ライフサイエンスコーパス: instability

1 nancies as part of a signature of chromosome instability.

2 UNX3 loss exhibited higher levels of genomic instability.

3 n and transcription, and may lead to genomic instability.

4 n, repair and recombination to avoid genomic instability.

5 lead to insertional mutagenesis and genomic instability.

6 evious expectations for the Kelvin-Helmholtz instability.

7 collapsed in culture, indicating structural instability.

8 ing agents, defective DNA repair and genomic instability.

9 uracil misincorporation into DNA and genome instability.

10 tumor evolution, rather than ongoing genomic instability.

11 show a high level of aneuploidy and genomic instability.

12 diabetic retinopathy, resulting in vascular instability.

13 ng the classification of tumors with genetic instability.

14 ctures involved in transcription and genetic instability.

15 ve stress, chromatin remodeling, and genomic instability.

16 ts were compromised, without interphalangeal instability.

17 others did not significantly affect tau mRNA instability.

18 c alterations contributing to microsatellite instability.

19 ermutation, which are all sources of genomic instability.

20 by Smarcal1 and Mre11 predisposes to genome instability.

21 hat aneuploidy itself is a nidus for genomic instability.

22 ncy results in impaired HR repair and genome instability.

23 gnaling through the induction of chromosomal instability.

24 A), has emerged as a major source of genomic instability.

25 hamper optimal HR and trigger global genomic instability.

26 underlie age- and disease-associated genome instability.

27 some structures and protects the genome from instability.

28 single-stage MS, after correction for spray instability.

29 ect in Hxt6 endocytosis associated with Art4 instability.

30 tion might identify a risk factor for asthma instability.

31 obstruction phenotypes that relate to asthma instability.

32 levels in nuclear DNA, and increased genome instability.

33 directly responsible for Myc-induced genetic instability.

34 promised DSB repair resulting in chromosomal instability.

35 ARN deficiency leads to human telomerase RNA instability.

36 identified as endogenous sources of genomic instability.

37 ional generalism is rare due to evolutionary instability.

38 ay that protects the genome from chromosomal instability.

39 thereby amplifying the potential for genome instability.

40 an malignancies, and is linked to chromosome instability.

41 ) is frequently characterized by chromosomal instability.

42 tions, chromosome translocations, and genome instability.

43 e indicators of risk for asthma severity and instability.

44 f chromosome segregation and promote genetic instability.

45 gan dysfunction, and profiles of hemodynamic instability.

46 opagate structural and numerical chromosomal instabilities.

47 l telomeric sequences (ITSs) promotes genome instabilities.

48 ested that the ripples were Kelvin-Helmholtz Instabilities.

49 ancer, since short telomeres lead to genomic instability - a hallmark of cancer.

50 , however, suffer from limitations including instability, a burst release of the drug, and limited su

51 ation (CNA) is a major contributor to genome instability, a hallmark of cancer.

52 duction, oxidative stress, mitochondrial DNA instability, abnormalities in the regulation of mitochon

53 /BLM in suppressing R-loop-associated genome instability across species.

54 Microtubule dynamic instability allows search and capture of kinetochores du

55 The lymphoma cells demonstrated chromosome instability along with upregulation of several signaling

56 that is associated with the system-spanning instabilities (also known as shear bands), which are typ

57 membrane core leading to further structural instabilities and increased water intake.

58 elp in understanding the origin of interface instabilities and the resulting non-uniform phase distri

59 from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopathy.

60 that lead to intracellular Ca(2+) signalling instability and Ca(2+) -based arrhythmogenicity.

61 g and replicative senescence prevent genomic instability and cancer by limiting the number of cell di

62 s in this DNA repair pathway lead to genomic instability and cancer predisposition.

63 ifies genes implicated in aneuploidy, genome instability and cancer susceptibility.

64 inhibition, ACLY silencing promotes genomic instability and cell death.

65 but not its isoform MCL-1S increases genomic instability and cell sensitivity to ionizing radiation (

66 ight be impeded, adding to increased genomic instability and contributing to disease.

67 etermine how RecQ4 mutations lead to genomic instability and disease.

68 hat aneuploidy can directly cause epigenetic instability and disrupt cellular differentiation.

69 neuploid cells display increased chromosomal instability and DNA damage, a mutator phenotype associat

70 We evaluated genetic instability and DNA repair defects by direct and indirec

71 of ILF2 in MM promotes tolerance of genomic instability and drives resistance to DNA-damaging agents

72 anging larval body composition, exacerbating instability and eliciting more frequent swimming.

73 However, high instability and extremely low oral bioavailability limit

74 cause the human Immunodeficiency, Centromere instability and Facial anomalies (ICF) syndrome, which i

75 e rare disorder Immunodeficiency, Centromere instability and Facial anomalies syndrome cases (ICF1).

76 facilitates replication, and prevents repeat instability and fragility.

77 al levodopa treatment response, and postural instability and gait difficulty motor PD subtype in line

78 nowledge on transcription-associated genomic instability and highlight recent discoveries in the fiel

79 genetic disease characterized by chromosomal instability and impaired DNA damage repair.

80 s are currently limited by their proteolytic instability and impermeability to the cell membrane.

81 it wine may provide a solution for its color instability and improvement of sensory attributes.

82 n in part be due to the induction of genomic instability and increased passenger load.

83 dynamic and kinetic requirements for dynamic instability and its elimination by MTAs have yet to be d

84 diac surgery, where pre-existing hemodynamic instability and metabolic abnormalities are combined wit

85 l, we have studied the importance of dynamic instability and microtubule rotational diffusion for kin

86 icant correlations of BRCA score with genome instability and neoadjuvant chemotherapy.

87 rgency program drives evasion of chromosomal instability and phagocytosis checkpoints by apoptotic ca

88 y, we report a novel linkage between genomic instability and phagocytosis evasion that is coordinated

89 ic outcomes, including anemia due to protein instability and red cell lysis.

90 structure, has been linked to induced genome instability and regulated gene expression.

91 r basket proteins show AID-dependent genomic instability and replication defects that were suppressed

92 leads to severe consequences, such as genome instability and replication stress.

93 ion forks can result in cell death or genome instability and resulting transformation to malignancy.

94 Loss of DEK induces genome instability and sensitizes cells to DNA double strand br

95 he critically short telomeres lead to genome instability and telomerase is further up-regulated to su

96 used by a 400 K non-linear-transport-driven instability and the latter is caused by the 1000 K Mott

97 otential role of metabolic stress in genomic instability and therapeutic response in cancer.

98 ical technology to assess and monitor plaque instability and thereby test potential plaque-stabilizin

99 (PVSCs), critical concerns pertaining to the instability and toxicity still remain that may potential

100 romises DNA replication, accumulates genomic instability and ultimately leads to cell death.

101 diative recombination, alleviates hysteresis instabilities, and improves V oc to 0.84 V.

102 AF- and KRAS-mutation status, microsatellite instability, and CpG island methylator phenotype were al

103 One such feature is persistent mood instability, and efforts are underway to understand its

104 ated with chromosomal abnormalities, genomic instability, and HSC aging and might promote hematologic

105 t in immunodeficiency, autoimmunity, genomic instability, and lymphoid and other cancers.

106 esulting in polyploid cell division, genomic instability, and oncogenesis.

107 llular transformation, exhibited chromosomal instability, and promoted increase in nuclear size.

108 ase: NOMS (neurologic, oncologic, mechanical instability, and systemic disease).

109 ship among centrosome amplification, genomic instability, and tumor development.

110 i microtubules treadmill and display dynamic instability, another hallmark of eukaryotic microtubules

111 replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic

112 these more accurate measures of past climate instability are likely to bring about a better understan

113 eration and keratinocytes displaying genomic instability are maintained within the proliferative comp

114 due to mega-wetlands extinction, and climate instability are suggested as the driving forces for ESD

115 t supports the potential value of chromosome instability as a prognostic predictor.

116 iopsies and does not reveal the same genetic instability as conventional genome assays opens new pers

117 ce of H-DNA implicates this structure in the instability associated with the human c-MYC oncogene.

118 ic instability checkpoint, expressed genomic instability-associated genes at distinct phases of cellu

119 ese results demonstrate a period of juvenile instability at CA1 synapses, followed by a period of adu

120 possible mechanism by which Sub1 suppresses instability at G4 DNA.

121 oponin C (cTnC) C-domain, causes generalised instability at multiple sites in the isolated protein.

122 efects are not only an impetus of chromosome instability but are also a cause of developmental disord

123 damage is an important contributor to genome instability, but how the formation and repair of these l

124 ing that MNase sensitivity does not indicate instability, but rather the preference of MNase for A/T-

125 tic mutations in SIRT2 contribute to genomic instability by impairing its deacetylase activity or dim

126 rce from actin polymerization can bypass the instability by inducing a smooth transition from an open

127 pression patterns associated with chromosome instability, called CIN25 and CIN70, were detected in HC

128 How a system that is prone to such instabilities can rveliably drive morphogenesis remains

129 This instability can be smoothed out by increasing the bendin

130 hat subtle enhancements of endogenous genome instability can exceed the tolerance of cancer cells and

131 Our findings highlight that sociopolitical instability can lead to biodiversity loss and undermine

132 Severe CRS was characterized by hemodynamic instability, capillary leak, and consumptive coagulopath

133 thymi and small intestines, the chromosomal instability caused by Atf3 deficiency was largely depend

134 (DDR) are often tumor prone owing to genome instability caused by oncogenic challenges.

135 Trinucleotide repeats are a source of genome instability, causing replication fork stalling, chromoso

136 lebbishield emergency program evaded genomic instability checkpoint, expressed genomic instability-as

137 Chromosomal instability (CIN) contributes to cancer evolution, intra

138 Chromosome instability (CIN) is deleterious to normal cells because

139 o support that [PSI (+)] induces chromosomal instability (CIN).

140 gene signatures associated with chromosomal instability (CIN); we investigated associations with ove

141 ient cells, and its depletion worsens genome instability, compromising cell survival.

142 al water stress increases the risk of social instability, conflict and sudden, uncontrolled populatio

143 Cancer genomic instability contributes to the phenomenon of intratumora

144 face and edge energies, the resulting growth instability criterion can be directly applied to other c

145 ed and when telomeres lengthened, chromosome instability decreased.

146 s, high-dimensional data are associated with instability, decreased classification accuracy and high-

147 Genome instability, defined as higher than normal rates of muta

148 s-causing TDP-43 mutations affected tau mRNA instability differentially, in that some promoted and ot

149 ontaneous reconnection, the Kelvin-Helmholtz instability driven by a super-Alfvenic velocity shear is

150 al outcome, strongly suggesting that genomic instability drives prognosis of the disease.

151 wer mass-transfer rates, when accretion-disk instabilities drop matter onto the white dwarfs.

152 g but face challenges of chronic gliosis and instability due to mechanical and structural mismatch wi

153 and epigenomic features that promote genomic instability during cancer evolution.

154 d, indicating that microtubules are far from instability during most of their time of growth.

155 are impractical today because morphological instability during recharge drives rough, dendritic elec

156 with the loss in forces caused by mechanical instability encountered in muscle diseases and cardiomyo

157 assium-ions causes structural distortion and instabilities even in layered electrodes.

158 is also predicted a strong dependence of the instability formation on biofilm viscosity explaining th

159 on between tremor dominant (TD) and postural instability/gait difficulty (PIGD) subtype patients duri

160 ent RhoA pacemaking oscillator controls this instability, generating a pulsatory pattern of myosin fo

161 test in Bi-Tg thyrocytes with a mean genetic instability (GI) index of 35.8+/-2.6%, as well as signif

162 inear vortex flows from the Kelvin-Helmholtz instability gives rise to vortex-induced reconnection an

163 distributed among coexisting clones, genomic instability has important therapeutic implications.

164 Studies of genomic instability have historically focused on intrinsic mecha

165 mesoporous silica formulations are colloidal instability, hemolysis and inefficient drug loading and

166 This avoids disadvantages such as thermal instability, high cost, and, especially, the need to sep

167 evolutionary product of Pleistocene climate instability, humans possess broad adaptations to environ

168 ed barriers to mobilization were hemodynamic instability, hypoxemia, and dependency on venovenous ext

169 to devise methods to overcome their genomic instability, immune reactivity, and tumorigenic potentia

170 Transient events that occur during plasma instabilities in fusion reactors impart large heat fluxe

171 movements are subject to noise and introduce instabilities in gaze direction across blinks [2].

172 is believed to be one of the most prevalent instabilities in nature.

173 responds to the onset of high energy dynamic instabilities in this driven vortex state just above [Fo

174 localizes to micronuclei arising from genome instability in a mouse model of monogenic autoinflammati

175 F, cause nascent DNA degradation and genomic instability in BRCA1/2-deficient cells upon replication

176 DNA replication stress promotes genome instability in cancer.

177 e found that rrMDD patients, who showed more instability in feeling down and irritated, had less conn

178 -2008, a deep analogy between the origins of instability in financial systems and complex ecosystems

179 hat Wwox loss is followed by mild chromosome instability in genomes of mouse embryo fibroblast cells

180 ubtle charge density wave-like Fermi surface instability in metallic electron doped Sr3Ir2O7 at tempe

181 ed our hypothesis that targeting chromosomal instability in MM would improve response to therapy.

182 ausative in TH1 immunodeficiency and genomic instability in patients with WAS.

183 nd of differentiation, and it contributes to instability in subsequent rounds of culture.

184 RNS-induced DNA lesions cause genomic instability in the absence of Brca2.

185 active RhoA and myosin induces a contractile instability in the cortex.

186 Taken together, our data suggest that instability in the genetic architecture of a subset of g

187 However, this process will induce instability in the iterative inversion regardless of whe

188 ations, suggesting a potential role for NBD2 instability in the pathology of CF.

189 ar to be responsible for the bulk of genomic instability in these tumors.

190 nal pathway that leads to amplifications and instability in this region.

191 osomes can lead to aneuploidy and chromosome instability in tumor cells, how untransformed ECs respon

192 omosome loss and the associated BFB-mediated instability in tumorigenesis and may shed light on the e

193 onal MdnCNV phenomenon resembles chromosomal instability in various cancers.

194 in non-native linkages that may suffer from instability in vivo and adversely affect the protein's s

195 show that TSI is associated with chromosome instabilities including chromosome loss, micronuclei for

196 ch that when telomeres shortened, chromosome instability increased and when telomeres lengthened, chr

197 It is unclear how this affective instability is associated with information processing re

198 We argue that this instability is induced by endogenous acoustic noise, whi

199 The mechanism for Myc-induced genetic instability is not well understood.

200 ions of larger size, especially when genomic instability is shared among a limited number of clones.

201 r, and no information regarding the seafloor instabilities island inception may cause.

202 However, as a consequence of instability, it can be impossible-using traditional meth

203 altered Cse4/CENP-A activity leads to genome instability, it is pivotal to understand the mechanism u

204 found that when microtubules undergo dynamic instability, lateral captures predominate even in the ab

205 argets against ATL and might explain genomic instability leading to the pathogenesis of ATL.

206 larly weak, the network operates close to an instability leading to unbounded cortical activation.

207 Modulational instability leads to Langmuir collapse and electron heat

208 aused lipid bilayer destabilization and pore instability, limiting the total number of recorded pulse

209 in the tumor microenvironment triggers Treg instability locally and restores anti-tumor immunity.

210 ilatory control system and suggests feedback instability (loop gain > 1) is responsible.

211 that cancers with extreme levels of genomic instability may be teetering on the brink of a threshold

212 r (MMR) deficiency (MMRD) and microsatellite instability (MSI) are prognostic for survival in many ca

213 Microsatellite instability (MSI) caused by mismatch repair deficiency (

214 ding major mutational events, microsatellite instability (MSI), epigenetic features, protein expressi

215 of colorectal cancers exhibit microsatellite instability (MSI), which leads to accumulation of large

216 ry of cancer or polyps, tumor microsatellite instability [MSI], mismatch repair [MMR] deficiency) is

217 n a range that corresponded to the degree of instability observed in the HD signal.

218 e models with persistent mitotic chromosomal instability, observing a decrease in proliferative expre

219 Turbulence through Kelvin-Helmholtz instabilities occurring at the interface demonstrated th

220 lts demonstrate that CD25(lo) Treg and iTreg instability occurs during a viral immunoinflammatory les

221 Plateau-Rayleigh (PR) instabilities of a free-falling jet of an aqueous medium

222 The flow instabilities of solutions of high molecular weight DNA

223 scuss the feasibility of observing excitonic instability of (Sb1-x Bi x )2Te3.

224 The results were explained in terms of the instability of an interface under perturbation during pu

225 trand contact sites, explaining the inherent instability of apicomplexan actin filaments.

226 Type 1 MIs result spontaneously from instability of atherosclerotic plaque, whereas type 2 MI

227 bnormalities including lengthened period and instability of behavioral rhythms, and elevated metaboli

228 The instability of cell components in the presence of desire

229 A similar instability of EFC proteins had previously been found wi

230 erized by transcription suppression and mRNA instability of eNOS complemented by upregulation of MCP1

231 tigated the impact of these compounds on the instability of F508del-CFTR, the most common CF mutation

232 fferently account for 2/3(rd) of the genomic instability of hCEB1 in two G4-stabilizing conditions.

233 this inhibitory mechanism contributes to the instability of IL-17-producing T cells.

234 However, it is the instability of mature nad5 rather than nad5T1 causing lo

235 electron microscopy (TEM) due to the extreme instability of MOFs upon electron beam irradiation.

236 However, the instability of naked dsRNA sprayed on plants has been a

237 ned over the potentially longer-term in vivo instability of noncovalent linkage of the trimers to the

238 However, the instability of peptide-receptive MHC molecules has hinde

239 Loss of Bcp1 causes instability of Rpl23 and deficiency of 60S subunits.

240 The instability of some serotypes, such as SAT2, affects the

241 n NBD2 has also been hampered by the overall instability of the domain and the difficulty of producin

242 y instability of the membrane voltage (Vm ), instability of the intracellular Ca(2+) ( Ca i2+) cyclin

243 Alternans can be caused by instability of the membrane voltage (Vm ), instability o

244 variable eye movements that lead to inherent instability of the optical image.

245 lly unstable and led to increased structural instability of the rod outer segments.

246 indicate that environmental cues dictate the instability of the Th9 phenotype, and they suggest appro

247 use of organic chromophores arising from the instability of their oxidized forms, the inability of th

248 on-scale essence of the spatial and temporal instability of two-phase flow in fractured media at the

249 The "instability" of the two dienic systems and of the stereo

250 ion and reveal two mechanisms for CAG repeat instability: one mediated by cytosine deamination of DNA

251 ous, glycolytic, enriched for microsatellite instability or KRAS mutations; (ii) CRIS-B: TGF-beta pat

252 tion on symptom status, presence of clinical instability or ongoing ischemic symptoms, prior reperfus

253 of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations.

254 ases because of complex anatomy, hemodynamic instability, or failed percutaneous coronary interventio

255 eases clot stiffness and triggers mechanical instability over time.

256 here is a variety of dynamical scenarios and instabilities, owing to the properties of the incoherent

257 to predict both the observed electrokinetic instability patterns and the measured threshold electric

258 is essential to prevent initiation of genome instability permissive for tumorigenesis.

259 and fluctuations in the rates of chromosome instability phenotypes, such that when telomeres shorten

260 d altered gene expression resulted from eNOS instability, possibly due to enhanced miR-155 expression

261 The instability primarily occurred with IL-2R(lo) Tregs and

262 (RJALS), a disorder characterized by genome instability, progeria and early onset hepatocellular car

263 The instability promotes vigorous lateral export, rapid dilu

264 ng of precisely how network topology creates instability remains lacking.

265 s and suggest a mechanistic basis for genome instability resulting from deregulated DNA replication,

266 Small-airways instability resulting in premature airway closure has be

267 ctivation as aggravating factors for genomic instability.Significance: RUNX3 inactivation in cancer r

268 d break repair pathway that leads to genomic instabilities similar to those observed in cancer.

269 ication involves the inherent risk of genome instability, since replisomes invariably encounter DNA l

270 MIRMMR predicts microsatellite instability status in cancer samples using methylation a

271 al not exposed to radiation, causing genomic instability, stress responses and altered apoptosis or c

272 slinks (ICLs) are associated with the genome instability syndrome Fanconi anemia (FA).

273 ibrium at the genomic level suggest internal instabilities that anticipate an unpredictable HCV evolu

274 Our work reveals how contractile instabilities that are natural to occur in mechanically

275 his feature of atrial cells leads to dynamic instabilities that may underlie atrial arrhythmias.

276 nflammatory response, with subsequent plaque instability that eventually favors atherothrombosis.

277 lf cavity triggers a centrifugal overturning instability that grows by extracting kinetic energy from

278 inogen susceptibility as an origin of genome instability that is regulated by nuclear architecture an

279 ependent, coding region determinant (CRD) of instability that limits its expression.

280 Telomere shortening induces chromosomal instability that, in the absence of functional tumor sup

281 inflammation, thrombosis, leakage, and wall instability; these changes were not observed in control

282 ack reduces the period and growth of coupled instability, thus favoring more frequent and weak El Nin

283 table tumors from tumors with microsatellite instability, thus potentially improving classification o

284 ress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer.

285 fusions that would otherwise promote genome instability to fuel tumorigenesis.

286 e for optoelectronics and photonics, yet its instability under environmental conditions and the lack

287 pment to be overcome, such as their chemical instability under operating conditions.

288 s a day for 6 days) and calculated affective instability using the mean adjusted absolute successive

289 The greatest cardiac electric instability was also observed after variable (short) CI

290 or heterogeneity mediated through chromosome instability was associated with an increased risk of rec

291 Microbiota community instability was associated with faster healing and impro

292 Consistent with this, genetic instability was greatest in Bi-Tg thyrocytes with a mean

293 ome doubling and ongoing dynamic chromosomal instability were associated with intratumor heterogeneit

294 to track and control the large dimension of instabilities, which strongly interact and exchange ener

295 One such example is modulational instability, which is believed to be one of the most pre

296 lindrical jets, but also exhibit a shrinking instability, which is inherent to the toroidal shape.

297 est are systems near the point of mechanical instability, which recently have been shown to distribut

298 ature in the pathogenesis of OSCC is genetic instability, which results in altered expression of gene

299 g, defective cell cycle control, and genomic instability, which was rescued by WT GINS1.

300 e progression and the development of genomic instability with aneuploidy.