ライフサイエンスコーパス: instruct

1 n poet Horace said poetry gives pleasure and instructs.

2 een instructed and experienced versus merely instructed.

3 e people, rather than the specific images as instructed.

4 We instructed 12 HSP patients and 12 matched controls to re

5 'hub' through which proinflammatory signals instruct a 'proliferation-permissive' state in NK cells,

6 linked to oncogene-initiated carcinogenesis instruct a long-lived granuloma-resident macrophage diff

7 such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger car

8 is microbial diversity might be necessary to instruct a well-adapted immune response and regulated in

9 Thus, Trx instructs a type II neuroblast functional identity by ep

10 These instructed actions were not fixed but rather were learne

11 Innate immunity instructs adaptive immunity, and suppression of innate i

12 Because innate immunity instructs adaptive immunity, we hypothesized that differ

13 pecific recruitment pattern centered on CatG-instructed adhesion strengthening.

14 How positional information instructs adult tissue maintenance is poorly understood.

15 At the end of the primary trial, we instructed all the participants to avoid peanuts for 12

16 a digital decision for Il4 reexpression, and instructs all reexpressing cells to express the same amo

17 is now recognized that PRRs are paramount in instructing an appropriate adaptive immune response.

18 ssues, where T follicular helper (Tfh) cells instruct and help B cells launch an effective humoral im

19 how differently composed Polycomb complexes instruct and maintain cell fate.

20 e successes and failures of this research to instruct and translate clinical practice.

21 at different periods while monkeys performed instructed and choice eye movement tasks, to determine t

22 between whether a CS-US contingency had been instructed and experienced versus merely instructed.

23 ng a category-independent neural response to instructed and experienced, but not merely instructed, C

24 while monkeys performed saccade tasks toward instructed and freely chosen targets.

25 ndings point to major roles for microglia in instructing and regulating the proper function of the ne

26 ng revealed a hierarchical organisation with instructing and responding roles: an inner, neural linea

27 yos where the maternal gradient Bicoid (Bcd) instructs anterior-patterning (AP) patterning.

28 Here we show the combination of enzyme-instructed assembly and disassembly to target downregula

29 ogy of molecular assemblies formed by enzyme-instructed assembly of small molecules.

30 ortant questions remain about the mechanisms instructing astrocyte cell fate.

31 lt, some journals, since at least 2013, have instructed authors to provide approximate Snellen equiva

32 October 2016, including 3 of 4 journals that instructed authors to provide Snellen equivalents for vi

33 Ligand receptor interactions instruct axon guidance during development.

34 al development, semaphorin-plexin signalling instructs axon guidance and neuronal morphogenesis.

35 ing errors, and typically disappeared during instructed behavior.

36 ow show that a single secreted molecule that instructs both proliferation and death in T cells establ

37 the transformation of selfhood, not by being instructed but by people changing in their own ways.

38 We found that the PVD branch pattern was instructed by adhesion molecule SAX-7/L1CAM, which forme

39 Cell division orientation is instructed by biochemical and mechanical signals from th

40 t that efficient induction of Treg cells was instructed by BTLA(+)DEC205(+)CD8(+)CD11c(+) DCs and the

41 ion in layer-2 suggests that this pattern is instructed by genetic information rather than experience

42 We propose that TlpD localisation is instructed by metabolic activity and protein interaction

43 of unfolded protein response (UPR), which is instructed by multiple transcriptional regulatory cascad

44 so that synaptic plasticity and learning is instructed by prediction error.

45 In one task, sequential movements were instructed by visual cues, whereas in the other task, mo

46 that polarized localization of Delta protein instructs by the progenitor eccentricity is an origin of

47 rs guidepost cells emitting guidance cues to instruct callosal axon navigation.

48 attributable to a MA delivered AdHu5 vaccine instructing CD8(+) T cell expression of CXCR3(+), CD103(

49 identical cationic and hydrophobic structure instruct cell death or cell survival.

50 rategies; however, it remains challenging to instruct cell differentiation within a scaffold to produ

51 ptional networks and epigenetic modifiers to instruct cell fate decisions.

52 ining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific s

53 d are self-selective binding agents for the 'instructing' cell types.

54 ern secretory cell specialization, including instructing cells to develop a unique cytoarchitecture,

55 must elicit information, calm and reassure, instruct, check procedures, ask for and give opinions,ag

56 th and that blood vessels secrete factors to instruct chondrocyte proliferation.

57 As calcium also instructs chondrocyte differentiation and collagen synth

58 to reductions in PN firing that subsequently instruct circuit changes in the cerebellar nucleus.

59 Signaling through the Valpha14-Jalpha18 TCR instructs commitment to the NKT cell lineage, but the pr

60 scriptional regulation of thousands of genes instructs complex morphogenetic and molecular events for

61 firmed, they are going to be a milestone for instructing computational models of brain function.

62 ments were either instructed via color cues (Instructed condition), or chosen by the participant (Fre

63 ned sequences, typically disappearing during instructed control sequences with similar reward expecta

64 echanical properties of the microenvironment instruct crosstalk between different tissues to control

65 perienced CS-US contingencies than to merely instructed CS-US contingencies.

66 o instructed and experienced, but not merely instructed, CS presentations in the human right amygdala

67 ion through increased expression of the TH17-instructing cytokines IL-1beta, IL-6, and IL-23, whereas

68 Decoding the mechanisms that instruct dB1 circuit formation revealed a fundamental ro

69 indicate that sialic acid-modified antigens instruct DCs in an antigen-specific tolerogenic programm

70 ternal world, processing that information to instruct decision-making, and producing a motor action.

71 The task included separate instructed delay periods for object presentation and gri

72 cicularis monkeys were trained to perform an instructed-delay reach-to-grasp task in the dark and in

73 able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylat

74 ection; however, the signaling pathways that instruct developing memory CD8 T cells to distribute to

75 re, we identify a radial signaling axis that instructs developing islet cells to disperse throughout

76 e an array of cues from somatic tissues that instruct developmental processes.

77 he mouse anterior lateral motor cortex (ALM) instructs directional movements, often seconds before mo

78 brillator use and high-performance CPR), and instructing dispatch centers on recognition of cardiac a

79 remains unclear how distinct TCR signalling instructs distinct developmental outcomes.

80 We show that aggregation method instructs EB lineage bias, with faster aggregation promo

81 substrates for growth and survival, but also instruct effector functions, differentiation, and gene e

82 Subjects were instructed either to not intervene with the imposed pert

83 urons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus.

84 ion of the carrier biophysical properties to instruct entrapped human MSCs and ECFCs to simultaneousl

85 r the kidney's urine-concentrating function, instructs epithelial cells to produce chemokines that lo

86 Notch signaling instructs equivalent cells to form precise differentiati

87 brain regions containing movement plans for instructed (externally driven) movements, areas involved

88 Therefore CD5 instructs extrathymic Treg cell development in response

89 cells shape their local microenvironment by instructing fibroblasts to support Th17 cell infiltratio

90 ding training and feedback on new guidelines instructing for explicit targets for arterial oxygen ten

91 n to have selective persistent activity that instructs future actions.

92 MJD3 partner to alter the cardiac epigenome, instructing gene expression changes that drive cardiac d

93 on by regulating the transcriptional program instructing goblet cell development.

94 The signals that instruct hepatocytes to induce timely VEGF remain uniden

95 relay within the developmental HSC niche to instruct HSC fate.

96 dings reveal a novel transcription mechanism instructing HSC fate by pausing-mediated differential re

97 d PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is targeted to spec

98 web resource, will inform ongoing efforts to instruct HSPC ex vivo amplification and formation from p

99 ysis in human preimplantation development to instruct human stem cell biology.

100 Here, we instructed human volunteers to classify words with later

101 AT5 as a central node in the TF network that instructs ILC development, homeostasis, and function and

102 a demonstrate that resident epithelial cells instruct immune cells, highlighting the central role of

103 ant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapie

104 Here we show that memory T cells instruct innate cells to become potent effector cells in

105 known about how these extracellular factors instruct innate immune cell epigenomes to engage specifi

106 d initiate a tissue-wide anti-viral state by instructing innate immune cells.

107 erning topical steroids, the most frequently instructed item was "Explanation of application site"(86

108 subtype-specific transcription factors (TFs) instruct key features of neuronal function and connectiv

109 ular signaling mechanisms by which cytokines instruct lineage choice.

110 Under an instructed low-Ca and low-Na diet, urinary pH was higher

111 ther, these data show that tubular cells can instruct macrophage activation by secreting GM-CSF, lead

112 and mitochondrial oxidative phosphorylation instructs macrophage inflammatory polarization and shape

113 cluding cytokines and types of inflammation, instructs macrophage specialization.

114 this review, we discuss the mechanisms that instruct macrophages to adopt pro-inflammatory, pro-woun

115 While spontaneous activity has been shown to instruct map formation in sensory circuits, it is unknow

116 Observational or controlled trials instructing medical professionals in direct or fiberopti

117 ue the adhesive capacity of the surfaces and instruct mesenchymal stem cell (MSC) response.

118 It instructs most DNA polymerases to preferentially insert

119 e the stem cell niche within a tissue and to instruct MSC toward the creation of regeneration-permiss

120 emokine CXCL12, but whether a separate niche instructs multipotent progenitor (MPP) differentiation r

121 s may influence OPC function and selectively instruct myelination of an active neural circuit.

122 y-stimulating factor (CSF-1; M-CSF) directly instructed myeloid commitment in HSCs.

123 Microvascular ECs instruct neighboring cells in their organ-specific vascu

124 The mechanisms instructing neural stem cells to generate the appropriat

125 tive ion channels, is critically involved in instructing neuronal growth in vivo.

126 dynamics whereby ingression of pioneer cells instructs neuronal specification.

127 important mechanism by which G-CSF and M-CSF instruct neutrophil versus monocyte lineage choice, i.e.

128 vitamin D3, or vitamin D3 and dexamethasone instructed NK cells to secrete lower amounts of IFN-gamm

129 S cell- and adult progenitor-derived, GM-CSF-instructed, nonconventional DC subsets.

130 Participants will be instructed not to change their exercise habits during th

131 during the trials in which participants were instructed not to encode the presented stimulus.

132 Bone morphogenetic proteins (BMPs) instruct NSCs to adopt an astrocyte fate and are propose

133 Before the search tasks, a cue instructed observers which item to look for first (curre

134 ma in children and adolescents as well as to instruct on proper biopsy technique of suspicious lesion

135 re given two oral-fluid-based HIV test kits, instructed on how to use them, and encouraged to distrib

136 as knowing, rather than reckless, even when instructed on the relevant legal criteria.

137 cipants attended the clinic monthly and were instructed on the specific types of foods and quantities

138 th the management of patients with ELVO were instructed on the use of the following protocol for pati

139 Participants gave informed consent and were instructed on use of oral fluid based rapid HIV tests.

140 modifications and between species that could instruct ongoing efforts to understand how specific mRNA

141 t neuronal activity and release of glutamate instruct OPCs to differentiate into new myelinating olig

142 key signals to dendritic cells that in turn instruct optimal antiviral CD8 T cell responses.

143 articles can serve as carriers or sensors to instruct or characterize tissue biology.

144 A double-duty lexical decision paradigm instructed participants to detect RW while ignoring nonw

145 echanism that integrates distinct signals to instruct pathological axon degeneration.

146 It is suggested that we should instruct patients to inhaler DPI based on inspiratory re

147 the importance of positional information to instruct pattern formation during regeneration.

148 f the properties of morphogen gradients that instruct patterning.

149 injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation.

150 The extent to which the skin instructs peripheral somatosensory neuron maturation is

151 hat localized MP expression is sufficient to instruct PIN1 polarity directions non-cell autonomously,

152 omoted by EXD1, ensures that the same guides instruct PIWI proteins in the nucleus and cytoplasm.

153 onaute3 to cleave transposon transcripts and instruct Piwi to repress transposon transcription, there

154 sults reveal that glutamatergic synapses can instruct plasticity at electrical synapses, providing a

155 ions and factors that would be sufficient to instruct pluripotent cells to organize the embryo.

156 w lineage-specific transcription factor that instructs PN dendrite targeting.

157 persistent Toll-like receptor (TLR) 2 signal instructs polyploid macrophage fate by inducing replicat

158 Combinations of transcription factors (TFs) instruct precise wiring patterns in the developing nervo

159 and cellular responses to diverse signals by instructing precise spatiotemporal patterns of gene expr

160 es and suggest that central amygdala neurons instruct predatory hunting across jawed vertebrates.

161 thermore, we show that cervical cancer cells instructed primary cervical fibroblasts to produce high

162 ar and cellular processes that progressively instruct proliferating embryonic cells about their ident

163 In contrast, a CCR6/CCL20 chemokine loop instructed rapid increase of B cells in the spleen in re

164 athogens by innate and adaptive immune cells instructs rapid alterations of cellular processes to pro

165 rom those found in studies of experimentally instructed reappraisal or value.

166 essings were applied by nursing staff (or by instructed relatives for some outpatients).

167 egenerative niches capable of recruiting and instructing resident cells toward the formation of a spe

168 second task required participants to make an instructed response.

169 s modulate concurrent RNA-processing events, instruct RNA polymerase where to pause and terminate tra

170 lecular resources to invest in the future of instructing robust embryonic patterning.

171 In a fifth data-set using instructed rules, this bias was strong enough to counter

172 ccadic reaction times, depending on the task-instructed saccade, while rostral stimulations of 8Av/45

173 ted for an interaction between decisions and instructed saccades unrelated to the perceptual decision

174 the motion stimulus but still made the same instructed saccades, and when manual reaction times were

175 molecular and cellular validation of enzyme-instructed self-assembly (EISA) as a multiple step proce

176 Enzyme-instructed self-assembly (EISA) represents a dynamic con

177 Here we show the use of enzyme-instructed self-assembly (EISA) to generate intracellula

178 ding the first direct evidence that the skin instructs sensory neuron molecular and functional matura

179 ng molecules CCL9 and IL-23 as the principal instructing signals for stromal reprogramming.

180 Enhancers instruct spatio-temporally specific gene expression in a

181 ision of existing guidelines is necessary to instruct specific pediatric management.

182 findings, and revealed that both pooled and instructed spot sputum collections were similarly effect

183 y brought their beta oscillatory power to an instructed state and subsequently executed an arm reach.

184 nment, triggering production of signals that instruct stem cell fate choices.

185 vel analyses identified a duration code that instructs stimulus specific crosstalk between TLR4-activ

186 derstanding of the role of these proteins in instructing structural plasticity.

187 modulates the expression of target genes and instructs synaptic growth; a role for synaptic pMad rema

188 istinct structural features are important in instructing synaptogenesis.

189 This 'bacteria-instructed synthesis' can be carried out with a variety

190 is predicated on gene transfer technology to instruct T lymphocytes to recognize and reject tumor cel

191 the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (Fc

192 oduced HGF during priming in the lymph nodes instructs T cell cardiotropism, which was associated wit

193 ial remodeling is a signaling mechanism that instructs T cell metabolic programming.

194 er infection risk in future time periods can instruct targeted prevention and treatment efforts, espe

195 ly, reaching and saccade movements to single instructed targets remained largely intact.

196 al prefrontal cortex, typically observed for instructed task rules, were stratified according to indi

197 ying genes, as well as repressing genes that instruct Th17-cell fate.

198 Although the mechanisms by which they instruct TH2 differentiation are still poorly understood

199 hich PKC-theta drives innate immune cells to instruct TH2 responses in patients with allergic lung in

200 Two experimental groups were instructed that treatment with peripheral low-frequency

201 components and the molecular mechanisms that instruct the assembly of the spinal sensorimotor system

202 DNA (or potentially a simplified genome) to instruct the cell to carry out novel, specific tasks.

203 For example, we instruct the computer "to form a hydrophobic core," "to

204 ex (V1) embodies the target interval and may instruct the decision to time the action on a trial-by-t

205 lished by advanced imaging showing that TAMs instruct the deposition, cross-linking, and linearizatio

206 r GBM progression are therefore necessary to instruct the development of novel targeted agents and en

207 Adhesive interactions in the retina instruct the developmental specification of inner retina

208 al brain sections from patients with SLE may instruct the evaluation of ongoing clinical trials of an

209 Many factors instruct the formation and function of these synapses; h

210 ar recognition properties of the nucleobases instruct the formation of complex three-dimensional arch

211 Our studies reveal that Act-A-iTreg cells instruct the generation of a highly effective immunoregu

212 at function during development to define and instruct the generation of diverse neuronal populations

213 M) development, has been shown to be able to instruct the lineage choice of uncommitted granulocyte M

214 the intrinsic and extrinsic mechanisms that instruct the neurons to form cell type-specific dendriti

215 xanthophores, respectively, and those cells instruct the patterning of the iridophores.

216 orrelation-based plasticity mechanisms could instruct the precise spatiotemporal selectivity that und

217 highly correlated spiking activity that may instruct the refinement of neural circuits.

218 gical pattern formation, can be harnessed to instruct the refinement of postsynaptic receptive fields

219 and embryonic patterning, cell autonomously instruct the targeting of specific classes of PN dendrit

220 tivation and might be necessary for ILC2s to instruct the TH2 response.

221 osome on the hypodermal cells, which in turn instructed the SAX-7 stripes and PVD dendrites.

222 ine the positions of cusp tips in a tooth by instructing the adjacent epithelium to fold and prolifer

223 Instructing the annexin A1-FPR2 axis harbors a novel app

224 and recommendations by Health Canada in 2007 instructing the food manufacturers and restaurants to li

225 esponded to both the onset of the visual cue instructing the monkey to initiate the saccade and again

226 Previously, we showed that retinal input instructs the alignment of V1 inputs in the SC in a mann

227 Our results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell-c

228 enger complex (CPC) and centralspindlin that instructs the cleavage furrow.

229 d suggest a model whereby the dominant input instructs the development of the weaker input.

230 in with a single immunoglobulin (Ig) domain, instructs the distinct, neuron-type-specific elaboration

231 ulatory domain (or expression platform) that instructs the expression machinery.

232 hese results suggest that early connectivity instructs the functional development of the VWFA, possib

233 Here, we show that the cytokine activin-A instructs the generation of CD4(+) T cells that express

234 was hypothesised that DBN protein abundance instructs the integrity and function of synapses.

235 ein laminin conveys spatial information that instructs the migration, process outgrowth, and reorgani

236 The tutorial instructs the reader how to construct the VB diagrams an

237 piratory epithelial cells to respond to and 'instruct' the professional immune system to protect the

238 ion of the Nrp2 gene in MCs is sufficient to instruct their circuit formation from the PV MOB to the

239 e, but the precise signaling mechanisms that instruct their lineage choice are unclear.

240 way impinges upon various organ primordia to instruct their side-specific development.

241 ' erroneous predictions, when monitoring and instructing their learning.

242 ular milieus where they receive signals that instruct them to invade their target tissues.

243 etabolic reprogramming; however, the signals instructing these adaptations remain poorly defined.

244 To address this question, an instructed threat of shock paradigm was used while recor

245 n and unique mechanisms by which macrophages instruct tissue repair in the liver, nervous system, hea

246 fness gradient in the Drosophila egg chamber instructs tissue elongation.

247 ergy with tumor-redirected lymphocytes, they instructed TNFalpha expression, endothelial cell activat

248 requires that the maternal immune system is instructed to a state of tolerance to avoid rejection of

249 , and "depthSTOP" in which participants were instructed to abort their ongoing movements after the ta

250 Twelve participants (instructed to act in three prescribed ways) manually con

251 Parents in the intervention arm were instructed to apply full-body emollient therapy at least

252 regions were stronger when participants were instructed to attend orientation relative to luminance.

253 Patients were offered supportive care and instructed to avoid fasting and continue all their chron

254 heral self-reactive T cells are specifically instructed to become Treg cells.

255 es hypoxia-induced QIPAVA , individuals were instructed to breathe room air and three levels of hypox

256 The institutions were instructed to collect data on 6-hour bundle compliance a

257 74% were instructed to consult an allergologist for adequate diag

258 During retrieval, subjects were instructed to differentiate among new, old, and altered

259 Participants were instructed to discriminate between the standard and oddb

260 deo of a moving hand or spatial cue and were instructed to either execute finger movements associated

261 vidual yawning and, in separate blocks, were instructed to either resist yawning or allow themselves

262 y; thus, program directors were specifically instructed to exclude any preliminary residents in their

263 experimental conditions where subjects were instructed to expect the same CS-US contingencies while

264 Observers were instructed to fixate a visual target while gaze directio

265 dification treatment by a dietitian and were instructed to gradually implement a diet plan based on t

266 5 targets of varying size and value and were instructed to harvest as much reward as possible by eith

267 jumps to a new location and participants are instructed to inhibit the initially planned saccade and

268 Subjects were instructed to look directly at T2.

269 A wait-list control group was instructed to maintain their usual activities during the

270 in an experimental condition were repeatedly instructed to make and act on quantitative comparisons b

271 Critically, animals were instructed to make the choice using one of two actions:

272 rdized self-tonometry training and were then instructed to measure their own IOP under observation.

273 of "syllables." We found that when birds are instructed to modify a syllable in one sequential contex

274 The CD group was instructed to perform exercises 5 times per week or more

275 Organizations were instructed to procure protocols specific to brain death

276 Lung stem cells are instructed to produce lineage-specific progeny through u

277 Even though instructed to rate the specific images, not the people,

278 Patients were instructed to record a 30-second ECG everyday between th

279 tterns (40 degrees apart), participants were instructed to report a perceived motion direction by usi

280 Participants were instructed to respond to the stimuli by a button press.

281 environment within the scanner and were then instructed to retrieve selectively either the particular

282 Patients initiated on ART were instructed to return at 6 and 12 months post-initiation

283 Patients referred to pre-ART care were instructed to return every 6 months for CD4 monitoring.

284 Patients were instructed to return to clinic for routine follow-up at

285 All individuals were instructed to rinse with their respective mouthwash twic

286 man participants (both male and female) were instructed to saccade toward a face or a house that, on

287 When observers were instructed to store one of two simultaneously presented

288 Participants were instructed to take 1 or 2 of these tablets every 8 hours

289 ade available to each patient, and they were instructed to take it as necessary.

290 e lymphoblastic leukemia (ALL) are generally instructed to take mercaptopurine (6-MP) in the evening

291 Volunteers were instructed to take the cobalt dietary supplement in the

292 ontrolled by a stochastic decision in R7 and instructed to the underlying R8.

293 standard oddball paradigm, participants were instructed to view a serial input stream of visual stimu

294 tor the external environment, and in health, instruct tolerance to innocuous inhaled particles while

295 Free-choice trials were interleaved with instructed trials, in which a single cue presented in th

296 Thus, environmental cues instruct TRMs to express CRIg, which functions as an imm

297 Chronic myeloid leukaemia continues to instruct us in the mechanisms of leukaemogenesis and pro

298 e further show that disorders in phyllotaxis instruct us on the parameters governing phyllotaxis dyna

299 rate blocks of trials, movements were either instructed via color cues (Instructed condition), or cho

300 The rule was instructed with a color cue before each delay period and