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1 etic responses to light fluctuations are not instantaneous.
2 reduction of quinoline by SmI2 results in an instantaneous [2 + 3] cyclization reaction, forming a br
3                                              Instantaneous 30-day adjusted hazard ratios for cTn+ ver
4                    These results demonstrate instantaneous acquisition and global aggregation of diag
5                           First we note that instantaneous action at a distance should not be possibl
6 he negative slope conductance and the almost instantaneous activation are critical for producing thes
7 s (IKir) had the canonical features of quasi-instantaneous activation, strong inward rectification, d
8 alography (MEG) and multivariate analyses of instantaneous activity in reconstructed sources.
9  a more accurate indicator of a population's instantaneous activity than 16S rRNA gene copies alone a
10 re we use a newly devised technique to study instantaneous adaptation to audiovisual asynchrony in au
11 ers of von Willebrand factor defect could be instantaneous after acute changes in blood flow, (2) a b
12 he DNA target with the DNA probes results in instantaneous aggregation of AuNPs into nanoballs, leadi
13 oncentration dependent, and control over the instantaneous amount of NO available to cells is essenti
14 utomated to provide objective, holistic, and instantaneous analysis and communication of LO progressi
15 hniques capable of nondestructive and nearly instantaneous analysis of a wide variety of forensic evi
16 and arsenite, with the exception of the near instantaneous and complete sorption of monothioarsenate
17 verexpressing plants (EPF2OE) increased both instantaneous and long-term WUE without altering signifi
18 tat suitability predicted by an RSF had both instantaneous and longer-term seasonal effects on surviv
19 r review websites are designed to facilitate instantaneous and public communication among patients.
20 Brain-computer interfaces (BCIs) can provide instantaneous and quantitative measure of cerebral funct
21                                              Instantaneous and relaxed moduli showed no significant d
22  (i) Considering the 28pi-conjugated system, instantaneous and site-selective Zn(II) metalation at th
23  inhibiting the mutant channel, reduced both instantaneous and steady state HET-IKs to levels that we
24            The response time was found to be instantaneous and the detection limit was achieved even
25 scribe a method for directly quantifying the instantaneous and total amounts of NO from commonly used
26 ation of diffusion, which can arise from the instantaneous bleaching assumption.
27                                          The instantaneous blink rate of all four animals decreased d
28 opensity quantifying the non-local effect of instantaneous bond fluctuations propagating through the
29                    SN/VTA adaptation was not instantaneous but developed across trials.
30 that the active process is neither local nor instantaneous, but requires mechanical waves traveling f
31  the Drosophila embryo epidermis triggers an instantaneous calcium flash, which travels as a wave via
32 rsial, as they seem to indicate geologically instantaneous carbon release and anomalously long ocean
33  been interpreted as indicating geologically instantaneous carbon release.
34 rming does not support the interpretation of instantaneous carbon release.
35 n-based stresses match those calculated from instantaneous cell shapes.
36 ctors was assessed over time by studying the instantaneous cell viability, the colony-forming unit co
37  pulses as optical "switches" introducing an instantaneous change of the pH-value for activation of p
38  between deviations from criticality and the instantaneous changes in EIB.
39 tion/recovery of HMW multimers defects under instantaneous changes in shear stress in an aortic steno
40                                              Instantaneous changes of the environment stiffness are f
41 instem pathways display complementary nearly instantaneous changes, contributing to compensating for
42 ion is investigated under the assumptions of instantaneous chemical equilibrium, and that the dissipa
43            Synergistic dual-site binding and instantaneous chirality imprinting result in characteris
44 an cause a 1.8-2.0 W m(-2) difference in the instantaneous clear-sky OLR.
45  with interpretations of LIP as providing an instantaneous code for decision variables, we found that
46 ual microstates were characterized by unique instantaneous combinations of neural phase in the delta,
47 ed by nonlinear least-squares fitting of the instantaneous comonomer concentrations according to the
48  a feedforward framework as a consequence of instantaneous computations performed upon time-varying i
49                Additionally, by boosting the instantaneous concentration of LA aerosol into the ICP w
50 istances of electrically coupled neurons and instantaneous conductance-voltage rectification of gap j
51 irection of a travelling wave and from which instantaneous conduction velocity amplitude and directio
52                                         LeuT instantaneous conformation as it reconfigures from subst
53 ydrophobic moment vector is specific for the instantaneous conformation, and it takes into account al
54 ively reduced by spectral phase encoding and instantaneous correlation among the A-scans.
55 imes of the dynamical phase change: a nearly instantaneous crossover into an intermediate state and i
56                    Accordingly, the measured instantaneous CTE of polystyrene resin varied from 5.86
57 ges were observed and recorded to derive the instantaneous CTE of the packaged LED under different in
58 ter for immediate sensory integration during instantaneous decision making.
59  contaminants as electron donors may lead to instantaneous degradation kinetics in the capillary frin
60 sor, aquacyanocobyrinic acid (ACCA), for the instantaneous detection and rapid quantification of endo
61 istic ultraviolet and CD readouts that allow instantaneous determination of the absolute configuratio
62  well balanced, and co-fluctuate with slight instantaneous deviations from perfect balance, mostly in
63 termined, for the first time, the global and instantaneous diffusivity of defect clusters in both coa
64 nspecific (dipole-dipole, dipole-induced and instantaneous dipole induced forces) intermolecular inte
65  the amount of information flowing along the instantaneous direction of the gamma wave.
66 noise in receptor activity may determine the instantaneous direction, but because noise is spatially
67 to overcome this limitation by providing the instantaneous distance distribution between pairs of gol
68 an N-limited system is inconsistent with the instantaneous downregulation of photosynthesis formalize
69 mum power generation potential is 26% of the instantaneous downward transport of kinetic energy using
70 sed electric fields exposure, we observed an instantaneous drop of ~50% in SHG signal from the anodic
71 to increased predation risk had a relatively instantaneous effect on survival outcomes, whereas varia
72 obtained by the adiabatic path traced by the instantaneous eigenstate.
73 remodeling, and that strain triggered a near-instantaneous elastin-remodeling response.
74 ch ions interact via forces derived from the instantaneous electronic ground state.
75                                         Such instantaneous energetics help to explain why most felids
76 irect solid sampling because of the enhanced instantaneous energy.
77 capacity of florfenicol to soil, enhance the instantaneous equilibrium adsorption, and suppress the t
78 be overpredicted by an order of magnitude if instantaneous equilibrium partitioning is assumed in the
79  GEOS-Chem default configuration, which uses instantaneous equilibrium partitioning to divide PAHs am
80        Most chemical transport models assume instantaneous equilibrium to represent gas-particle part
81 p to cubic-order nonlinearities allow for an instantaneous estimation of the dynamic spectrum and bis
82 iation as an extended process rather than an instantaneous event and carry out species delimitation i
83 der this model, speciation was treated as an instantaneous event rather than as an extended process i
84 ransferred into ice-cold organic solvent for instantaneous extraction of the cellular PQ plus PQH2 co
85 mped corollary discharge signal that encodes instantaneous eye position.
86 eurological signals and modulating them with instantaneous feedback.
87 erm dynamics of the ecosystem as recorded by instantaneous field measurements.
88 history of the axon, but also determines the instantaneous firing frequency that encodes pain intensi
89 ry Spike Train (LOST) model to decompose the instantaneous firing rate in biologically and behavioral
90  a spectro-temporal acoustic stimulus to the instantaneous firing rate of a central auditory neuron.
91 iability is caused by the variability of its instantaneous firing rate, and how much is caused by spi
92 ing to the SA category without affecting the instantaneous firing rate.
93 e, i.e. electrically-quiescent, muscles, the instantaneous firing rates (IFRs) of muscle spindles are
94                           By considering the instantaneous firing rates of both ON and OFF cell popul
95 te), allowing us to predict arm resting from instantaneous firing rates with 98% accuracy using a sim
96 ibited twofold greater excitability and peak instantaneous firing rates.
97 would expect from the covariability of their instantaneous firing rates?" For another example, "How m
98 n of heartbeats - a multiscale regulation in instantaneous fluctuations - is well known for vertebrat
99                                  We built an instantaneous fluorescence polarization microscope, whic
100 rs are seeding the development of novel high instantaneous flux applications, combining the ultrashor
101 e-of-the-art accelerators optimized for high instantaneous flux.
102 r matched the direction and amplitude of the instantaneous force increments over time.
103 owledge, how neutrophil tethers shorten upon instantaneous force removal, and furthermore, they illus
104 stributed control of hand force, by encoding instantaneous force variations and serving as a memory r
105                                              Instantaneous formation of aminobromine was observed whe
106    While the previous pathway results in the instantaneous formation of mono- and polyhydroxylated ar
107  with B(C6F5)3 under 1 bar of CO2 led to the instantaneous formation of the frustrated Lewis pair (FL
108  hippocampal CA1 pyramidal neurons with peak instantaneous frequencies occurring in both the gamma an
109 ypically, modulations in alpha amplitude and instantaneous frequency are thought to reflect independe
110 matical principle of synchronization through instantaneous frequency modulations applies to gamma in
111           Here, we demonstrate the opposite: instantaneous frequency modulations are critical to regu
112                                          The instantaneous frequency of sIPSCs that result from excit
113 ed oscillators, we show that fluctuations in instantaneous frequency predict alpha amplitude on a sin
114 jects and show that both alpha amplitude and instantaneous frequency predict behavioral performance i
115 dence suggests that changes in amplitude and instantaneous frequency reflect a common change in the e
116  delay has a non-monotonic relationship with instantaneous frequency, which depends on the gating rat
117      The measured linear response reveals an instantaneous friction kernel despite the complexity of
118     We examined these questions by comparing instantaneous functional connectivity (IFC) and directed
119 spheric models is based on the assumption of instantaneous gas-particle equilibrium for the condensin
120 one of which is characterized by effectively instantaneous gene replacement, and the other consists o
121 ld TPV insufficiency, and the median maximum instantaneous gradients across the RVOT was 23 mm Hg.
122                                           An instantaneous ground state-initially a symmetric superpo
123 ute growth rate, justification for not using instantaneous growth rate (or a measure of growth in pro
124 find that the clock generates rhythms in the instantaneous growth rate of the cell, and that the time
125 e show that TrmB-DNA binding correlates with instantaneous growth rate, likely because S-layer glycos
126 rpart's production so as to maximize its own instantaneous growth rate, only to achieve a lower final
127 ar and persisted at 5 years postoperatively (instantaneous hazard at 5 years, hazard ratio, 0.67 [95%
128        Cox regression analysis estimated the instantaneous hazard of recurrence (ie, disease-free sur
129  released, the MD simulations show an almost instantaneous healing of pressure-induced defects in goo
130  of bound electrons to optical fields is not instantaneous; however, a complete spectral characteriza
131 specific point-process model was devised for instantaneous identification considering autoregressive
132 ficient information for spontaneous and near-instantaneous identification of a subject's perceptual s
133 ion of a steady-state contact area is almost instantaneous if the counter surface is soft relative to
134 c fluorescence changes which can be used for instantaneous in situ determination of the absolute conf
135 odel was acutely sensitive to assumptions of instantaneous incorporation of atmospheric C14 into the
136              [Re(CO)3(dppz)(Py)](+) shows an instantaneous increase in photoluminescence with fibrill
137                              We simulated an instantaneous increase or decrease of central chemorecep
138 nhibition with archaerhodopsin, simulated an instantaneous increase or decrease of central chemorecep
139 ionally, a single dose of HRP resulted in an instantaneous increased incorporation of (14)C-DNAN into
140 pacity of optical stretching to produce near-instantaneous increases in cell temperature, we establis
141 ubtypes could be principally correlated with instantaneous (initial) and steady-state firing rates.
142 jury, and rapid nerve conduction can provide instantaneous input for modulating inflammation.
143                                  Here we use instantaneous interference with Arp2/3 complex function
144                                              Instantaneous intersubject phase synchronization (ISPS)
145                                         This instantaneous, intravascular terminal complement activat
146              This method, which gives a near-instantaneous isolation, enables significantly higher re
147          Statistical rate theories, assuming instantaneous IVR, predict exponential decay of the popu
148 -averaged responses could instead arise from instantaneous jumps at different times on different tria
149 association with graft survival; a decreased instantaneous late hazard for death or graft failure amo
150                                     The peak instantaneous left ventricular outflow tract gradient de
151 l core of filopodia, largely determine their instantaneous lengths and overall lifetimes.
152                Results demonstrated that our instantaneous linear and nonlinear features were able to
153 g 30-Hz integral linewidth as well as sub-Hz instantaneous linewidth.
154 nd thus could be inaccurate in measuring the instantaneous lipogenesis of the living cells.
155                   Despite inactivating BSSL, instantaneous lipolysis was not affected by pasteurizati
156 lexity variability, in which the variance of instantaneous Lyapunov spectra estimated over time serve
157 d glucose meters, allowing for continuous or instantaneous measurement of blood borne biomarkers with
158                                              Instantaneous measurements such as surface pH did not re
159 mple-indicator mixing design to achieve near instantaneous measurements.
160 tions of delta(18)O(TW) were consistent with instantaneous measurements.
161 ered cardiovascular dynamics, as well as for instantaneous measures of complexity, through Lyapunov e
162  the Chang'e 3 mission provides a global and instantaneous meridian view (side view) of the Earth's p
163 he cap size has been shown to correlate with instantaneous microtubule stability.
164 so enables QED, provided degradation follows instantaneous mixing of two sources.
165 on tests, the ratio of relaxation modulus to instantaneous modulus was significantly smaller with CTG
166 ound state, and UV-B exposure results in its instantaneous monomerization followed by interaction wit
167 lly defined quantities, with MT representing instantaneous motion evidence and LIP reflecting the acc
168                     Our results suggest that instantaneous mRNA abundance of canonical markers is ten
169 lly distinguishable from the neuron's actual instantaneous multisensory response at any phase through
170 rted by kinetic studies that indicate almost instantaneous N-chlorination of DCAM even at low chlorin
171 r K N -values, 2) K N is a good predictor of instantaneous net ecosystem CO2 exchange and 3) function
172 otal NO release from the NO donor as well as instantaneous NO concentrations.
173 ies of a single filter, followed by a common instantaneous nonlinearity.
174 ponses and passes the result through a final instantaneous nonlinearity.
175       This paper explores the sensitivity of instantaneous OLR and cooling rates to changes in far-IR
176                  These reactions were almost instantaneous on the nanocatalyst-embedded paper, which
177 nosecond laser pulses, which are essentially instantaneous on the timescale of the spin dynamics, all
178 -band spectrum, the latter, involving almost instantaneous optical transitions, has a broad bandwidth
179 tion value was manifested temporally through instantaneous or seasonal effects on survival outcomes.
180 1) exhibits high-electrical performances: an instantaneous output voltage of 200 V and a current of 6
181 he slope and intercept of the line that fits instantaneous, overtone-dependent QCM data on (delta/a,
182 g filtration level decreased the effluent's (instantaneous) ozone demand and increased removal of eff
183                Furthermore, we observed that instantaneous pasteurisation at 107 degrees C for 6s, su
184 e exist two parallel competing mechanisms of instantaneous PD arising from the As part of the network
185 creased biventricular stroke work however RV instantaneous peak pressure (dP/dtmax) and end-systolic
186 oscillatory activity (amplitude envelope and instantaneous phase).
187  In the 50% of the cases remaining after the instantaneous photogeneration of the charge-separated st
188 d nitrogen costs, invaders exhibited greater instantaneous photosynthetic energy-use efficiency (PEUE
189 tion of elliptical beams enable acquiring an instantaneous picture of the deposition of energy inside
190 nderlying the classical description: (i) The instantaneous potential field experienced by dopants bec
191                                         Both instantaneous power and phase of these ongoing oscillati
192 ensities up to 2mAcm(-2) supplying a maximum instantaneous power density of 676 muW cm(-2), which is
193 traoral pressure recordings to calculate the instantaneous power required for suction feeding.
194 sts of speed (absolute velocity), intensity (instantaneous power), and frequency (spectral centroid).
195 nance of expected prediction errors in dACC, instantaneous prediction errors in the ventral striatum
196 nd electroencephalography (EEG), we assessed instantaneous prefrontal-to-motor cortex connectivity in
197 H itself but, rather, could be attributed to instantaneous PRH computations performed upon an input r
198 t suppression probability (BSP), the brain's instantaneous probability of being in the suppressed sta
199 data from healthy subjects, and estimate the instantaneous probability that a subject is awake during
200  reveal that coincidence detection is not an instantaneous process, but is instead shaped by the inte
201 s opens up the possibility of simple, almost instantaneous production of highly active nanostructures
202         Shock compression generates a nearly instantaneous propagating high-pressure/temperature cond
203 Hoolock and Symphalangus) experienced a near-instantaneous radiation approximately 5 million years ag
204                            Correction of the instantaneous radiative efficiency (0.36 W m(-2).ppbv(-1
205  as a powerful approach for acquiring nearly instantaneous Raman and optical spectra with unprecedent
206 ar exceeding a small global average decline (instantaneous rate of change = -0.018 y(-1)).
207    To quantify HCE, we calculated the median instantaneous rate ratio (MIRR) for LOS and median odds
208               We propose a model whereby the instantaneous rates of surface and volume synthesis both
209  information from which to calculate forces (instantaneous rates) of infection, but waning immunity a
210 erence contrast microscopy to provide nearly instantaneous reconstruction of an arbitrary convex obje
211 wed that, on removal of the bending load and instantaneous recovery of the elastic strain, a substant
212 ric transjunctional [Mg(2+)]i induces strong instantaneous rectification, providing a novel mechanism
213 nd economical mechanism, which allows a near-instantaneous reduction in Crl synthesis without the nee
214 's laws and the Norton-Simon hypothesis from instantaneous regression rates to the cumulative effect
215 y representations result from estimating the instantaneous relation between the expected and observed
216 ling and transcriptional domains based on an instantaneous relationship between the molecular activit
217 ining the CIE onset, which requires a large, instantaneous release of (13)C-depleted carbon.
218 en S(-II) and U(VI) for surface sites caused instantaneous release of adsorbed U(VI).
219  imidazole to hydrophilic urea, resulting in instantaneous release of Ce6 and rapid intracellular dis
220                         Reproducibility, and instantaneous repeatability, is built in to the ReproPhy
221 ntations are distinct and also revealed that instantaneous representations become more stable over ti
222                       In freely moving mice, instantaneous respiration rate is extremely variable, an
223            Compared to new baseline, revised instantaneous response decreases R p for mid-latitudes,
224 sists only during the pulse duration with an instantaneous response time.
225                      Leveraging the merit of instantaneous response, as well as the flexible lens str
226 enic tether reports the bond formation by an instantaneous rise in (blue) fluorescence intensity prov
227 (i.e., cumulative risk, prospective risk, or instantaneous risk (hazard)) and suggest the appropriate
228 for each individual, we derived estimates of instantaneous risk for developing AD, based on genotype
229          LT conferred a 69% reduction in the instantaneous risk of death (51-80%).
230 es for death and discharge to assess how the instantaneous risk of these events changed across time.
231 iation of seizure susceptibilities, with the instantaneous seizure rate during REM nearly 10 times hi
232 s that enable unusual 'cold' programming and instantaneous shape recovery triggered by applying a con
233 ration for the entire shape-memory cycle and instantaneous shape recovery triggered by exposure to a
234 ak-to-peak open-circuit voltage of 157 V and instantaneous short-circuit current of 4.6 muA, within s
235                               Despite nearly instantaneous signal acquisition, a limitation of D-DNP
236 ound, a time course that was mimicked by the instantaneous silence density.
237 amplifying sound-evoked movement, and nearly instantaneous, since amplification can work for sounds a
238 resolution of 2D IR spectroscopy provides an instantaneous snapshot of the multi-ion configurations a
239 itative determination of plume age (5 h) and instantaneous SO2 oxidation rate (2.4 x 10(-6) s(-1) at
240 ch, but instead were dependent upon both the instantaneous social value intake rate and current time
241                       Our detector relies on instantaneous spectral cloning and a single-step, cohere
242                            Features from the instantaneous spectrum and bispectrum, as well as the do
243 y neurons encode stimulus intensity in their instantaneous spike rate and adjust the set-points of th
244 rmanding framework and that they reflect the instantaneous state of visual representations expected i
245 tal muscle bears higher force and has higher instantaneous stiffness than during isometric contractio
246 re temperature may provide a global and near instantaneous stimulus to measure the need for cooling,
247                                              Instantaneous stroke risk peaked on day 2, then fell to
248 methods to visualize--in one laser shot--the instantaneous structure and evolution of a laser-induced
249 f both the fate of elongating filaments upon instantaneous suppression of Arp2/3 complex activity and
250 roduction of this short-course regimen as an instantaneous switch in 2016.
251 te-and-fire neurons that communicate through instantaneous synapses.
252 ompute bounds on the network response to non-instantaneous synapses.
253 ude soils by a factor of 1.4 compared to the instantaneous temperature response.
254 his allows characterisation of baseline R d, instantaneous temperature responses and longer-term ther
255 ng and fluorescence signatures are virtually instantaneous, the cell stress relaxation, typically occ
256 tion of TLR signaling by Semapimod is almost instantaneous: the drug is effective when applied simult
257 rresponded with the theoretical model; while instantaneous threat of punishment caused subjects to in
258                         Utilizing the nearly instantaneous time-resolution of 2D IR spectroscopy, par
259 fected carbon balances on short time scales (instantaneous to a few months), drought conditions over
260 duli experienced a significant decrease from instantaneous to steady state, while the posterior regio
261 sed solution that provides secure and nearly instantaneous transfer of patient information to a cloud
262 op a general mathematical framework based on instantaneous transformation of the clock cycle by exter
263                                 The observed instantaneous transition from the damage-like to nanogra
264 l nights, and significantly outperformed the instantaneous transition models implicit in clinical def
265      It gives users options to customize the instantaneous transition rate matrices, or to choose pre
266 6 and E. coli was exploited to calculate the instantaneous turgor pressure within cultured bacterial
267        We show that nonlethal attacks caused instantaneous turn-over and mixing of group composition
268  feedback signal that is proportional to the instantaneous value of the measured sensory signal.
269  retained their shear modulus within 0.5% of instantaneous values when shear was applied in the medio
270 f the new engine to both sublimation and the instantaneous vapourization of liquids.
271 ic flow is, and should be, represented as an instantaneous vector field.
272 reefold larger for velocity increases in the instantaneous velocity change condition, as compared to
273 us velocity change condition, as compared to instantaneous velocity decreases or thresholds for the d
274                                     However, instantaneous velocity has eluded experimental observati
275                  We observe the hydrodynamic instantaneous velocity of Brownian motion in a liquid, w
276                           Measurement of the instantaneous velocity of Brownian motion of suspended p
277 and pleckstrin homology domains, reduced the instantaneous velocity of intrafilopodial movement but d
278  secretion of cells correlates with a higher instantaneous velocity, but with lower directional persi
279          Stepwise regressions confirmed that instantaneous velocity, extensor, and flexor muscle acti
280 sers enable single-shot imaging allowing for instantaneous views of nanostructures at ambient tempera
281 ps the applied pressure but also provides an instantaneous visual response through a built-in active-
282 ions of time: water level in the filter (h), instantaneous volumetric flow rate of filtrate (Q), and
283 ld type under stress to maintain a favorable instantaneous water use efficiency and better assimilati
284                          Although C4 average instantaneous water-use efficiencies were higher (2.4-8.
285 ly appraise the scientific background of the instantaneous wave-free ratio (iFR) and fractional flow
286 performance of and theoretical basis for the instantaneous wave-free ratio (iFR) approximation to the
287 oronary to aortic pressure ratio (Pd/Pa) and instantaneous wave-free ratio (iFR) are indices of funct
288                We evaluated whether baseline instantaneous wave-free ratio (iFR) could provide an imp
289 mpare fractional flow reserve (FFR) with the instantaneous wave-free ratio (iFR) in patients with cor
290                                          The instantaneous wave-free ratio (iFR) is a vasodilator-fre
291                                          The instantaneous wave-free ratio (iFR) is an index used to
292  assessed for fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and whole-cycle dis
293 ment of coronary stenosis severity using the instantaneous wave-free ratio (iFR).
294 The overall accuracy of cFFR is greater than instantaneous wave-free ratio and distal pressure/aortic
295 vascular ultrasound) or being validated (eg, instantaneous wave-free ratio and optical coherence tomo
296  fractional flow reserve of 0.69 (0.16), and instantaneous wave-free ratio of 0.76 (0.22).
297                            METHODS AND cFFR, instantaneous wave-free ratio, distal pressure/aortic pr
298 em to changes in temperature appeared almost instantaneous whereas equilibration of casein was consid
299 h the illusion, indicating that knowledge of instantaneous whisker position is unnecessary for discri
300 r stomatal density, higher gw(max) and lower instantaneous WUE, as well as lower (but not significant

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