when inotropic agents are used for hypotension.

20 The negative inotropic agents BDM (5 mm) or blebbistatin (10 microM)

21 Use of intravenous inotropic agents during hospitalization for heart failur

22 The positive inotropic agents EMD 57033 or CGP 48506 (1 microM) incre

23 cement of an RV assist device, or the use of inotropic agents for >14 days.

24 m for the development of Ca2+ sensitizers as inotropic agents for heart failure has been tempered by

25 We found marked differences in the use of inotropic agents for heart failure patients among a dive

26 uidelines recommend targeted use of positive inotropic agents in highly selected patients, but data a

27 ne hospital variation in the use of positive inotropic agents in patients with heart failure.

28 a series of oxadiazolothiazinones, selective inotropic agents on isolated cardiac tissues, devoid of

29 The inotropic agents or an equivalent volume of placebo dilu

30 There is a pressing need for new inotropic agents that avoid these harmful effects.

31 e of pulmonary vasodilators, optimization of inotropic agents to support cardiac function, maintenanc

32 We postulated that administration of inotropic agents via indwelling intravenous catheters ma

33 ar tachycardia, profound shock refractory to inotropic agents, and metabolic acidosis developed in th

34 lay robust contractile responses to positive inotropic agents, such as myofilament calcium sensitizer

35 is generally modified by the use of positive inotropic agents, volume resuscitation, and pacing.

36 nd the clinical utility of some of the older inotropic agents, which are still commonly used, and pro

37 nearly 80% of patients receiving intravenous inotropic agents.

38 a lead compound for a new class of positive inotropic agents.

39 both eNOS coupled activity and the negative inotropic and [Ca(2+)](i) transient response to beta(3)-

40 lytic substrate for ACE2 and functions as an inotropic and cardioprotective peptide.

41 plications of this approach, we examined the inotropic and chronotropic responses of cardiomyocyte co

42 We evaluate both inotropic and chronotropic responses of the heart of zeb

43 T) at the leaflet approximation point during inotropic and chronotropic stimulation.

44 ular decompensation related through negative inotropic and hypotensive effects.

45 uded UNOS status 1A, mechanical ventilation, inotropic and intra-aortic balloon pump support, pulmona

46 tment augmented heart rate, exhibited potent inotropic and lusitropic actions on the left ventricle,

47 Stimulation with the inotropic and lusitropic agent isoproterenol eliminated

48 te expression of R9C-PLB exerts a positively inotropic and lusitropic effect in cardiomyocytes.

49 ndent binding to troponin C, exerts positive inotropic and lusitropic effects in failing human myocar

50 sensitization with levosimendan exerts mild inotropic and lusitropic effects in humans with left ven

51 pe 1A receptor (AT(1A)R) results in positive inotropic and lusitropic effects in isolated adult mouse

52 Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part

53 classical PKC isoforms relieved the negative inotropic and lusitropic effects of ET-1 after CA.

54 nt mice) produced significant enhancement of inotropic and lusitropic effects on left ventricular fun

55 tidine-modified troponin I maintains cardiac inotropic and lusitropic performance and markedly improv

56 Istaroxime is a novel intravenous agent with inotropic and lusitropic properties related to inhibitio

57 w that miR-22-deficient mice are impaired in inotropic and lusitropic response to acute stress by dob

58 lerates muscle relaxation, and amplifies the inotropic and lusitropic response to increased stimulati

59 ospholamban phosphorylation and the positive inotropic and lusitropic responses in cardiomyocytes.

60 cient knockout (KO) mice, exhibited positive inotropic and lusitropic responses to both ANG and SII.

61 r-cAMP treatment, diabetic mice had impaired inotropic and lusitropic responses, thus demonstrating p

62 renol (ISO), a beta-AR agonist, led to small inotropic and lusitropic responses.

63 ercise training in hypertension improves the inotropic and lusitropic responsiveness to beta-adrenerg

64 t, cardiac GRK2 is a major factor regulating inotropic and lusitropic tachyphylaxis to beta-adrenergi

65 ist isoproterenol, with impairment of normal inotropic and lusitropic tachyphylaxis, and exhibited ac

66 osimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes

67 Future studies should prespecify analyses of inotropic and other therapies to determine how disease s

68 Lipid emulsion exerts rapid, positive inotropic and positive lusitropic effects in both intact

69 inase A (PKA) pathway, resulting in positive inotropic and relaxant effects in the heart.

70 ibitors, by raising cAMP content, have acute inotropic and vasodilatory effects in treating congestiv

71 Inotropic and vasopressor drugs are routinely used in cr

72 hemodynamic derangement despite intravenous inotropic and/or vasodilator therapy, CAFA improved hemo

73 derangement despite intravenous diuretic and inotropic and/or vasodilator treatment.

74 Aging is accompanied by a blunted inotropic but preserved chronotropic response to steady-

75 Apelin-13 is a powerful inotropic candidate that could be considered as an alter

76 increase contractile performance upon acute inotropic challenge in hearts from R92Q mice.

77 rdiac function, but a blunted response to an inotropic challenge.

78 e shown that local epicardial application of inotropic compounds drives myocardial contractility with

79 clear how long-term application of negative inotropic compounds improves cardiac performance, slows

80 Local epicardial inotropic delivery illustrates then a paradigm of how ta

81 essive decline) in 291, INTERMACS profile 3 (inotropic dependence) in 176, and INTERMACS profile 4 (r

82 stay, length of hospital stay, peak glucose, inotropic dose, graft dysfunction, and survival after HT

83 is the currently recommended beta-adrenergic inotropic drug for supporting sepsis-induced myocardial

84 nt improvement in myocardial pathology after inotropic drug withdrawal.

85 Inotropic drugs are commonly used perioperatively to sup

86 Inotropic drugs are frequently administered in hypotherm

87 uide administration of intravenous fluid and inotropic drugs as part of a hemodynamic therapy algorit

88 study tested the hypothesis that the use of inotropic drugs is associated with postoperative AF.

89 OF mutants and will guide the development of inotropic drugs that target TnC.

90 The ability of catecholamine inotropic drugs to stimulate bacterial proliferation and

91 e for physicians on the development of newer inotropic drugs.

92 Ca2(+) current amplitude, and abolished the inotropic effect following acute beta-AR stimulation, wi

93 Albumin exerts a positive cardiac inotropic effect in rats with cirrhosis and ascites coun

94 les eNOS activity and abolishes the negative inotropic effect of beta(3)-AR stimulation in nNOS(-/-)

95 TRPM4 proteins are novel determinants of the inotropic effect of beta-adrenergic stimulation on the v

96 rs and "deep" release mimicking the positive inotropic effect of ET-1.

97 ogous PKD expression suppressed the positive inotropic effect of ET1 seen in control cells, without a

98 treatment significantly reduced the positive inotropic effect of isoproterenol in NTG myocytes but no

99 rate of SERCA2a activity, accounting for an inotropic effect of metformin.

100 ow that lack of IP3R2 abolishes the positive inotropic effect of neurohumoral stimulation with ET-1 a

101 cellular mechanisms underlying the positive inotropic effect of pyruvate, however, are contradictory

102 nstitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor

103 ic receptor (beta(3)-AR) produces a negative inotropic effect that is dependent on eNOS.

104 compound 5 exhibited a significant in vitro inotropic effect up to 283% of the baseline value and in

105 lated cardiomyocytes demonstrated a positive inotropic effect via increasing calcium transient amplit

106 hich, in turn, negates cAMP-induced positive inotropic effect via inhibiting sarcolemmal Ca2+ influx

107 diomyocytes, either beta-AR subtype-mediated inotropic effect was markedly diminished, whereas G(i) p

108 SSA78 infusion in mice results in a positive inotropic effect with enhanced contractile function yet

109 ith congestive heart failure have a negative inotropic effect, resulting in reduced cardiac contracti

110 BID; chosen to reduce dronedarone's negative inotropic effect-see text below) over 12 weeks in 134 pa

111 ich contributes to the NOS1-induced positive inotropic effect.

112 rial Ca(2+) signalling and exerts a positive inotropic effect.

113 sulted in: 1) positive left ventricular (LV) inotropic effects (adjusted peak left ventricular pressu

114 DE3B, is the subfamily responsible for these inotropic effects and that murine PDE3A1 associates with

115 s the first to show that apelin has positive inotropic effects in vivo in both normal rat hearts and

116 , indicating that conoCAP-a cardiac negative inotropic effects might be mediated via impairment of in

117 ctivity probably contributes to the positive inotropic effects observed at EGCG concentrations >1 muM

118 Inotropic effects of AS were additive to dobutamine, whe

119 the myocyte "surface" mimicking the negative inotropic effects of bath-applied PKC activators and "de

120 Na(+)-free solution (replaced by Li(+)) the inotropic effects of DIG and ACS were completely prevent

121 We conclude that the acute inotropic effects of DIG, ACS and OUA (and the effects o

122 Accordingly, the inotropic effects of Hsp20 were abrogated in cardiomyocy

123 been associated with NO-associated negative inotropic effects of IL-6 during acute exposure; however

124 rts from Tpcn2(-/-) mice also showed reduced inotropic effects of isoproterenol and a reduced tendenc

125 ure, enhanced CaTs during ECC exert positive inotropic effects on atrial contractility which facilita

126 beta-Adrenergic signalling induces positive inotropic effects on the heart that associate with pro-a

127 reduce arterial pressure and exert positive inotropic effects on the heart.

128 e stimulating cardioprotective signaling and inotropic effects through the beta2AR and serves as a mo

129 ptor (beta-AR) stimulation leads to positive inotropic effects, it can also induce arrhythmogenic Ca2

130 hanistic insights into Akt-mediated positive inotropic effects, transcriptional profiles in the heart

131 lammatory mediators with negative myocardial inotropic effects.

132 id emulsion infusion exerts direct, positive inotropic effects.

133 recently been identified as a Ca2+-dependent inotropic factor in the heart, this study sought to expl

134 into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysi

135 dopamine, tapering or discontinuation of the inotropic infusion resulted in a significant diminution

136 t follow-up for patients undergoing baseline inotropic infusions (P=0.0014); for the LVAD group versu

137 spite severe compromise, patients undergoing inotropic infusions at randomization derived major LVAD

138 t hoc basis, outcomes in patients undergoing inotropic infusions at randomization.

139 Nineteen patients (70%) were receiving inotropic infusions at the time of organ availability.

140 Patients not undergoing inotropic infusions had higher survival rates both with

141 For 38 patients not undergoing inotropic infusions, 6-month survival was 61% for those

142 culae from vehicle-treated mutants displayed inotropic insufficiency, increased diastolic tension, an

143 (HNO) donor, Angeli's salt, exerts positive inotropic, lusitropic, and vasodilator effects in vivo t

144 lar function, combining concomitant positive inotropic, lusitropic, and vasodilator properties.

145 This has an acute inotropic/lusitropic effect but yields negative conseque

146 Patients requiring intravenous inotropic/mechanical support or listed status 1A/1B for

147 R, 1.61; 95% CI, 1.26-2.05), and vasopressor/inotropic medications (p = .035; OR, 1.22; 95% CI, 1.01-

148 Although LTCC inhibition is negative inotropic, NCX inhibition has the opposite effect.

149 or antagonist, esmalol, had no effect on the inotropic or lusitropic effects of UcnII in vivo, indica

150 higher in patients who require perioperative inotropic or mechanical cardiovascular support, compared

151 so higher in those who require postoperative inotropic or mechanical cardiovascular support, compared

152 lic blood pressure <90 mm Hg or the need for inotropic or vasoactive medication and the requirement f

153 ion for HF, or administration of intravenous inotropic or vasodilator drugs for 4 hours or more witho

154 d ACR 2 were higher in patients who required inotropic or vasopressor support and correlated with dur

155 llitus (OR, 1.39; P=0.005), and preoperative inotropic (OR, 2.61; P=0.001) and extracorporeal membran

156 Inotropic (peak +dP/dt) and lusitropic (Tau) responses w

157 An inotropic peptide (BjIP) isolated from the full venom by

158 port the cardiac effects of a novel positive inotropic peptide isolated from the toxin of the Black J

159 icate a calciotropic role in addition to the inotropic property of beta1-AR.

160 unlike classical neurotransmitters, have no inotropic receptors.

161 ar dysfunction or hypertrophy, and high-dose inotropic requirement.

162 creases circulating CAs and improves cardiac inotropic reserve and function.

163 can impair beta-adrenergic receptor-mediated inotropic reserve and its inhibition, or molecular reduc

164 r inducible NOS) contributes to this loss of inotropic reserve in human HF.

165 drenergic and dopaminergic receptors impairs inotropic reserve in PAH-RVH.

166 of low-dose dobutamine and quantification of inotropic reserve in segments with 1%-50% infarct transm

167 Inotropic reserve was assessed in RV- and left ventricul

168 A loss of inotropic reserve, uncovered during beta-adrenergic stim

169 did not affect baseline cardiac function or inotropic reserve, we focused on the involvement of skel

170 protein-coupled receptor activation provides inotropic reserve, which is hampered by electric instabi

171 f beta-adrenergic receptor signaling impairs inotropic reserve.

172 h, reduced beta1AR expression, and decreased inotropic reserve.

173 ing that both cell types maintained a strong inotropic reserve.

174 ocyte deletion of insulin receptors (CIRKO), inotropic reserves were reduced, and mitochondria manife

175 muscle displays an increased beta-adrenergic inotropic response both in vitro and in vivo.

176 pholamban, beta-adrenergic receptor, and the inotropic response fully recovered.

177 - but not beta1-AR to induce a full positive inotropic response in SHR myocytes.

178 tudy, the molecular mechanism underlying the inotropic response in skeletal muscle is not well unders

179 lly loaded ssTnI hearts whereas the positive inotropic response of isovolumic hearts or unloaded isol

180 that cTnI has a pivotal role in the positive inotropic response of the murine heart to beta-adrenergi

181 ity but does not inhibit the native positive inotropic response of the right ventricle to increased a

182 ecreased ERO1 activity blunted cardiomyocyte inotropic response to adrenergic stimulation and sensiti

183 atients with diabetes show a blunted cardiac inotropic response to beta-adrenergic stimulation despit

184 pendent cTnI phosphorylation in the positive inotropic response to beta-adrenergic stimulation is unc

185 ession in hESC/iPSC-vCMs restores a positive inotropic response to beta-adrenergic stimulation.

186 from normal and failing hearts displayed no inotropic response to CGRP, further supporting indirect

187 WT mice maintained a positive inotropic response to dobutamine 8 weeks after MI.

188 Basal LV hemodynamics and the inotropic response to dobutamine infusion (4 and 16 ng.g

189 d-recruitable stroke work) but an attenuated inotropic response to dobutamine infusion (P<0.01 versus

190 ostatin significantly decreased the positive inotropic response to endothelin-1 (ET-1).

191 However, the positive inotropic response to isoprenaline was also blunted in s

192 S1P inhibits the positive inotropic response to isoproterenol and this response is

193 re are two mechanisms that underlie the slow inotropic response to stretch: activation of NHE; and of

194 se to external stretch, and a dose-dependent inotropic response to the beta-adrenergic agonist isopro

195 The inotropic response was markedly blunted by heart failure

196 beta-Adrenergic receptor and inotropic response were decreased in failing hearts.

197 hearts, TG-LVH hearts showed no increase in inotropic response when compared with WT-LVH hearts.

198 ssion in the normal heart allows an enhanced inotropic response with no compromise in energy supply a

199 g rise in LA pressure, greatly attenuated LV inotropic response, and markedly reduced survival.

200 cited a positive chronotropic but negligible inotropic response, suggesting sarcoplasmic reticulum im

201 c stimulation may synergistically facilitate inotropic responses and contribute to a CaMKII-Ca(2+)-Ca

202 The mechanisms underlying both the inotropic responses and hyperglycemia's effects on them

203 effect on diastolic function and blunted the inotropic responses of cardiac muscle to beta-adrenergic

204 However, no differences of maximal inotropic responses of myocardial fibers from Tg-CTGF mi

205 vascular tone and depressed beta-adrenergic inotropic responses that were associated with impaired b

206 However, attenuation of the chronotropic and inotropic responses to a beta-AR agonist may depend upon

207 Hyperglycemia diminishes positive inotropic responses to agonists that activate phospholip

208 Mammalian hearts exhibit positive inotropic responses to beta-adrenergic stimulation as a

209 (3) a positive force-frequency response; (4) inotropic responses to beta-adrenergic stimulation media

210 rly displayed positive chronotropic but null inotropic responses to beta-adrenergic stimulation.

211 ne metabolites to hyperglycemia's effects on inotropic responses was examined in isolated perfused ra

212 and abolished for forskolin, whereas maximum inotropic responses were markedly blunted only for serot

213 that isoform-selective inhibition may allow inotropic responses without an increase in mortality.

214 racterized by diminished frequency-dependent inotropic responses.

215 oproterenol displayed attenuation of maximal inotropic responses.

216 Reduced inotropic responsiveness is characteristic of heart fail

217 (P<0.001) common atrial pressure (P=0.042), inotropic score (P<0.001), and need for greater volume r

218 in cardiac index, arrhythmias, peak lactate, inotropic scores, urine output, duration of mechanical v

219 ecific GRK2 knockout mice exhibited enhanced inotropic sensitivity to the beta-adrenergic receptor ag

220 Isolated increase in heart rate or inotropic state did not alter peak stitch tension wherea

221 rial pacing at 130 minutes(-1) (n=5) whereas inotropic state was increased with i.v.

222 T mice could limit the isoproterenol-induced inotropic state.

223 1%; this was true also over a wide range of inotropic states induced by varied [Ca(2+)](o).

224 raction coupling, and the effect of positive inotropic stimulation on the spatial profile of the Ca(2

225 o quantify the influence of chronotropic and inotropic stimulation on torsion, nine healthy volunteer

226 However, when acutely stressed by inotropic stimulation or ischemia/reperfusion, GAMT-/- m

227 However, during inotropic stimulation with dobutamine, preload-recruitab

228 and relaxation in normal mouse hearts during inotropic stimulation with isoproterenol.

229 During inotropic stimulation, DKO/mCryAB(Tg) showed blunted sys

230 spectroscopy experiments showed that during inotropic stimulation, isolated WT hearts utilized PCr,

231 stressed with either ischemia/reperfusion or inotropic stimulation.

232 reduce the responsiveness of mouse hearts to inotropic stimuli.

233 rdiac energetics are further deranged during inotropic stress, in association with continued diastoli

234 For similar levels of inotropic stress, there were smaller increases in peak f

235 apsibility of the superior vena cava>/=36%), inotropic support (left ventricular fractional area chan

236 n cases where circulatory arrest (P=0.01) or inotropic support (P=0.01) was necessary during operatio

237 s with decompensated CHF requiring transient inotropic support and 6 age-matched, healthy controls we

238 without EM, except for a higher frequency of inotropic support and assist devices in EM patients.

239 gic receptors (beta-ARs) provide a source of inotropic support and influence the evolution of heart f

240 ioplegic technologies, some patients require inotropic support and/or mechanical assist devices posto

241 ular resistance decreased significantly, and inotropic support became unnecessary.

242 und in the prescription of fluid loading and inotropic support derived from early transesophageal ech

243 right-sided circulatory support, continuous inotropic support for >/=14 days, or nitric oxide ventil

244 accumulation and truncated beta2-ARs provide inotropic support in adult cardiomyocytes.

245 Acute inotropic support in RVH is best accomplished by dobutam

246 ed management guidelines for vasopressor and inotropic support in septic shock that would be of pract

247 It is hypothesized to be related to inotropic support or metabolic derangements from chronic

248 long-term clinical outcomes irrespective of inotropic support or renal dysfunction and remains an ex

249 SNP was not associated with higher rates of inotropic support or worsening renal function during hos

250 Surgical procedure, bypass details, inotropic support requirement, and postoperative recover

251 sarcoplasmic reticular Ca2+ uptake, provide inotropic support through reverse-mode Ca2+ entry, and/o

252 hemodynamic monitoring, management of proper inotropic support to maintain left ventricular and right

253 tween the two approaches for the decision of inotropic support was weak (kappa: 0.23 [-0.04;0.50]).

254 al class IV symptoms who failed weaning from inotropic support were offered a Novacor LVAD.

255 pronounced hemodynamic compromise requiring inotropic support whereas those in Group III remained he

256 ne sodium-potassium pump inhibitors, provide inotropic support without arrhythmogenic increases in cy

257 uid resuscitation > 5 L/24 hr, vasoactive or inotropic support, and renal replacement therapy); 2) 20

258 ive care unit stay, length of hospital stay, inotropic support, and survival.

259 al fibrillation, the need for post-operative inotropic support, and the length of hospital stay.

260 Adequate fluid resuscitation, appropriate inotropic support, attention to rewarming, and ventilato

261 Thus, INaL offers inotropic support, but negatively interferes with cellul

262 ion, base deficit, serum osmolarity, sepsis, inotropic support, platelet count, creatinine, and venti

263 treatment of cardiogenic shock refractory to inotropic support, thereby minimizing the detrimental ef

264 occal septic shock who are not responsive to inotropic support.

265 of low cardiac output state and the need for inotropic support.

266 r right ventricular dysfunction, and lack of inotropic support.

267 ained high at 24 hours in patients requiring inotropic support.

268 ion therapy but not dependent on intravenous inotropic support.

269 diac function by echocardiography on minimal inotropic support.

270 iably implement these potentially beneficial inotropic therapies in humans without introducing negati

271 there is a need to develop and explore novel inotropic therapies that can act via calcium-independent

272 Current inotropic therapies used to increase cardiac contractili

273 the efficacy of fluid resuscitation (1C) and inotropic therapy (2C), presence of RV dysfunction (2C)

274 icacy and hemodynamic changes of patients on inotropic therapy (milrinone, levosimendan, and istaroxi

275 management of these patients with empirical inotropic therapy (with or without a vasodilator), morta

276 ts randomized, 91 were receiving intravenous inotropic therapy at randomization to LVAD or optimal me

277 Median days out of hospital for patients on inotropic therapy at randomization were 255 with LVAD an

278 A minority of patients can discontinue inotropic therapy because of clinical improvement.

279 Outpatient intravenous inotropic therapy can be safely used as a bridge to tran

280 Intravenous inotropic therapy can be used to support children awaiti

281 analyses suggest that the use of intravenous inotropic therapy for patients hospitalized with heart f

282 gan Sharing status 1A patients discharged on inotropic therapy from 1999 until 2012.

283 Inotropic therapy has been predominantly used in the man

284 ly lower in-hospital mortality than positive inotropic therapy in patients hospitalized with ADHF.

285 s explain observed differences in the use of inotropic therapy is not known.

286 s in HF, but its relationship to response to inotropic therapy is unknown.

287 turn to a compensated state after short-term inotropic therapy results in a significant reduction in

288 Intravenous inotropic therapy was initiated for cardiac symptoms not

289 al pressure > or = 65 mm Hg (1C); dobutamine inotropic therapy when cardiac output remains low despit

290 l realize the potential clinical benefits of inotropic therapy without the risk remains a subject of

291 EM may be related to intravenous inotropic therapy, and this is the first study to docume

292 24 hours after discontinuation of short-term inotropic therapy, when patients had returned to a stead

293 transplant or receiving chronic intravenous inotropic therapy.

294 t failure and high prevalence of intravenous inotropic therapy.

295 infusion in a rat model of local epicardial inotropic therapy.

296 sm-related adverse effects restrict existing inotropic treatments.

297 uirement for, or withdrawal of, conventional inotropic vasoconstrictor agents (i.e., dopamine and nor

298 low despite fluid resuscitation and combined inotropic/vasopressor therapy (1C); stress-dose steroid

299 otension, requiring fluid administration and inotropic/vasopressor therapy, occurred in all the mothe

300 r (Apelin peptide jejunum) to exert singular inotropic/vasotropic actions and to optimize body fluid