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1 cur, causing embryos to complete development inside out.
2 a folded polypeptide globular domain turned inside-out.
3 examine the incidence and time dependence of inside-out abrasion in asymptomatic patients implanted w
4 y has posed a unique clinical scenario where inside-out abrasion results in externalization of conduc
6 motaxis in vitro and in vivo with failure of inside-out activation and trafficking of the Mac1 integr
7 ier in integrin activation, and suggest that inside-out activation in intact cells may involve confor
8 ent conformation with disulfide bonds resist inside-out activation induced by cytoplasmic domain muta
9 ation, secretion, and integrin alphaIIbbeta3 inside-out activation induced by several agonists were n
11 n the basis of the results, we propose a new inside-out activation mechanism for integrin alpha(IIb)b
12 genetic variability in proteins that mediate inside-out activation of alphaIIbbeta3 The RASGRP2 gene
13 ting monocytes through beta(2) integrins and inside-out activation of beta(2) integrins by monocyte c
15 s is critically dependent on agonist-induced inside-out activation of heterodimeric integrin receptor
16 elet aggregation was accompanied by impaired inside-out activation of integrin alpha(IIb)beta(3) and
17 nd PI3Kbeta in integrin alpha2beta1 promoted inside-out activation of integrin alphaIIbbeta3 and thro
20 Although talin binding is sufficient for inside-out activation of integrin, other cytoplasmic pro
21 actin-binding protein that controls both the inside-out activation of integrins and actin filament an
22 tems, we show that Akt1 is essential for the inside-out activation of integrins in endothelial cells
24 ein, is thought to have two roles: mediating inside-out activation of integrins, and connecting extra
25 signals involving TLR2 and PI3k that promote inside-out activation of Mac-1, thereby enhancing spore
31 )-mediated activation of nmMYLK resulted in "inside-out" activation of beta1 integrin, followed by "o
32 -methionyl-leucine-phenylalanine to trigger "inside-out" activation, the effects of hyperoxia are rev
35 oocytes and measured unitary currents in the inside-out and cell-attached modes of the patch-clamp te
37 n receptor plays key roles in mediating both inside-out and outside-in signaling between cells and th
38 fetimes of cell surface attachments for both inside-out and outside-in signaling exhibit single-bond-
39 In this article, we examine the impact of inside-out and outside-in signaling in neutrophils on th
40 ration of these domains is required for both inside-out and outside-in signaling, the role of TM homo
42 ells, at the single-molecule level, from the inside out, and all the way up to cell-cell interactions
43 odels to take a comprehensive outside-in and inside-out approach at exploring how integrin alphaIIbbe
45 , Terada and colleagues demonstrate a novel 'inside-out' attachment sensing role for the adapter prot
48 hough abscission could be organized from the inside out by the microtubule-based midbody or from the
49 rtery wall is constructed radially, from the inside out, by two separate but coordinated processes.
50 macromolecular complex functioned to amplify inside-out Ca(2+) signaling in response to IL-8 stimulat
52 c cancer selectively affect the mechanism of inside-out cell surface regulation without inhibiting ba
58 ed spiroligozymes) were designed, using the "inside-out" design strategy, and mutated synthetically t
59 Thus, initial segments assemble from the inside out driven by the intrinsic accumulation of ankyr
60 nverts changes in external K(+) into rapid, 'inside-out' electrical signaling to direct blood flow to
63 ted vagus and patch clamp and single-channel inside-out experiments showed that the effect of theophy
65 ing this region, calmodulin regulates in an "inside-out" fashion the ectodomain shedding of the recep
66 esions and a chronically elevated outside-in/inside-out focal adhesion (FA) kinase (FAK)-Rho signalin
68 sized to occur due to modulation of cellular inside-out forces in response to changes in the external
70 dure that enabled us to image reconstructed, inside-out FtsZ rings by negative-stain EM, revealing th
72 re that we discovered here for reconstituted inside-out FtsZ rings provides what to our knowledge is
73 iphosphine ((CH2)14)3 P (1) can rapidly turn inside-out (homeomorphic isomerization) to give a mixtur
74 hesis that teeth evolved before jaws and the inside-out hypothesis of dental evolution must be reject
75 on in the vertebrate lineage, inspiring the 'inside-out' hypothesis that teeth evolved independently
76 orces using nanonet force microscopy in both inside-out (I-O intrinsic contractility) and outside-in
77 colony-stimulating factor (M-CSF)-stimulated inside-out integrin activation and cytoskeleton organiza
79 Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on mic
81 and spontaneously adhesive in the absence of inside-out integrin signaling but that LFA-1-mediated fi
82 roton fluxes indicated that IAR was inserted inside-out into our sealed LUV system, which we confirme
84 etach and go' model explains many aspects of inside-out lamination, defects in the Reeler mutant and
87 ates heterologously expressed rat NBCe1-A in inside-out macropatches excised from Xenopus laevis oocy
92 urons do not integrate into the cortex in an inside-out manner but preferentially (75%) occupy superf
94 uired to modulate the FHOD1 activity and the inside-out mechanical coupling that tunes the cell inter
96 of these mutations by radiotracer efflux and inside-out membrane patch clamping in COSm6 cells expres
98 mon CF mutation, F508del-CFTR, using excised inside-out membrane patches from transiently transfected
100 in blocking TRPC5 single channels in excised inside-out membrane patches, hinting to a direct block o
101 ensitization can be recapitulated in excised inside-out membrane patches, reversed by strong reducing
102 d acutely suppresses P/Q channel activity in inside-out membrane patches, that this action requires C
103 in physiological saline, and yet in excised inside-out membrane patches, the Na+ EC50 for KNa channe
108 e cross-linking studies on the McjD dimer in inside-out membrane vesicles of E. coli confirmed the pr
110 cium transport measurements in intact cells, inside-out membrane vesicles, and proteoliposomes contai
111 take of tritiated estradiol glucuronide into inside-out membrane vesicles, their affinity for and abi
113 evelopment of a sterol transfer assay using "inside-out" membrane vesicles from Sf9 cells expressing
114 to "outside-in" primary immune mediated and "inside-out" metabolic stress of oligodendrocyte (OL) rel
118 alaxies, star formation is quenched from the inside out, on time scales less than 1 billion years in
120 notype-dependent effect was observed for the inside-out or outside-in physical skin barrier function.
126 lower in the permeabilized cell than in the inside-out patch and that this is caused by interaction
127 ermined by RT-PCR, immunohistochemistry, and inside-out patch clamp in human trabecular meshwork (TM)
129 ombined with single-channel recording in the inside-out patch configuration showed that ATP efflux co
132 tigated this point using both whole-cell and inside-out patch recordings from human Na(v)1.7 channels
133 nels were detected in both cell-attached and inside-out patch recordings in C6 cells expressing Cx43,
136 ving this process by using two-electrode and inside-out patch voltage clamp in normal and truncated (
143 Zn(2+) to the intracellular face of excised, inside-out patches activates TRPA1 with an EC(50) value
144 ibodies markedly reduced channel activity in inside-out patches and also produced a pronounced reduct
145 K(ATP) channel activity was measured in inside-out patches and plasma membrane potential in perf
146 o TEA, iberiotoxin, was activated in excised inside-out patches by Ca 2+(i) and is the type I maxi-K+
149 d CNBD, application of cyclic nucleotides to inside-out patches did not affect currents recorded from
150 a water soluble form of PIP(2), to quiescent inside-out patches evoked single channel currents with a
154 n of anti-TRPC6 and anti-TRPC1 antibodies to inside-out patches inhibited Icat1 and Icat2, respective
155 ified Gbetagamma proteins applied to excised inside-out patches inhibited TRPM3 currents, indicating
156 n of anti-TRPC3 and anti-TRPC7 antibodies to inside-out patches markedly inhibited ET-1-evoked I(cat)
157 potassium (BK(Ca)) channels were studied in inside-out patches of human NTERA2 neuronal cells (NT2-N
158 ent chemicals; no activation was observed in inside-out patches unless a polyphosphate was present.
159 matched the maximum activation achieved with inside-out patches with zero cytosolic Ca(2+), whereas t
160 uced the gamma of 5-HT(3A)(QCA) receptors in inside-out patches, an effect reversed by the reducing a
165 K(ATP) channel density, recorded in excised inside-out patches, was larger at the cell end when comp
181 els inactivate upon prolonged stimulation in inside-out patches; this "rundown" is due to PIP(2) depl
182 Inhibition of kindlin-dependent steps in the inside-out pathway as an approach to block platelet aggr
184 nction, the identity of the T cell receptor "inside-out" pathway for lymphocyte function-associated a
187 pregnated neurons conformed to the expected "inside-out" pattern of development, meaning that cells p
189 olves a novel process whereby large, intact, inside-out phosphatidylserine (PS)-exposed autophagic ve
191 indicated that the receptors involved in the inside-out proadhesive pathway (CD14, TLR2, and CD11b/CD
193 circulating mature reticulocytes expressing inside-out PS-exposed autophagic vesicles because of asp
195 pletion of DISABLED-1, which compromises the inside-out radial neuronal migration pattern in the deve
196 nnexin B12 showed that the protein underwent inside-out refolding that brought previously buried hydr
197 ellular catalytic domain can be activated by inside-out regulation is not completely understood.
198 d a fluorescent probe that shed light on the inside-out regulation of one of the major leukocyte inte
200 Reelin is essential for the stereotypical inside-out sequential lamination of the neocortex, but t
201 eric membrane proteins that uniquely mediate inside-out signal transduction, whereby adhesion to the
202 tant gap in understanding substrate-specific inside-out signal transfer along cleaved transmembrane p
204 These cells exhibit increased beta2 integrin inside-out signaling (binding affinity and avidity), and
205 dlins are cytoplasmic molecules that mediate inside-out signaling and activation of the integrins.
208 dulates ethanol inhibition of L1 adhesion by inside-out signaling and that differential regulation of
209 required for ligand binding during integrin inside-out signaling and that the deadbolt does not regu
211 gain of function is not because of enhanced inside-out signaling because granular secretion, Thrombo
212 s, licensing controls signals as proximal as inside-out signaling by activating receptors but not int
213 zation step is mediated by the activation of inside-out signaling by integrins and by the secretion o
215 a1, beta2 and beta3 integrins, but defective inside-out signaling causes immune deficiency and bleedi
216 ssue macrophages and the requirement of TLR2 inside-out signaling for CR3 exploitation by P. gingival
217 ngs provide evidence for a novel paradigm of inside-out signaling in platelets, whereby beta3 integri
221 lets, is known to regulate receptor-mediated inside-out signaling leading to integrin activation and
222 regulates integrin activation, TCR-initiated inside-out signaling may induce a conformational change
223 E-cadherin present at the cell surface by an inside-out signaling mechanism is important in cancer.
224 at upon binding Syk opens the receptor by an inside-out signaling mechanism that amplifies BCR signal
225 rolling activation of these receptors via an inside-out signaling mechanism, but the precise structur
227 We present evidence that LapD utilizes an inside-out signaling mechanism: binding c-di-GMP in the
228 , with activators, inhibitors, and elaborate inside-out signaling mechanisms controlling its conforma
229 mechanism impairs the activation of a major inside-out signaling pathway that triggers the conformat
230 pon denervation, demonstrating an unexpected inside-out signaling pathway; the receptor up-regulation
232 ese studies establish ADAP as a component of inside-out signaling pathways that couple GP Ib-IX-V and
236 at-H-depleted cells coincided with defective inside-out signaling shown by diminished chemokine-induc
238 duce a cascade of signaling events termed as inside-out signaling that culminate in exposure of high-
239 apid activation of Pyk2 and JNK, followed by inside-out signaling that leads to cell detachment-induc
240 through Itgbeta1 to drive cell invasion, and inside-out signaling that maintains tumor cell-matrix co
241 TLR2 proadhesive pathway is characterized by inside-out signaling that transactivates beta(2) integri
242 V-containing ligand to study the role of the inside-out signaling through formyl peptide receptor and
246 l cytotoxicity and that steps as distinct as inside-out signaling to LFA-1 and signals for granule re
247 -1 properties but was instead due to reduced inside-out signaling to LFA-1 by activating receptors.
250 phils in Mg2+ plus the chemokine IL-8 (i.e., inside-out signaling) induces several-hundred-fold longe
266 ITAM to recruit activated Syk family kinases Inside-out signaling: signals initiated by engagement of
268 of responsiveness of LFA-1 to SDF-1-induced "inside-out" signaling involving CXCR4 and Lyn, leading t
269 ble IFNAR1 degradation, the existence of an "inside-out" signaling that accelerates IFNAR1 turnover i
271 ly to their ligands but become active after 'inside-out' signaling through other membrane receptors.
277 d platelet aggregation, providing proof that inside-out signals that activate alpha(IIb)beta(3) requi
280 tion of beta1 integrins can be regulated by "inside-out" signals leading to extravasation from the ci
281 n platelets alphaIIbbeta3 integrins require "inside-out" signals to bind fibrinogen and form thrombi.
282 dence that epidermal Par3 loss disturbed the inside-out skin barrier, coinciding with altered express
283 se results delineate a novel force-activated inside-out Src/PI3K/FAK/Akt pathway by which cancer cell
290 w the key signaling events that occur in the inside-out versus outside-in pathways, highlighting rece
292 screening (VLS) were tested in vitro, using inside-out vesicles (IOV), for inhibition of cGMP efflux
293 es from our laboratory using plasma membrane inside-out vesicles (ISOV) prepared from yeast expressin
294 amined the rate of ankyrin displacement from inside-out vesicles by the hexahistidine-tagged cytoplas
295 ntly, purified dematin binds to the stripped inside-out vesicles in a saturable manner, and dematin-m
296 gy with the sequence seen during spontaneous inside-out vesiculation of erythrocyte membranes suggest
297 of the patch-clamp technique (cell-attached, inside-out, whole-cell, outside-out and perforated patch
298 sh that the channels are inserted uniformly "inside-out" with their cytoplasmic surface facing the me
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