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1 somatic mosaicism during neurodevelopment by insertional mutagenesis.
2 d catalog of common and rare variants due to insertional mutagenesis.
3 MKL mouse model generated through retroviral insertional mutagenesis.
4 erating mutations were induced by retroviral insertional mutagenesis.
5 ding the putative adhesins were disrupted by insertional mutagenesis.
6 a (SREBP-1a) was specifically inactivated by insertional mutagenesis.
7 ro and in vivo with any organism amenable to insertional mutagenesis.
8 episome in replicating cells while avoiding insertional mutagenesis.
9 ncorporate weaker enhancer elements to avoid insertional mutagenesis.
10 odifications may protect coding regions from insertional mutagenesis.
11 f their discovery as an endogenous source of insertional mutagenesis.
12 d forward genetic screening using transposon insertional mutagenesis.
13 ing strain M101, created by single-crossover insertional mutagenesis.
14 ple proviral integrations pose the danger of insertional mutagenesis.
15 encing, likely to protect the germ line from insertional mutagenesis.
16 en using a combination of DNA sequencing and insertional mutagenesis.
17 entified 55 mutants using either chemical or insertional mutagenesis.
18 viding cells, exhibiting a decreased risk of insertional mutagenesis.
19 cells, likely to protect the germ line from insertional mutagenesis.
20 s carries with it a finite chance of causing insertional mutagenesis.
21 al negative effect of transgene products and insertional mutagenesis.
22 ing, aberrant transcriptional regulation and insertional mutagenesis.
23 years since the completion of a large-scale insertional mutagenesis.
24 disease can be corrected without the risk of insertional mutagenesis.
25 stable transgene expression while minimizing insertional mutagenesis.
26 his system substantially reduces the risk of insertional mutagenesis.
27 to minimize the deleterious consequences of insertional mutagenesis.
28 as well as the reported toxicity related to insertional mutagenesis.
29 ntified through oncogenic-retrovirus-induced insertional mutagenesis.
30 ons in mammalian genomes that are capable of insertional mutagenesis.
31 sland was cloned, sequenced and subjected to insertional mutagenesis.
32 eletions, which may lead to loss-of-function insertional mutagenesis.
33 tion, similar to retroviral gain-of-function insertional mutagenesis.
34 reduced vector-related toxicity and without insertional mutagenesis.
35 to design better strategies for genome-wide insertional mutagenesis.
36 cerns about the potential for rAAV2-mediated insertional mutagenesis.
37 vation of embC in Mycobacterium smegmatis by insertional mutagenesis.
38 a Chlamydomonas motility mutant obtained by insertional mutagenesis.
39 igh-level expression and reduce the risk for insertional mutagenesis.
40 e through a variety of mechanisms, including insertional mutagenesis.
41 em by complementation of Pgl- mutants and by insertional mutagenesis.
42 equence analysis and then was inactivated by insertional mutagenesis.
43 vel proto-oncogenes identified by retroviral insertional mutagenesis.
44 e genome than obtained with methods based on insertional mutagenesis.
45 screen of mutant mice generated by piggyBac insertional mutagenesis.
46 olet (UV) light and chemical mutagens, or by insertional mutagenesis.
47 for therapeutic application due to potential insertional mutagenesis.
48 ant near-haploid KBM-7 cells using gene-trap insertional mutagenesis.
49 ld pose a risk for neoplasia, independent of insertional mutagenesis.
50 ing data for 97 tumors induced by retroviral insertional mutagenesis.
51 -causing mutations and eliminate the risk of insertional mutagenesis.
52 coding gene cluster, which was identified by insertional mutagenesis.
54 to study the mechanisms of insertions of the insertional mutagenesis agents and to design better stra
55 endogenous L1s suggests that it is unlikely insertional mutagenesis alone accounts for the Mov10l1(-
61 experimentally profile Cas9 using randomized insertional mutagenesis and delineate hotspots in the st
63 eveloped a genetic screening strategy called insertional mutagenesis and depletion (iMAD) that combin
65 tegrating vectors pose risks associated with insertional mutagenesis and disruption of gene expressio
66 L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, bo
67 r suppressor using mouse transposon-mediated insertional mutagenesis and Drosophila cancer models.
70 This study describes the combined use of insertional mutagenesis and immunochemical approaches to
71 al dominance that could not be attributed to insertional mutagenesis and instead likely resulted from
72 n, a method that is associated with unwanted insertional mutagenesis and positional effects on transg
73 r, their clinical use raises the concerns of insertional mutagenesis and potential oncogenesis due to
75 etrotransposon can damage the genome through insertional mutagenesis and the generation of DNA double
76 for transposon-mediated genome engineering, insertional mutagenesis and the genome-wide mapping of t
77 new insights into the risk of rAAV-mediated insertional mutagenesis and the mechanisms of rAAV integ
78 , association analysis, expression analysis, insertional mutagenesis and transgenic validation, we de
79 integration into the host genome results in insertional mutagenesis and variable position effects.
81 ta suggest that ALV-J induces oncogenesis by insertional mutagenesis, and integrations in the MET onc
83 for transcriptional activation by retroviral insertional mutagenesis, and the oncogenic potential of
85 y-one gene studies using positional cloning, insertional mutagenesis, antisense morpholino oligonucle
86 method for gene therapy because the risks of insertional mutagenesis are eliminated provided that a "
87 previously described methods for retroviral insertional mutagenesis are hindered by low mutagenesis
88 acity, host immune response, and the risk of insertional mutagenesis are limiting factors and of conc
91 olation of mutants by classical genetics and insertional mutagenesis, as well as by the disruption of
93 nt populations on par with those produced by insertional mutagenesis, but systematic cataloguing of m
95 ha(-/-) and DAGLbeta(-/-) mice generated via insertional mutagenesis by gene-trapping with retroviral
97 tracellular domain of SR-BI was subjected to insertional mutagenesis by strategically placing an epit
101 n that sleeping beauty (SB) transposon-based insertional mutagenesis can also identify novel candidat
102 Together, these results indicate that SB-insertional mutagenesis can identify high-grade astrocyt
104 up-regulated, demonstrating that retroviral insertional mutagenesis can target miRNA loci as well as
105 with the cellular receptors, we implemented insertional mutagenesis, carbohydrate shielding, and ala
106 g capacity, lack of copy number control, and insertional mutagenesis caused by integration into host
107 correction of monogenic diseases without the insertional mutagenesis caused by multisite integration
110 etic manipulation including genetic crosses, insertional mutagenesis, chemical mutagenesis, homologou
111 allenge that remains is reducing the risk of insertional mutagenesis due to random insertion by both
115 ac transposon system for tamoxifen inducible insertional mutagenesis from a stably integrated chromos
117 L1 expression has been shown to result in insertional mutagenesis, genomic deletions and rearrange
119 d donors, leukemia caused by vector-mediated insertional mutagenesis has been reported in some indivi
121 cal occurrence of T cell malignancies due to insertional mutagenesis has raised concerns about the sa
123 SCID) gene therapy that increase the risk of insertional mutagenesis; (ii) what other genetic lesions
125 complicated by acute leukemia as a result of insertional mutagenesis in a high proportion of patients
126 ates tumorigenesis following Sleeping Beauty insertional mutagenesis in a mouse model of melanoma.
127 use Sleeping Beauty (SB) transposon-mediated insertional mutagenesis in a mouse model of pancreatic d
132 tudy describes a tool, Lentihop, for somatic insertional mutagenesis in human cells and uses this sys
134 screen for potential tumor suppressors using insertional mutagenesis in immortalized fibroblasts.
136 oid leukemias (AMLs) generated by retroviral insertional mutagenesis in Kras(G12D) "knockin" mice wit
137 in a recent issue of Nature now reveals that insertional mutagenesis in mammalian cells is possible t
138 ion efficiency, recent reports of retroviral insertional mutagenesis in mice and two human subjects h
143 genous MLL-AF9 and MLL-ENL oncogenes through insertional mutagenesis in primary human hematopoietic s
151 hroughout the genome, potentially leading to insertional mutagenesis, inappropriate activation of nea
152 cterizing site selection for integration and insertional mutagenesis indicate that the Sleeping Beaut
153 dentity was identified in S. coelicolor, and insertional mutagenesis indicated that this gene was not
154 n average represent fairly small targets for insertional mutagenesis, indicates the general utility o
155 the deepest rough C. jejuni 81-176 mutant by insertional mutagenesis into the waaC gene, encoding hep
163 Drosophila melanogaster, P element-mediated insertional mutagenesis is a versatile tool for the diss
165 in OPA and add weight to the hypothesis that insertional mutagenesis is involved in the development o
167 Our results provide strong evidence that insertional mutagenesis is not required for in vitro rep
169 ration in each transformant, indicating that insertional mutagenesis is useful for generating single-
171 red in HYDA1 gene expression by screening an insertional mutagenesis library for HYDA1 promoter activ
175 developed a web application called iMapper (Insertional Mutagenesis Mapping and Analysis Tool) for t
177 e developed an efficient transposon-mediated insertional mutagenesis method much needed for high-thro
178 r results demonstrate that extensive somatic insertional mutagenesis occurs very early during the dev
179 RISPR-Cas9 reverse-genetics pipeline enabled insertional mutagenesis of 18 of these 20 transcription
182 viruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valu
183 ilization likely promotes tumor formation by insertional mutagenesis of cancer genes, and not by prom
192 functional genomics of photosynthesis using insertional mutagenesis of the Chlamydomonas nuclear gen
193 "complex interaction" model was tested with insertional mutagenesis of the Drosophila Hsp70 core pro
196 We describe and characterize a method for insertional mutagenesis of the yeast pathogen Candida gl
197 and tractable manner, using transposon-based insertional mutagenesis on the background of chronic pha
198 of the encoded CPS and KS, and the impact of insertional mutagenesis on virulence and the plant defen
200 Lines in which FHL function was abolished by insertional mutagenesis or attenuated by RNAi-mediated s
202 ation, as a unique tool for genomic studies (insertional mutagenesis or targeted DNA integration) and
203 use of viral vectors prone to silencing and insertional mutagenesis or the use of nonhuman genes.
205 We have developed a high-throughput T-DNA insertional mutagenesis program in tomato using activati
209 ow that retroviruses that engender different insertional mutagenesis risks can have similar integrati
210 eted gene disruption or allele substitution, insertional mutagenesis, RNA interference and homologous
211 nt mutant from a restriction enzyme-mediated insertional mutagenesis screen and have obtained its cDN
213 r MPXV infection, we performed a genome-wide insertional mutagenesis screen in human haploid cells.
215 ducted a Sleeping Beauty transposon-mediated insertional mutagenesis screen in Rassf1a-null mice to i
218 elopment, we are carrying out a large-scale, insertional mutagenesis screen in zebrafish, using mouse
220 ansform mammary epithelial cells, we used an insertional mutagenesis screen on cells isolated from wi
222 67 stable transgenic lines generated from an insertional mutagenesis screen using a transposon-based
223 To identify these genes, we performed an insertional mutagenesis screen using the Sleeping Beauty
225 ctable marker for nuclear transformation, an insertional mutagenesis screen was performed to select f
227 hat mutations in CKA2, identified through an insertional mutagenesis screen, confer fluconazole resis
233 Consistent with these findings, retroviral insertional mutagenesis screening of our T-cell leukemia
235 recent major advances in transposon-mediated insertional mutagenesis screens and compare this technol
237 elements, have been successfully applied for insertional mutagenesis screens in both the mouse and ra
238 nal annotation of cancer genomes by enabling insertional mutagenesis screens in higher eukaryotes tha
241 t to identify DNA integration sites, such as insertional mutagenesis screens, gene and enhancer trap
243 cell proliferative capacity without risk of insertional mutagenesis should have broad utility in dis
244 t to this process, we utilized a Tn917-based insertional mutagenesis strategy to generate a mutant ba
246 axel resistance in breast cancer, we used an insertional mutagenesis strategy to identify proteins wh
247 essed in meristematic cells, a promoter trap insertional mutagenesis strategy was used in Arabidopsis
249 id piggyBac/Sleeping Beauty transposon-based insertional mutagenesis system that can be mobilized by
251 dology with a tight integration of gene-trap insertional mutagenesis testing and systems biology to i
252 cribe here a large series of mouse lines for insertional mutagenesis that are compatible with two tra
253 that these vectors are an effective tool for insertional mutagenesis that can be used for either gene
254 selection and also explain the high risk of insertional mutagenesis that is associated with gene the
258 n this study, we have exploited the power of insertional mutagenesis to elucidate tumor progression p
259 Here we combined retroviral and transposon insertional mutagenesis to enable cancer gene discovery
260 e unicellular green alga Chlamydomonas using insertional mutagenesis to find mutants that conferred h
261 nzyme, we performed large scale pentapeptide insertional mutagenesis to generate insertions of five a
263 In the present study, we used retroviral insertional mutagenesis to identify genes that might col
264 n in Chinese hamster ovary (CHO) cells using insertional mutagenesis to identify genes that regulate
265 used genome-wide CRISPR libraries as well as insertional mutagenesis to identify synthetic viable (ge
266 used an unbiased method for validation-based insertional mutagenesis to isolate a quinacrine-resistan
269 ned the assay with Agrobacterium tumefaciens insertional mutagenesis to screen for hyphal mutants.
270 y (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer ge
271 otential hazards to genome integrity through insertional mutagenesis, unequal recombination and chrom
273 w drivers of intestinal cancer, we performed insertional mutagenesis using the Sleeping Beauty transp
275 efficient use of lentiviral validation-based insertional mutagenesis (VBIM) to generate large populat
277 ngineered Arabidopsis (Arabidopsis thaliana) insertional mutagenesis vectors that are based on the ma
280 6a12 hypomorphic rat generated by transposon insertional mutagenesis was characterized using RT-PCR,
281 l importance within proLasA, linker-scanning insertional mutagenesis was employed using a plasmid con
286 s of XMRV and the potential risk of proviral insertional mutagenesis, we carried out a genome-wide an
291 te cellular promoters pose a reduced risk of insertional mutagenesis when compared with vectors with
292 study provides a new mechanism of retrovirus insertional mutagenesis whereby spatial chromatin organi
293 could be modified to drive transposon-based insertional mutagenesis wherever tissue-specific Cre exp
294 erapy strategies, e.g., immune rejection and insertional mutagenesis, which are associated with viral
295 ion of gene expression - carries the risk of insertional mutagenesis, which can lead to activation of
296 retroid agents are implicated in disease via insertional mutagenesis, while others have been found to
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