ライフサイエンスコーパス: instigate

1 unknown, and often no specific treatment is instigated.

2 tive causes, including malignancy, should be instigated.

3 object decision making in the human brain is instigated.

4 2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells

5 The cells instigate a fast transcriptome and proteome response, in

6 tro to examine the molecular events that can instigate a genetic load.

7 ility influence motility mode plasticity and instigate a mode termed stable bleb migration in embryon

8 lieu in a rapidly proliferating tissue might instigate a proinflammatory response.

9 ed mitogen-activated protein kinase cascades instigate a range of changes to enable eukaryotic cells

10 ment should be present to disrupt anergy and instigate a response that might cause disease.

11 terior cruciate ligament (except for 6N) and instigated a cascade of temporal and topographical featu

12 Further reduction of the leaf RWC to 60% instigated a metabolic shift in S. stapfianus toward the

13 Inactivation of this pathway instigated a rapid onset of anoxia induced death in infe

14 ines to their cognate receptors on monocytes instigates a cascade of events that directs these cells

15 n underlying cause of cardiac senescence and instigates a decline in cardiac function.

16 I think Just's life story instigates a discussion on diversity in science, as well

17 ions, we propose that the force transduction instigates a partial unfolding of the pore-occluding lum

18 Preceding apoptosis, RES instigates a rapid dissipation of mitochondrial membrane

19 Here we show that DNA recombination by Cre instigates a robust antiviral response in mammalian cell

20 Interaction of PRRs with viral compounds instigates a signaling pathway(s), resulting in the acti

21 We conclude that smoking (through nicotine) instigates AAA through AMPK-alpha2-mediated AP-2alpha-de

22 an important role and that supercoiling can instigate additional ligand-DNA contacts that would not

23 ificant source of carbon in these sites, and instigate additional research into the nature and origin

24 temporary exposure to developmental signals instigates adipocyte differentiation are unknown.

25 The instigating agent typically triggers an inflammatory res

26 ical properties affect protein stability and instigate aggregation is essential for the engineering o

27 uggested that oxidation of methionine 46 may instigate aggregation.

28 d a highly amyloidogenic sequence motif that instigates aggregation and forms the core of the growing

29 n asthma, but the environmental factors that instigate allergic airway disease remain poorly understo

30 To identify IFN-stimulated genes (ISGs) that instigate an antiviral state against two medically impor

31 Phosphor-residues at the amino-terminus instigate an intra-molecular interaction that enlists bo

32 es was taken forward to an in vivo model and instigated an increase in tumor cell necrosis.

33 d acting as incentive stimuli, such cues can instigate and invigorate drug-seeking behavior.

34 hosphorylated MRLC are essential for PDGF to instigate and maintain control over the actin-myosin-bas

35 hese cues can evoke motivational states that instigate and maintain drug-seeking behavior.

36 search for the location of the ODD locus was instigated and linkage to polymorphic markers located on

37 vational state ("wanting" or "craving") that instigates and/or invigorates drug-seeking behavior.

38 alk with BrCa cells by utilizing exosomes to instigate antiviral signaling.

39 esponses as well as the molecular mechanisms instigating apoptosis via IRE1 and PERK signaling.

40 The gene regulation mechanisms they instigate are largely mediated through the CCR4-NOT dead

41 s suggest that astrogliosis, physiologically instigated as a brain tissue damage response, is hijacke

42 educe short-term risk of death, and hence DR instigated at any age could generate a full reversal of

43 Such ACC signals may instigate attentionally demanding and difficult processe

44 tylase SIRT1 displaces chromatin-bound BRD4, instigating autophagy gene activation and cell survival.

45 However, the signal in dACC that instigates behavioral change need not itself be a confli

46 e two eyes, a stimulation condition known to instigate binocular rivalry, during which one image is s

47 d surfaces of most multicellular species and instigate both beneficial and harmful infections.

48 elanocyte death in vitiligo is thought to be instigated by a highly pro-oxidant state in the epidermi

49 Instead it appears to be instigated by a substantial drop in cellular NADPH, whic

50 Reduction in ChAT activity instigated by AbetaOs may thus be a relevant event in ea

51 Allograft rejection can thus be instigated by activated platelets through CD154.

52 ich MMR proteins convert single-strand nicks instigated by activation-induced cytidine deaminase (AID

53 Class switch recombination (CSR) is instigated by activation-induced cytidine deaminase, whi

54 series of events that we demonstrate can be instigated by an LPS-negative pathogen in the absence of

55 revealed that augmentation of renal fibrosis instigated by AT1 receptor-deficient macrophages is medi

56 es a nexus between TLR ligation and fibrosis instigated by binding of anti-Ro Abs to the target prote

57 athway requires Syk activity and Ca(2+) flux instigated by CD14/TLR4-mediated LPS internalization.

58 While continuing its meteoric rise instigated by constant technological refinements and con

59 the ALS-like phenotype of SOD1(G93A) mice is instigated by expression of the mutant SOD1, we show the

60 gation, the misfolding process is frequently instigated by flanking domains.

61 by skill, fast behavior in novices is likely instigated by high stress levels, at the expense of accu

62 ifying that auto-inhibition is paradoxically instigated by incipient auto-phosphorylation.

63 Unlike circuits instigated by individual factors, efforts to identify ge

64 al processes, and such networks are commonly instigated by master regulators for development.

65 Such networks are commonly instigated by master regulators of development.

66 s an aberrant epithelial barrier that can be instigated by microbial toxins, environmental insults, o

67 the interleukin-2 (IL-2) and IL-6 production instigated by ODN D19 exposure was blocked.

68 murine tumours exhibit PTEN loss of function instigated by reduced PTEN mRNA, and increased phosphory

69 id increases in sediment flux and discharge, instigated by regional vegetation overturn and enhanced

70 allow the RPE to integrate multiple signals instigated by shed POS at different stages of the phagoc

71 is likely that this sustained activation is instigated by signal transduction occurring specifically

72 te under a general base catalysis mechanism, instigated by the beta-phosphonium enoate alpha-vinyl an

73 of Col108 in which the axial periodicity is instigated by the built-in sequence periodicity and stab

74 pulations declined between 1492 and 1900 CE, instigated by the European colonization of the Americas.

75 Melioidosis, instigated by the Gram-negative bacterium Burkholderia p

76 DNTF can be instigated by the insertion of a telomere repeat array (

77 V(D)J recombination is instigated by the recombination-activating proteins RAG1

78 y within the H3K36me3-containing nucleosome, instigated by the Tudor binding to H3K36me3, is dramatic

79 Surface nucleation appears to be instigated by these [Cdx (CH3 CO2 )y (C5 H7 N2 /C5 H8 N2

80 Furthermore, the G1 arrest instigated by these DP-1 mutants could be rescued by coe

81 s disease (AD) is increasingly thought to be instigated by toxic oligomers of the amyloid beta peptid

82 omises the initiation and maintenance of EMT instigated by various signaling pathways, including Snai

83 Either guided and instigated by, or independent of, the results of gene in

84 -induced IL-12p70, whereas the same pathogen-instigated C5aR-TLR2 crosstalk upregulates other inflamm

85 breaching of a rock dam at the Dover Strait instigated catastrophic drainage of a large pro-glacial

86 development establishes a genetic network to instigate cell-type-specific autophagy.

87 erturbation of chloride homeostasis in cells instigates cell death by inducing the caspase-mediated i

88 This hitherto unknown trigger for instigating cellular differentiation in a distinctive ma

89 ible individuals, the type I IFN pathway can instigate certain features of SS.

90 nd harboring proteobacteria can drive and/or instigate chronic colitis.

91 brin clot, which could explain how protamine instigates clot lysis and increases bleeding after surge

92 loud activity generated planetary waves that instigated cloud activity at other latitudes across Tita

93 Our data indicate that STING instigates cytoplasmic DNA-mediated cellular defense gen

94 fic role for IL-1beta, but not IL-1alpha, in instigating dermatitis in Sharpin(cpdm) mice.

95 ory response in vitro and in vivo, which can instigate development of pulmonary hypertension.

96 The specific IL-1 cytokine instigating development of FMF and the enzymatic caspase

97 el system, the pathobiont Helicobacter bilis instigates disease following sub-pathological dextran su

98 the core affect of threat, disgust and fear instigate distinct response profiles, providing novel in

99 the RPC has fast exchange of the bitterness-instigating diterpene of Reb A into the binding sites of

100 not exclusive to immunoglobulin loci; it can instigate DNA lesions in non-immunoglobulin genes and th

101 activation-induced cytidine deaminase (AID)-instigated DNA double-strand breaks into the IgH loci.

102 During CSR, AID instigates DNA double-strand break (DSB) formation in sw

103 Activation of PKR by hPNPase(old-35) also instigates down-regulation of the antiapoptotic protein

104 Ca(2+)(o) also instigates E-cadherin-mediated cell-cell adhesion, which

105 diet accelerates endothelial senescence and instigates endothelial inflammation.

106 To identify the true instigating event of GAPDH misfolding, we mapped the pos

107 Signals that instigate Eya1 oncogenic activities remain to be determi

108 "Spontaneous" perforation in CC, in which no instigating factor is identified, is even less common, w

109 monocyte-derived tissue factor are important instigating factors driving the thrombotic, inflammatory

110 ent-stimulation also has drive-like effects, instigating feeding, copulation, predation, and other mo

111 This observation instigated further genetic screening for prostacyclin re

112 We propose that GATA-1 instigates GATA-2 repression by means of disruption of p

113 -of-function strategies to define the GATA-2-instigated genetic network in human endothelial cells.

114 Spontaneous DNA breaks instigate genomic changes that fuel cancer and evolution

115 This can instigate genomic instability resulting from a gain or l

116 t single-stranded nicks, producing ends that instigate genomic instability.

117 pro-inflammatory cytokines such as TNF-alpha instigate gradual suppression of MITF expression through

118 rated by nitric oxide and superoxide anions, instigates GTPCH1 ubiquitination and degradation.

119 g389 variant predisposes to heart failure by instigating hyperactive signaling programs leading to de

120 such as anti-dsDNA and anti-histone Abs, can instigate I/R injury and suggest that they are involved

121 -13Ralpha1) expressed on dendritic cells and instigates IL-12 downregulation.

122 another mechanism by which MPK4 may rapidly instigate immune responses.

123 suggests a novel function of p30, which may instigate immune tolerance by reducing activation of ada

124 terns (PAMPs) are known to be fundamental in instigating immune responses, but their role in influenc

125 urther decontamination procedures need to be instigated in sterile-service departments (SSDs) to redu

126 A community annotation project has been instigated in which acknowledged experts are invited to

127 meres represent genomic hazards, as they can instigate inappropriate repair reactions.

128 he infection process takes 1-2 days, the PFP-instigated infection process is irreversibly established

129 he ability to infiltrate various tissues and instigate inflammation.

130 , our findings demonstrate that a pathobiont instigates inflammation without being the primary target

131 indicate that IKKbeta is an IRF5 kinase that instigates inflammation.

132 e receptor 5 (TLR5) recognition of flagellin instigates inflammatory signalling.

133 study was to test whether higher 5-HT levels instigate inhibition specifically in the face of errors,

134 ns of macrophage Nrp1 in high-fat diet (HFD)-instigated insulin resistance in vivo.

135 ndicating that Nrp1 reduction in macrophages instigates insulin resistance by increasing macrophage N

136 Moreover, angiotensin II infusion instigated interferon-gamma, which induced the expressio

137 areas, such that the accumulation process is instigated, is not well understood.

138 ring CSR or inhibited from accessing the AID-instigated lesions, or whether the numerous AID-initiate

139 y several factors, including an inability to instigate long-term effective functional antitumor immun

140 ment of C. elegans with Cry5B PFP is able to instigate many other Bacillus species, including B. anth

141 entanglement convolutes understanding of the instigating mechanism.

142 now thought that early-stage biomarkers that instigate memory loss are composed of Abeta oligomers.

143 ways activated by extracellular signals that instigate migration are mostly undefined in smooth muscl

144 osine triphosphate (GTP)-Rab7 effectors that instigate minus end-directed microtubule transport.

145 The discovery of instigating molecular toxicities or disease progression

146 adenine nucleotides and phosphorylation may instigate movement of lipoyl domain-held kinase to a new

147 ergo significant conformational changes that instigate movement of the EF helix-loop region and make

148 stablish a conserved mechanism in which NK-B instigates multiple activities that collectively oppose

149 Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that und

150 The resulting mTOR activation instigates MZ B-cell proliferation, immunoglobulin G (Ig

151 k regulation of tissue inflammation that may instigate NAFLD severity.

152 blood supply through end plate changes could instigate NC disappearance.

153 have been shown to have an important role in instigating neuronal degeneration.

154 ells and sera of patients with breast cancer instigate nontumorigenic epithelial cells to form tumors

155 Nitroalkenes react with Keap1 to instigate Nrf2 signaling, activate heat shock response g

156 We conclude that the HFD-instigated Nrp1 reduction in macrophages exacerbates ins

157 blastoma cells increased ATM phosphorylation instigating nuclear translocation and increased gamma-H2

158 studies have shown a mechanism for HTRA1 to instigate ocular tissue abnormalities.

159 nhancer elements, including super-enhancers, instigating oncogenic activity.

160 lite to control tolerance and immunity or to instigate pathology.

161 anisms and biological pathways by which TLR9 instigates periodontal inflammation are yet to be identi

162 o determine whether this microbial imbalance instigates perturbation of the host intestinal mucosal i

163 o be used as weapons of mass destruction and instigate population-based fear.

164 ssociated neurocognitive disorders (HAND) by instigating primary dysfunction and subsequent death of

165 low to the high-carbohydrate diet, which if instigated prior to the development of HCC, resulted in

166 ation permitted IP(3)RII levels to increase, instigating pro-hypertrophic calcium signaling and conco

167 production trigger marrow vessel leakiness, instigating pro-leukemic function.

168 ed that the process of meiotic recombination instigates programmed activation of p53 in the germ line

169 a disease is diagnosed, the first step is to instigate protective measures to prevent further degener

170 in the bone microenvironment necessitate and instigate rapid and temporal changes in gene expression

171 t reduced Smn levels induce SMA pathology by instigating rapidly progressive neurodegenerative pathwa

172 Although mechanisms that instigate rDNA recombination have been identified, none

173 merase backtracking promotes break repair by instigating RecA loading by RecBCD, without the influenc

174 heterotypic fibroblasts, which subsequently instigate reciprocal signaling in the tumor cells.

175 Both warming and acidification instigate reduced calcification in tropical and temperat

176 genic rewiring by transduction of (V12)HaRas instigates regulation of RhoA-ROCK signalling through an

177 armacological agents that target CK2 and PKA instigated relocalization of endogenous APC.

178 fetal trophoblast invading from the placenta instigate remodeling by triggering cell death in vascula

179 Although immune parameters that instigate renal damage have been characterized, their li

180 Whereas ER-GATA-1-instigated repression abolished the -1.8-kb HS, the -3.9

181 nserved C-4 type ZF family of viral proteins instigate reprogramming of plant development by mimickin

182 The advent of autonomous self-propulsion has instigated research towards making colloidal machines th

183 o protein-coding genes and could potentially instigate RNA interference (RNAi) responses.

184 ide pervasive transcription is sufficient to instigate RNAi, and propose that pervasive transcription

185 tudy, we report that model RNA, but not DNA, instigated robust cytokine and chemokine production from

186 est that protein carbonylation plays a major instigating role in cytokine-dependent mitochondrial dys

187 s faithful repair, it is unclear how the AID-instigated S region lesions are converted into DSBs rath

188 anulin (GRN) as the most upregulated gene in instigating Sca1+ cKit- BMCs relative to counterpart con

189 inistration of trichloroethylene for 6 weeks instigated selective complex 1 mitochondrial impairment

190 athways and sensors that are responsible for instigating self-DNA triggered autoinflammatory events i

191 he largest family of membrane receptors that instigate signalling through nucleotide exchange on hete

192 preventing responsiveness to erythropoietin-instigated signals that promote differentiation.

193 preparations for human health should also be instigated, since they can suppress hyperglycemia and in

194 e possibility of a recent progenitor of WPV1 instigating single-source transmission across the countr

195 -1beta, both of which signals through IL-1R, instigates skin inflammation and systemic disease is not

196 le or unwilling to stop smoking, they should instigate smoke-free homes.

197 tated into negatively charged glutamic acids instigates spontaneous bona fide receptor activator of N

198 al state of the track does not automatically instigate stepping in the absence of an additional stimu

199 t accumulate in AD brains and are thought to instigate synapse damage and memory loss, induce depress

200 of subunit vaccine history as it pertains to instigating T cell responses.

201 otein-coupled receptor (GPCR) kinases (GRKs) instigate the desensitization of activated GPCRs via pho

202 that in RAW macrophages TLR2 is essential to instigate the early immune response to OmpA via NF-kappa

203 tunity for the active enhancer to locate and instigate the expression of Shh.

204 Here, we find that human breast carcinomas instigate the growth of otherwise-indolent tumor cells,

205 The rods may instigate the vascular abnormalities that are the clinic

206 These limitations instigated the development of supramolecular platforms t

207 mosphere of Titan; this observation likewise instigated the study of fundamental chemical processes i

208 Tissue factor (TF) instigates the extrinsic pathway of blood coagulation.

209 rotein pathology in the medial temporal lobe instigates the loss of episodic memory in Alzheimer's di

210 alculations suggest that a B...F interaction instigates the reaction chemistry, the magnitude of whic

211 These data suggest that CLA instigates the release of inflammatory signals from adip

212 eceptors to novel downstream molecules or by instigating their degradation.

213 to resolve conflicts of interest, as well as instigate them.

214 certain whether metabolic derangements might instigate this arrhythmia.

215 The binding of ATP provides the signal to instigate this change, while release of phosphate post-A

216 nto nonphagocytic cells; however, the events instigating this process are incompletely understood.

217 icion, particularly in the acute setting, to instigate timely coordination of appropriate care and ma

218 ptional high mortality of lung cancer can be instigated to a high degree by late diagnosis.

219 Consequently, these studies were instigated to identify sequences within the primary RNA

220 mperative to ensure appropriate measures are instigated to reduce associated morbidity and mortality.

221 -bound ePAB also interacts with eIF4G, which instigates translation initiation of CPEB-bound mRNAs.

222 d binding promotes receptor dimerization and instigates transmembrane signaling and receptor kinase a

223 o initiate appropriate investigations and to instigate treatments that could dramatically improve pat

224 Furthermore, instigating tumor infiltration by T cells sensitized tum

225 We find that BMCs of hosts bearing instigating tumors are functionally activated prior to t

226 Secretion of osteopontin by instigating tumors is necessary for BMC activation and t

227 t- hematopoietic BMCs of mouse hosts bearing instigating tumors promote the growth of responding tumo

228 vel by endocrine factors released by certain instigating tumors, and hold important experimental and

229 BMCs mimic the systemic effects imparted by instigating tumors.

230 , autoimmunity and transplant rejection, DCs instigate unwanted responses that cause disease, but, ag

231 , rather than all cells within a tumour, may instigate VM, supplant host-derived endothelium, and for

232 the propensity for surface-reaching holes to instigate water-splitting chemistry by serially applying

233 pecific CD8(+) T cell populations, which may instigate ways to augment therapies depending on fit CD8

234 d destabilize TCP transcription factors, but instigated weaker changes in leaf morphogenesis than wil

235 infection of neurons, but, as a consequence, instigates ZIKV-associated paralysis.