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1 somatic mosaicism during neurodevelopment by insertional mutagenesis.
2 d catalog of common and rare variants due to insertional mutagenesis.
3 MKL mouse model generated through retroviral insertional mutagenesis.
4 erating mutations were induced by retroviral insertional mutagenesis.
5 ding the putative adhesins were disrupted by insertional mutagenesis.
6 a (SREBP-1a) was specifically inactivated by insertional mutagenesis.
7 ro and in vivo with any organism amenable to insertional mutagenesis.
8  episome in replicating cells while avoiding insertional mutagenesis.
9 ncorporate weaker enhancer elements to avoid insertional mutagenesis.
10 odifications may protect coding regions from insertional mutagenesis.
11 f their discovery as an endogenous source of insertional mutagenesis.
12 d forward genetic screening using transposon insertional mutagenesis.
13 ing strain M101, created by single-crossover insertional mutagenesis.
14 ple proviral integrations pose the danger of insertional mutagenesis.
15 encing, likely to protect the germ line from insertional mutagenesis.
16 en using a combination of DNA sequencing and insertional mutagenesis.
17 entified 55 mutants using either chemical or insertional mutagenesis.
18 viding cells, exhibiting a decreased risk of insertional mutagenesis.
19  cells, likely to protect the germ line from insertional mutagenesis.
20 s carries with it a finite chance of causing insertional mutagenesis.
21 al negative effect of transgene products and insertional mutagenesis.
22 ing, aberrant transcriptional regulation and insertional mutagenesis.
23  years since the completion of a large-scale insertional mutagenesis.
24 disease can be corrected without the risk of insertional mutagenesis.
25 stable transgene expression while minimizing insertional mutagenesis.
26 his system substantially reduces the risk of insertional mutagenesis.
27  to minimize the deleterious consequences of insertional mutagenesis.
28  as well as the reported toxicity related to insertional mutagenesis.
29 ntified through oncogenic-retrovirus-induced insertional mutagenesis.
30 ons in mammalian genomes that are capable of insertional mutagenesis.
31 sland was cloned, sequenced and subjected to insertional mutagenesis.
32 eletions, which may lead to loss-of-function insertional mutagenesis.
33 tion, similar to retroviral gain-of-function insertional mutagenesis.
34  reduced vector-related toxicity and without insertional mutagenesis.
35  to design better strategies for genome-wide insertional mutagenesis.
36 cerns about the potential for rAAV2-mediated insertional mutagenesis.
37 vation of embC in Mycobacterium smegmatis by insertional mutagenesis.
38  a Chlamydomonas motility mutant obtained by insertional mutagenesis.
39 igh-level expression and reduce the risk for insertional mutagenesis.
40 e through a variety of mechanisms, including insertional mutagenesis.
41 em by complementation of Pgl- mutants and by insertional mutagenesis.
42 equence analysis and then was inactivated by insertional mutagenesis.
43 vel proto-oncogenes identified by retroviral insertional mutagenesis.
44 e genome than obtained with methods based on insertional mutagenesis.
45  screen of mutant mice generated by piggyBac insertional mutagenesis.
46 olet (UV) light and chemical mutagens, or by insertional mutagenesis.
47 for therapeutic application due to potential insertional mutagenesis.
48 ant near-haploid KBM-7 cells using gene-trap insertional mutagenesis.
49 ld pose a risk for neoplasia, independent of insertional mutagenesis.
50 ing data for 97 tumors induced by retroviral insertional mutagenesis.
51 -causing mutations and eliminate the risk of insertional mutagenesis.
52 coding gene cluster, which was identified by insertional mutagenesis.
53                     There is no evidence for insertional mutagenesis after 21-36 months of observatio
54 to study the mechanisms of insertions of the insertional mutagenesis agents and to design better stra
55  endogenous L1s suggests that it is unlikely insertional mutagenesis alone accounts for the Mov10l1(-
56 esis, we generated Cfp4-deficient strains by insertional mutagenesis and by RNA interference.
57                           Through retroviral insertional mutagenesis and chemical mutagenesis experim
58      This can lead to genetic damage through insertional mutagenesis and chromosomal rearrangements b
59 hough powerful enhancer elements have caused insertional mutagenesis and clonal dysregulation.
60 g concerns related to persistent expression, insertional mutagenesis and cytotoxicity.
61 experimentally profile Cas9 using randomized insertional mutagenesis and delineate hotspots in the st
62                                              Insertional mutagenesis and depletion (iMAD) is a geneti
63 eveloped a genetic screening strategy called insertional mutagenesis and depletion (iMAD) that combin
64 e families (L1, Alu and SVA) associated with insertional mutagenesis and disease.
65 tegrating vectors pose risks associated with insertional mutagenesis and disruption of gene expressio
66     L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, bo
67 r suppressor using mouse transposon-mediated insertional mutagenesis and Drosophila cancer models.
68 red potentially hazardous, as it can lead to insertional mutagenesis and genomic instability.
69                                              Insertional mutagenesis and genotoxicity, which usually
70     This study describes the combined use of insertional mutagenesis and immunochemical approaches to
71 al dominance that could not be attributed to insertional mutagenesis and instead likely resulted from
72 n, a method that is associated with unwanted insertional mutagenesis and positional effects on transg
73 r, their clinical use raises the concerns of insertional mutagenesis and potential oncogenesis due to
74 ecific integration events that may result in insertional mutagenesis and reduced fitness.
75 etrotransposon can damage the genome through insertional mutagenesis and the generation of DNA double
76  for transposon-mediated genome engineering, insertional mutagenesis and the genome-wide mapping of t
77  new insights into the risk of rAAV-mediated insertional mutagenesis and the mechanisms of rAAV integ
78 , association analysis, expression analysis, insertional mutagenesis and transgenic validation, we de
79  integration into the host genome results in insertional mutagenesis and variable position effects.
80 ful tools for creating transgenic organisms, insertional mutagenesis, and genome engineering.
81 ta suggest that ALV-J induces oncogenesis by insertional mutagenesis, and integrations in the MET onc
82               These include transposon-based insertional mutagenesis, and systematic deletions using
83 for transcriptional activation by retroviral insertional mutagenesis, and the oncogenic potential of
84               The ylxL gene was disrupted by insertional mutagenesis, and the resultant mutant strain
85 y-one gene studies using positional cloning, insertional mutagenesis, antisense morpholino oligonucle
86 method for gene therapy because the risks of insertional mutagenesis are eliminated provided that a "
87  previously described methods for retroviral insertional mutagenesis are hindered by low mutagenesis
88 acity, host immune response, and the risk of insertional mutagenesis are limiting factors and of conc
89 nd helps define optimal strategies for using insertional mutagenesis as a genomic tool.
90          A clc-a mutant, Mlac3, generated by insertional mutagenesis as well as a targeted Deltaclc-a
91 olation of mutants by classical genetics and insertional mutagenesis, as well as by the disruption of
92 ment potential of CD34+ progenitor cells via insertional mutagenesis at this specific locus.
93 nt populations on par with those produced by insertional mutagenesis, but systematic cataloguing of m
94                                   The use of insertional mutagenesis by Agrobacterium has uncovered a
95 ha(-/-) and DAGLbeta(-/-) mice generated via insertional mutagenesis by gene-trapping with retroviral
96                                              Insertional mutagenesis by retroviral vectors is a major
97 tracellular domain of SR-BI was subjected to insertional mutagenesis by strategically placing an epit
98                           Here, we show that insertional mutagenesis by the PiggyBac transposon can b
99                          Genes identified by insertional mutagenesis by their nature could also be in
100                            Here we show that insertional mutagenesis can also identify genes that pro
101 n that sleeping beauty (SB) transposon-based insertional mutagenesis can also identify novel candidat
102     Together, these results indicate that SB-insertional mutagenesis can identify high-grade astrocyt
103          Genome-wide functional profiling by insertional mutagenesis can reveal protein domains essen
104  up-regulated, demonstrating that retroviral insertional mutagenesis can target miRNA loci as well as
105  with the cellular receptors, we implemented insertional mutagenesis, carbohydrate shielding, and ala
106 g capacity, lack of copy number control, and insertional mutagenesis caused by integration into host
107 correction of monogenic diseases without the insertional mutagenesis caused by multisite integration
108                          Although L1-induced insertional mutagenesis causes Mendelian disease, their
109                           On the other hand, insertional mutagenesis causing liver cancer has been im
110 etic manipulation including genetic crosses, insertional mutagenesis, chemical mutagenesis, homologou
111 allenge that remains is reducing the risk of insertional mutagenesis due to random insertion by both
112                                        Using insertional mutagenesis each gene was characterized and
113                       To assess whether this insertional mutagenesis event results in alteration of t
114         These studies establish a profile of insertional mutagenesis for AAV vectors and provide uniq
115 ac transposon system for tamoxifen inducible insertional mutagenesis from a stably integrated chromos
116                                              Insertional mutagenesis generated avirulent isolates of
117    L1 expression has been shown to result in insertional mutagenesis, genomic deletions and rearrange
118                                              Insertional mutagenesis has been carried out on this par
119 d donors, leukemia caused by vector-mediated insertional mutagenesis has been reported in some indivi
120                          Although retroviral insertional mutagenesis has proven to be an effective to
121 cal occurrence of T cell malignancies due to insertional mutagenesis has raised concerns about the sa
122                      Malignant outcomes from insertional mutagenesis have featured prominently in the
123 SCID) gene therapy that increase the risk of insertional mutagenesis; (ii) what other genetic lesions
124                                              Insertional mutagenesis in a haploid background can disr
125 complicated by acute leukemia as a result of insertional mutagenesis in a high proportion of patients
126 ates tumorigenesis following Sleeping Beauty insertional mutagenesis in a mouse model of melanoma.
127 use Sleeping Beauty (SB) transposon-mediated insertional mutagenesis in a mouse model of pancreatic d
128                           We used retroviral insertional mutagenesis in an effort to identify which g
129                           The combination of insertional mutagenesis in Blm-deficient ES cells establ
130                                   Retroviral insertional mutagenesis in BXH2 and AKXD mice induces a
131 urther exploring the risk factors leading to insertional mutagenesis in gene therapy trials.
132 tudy describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this sys
133 ee) iPSCs, which avoid the potential risk of insertional mutagenesis in humans.
134 screen for potential tumor suppressors using insertional mutagenesis in immortalized fibroblasts.
135                                   Retroviral insertional mutagenesis in inbred mouse strains provides
136 oid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras(G12D) "knockin" mice wit
137 in a recent issue of Nature now reveals that insertional mutagenesis in mammalian cells is possible t
138 ion efficiency, recent reports of retroviral insertional mutagenesis in mice and two human subjects h
139                                              Insertional mutagenesis in mice demonstrates that Rfx4_v
140 deficiency, the UCE gene was inactivated via insertional mutagenesis in mice.
141                                   Retroviral insertional mutagenesis in mouse hematopoietic tumors pr
142                                   Retroviral insertional mutagenesis in mouse hematopoietic tumors pr
143 genous MLL-AF9 and MLL-ENL oncogenes through insertional mutagenesis in primary human hematopoietic s
144         We have developed a novel system for insertional mutagenesis in rice (Oryza sativa) based on
145               Thus, electroporation-mediated insertional mutagenesis in S.pombe is preceded by exonuc
146 m that can be used for effective large-scale insertional mutagenesis in soybean.
147                                              Insertional mutagenesis in the first predicted intermemb
148                                          DNA insertional mutagenesis in the model organism Chlamydomo
149 s method in other vertebrate species and for insertional mutagenesis in the mouse.
150                              Sleeping Beauty insertional mutagenesis in this model led to accelerated
151 hroughout the genome, potentially leading to insertional mutagenesis, inappropriate activation of nea
152 cterizing site selection for integration and insertional mutagenesis indicate that the Sleeping Beaut
153 dentity was identified in S. coelicolor, and insertional mutagenesis indicated that this gene was not
154 n average represent fairly small targets for insertional mutagenesis, indicates the general utility o
155 the deepest rough C. jejuni 81-176 mutant by insertional mutagenesis into the waaC gene, encoding hep
156                                              Insertional mutagenesis is a cornerstone of functional g
157                                    Gene-trap insertional mutagenesis is a high-throughput forward gen
158                                              Insertional mutagenesis is a powerful method for gene di
159                                              Insertional mutagenesis is a powerful tool for determini
160                                              Insertional mutagenesis is a powerful tool for generatin
161                                   Retroviral insertional mutagenesis is a powerful tool for identifyi
162 ate near genes and regulatory regions; thus, insertional mutagenesis is a substantial risk.
163  Drosophila melanogaster, P element-mediated insertional mutagenesis is a versatile tool for the diss
164                                   Transposon insertional mutagenesis is an effective alternative to T
165 in OPA and add weight to the hypothesis that insertional mutagenesis is involved in the development o
166             To test the hypothesis that JSRV insertional mutagenesis is involved in the oncogenesis o
167     Our results provide strong evidence that insertional mutagenesis is not required for in vitro rep
168 hether mature lymphocytes are susceptible to insertional mutagenesis is unknown.
169 ration in each transformant, indicating that insertional mutagenesis is useful for generating single-
170                   However, in some patients, insertional mutagenesis led to leukemia or myelodysplasi
171 red in HYDA1 gene expression by screening an insertional mutagenesis library for HYDA1 promoter activ
172 tion of multiple insertion sites in a random insertional mutagenesis library.
173  mapping double-insertion events in a random insertional-mutagenesis library.
174 abase for archiving, searching and analyzing insertional mutagenesis lines.
175  developed a web application called iMapper (Insertional Mutagenesis Mapping and Analysis Tool) for t
176 ediated leukemogenesis as well as retroviral insertional mutagenesis mechanisms.
177 e developed an efficient transposon-mediated insertional mutagenesis method much needed for high-thro
178 r results demonstrate that extensive somatic insertional mutagenesis occurs very early during the dev
179 RISPR-Cas9 reverse-genetics pipeline enabled insertional mutagenesis of 18 of these 20 transcription
180                                              Insertional mutagenesis of abp2 and abp3 blocked express
181                                              Insertional mutagenesis of Arabidopsis ecotype C24 was u
182 viruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valu
183 ilization likely promotes tumor formation by insertional mutagenesis of cancer genes, and not by prom
184                   The tumours result from SB insertional mutagenesis of cancer genes, thus facilitati
185                                              Insertional mutagenesis of cooperating cancer genes by a
186                                              Insertional mutagenesis of exsM in Bacillus anthracis De
187                                              Insertional mutagenesis of legume genomes such as soybea
188                                              Insertional mutagenesis of nocJ abolished nocardicin A p
189                                              Insertional mutagenesis of regions upstream of the chara
190 olecules also may be useful as tools for the insertional mutagenesis of target mRNAs.
191           Second, the H-2Z1 transgene causes insertional mutagenesis of Tbc1d5 and Satb1, leading to
192  functional genomics of photosynthesis using insertional mutagenesis of the Chlamydomonas nuclear gen
193  "complex interaction" model was tested with insertional mutagenesis of the Drosophila Hsp70 core pro
194                                 We show that insertional mutagenesis of the previously uncharacterize
195                                              Insertional mutagenesis of the undomesticated 3610 strai
196    We describe and characterize a method for insertional mutagenesis of the yeast pathogen Candida gl
197 and tractable manner, using transposon-based insertional mutagenesis on the background of chronic pha
198 of the encoded CPS and KS, and the impact of insertional mutagenesis on virulence and the plant defen
199 ted in single-gene disease in humans through insertional mutagenesis or aberrant mRNA splicing.
200 Lines in which FHL function was abolished by insertional mutagenesis or attenuated by RNAi-mediated s
201                                              Insertional mutagenesis or RNA-mediated silencing of Os-
202 ation, as a unique tool for genomic studies (insertional mutagenesis or targeted DNA integration) and
203  use of viral vectors prone to silencing and insertional mutagenesis or the use of nonhuman genes.
204 ive treatment in humans, some concerns about insertional mutagenesis persist.
205    We have developed a high-throughput T-DNA insertional mutagenesis program in tomato using activati
206                                  By using an insertional mutagenesis protocol that relies on in vitro
207  cancers in mice using a transposon-mediated insertional mutagenesis protocol.
208                        Disruption of chiA by insertional mutagenesis resulted in cells that failed to
209 ow that retroviruses that engender different insertional mutagenesis risks can have similar integrati
210 eted gene disruption or allele substitution, insertional mutagenesis, RNA interference and homologous
211 nt mutant from a restriction enzyme-mediated insertional mutagenesis screen and have obtained its cDN
212                                           An insertional mutagenesis screen identified roles for the
213 r MPXV infection, we performed a genome-wide insertional mutagenesis screen in human haploid cells.
214         Here we developed a novel whole-body insertional mutagenesis screen in mice, which was design
215 ducted a Sleeping Beauty transposon-mediated insertional mutagenesis screen in Rassf1a-null mice to i
216 have been used as mutagens for a large-scale insertional mutagenesis screen in the zebra fish.
217                         We completed a large insertional mutagenesis screen in zebrafish to identify
218 elopment, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse
219                                        In an insertional mutagenesis screen in zebrafish, we identifi
220 ansform mammary epithelial cells, we used an insertional mutagenesis screen on cells isolated from wi
221                            We carried out an insertional mutagenesis screen to isolate bypass suppres
222 67 stable transgenic lines generated from an insertional mutagenesis screen using a transposon-based
223     To identify these genes, we performed an insertional mutagenesis screen using the Sleeping Beauty
224                                           An insertional mutagenesis screen was performed by intercro
225 ctable marker for nuclear transformation, an insertional mutagenesis screen was performed to select f
226                                      From an insertional mutagenesis screen we identified a novel gen
227 hat mutations in CKA2, identified through an insertional mutagenesis screen, confer fluconazole resis
228           Recently, a large-scale retroviral insertional mutagenesis screen, in which 315 different g
229                            Using a gene-trap insertional mutagenesis screen, we identified poliovirus
230                   In a large-scale zebrafish insertional mutagenesis screen, we identified the pinbal
231 f rapamycin (ztor) mutant identified from an insertional mutagenesis screen.
232 ets of new cancer genes through a pancreatic insertional mutagenesis screen.
233   Consistent with these findings, retroviral insertional mutagenesis screening of our T-cell leukemia
234           To manage multiple high-throughput insertional mutagenesis screening projects, we developed
235 recent major advances in transposon-mediated insertional mutagenesis screens and compare this technol
236                              Yet, retroviral insertional mutagenesis screens identify RUNX genes as c
237 elements, have been successfully applied for insertional mutagenesis screens in both the mouse and ra
238 nal annotation of cancer genomes by enabling insertional mutagenesis screens in higher eukaryotes tha
239                                              Insertional mutagenesis screens in mice are used to iden
240                                              Insertional mutagenesis screens play an integral part in
241 t to identify DNA integration sites, such as insertional mutagenesis screens, gene and enhancer trap
242  into genomic DNA is a method widely used in insertional mutagenesis screens.
243  cell proliferative capacity without risk of insertional mutagenesis should have broad utility in dis
244 t to this process, we utilized a Tn917-based insertional mutagenesis strategy to generate a mutant ba
245                          We have now used an insertional mutagenesis strategy to generate two differe
246 axel resistance in breast cancer, we used an insertional mutagenesis strategy to identify proteins wh
247 essed in meristematic cells, a promoter trap insertional mutagenesis strategy was used in Arabidopsis
248                      We demonstrate that the insertional mutagenesis system based on Tnt1 and the 523
249 id piggyBac/Sleeping Beauty transposon-based insertional mutagenesis system that can be mobilized by
250                                              Insertional mutagenesis techniques, including transposon
251 dology with a tight integration of gene-trap insertional mutagenesis testing and systems biology to i
252 cribe here a large series of mouse lines for insertional mutagenesis that are compatible with two tra
253 that these vectors are an effective tool for insertional mutagenesis that can be used for either gene
254  selection and also explain the high risk of insertional mutagenesis that is associated with gene the
255                       To deal with potential insertional mutagenesis, the vector integrations are the
256        Here we used piggyBac (PB) transposon insertional mutagenesis to anticipate resistance mechani
257                                      We used insertional mutagenesis to develop a screening method to
258 n this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression p
259   Here we combined retroviral and transposon insertional mutagenesis to enable cancer gene discovery
260 e unicellular green alga Chlamydomonas using insertional mutagenesis to find mutants that conferred h
261 nzyme, we performed large scale pentapeptide insertional mutagenesis to generate insertions of five a
262            In this study, we used retroviral insertional mutagenesis to identify genes that accelerat
263     In the present study, we used retroviral insertional mutagenesis to identify genes that might col
264 n in Chinese hamster ovary (CHO) cells using insertional mutagenesis to identify genes that regulate
265 used genome-wide CRISPR libraries as well as insertional mutagenesis to identify synthetic viable (ge
266 used an unbiased method for validation-based insertional mutagenesis to isolate a quinacrine-resistan
267                Here, we recruited retroviral insertional mutagenesis to obtain induction of an arbitr
268 sposase alleles to allow transposon-mediated insertional mutagenesis to occur.
269 ned the assay with Agrobacterium tumefaciens insertional mutagenesis to screen for hyphal mutants.
270 y (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer ge
271 otential hazards to genome integrity through insertional mutagenesis, unequal recombination and chrom
272                                              Insertional mutagenesis using engineered transposons is
273 w drivers of intestinal cancer, we performed insertional mutagenesis using the Sleeping Beauty transp
274                                              Insertional mutagenesis using transfer DNA or transposab
275 efficient use of lentiviral validation-based insertional mutagenesis (VBIM) to generate large populat
276                       Using validation-based insertional mutagenesis (VBIM), we identified family wit
277 ngineered Arabidopsis (Arabidopsis thaliana) insertional mutagenesis vectors that are based on the ma
278                         Owing to the risk of insertional mutagenesis, viral transduction has been inc
279                                              Insertional mutagenesis was achieved by electroporation
280 6a12 hypomorphic rat generated by transposon insertional mutagenesis was characterized using RT-PCR,
281 l importance within proLasA, linker-scanning insertional mutagenesis was employed using a plasmid con
282                                              Insertional mutagenesis was used to abrogate gene functi
283                    Here, transposon-mediated insertional mutagenesis was used to create 5 libraries o
284                                 Chimeric and insertional mutagenesis was used to generate mutants of
285                                   Retroviral insertional mutagenesis was used to produce a mutant Chi
286 s of XMRV and the potential risk of proviral insertional mutagenesis, we carried out a genome-wide an
287                                        Using insertional mutagenesis, we identified a gene, RYP1 (req
288                           By using gene trap insertional mutagenesis, we identified Rab9, which media
289                                        Using insertional mutagenesis, we isolated a UV-sensitive muta
290           Using piggyBac transposon-mediated insertional mutagenesis, we screened for parasites that
291 te cellular promoters pose a reduced risk of insertional mutagenesis when compared with vectors with
292 study provides a new mechanism of retrovirus insertional mutagenesis whereby spatial chromatin organi
293  could be modified to drive transposon-based insertional mutagenesis wherever tissue-specific Cre exp
294 erapy strategies, e.g., immune rejection and insertional mutagenesis, which are associated with viral
295 ion of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of
296 retroid agents are implicated in disease via insertional mutagenesis, while others have been found to
297                                              Insertional mutagenesis with a heterologous transposon p
298                  TraSH combines high-density insertional mutagenesis with microarray mapping of pools
299           We describe an improved method for insertional mutagenesis with retroviral vectors and show
300                                 We performed insertional mutagenesis with the MOL4070LTR retrovirus i

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