ライフサイエンスコーパス: insight

1 satellite observations can provide essential insight.

2 ned by, risk factors may provide etiological insight.

3 unscathed by the onslaught of new scientific insights.

4 ay be informed by new anatomic and perfusion insights.

5 aired in Trpc3-deficient M1 cells, gathering insight about other molecular signatures within macropha

6 of this review is to provide a comprehensive insight about physiology of autoregulation, measurement

7 xchange mass spectrometry revealed molecular insights about molecular factors controlling the antipar

8 set AD and genetic risk factors that provide insights about molecular pathophysiology and potential d

9 zation to literature compounds gave valuable insights about the aromaticity of these symmetrically fu

10 the intermediates, theoretical studies, and insights about the challenges and future directions for

11 The provided insights and framework for structure-activity relationsh

12 etween diversity and function, providing key insight as to how and when losses in biodiversity will i

13 These studies have yielded not only new insights but also a plethora of experimental approaches,

14 To provide a "bottom-up" fundamental insight, C-H bond cleavage in methane over Ni-based cata

15 This insight can be invoked to design polymer electrodes with

16 elivery need to be accounted for before such insights can be translated into policy.

17 Using structural insight combined with bioinformatics and functional anal

18 The current findings provide novel insights concerning the regulation of effector function

19 Structural and biochemical insights confirmed the potential of pathway components t

20 The insights disclosed by our simple model contribute a more

21 ese result files provide greater control and insight during experimental design and troubleshooting.

22 e isotope tracers, which limit physiological insight, e.g. the need for intravenous infusions and res

23 disease as well as highlights the biological insights each model has provided into MLL-FP leukemogene

24 ancer cells, this work provides an important insight for developing a molecular dynamic continuum for

25 transcription factors and provide structural insight for therapeutic interventions targeting AP-1 pro

26 tive and arthritogenic T cells, provides new insight for understanding the regulation of autoimmune d

27 The study offers design insights for developing low-cost surface microfluidic mi

28 new hypotheses on compound MoA and potential insights for drug repurposing.

29 itors with a compact scaffold and structural insights for further inhibitor improvement.

30 To address this conundrum and provide insights for future public health efforts, we analyze th

31 These findings provide important insights for infection control practice and signpost are

32 r of drug-loaded nanoparticles, and provides insights for the design of the next-generation of nanosc

33 In this issue of Cell, insights from a longitudinal multi-omics analysis of the

34 es of splicing factor mutations, mechanistic insights from animal models, and implications for develo

35 Insights from experimental studies support causal effect

36 In this Review, we discuss new insights from patient-oriented research completed during

37 ajor depressive disorder (MDD), highlighting insights from positron emission tomography studies.

38 lights the contrast between the abundance of insight gained into the events that constitute the metas

39 More generally, the insights gained from this structure-reactivity relations

40 Although some insights have been gained into the pathogenesis of these

41 Computational insights have given reasons for their stability and unus

42 These methods highlight detailed insights in the structure and dynamics of urban segregat

43 -natal lung development and revealed several insights, including in sphingolipid-mediated apoptosis,

44 0, and subsequently has been used to provide insight into a range of biological and synthetic systems

45 and its consequences would provide essential insight into allograft rejection and lead to better ther

46 e study of this simple enzyme mimic provides insight into analogous behavior in biophysics and enzymo

47 DFT calculations provide insight into binding modes in line with experimental dat

48 Our findings provide mechanistic insight into Ca(2+)/calpain regulation of growth cone mo

49 ne for biological discovery and increase our insight into cancer and its treatment.

50 associated with disease may lead to improved insight into CCC pathogenesis and the identification of

51 cular SNARE complexes, providing mechanistic insight into compound fusion at ribbon-style synapses.

52 Our findings provide insight into cytokine recognition by the IL-10R family a

53 s in Down syndrome model mice, which provide insight into defects in the function of neural circuits

54 This may provide insight into disease pathogenesis, diagnosis, and therap

55 critical stages of development and provides insight into factors (window of exposure, exposure conce

56 e mechanism behind this mutation can provide insight into functional differences that exist in cultur

57 Mechanistic insight into how polycations disrupt and cross cell memb

58 why CMV infection usually fails may provide insight into how to prevent it from succeeding.

59 These results provide a first insight into how we might measure the genotoxic and cyto

60 nals alike, but may also provide speculative insight into models of care that attenuate the weekend e

61 This structure provides essential insight into multiple mechanisms by which pathogenic mut

62 and complex ligands augmented by structural insight into murine langerin.

63 c view provides a unique resource and deeper insight into normal pulmonary development.

64 e following RVFV infection, which could give insight into novel host responses that have not yet been

65 This mechanism adds significant insight into our knowledge of mRNA-specific translationa

66 ociated with systemic sclerosis that provide insight into pathogenesis and potential targets for ther

67 aling during morphogenesis, and provides new insight into PCP-related disorders in humans.

68 ns of interatomic forces, giving researchers insight into protein function at unparalleled spatial an

69 Our data provide mechanistic insight into RNR biology, highlighting RRM2B as a hypoxi

70 To gain insight into spanin function, pseudorevertant alleles th

71 devoid of preexisting CVD and provide unique insight into specific uremia- and PD-induced pathomechan

72 ge on novel sRNAs but would also give us new insight into sRNA degradation.

73 and function together as well as unexpected insight into telomerase interaction at telomeres.

74 siological models, our results provide novel insight into the atypical interactions between copper an

75 of this inactivated assembly provides first insight into the binding interactions between an antivit

76 nce imaging techniques have provided limited insight into the causes of persistent postoperative seiz

77 To gain insight into the cellular and molecular interactions med

78 These results provide insight into the clinical and genomic dynamics of tumor

79 ral protein function and provides additional insight into the complex interplay between papillomaviru

80 investigations in the solution phase provide insight into the correlation of energy-transport process

81 To gain mechanistic insight into the CYP121-catalyzed reaction, we tested th

82 These findings provide insight into the cytotoxic effects of PARP inhibition, a

83 Genomic studies have provided new insight into the demographic and adaptive history of our

84 to structural features and therefore offers insight into the design of hydrolytically stable porous

85 the exoskeleton formation provides a unique insight into the different processes involved during met

86 cle provides the first detailed experimental insight into the distribution of extreme states within a

87 n rate of individual amino groups could give insight into the dynamic processes occurring at specific

88 tion of receptor desensitization and provide insight into the dysregulation of CXCR4 observed in pati

89 Our results provide insight into the effects of regulatory variants and thei

90 Recent work has provided deeper insight into the elaborate mechanisms that control the r

91 de novo in the manual modality, this offers insight into the emergence of language in ways that the

92 yzed by a single enzyme, and it offers novel insight into the engineered biosynthesis of prenylated n

93 ctive registries will likely provide further insight into the etiology and management of ILD worldwid

94 ms are evolutionarily conserved offering new insight into the etiology of human disorders linked to l

95 of the ancestral reaction center, providing insight into the evolution of photosynthesis.

96 the Ift56(hop) mouse mutant and reveal novel insight into the function of IFT56, a poorly understood

97 ements to provide high-resolution structural insight into the functional amyloid transporter from Pse

98 Our investigation provides insight into the functional impact and association with

99 ent approaches have limitations in providing insight into the functional properties of particular nuc

100 igh-quality genome and transcriptome provide insight into the green algal lineage and carotenoid prod

101 These data provide the first mechanistic insight into the heightened caries susceptibility associ

102 ics simulations to provide atomic-resolution insight into the influence of cholesterol on oxygen diff

103 laxation pathways, and give an unprecedented insight into the interpretation of the spectral signatur

104 Sedimentation-velocity experiments provided insight into the isomerization process, showing that CfP

105 Here, we provide first insight into the key step of MSP-mediated phosphotransfe

106 is of the dodo and provides an unprecedented insight into the life history of this iconic bird.

107 Our structural analysis also provides novel insight into the location of other molecular components

108 er expansion of this study will provide more insight into the long-term safety and efficacy of bariat

109 In order to gain insight into the mango cuticle biogenesis and identify p

110 al role in neuronal excitability and provide insight into the mechanism and future treatment of epile

111 Of note, this is the first report providing insight into the mechanism of host lipid catabolism by a

112 Insight into the mechanisms of protection of these varia

113 and lipid metabolic pathways, providing new insight into the mechanisms underlying the beneficial me

114 For insight into the mechanistic details of hm(5)C function

115 Here we provide detailed insight into the mechanistic role of TTC19, by investiga

116 To gain insight into the molecular basis for how these mutations

117 This research provides new insight into the molecular mechanism utilized by C. jeju

118 Our study provides insight into the molecular mechanisms of cocaine's contr

119 Collectively, our study offers insight into the molecular organization of cytosolic tra

120 ross different domains of effort and provide insight into the multidimensional nature of motivation.

121 tion of C1QTNF5 remains unclear but this new insight into the pathogenetic basis of L-ORD has implica

122 o identify unique genes that may provide new insight into the pathophysiology of schizophrenia.

123 Our study provides novel insight into the photocycle of PR and also demonstrates

124 To gain insight into the physiological mechanisms involved, we e

125 in slowing disease progression and provides insight into the protective role of C1q in early atheros

126 Collectively, we provide molecular insight into the recognition mechanisms facilitating ant

127 Our results provide new insight into the regulation of humoral immunity.

128 epistasis in humans and provides mechanistic insight into the regulation of IL7R exon 6 splicing and

129 Together, these data provide mechanistic insight into the regulation of VM and suggest that miRNA

130 There is a lack of insight into the relationships between violent ideation,

131 Together, our results provide novel insight into the role of Nt17 post-translational modific

132 ted within motor-filament arrays and provide insight into the self-organization and mechanics of cyto

133 mass spectrometry (HDX-MS) provides detailed insight into the structural dynamics of each subunit in

134 e performance profiles mirror and provide an insight into the trajectory of the physiology of the hum

135 Together, our findings provide insight into the unique molecular architecture and expor

136 assorted ANT-associated diseases, including insight into their disparate phenotypic manifestations.

137 To gain insight into this phenomenon, we analyzed a cohort of 25

138 teins that bind 3',5'-cAMP might provide new insight into this question.

139 ale atomistic scheme providing a microscopic insight into this technologically promising material.

140 oit macrophage function will provide greater insight into viral pathogenicity and antiviral responses

141 provides important mechanistic neuromuscular insight into walking balance control and important refer

142 Our insights into a critical mechanism in satellite cell hom

143 This study provides fundamental insights into a general principle that confers the subst

144 lavin-dependent halogenases and provides new insights into a potentially unique reaction mechanism.

145 ness, and sleep from smartphones and to gain insights into activity patterns associated with life sat

146 In conclusion, this study gives insights into apoE biology and establishes a robust scre

147 ntial of both brain and blood-based DNAm for insights into ASD and psychiatric phenotypes more broadl

148 In this review, we consider recent insights into axon-glial interactions during development

149 get and SCZ-related deficits and provide key insights into beneficial LoF mutations and potential new

150 ctivity and structural underpinnings provide insights into biological mechanisms of polysaccharide de

151 mplementary assays to gain higher-confidence insights into cellular states.

152 Our study aims to uncover novel insights into channel gating through in-depth structure-

153 The present study provides mechanistic insights into cooperation between p17 and sigmaA protein

154 natural glycosylation may provide important insights into diabetes research and therapeutic treatmen

155 found on less contaminated soils can provide insights into ecological processes that demonstrate the

156 the field of functional genomics to provide insights into environmental and genetic influences on ph

157 ng set of compounds will continue to provide insights into fundamental questions about how aromatic c

158 f an additional binding site and provide new insights into GB1:IgG complex structure that amend and r

159 Our results provide new insights into genetic histories of Siberian and Northeas

160 of viral assemblies have revealed important insights into genome packaging, virion assembly, cell en

161 ion of its authenticity and attribution, for insights into historical or artist-specific techniques,

162 Collectively, this study offers insights into host-virus interaction in tomato and provi

163 me in honeybee health, but they also provide insights into how antibiotic treatment affects microbial

164 These findings provide new insights into how chromatin regulation modulates stochas

165 Thus, our data provide insights into how HMGA2 interacts with stalled RFs and t

166 Taken together, our results reveal new insights into how macrophages enhance cancer cell metast

167 These findings provide insights into how skeletal stem and progenitor cells int

168 This dataset yields insights into how vesicular transport is adapted to the

169 nown co-associations and provides functional insights into hundreds of poorly characterized proteins

170 cell pathways, and the results are providing insights into IBD pathogenesis and additional strategies

171 -dependent AAV2 replication may also provide insights into its functions in HBoV1 replication.

172 Both structures provide molecular insights into malonate decarboxylase catalysis.

173 ovel candidate gene for depression and offer insights into mechanisms through which RCL1 may be relev

174 Furthermore, our data provide new insights into microtubule regulation during axonal morph

175 These findings provide new insights into molecular convergence and building blocks

176 ial for "big data" techniques to provide new insights into movement behaviour when applied to large d

177 Besides providing insights into nonlinear resonator physics, they can be a

178 microviscosity provides critical biophysical insights into nuclear crowding, nucleic acid based pharm

179 Insights into nucleoprotein-nucleoprotein interactions h

180 orders and dyskinesias could provide crucial insights into other behavioural symptoms in Parkinson's

181 nse also has the potential to provide deeper insights into other host-pathogen interactions.

182 antitumor immune regulation and provide new insights into our understanding of the alterations of th

183 The mDOS system enables highly detailed insights into oxygen dynamics in various aquatic and ter

184 ive value and choice behaviour and may offer insights into psychopathologies characterized by dysfunc

185 Taken together, these results provide new insights into regulatory mechanisms of seed vigor and re

186 Our study provides crucial insights into RIBEs, and will facilitate the identificat

187 This study offers insights into spinach evolution and domestication and pr

188 vulatory stimuli, thus providing mechanistic insights into steroid signaling in Drosophila ovulation.

189 Our results provide insights into structural changes in the myosin motor dom

190 these virulence-associated PKs provides new insights into T. brucei-host interaction and reveals nov

191 er, these data provide important mechanistic insights into the activation of IL-36gamma and highlight

192 ells can be isolated and analyzed to provide insights into the biology of cancer spread and response

193 Overall the present study provides new insights into the chromatin landscape and Blimp1-depende

194 together, our study provides new mechanistic insights into the complex regulation of BACE1 traffickin

195 These data provide insights into the complex relationships between aneuploi

196 sequencing of tumor genomes in providing new insights into the contribution of mutagenic exposures to

197 control, optobiology promises to provide new insights into the coordination of signaling circuits in

198 mprehensive variation map to provide genomic insights into the divergence and dual domestication of t

199 nkages at different positions, providing new insights into the effects of these modifications and a d

200 This study provides mechanistic insights into the emergence of plant chemical novelty, a

201 Two new studies provide key insights into the evolution of hearing specializations a

202 These analyses provide insights into the generalizable, underlying features of

203 Here, we aimed to gain insights into the genetic architecture of biomarker trai

204 This study provides insights into the genetic correlation among complex trai

205 ly single cell analyses) are providing novel insights into the genetic, environmental, and cellular c

206 eterogeneity in glioblastoma and provide new insights into the genomic landscape of tumor cells that

207 ential connectivity analysis can provide new insights into the heterogeneity of drug treatment effect

208 In parallel, new structural insights into the HIV trimer, the target of these quater

209 However, mechanistic insights into the HSR in higher eukaryotes, in particula

210 Collectively, these findings provide new insights into the inhibitory effect of SFN on HCC tumor

211 arations have begun to provide important new insights into the interplay among: (i) ion fluxes, (ii)

212 national breast cancer prevention trial, and insights into the intricate germline-somatic-immunity in

213 both toluene and DMSO were assessed offering insights into the kinetics and thermodynamics of the swi

214 understanding of miRNA biology and critical insights into the many translational applications for th

215 We gained insights into the mechanism of acyl hydrolysis by observ

216 Thus, our studies provide new insights into the mechanism of ligand recognition by thi

217 ts because it can timely provide very useful insights into the mechanism of meiotic recombination and

218 These results provide important insights into the mechanism underlying eukaryotic transc

219 lectivity of lynx1 interactions provides new insights into the mechanisms and allosteric sites [alpha

220 ith early postnatal onset, we would gain new insights into the mechanisms by which maternal UBE3A los

221 rcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-de

222 The study provides critical insights into the mechanisms of strain relaxation of sus

223 To gain insights into the molecular mechanisms of Lrp4 function

224 This is the first report providing molecular insights into the molecular mechanisms regulating the se

225 rosophila eggshell patterning provide unique insights into the multiscale mechanisms that connect gen

226 Our results provide insights into the nature of neoantigen-specific T cells

227 Recently, insights into the network dynamics of cortical activity

228 e expression in cancer cells may offer novel insights into the onset and progression of cancer and ma

229 rimary objective of this study was to obtain insights into the outcomes of people living with HIV who

230 This study provides insights into the paleohistory of Cucurbitaceae genome e

231 ken together, our results provide additional insights into the pathogenesis of SFTSV infection and su

232 y causal of sero-negative RA and provide new insights into the pathogenesis of the disorder.

233 synapse formation, our findings provide new insights into the pathogenesis of Ube3A/E6AP-dependent A

234 hold, and their study can additionally yield insights into the pathophysiology of type 2 diabetes.

235 clinical samples, which may offer molecular insights into the physiopathology of tissues to assist i

236 onstellation of genetic markers has provided insights into the poorly understood phenomenon of AIV ai

237 e methods, are improving our ability to gain insights into the population history of species.

238 Our results provide insights into the potential role of mineral surfaces in

239 Recent findings provide insights into the problem of how epigenetic states are i

240 These studies provide new insights into the regulatory effect exerted by JMJD2B on

241 rgets for EOC and further provided important insights into the relationship between gene transcript l

242 These findings provide novel insights into the role of bacteriophages as potentially

243 achis, and provides molecular and functional insights into the role of expansin-like B, the less-stud

244 t in synaptic transmission and provide novel insights into the role of Unc-104 in synapse maturation.

245 lding, these results provide new fundamental insights into the rules governing mammalian genome organ

246 Our findings provide insights into the selective forces and ecological factor

247 ltiple traits' genetic profiles has provided insights into the shared genetic basis of many complex t

248 k like "good scientists." Our findings offer insights into the social psychology of science, and indi

249 Together, this imaging study provides insights into the spatial aspects of key events in oilse

250 These studies offer important insights into the structural bases for allosteric site-t

251 sis of intact biological systems can provide insights into the transcriptional basis of cellular iden

252 near dynamics of atrial cells and will yield insights into the trigger and maintenance of atrial fibr

253 is of cardiac structure and function provide insights into the underlying genetic architecture of car

254 The goal of this study was to gain new insights into the underlying genetics of body fat distri

255 ting NK cell receptor KIR2DS1, providing new insights into the underlying mechanisms involved in KIR2

256 ticles (NPs) with electrodes can provide new insights into their electrocatalytic behavior, mass tran

257 A capping molecules, and provide mechanistic insights into their incorporation.

258 astrocyte types in the adult CNS, providing insights into their origin and functional diversity.SIGN

259 multiomics approaches, we may gain valuable insights into their potential function.

260 tal pathway of these antibodies has provided insights into their precursors, and the viral strains th

261 ling of overexpressors and mutants, provided insights into their regulatory role in defined modules o

262 Here we report mechanistic insights into this association in multiple immunocompete

263 To obtain further mechanistic insights into this phenomenon, here we confirmed that th

264 iology using continuous approaches may yield insights into tumor heterogeneity; single cell analysis

265 demonstrated that DeBooster may provide new insights into understanding the regulatory functions of

266 tients with anorectal malformation and offer insights into various management philosophies.

267 New insight is presented on the individual reaction pathways

268 A key insight is that high-performing circuits can be engineer

269 Our structure provides novel mechanistic insights of how sulfonylureas and ATP interact with the

270 inding data and crystal structure, we gained insight on how the probe senses ligand-induced conformat

271 Our findings provide new insight on the microscopic mechanisms of atomic desorpti

272 th with unobtrusive laser probes should give insight on the particle formation mechanisms and may lea

273 ystallographic structures provide invaluable insight on the structural mechanism of the ion pumping p

274 We describe our approaches and insights on documenting and standardizing parameters acr

275 modular enzymes, like the PMT, provides new insights on interdomain communication in biosynthetic sy

276 ematological chromatin sample space gives us insights on the healthy cell types that are more epigene

277 These studies have raised several novel insights on transcriptional regulation such as the "hit-

278 These insights open new vistas on the neural basis of social b

279 These insights provide a foundation for understanding recognit

280 These microscopic insights provide a solid standing point, on which perovs

281 Such insight provides a framework to the discovery of much ne

282 Insight regarding how diverse enzymatic functions and re

283 of importance as it could provide important insights regarding P. aeruginosa's virulence mechanisms.

284 Although this advancing insight should improve clinical care, at present there i

285 These insights suggest possible new approaches to prevent CDI,

286 This structural insight suggests that subunit selectivity of glutamate-s

287 The resolution of this paradox required the insight that an intimate relationship exists between inf

288 Our study provides molecular insight that links metabolic adaptation to transgenerati

289 a is utilized by assemblers, provides useful insights that can inform the assembly process and result

290 evolutionary perspective yields a number of insights that may reveal important clues regarding the o

291 hereby enabling users to build intuition and insights that will inform their experimental strategy.

292 or impede HIV-1 infection may provide unique insight to exploit for novel therapeutic interventions.

293 , which hopefully will provide translational insights to stop the growing incidence of nephrolithiasi

294 Collectively, our data provides new insights to understand the evolutionary relationships be

295 fication of super-enhancers in DIPG provides insights toward the cell of origin, highlighting oligode

296 The structural insights underscore the adaptability of fusicoccin, pred

297 We tested our insights using data from language, gastronomy and techno

298 For an accurate insight, we performed in vitro studies on the response o

299 among mammalian tissues, and we expect this insight will decisively change our understanding of esse

300 In this Perspectives article, these new insights will be placed in the context of previously unr