ライフサイエンスコーパス: instructive

1 ional Cancer Institute-sponsored studies are instructive.

2 s the question of whether these dynamics are instructive.

3 Each signalling pathway has instructive activity: neither acts simply to repress act

4 l and gas deposits in shales demonstrated an instructive agreement with the prediction of the model.

5 een theory and evidence and show by means of instructive analysis and simulation how much of the expe

6 hat these chromatin-remodelling enzymes have instructive and programmatic roles during development.

7 however, and the respective contributions of instructive and selective processes to syntax ontogeny r

8 This gradient is functionally instructive, and represents a multistable, epigenetic an

9 atterns of silent synapses and thus provided instructive animal models to examine the role of NAc sil

10 toprotection point of view to that of a cell-instructive approach is examined, with advances in the u

11 t, we have adopted two parallel and mutually instructive approaches to mimic the human enzyme: firstl

12 ymatic degradation of Abeta fibrils would be instructive as a route to elucidating different structur

13 ndings in Df(16)A(+/-) mice are particularly instructive as they are localized to specific areas with

14 Our data identify an instructive astrogenic program that acts as a binary swi

15 Vocal imitation involves incorporating instructive auditory information into relevant motor cir

16 As a consequence of the polarity defects, instructive auxin gradients as well as embryonic and pos

17 Finally, Netrin localization is instructive because expression in ectopic layers can ret

18 Their activity is instructive because the A-neurons can induce scanning- a

19 nts a first step in the design of novel cell-instructive biomaterial surfaces.

20 cal development of ASIT for allergy has been instructive, but limited understanding of CD4 T cell epi

21 , although diagnosis may be complicated, and instructive cases are described.

22 quency-independent plasticity control by the instructive CF signal based on relative, not absolute, c

23 as the critical parameter contributed by the instructive CF signal.

24 In response to an instructive change in target direction, a neuron express

25 hat comprised at least 100 repetitions of an instructive change in target direction.

26 ves learning that is temporally linked to an instructive change in target motion, and that this may b

27 a single oriented grating) causes immediate, instructive changes in the firing of mouse lateral genic

28 by which physical cues are converted to cell-instructive chemical information to influence cell behav

29 eroxide released from a wound is the initial instructive chemotactic cue for the infiltration of infl

30 of its ligands in cancer, with reference to instructive clinical observations and translational appr

31 how that Dscam expression levels serve as an instructive code for the size control of presynaptic arb

32 ynaptic DSB processing by AdnAB and engender instructive comparisons with the RecBCD and AddAB clades

33 ropose that a terminal calcium wave is a key instructive component of the axon degeneration program.

34 adhesion protein E-cadherin functions as an instructive cue for cell division orientation.

35 esults support the model that Pyr acts as an instructive cue for mesoderm migration during gastrulati

36 this study, we report a role for Wnt5b as an instructive cue to regulate gastrulation movements throu

37 ins are one of the largest families of these instructive cues and are widely studied for their effect

38 Alginate hydrogels containing cell-instructive cues are the subject of intense interest for

39 t Dlg1 localization may additionally provide instructive cues for spindle orientation.

40 the local extracellular environment provides instructive cues for the regenerative process.

41 Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche to main

42 y of neural crest cell-intrinsic factors and instructive cues from the surrounding gut mesenchyme.

43 ting potentials among non-excitable cells as instructive cues in embryogenesis, regeneration, and can

44 How instructive cues present on the cell surface have their

45 ocation for brain tumor spread; however, the instructive cues responsible for this unique tropism wer

46 ory input; however, the experience-dependent instructive cues that organize retinotopy are unclear.

47 rein Notch signaling in vSMCs provides early instructive cues to neighboring ECs important for optima

48 muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites.

49 ce, using a two-action sequence task without instructive cues.

50 IL-33 is an instructive cytokine of type 2 inflammation whose expres

51 phenotype shortly after birth in response to instructive cytokines, and then self-maintain throughout

52 radients in HCM has triggered a periodic and instructive debate.

53 evelopmental history of a tissue is a highly instructive design template for the discovery of novel b

54 st, thus illustrating that miRNAs can act as instructive determinants of cell fate during development

55 n HSC niches, where they encountered lineage-instructive differentiation signals.

56 sms provide a symmetry-breaking seed for the instructive effects of visual experience.

57 it is not known whether the vasculature has instructive effects on the epithelium.

58 y for a requirement for endothelial cells in instructive epithelial patterning, we developed a novel

59 expected and obtained reward for generating instructive error signals.

60 Our results demonstrate that stochastic and instructive events differentially contribute to shaping

61 Copepod myelin is an instructive example of convergent evolution, with far-re

62 These findings represent an instructive example of how a positive regulator of an in

63 y from ischemic heart disease, as well as an instructive example of the challenges in obtaining and i

64 This tutorial review discusses instructive examples that have substantially broadened t

65 Our own Galaxy's SMBH provides an instructive exception, and we present a close-up view of

66 How instructive experience acts on the juvenile brain to tri

67 epends on the brain's capacity to respond to instructive experience and is often enhanced during a ju

68 ggest that behavioural learning results when instructive experience is able to rapidly stabilize and

69 important for the learned behaviour; second, instructive experience rapidly stabilizes and strengthen

70 of mitotic spindle alignment in response to instructive, external cues.

71 Recently, however, it is suggested that instructive extrinsic signals from the trunk and apical

72 we implicate endogenous bioelectricity as an instructive factor during brain patterning in Xenopus la

73 ctor, involved in lymphocyte survival, or an instructive factor, involved in lymphocyte differentiati

74 or passively confer competence to respond to instructive factors.

75 RNA and transcription factors interact in an instructive fashion in normal and malignant hematopoiesi

76 ely establish retinal waves as necessary and instructive for circuit refinement in the developing ner

77 seizures and epileptiform activity that are instructive for clinical practice and highlight similari

78 are highly expressed, our findings might be instructive for cost-effective experimental designs in N

79 This strategy might be instructive for designing assembly of various nanopartic

80 nfections, such as HIV and tuberculosis, are instructive for developing a more rational approach for

81 Notch is permissive but not instructive for differentiation of multiple cell types.

82 nvestigate H2O2 in AD brains and can be very instructive for drug development.

83 s suggest that asymmetric auxin distribution instructive for gravity-induced differential growth is c

84 rvous system; such activity is thought to be instructive for guiding developmental processes.

85 These findings are instructive for lignin engineering strategies to improve

86 genetically engineered mice (GEM) have been instructive for partly elucidating the cellular and mole

87 le transformations indicate that the code is instructive for sexual dimorphism.

88 hese genes in polarity is independent of and instructive for tail formation.

89 to the features of retinal waves that may be instructive for the formation of retinotopic maps.

90 erns encoded in the waves are believed to be instructive for the wiring of functional connections thr

91 ecific receptor guanylyl cyclases (rGCs) are instructive for thermosensation.

92 Genetic manipulation shows that the BM is instructive for tissue elongation and the determinant is

93 While it is clear that neural activity is instructive for topographic alignment of inputs from the

94 These results provide an instructive framework for assessing mechanisms of acquir

95 n altered chromosomes, indicating a powerful instructive function for CTCF in chromatin folding.

96 ggesting that BMP antagonists do not have an instructive function in sclerotome specification.

97 used inducible lineage-tracing from the MPC-instructive gene Ptf1a to define systematically in mice

98 ive domain and recruited other pancreas-fate-instructive genes, thereby spatially enlarging the poten

99 This paper provides instructive guidance on the usage of cooking technologie

100 these systems and explore the concept of an instructive heparan sulfate sugar code for modulating ve

101 ts program the precise PSC expression of the instructive Hh signal.

102 question, we planned to ectopically express instructive human FANCC (hFANCC) mutants in murine Fancc

103 ir interplay creates chaos is explained with instructive illustrations but without any equations.

104 olving the puzzle of homochirality, but also instructive in chiral separation and stereoselective cat

105 Mouse models are instructive in developing a mechanistic understanding of

106 ctrometry and ion mobility (IM-MS), are also instructive in exploring conformational landscapes in th

107 ine if these changes in gene expression were instructive in human disease, we compared our liver-spec

108 (OA) were either too slow or too small to be instructive in predicting near-future impacts.

109 Activity can be instructive in refining visual projections by directly m

110 retinal activity is not just permissive, but instructive in the emergence of eye-specific segregation

111 leavage stages in singleton embryos, a novel instructive influence from an early organizer can impose

112 Here we report instructive input of Frizzled-PCP (Fz/PCP) signalling in

113 ell niches, where neighbouring cells provide instructive inputs that govern cell fate decisions.

114 sulting in transmission to the fetus provide instructive lessons that can be applied to the prospecti

115 The spatiotemporally dynamic distribution of instructive ligands within embryonic tissue, and their f

116 tal Cell, Minegishi et al. (2017) uncover an instructive link from Wnt5a/b gradients to PCP-factor-re

117 nd in this context hydrogels can serve as an instructive matrix.

118 the possible His-E7 states as well as in two instructive Mb mutants: Ala-E7 and Trp-E7.

119 ies are not a surprise, providing in fact an instructive measure of the approximations used in the mo

120 nscription suggest drought sets in motion an instructive mechanism guiding epigenetic machinery towar

121 n through two general, inductive mechanisms: instructive mechanisms that act directly on muscle cells

122 hioalveolar stem cells (BASCs), to probe the instructive mechanisms.

123 patterned electrospun meshes will define an instructive microenvironment for guided tissue formation

124 ssible sequence divergence are essential and instructive modalities for functional assessment of huma

125 his form of gestural communication offers an instructive model for examining the origin and evolution

126 Chlorella virus DNA ligase (ChVLig) is an instructive model for mechanistic studies of the ATP-dep

127 lid tumors and provide strong support for an instructive model of oncoprotein-directed epigenetic sil

128 The "instructive" model holds that cell fate is initiated by

129 ed by the kinetic signaling and quantitative instructive models, respectively.

130 Gephyrin is the major instructive molecule at inhibitory synapses, where it cl

131 However, in the CNS, no such instructive molecules have been shown to be required, an

132 te this understanding, the role of Shh as an instructive morphogen is viewed as increasingly complex,

133 KEY POINTS: The inferior olive sends instructive motor signals to the cerebellum via the clim

134 surfaces thus prompting the search for cell-instructive nanoscale patterns.

135 h neurogenic potential and responsiveness to instructive neural patterning cues toward midbrain and h

136 longevity mutants discovered in the lab are instructive of cellular physiology, lab studies might mi

137 e manner of cell death is, therefore, highly instructive of the immunological consequences that ensue

138 ferent blood lineages by acting either in an instructive or a permissive manner.

139 le visual system to test whether activity is instructive or permissive for shaping development of the

140 n the epithelial plane, but whether Wnts are instructive or permissive is debated.

141 is unclear, however, whether Hand2 plays an instructive or permissive role during this process.

142 Whether changes in inhibition have an instructive or permissive role in plasticity remains unc

143 ctivity blockade, but whether TNFalpha is an instructive or permissive signal is not known.

144 eview key molecular regulators which mediate instructive or repellent signals from multiple sources i

145 ples, aiming at providing the reader with an instructive overview on how the wavelength-selective cle

146 erpinnings of glioblastomas has served as an instructive paradigm for other cancers.

147 this interaction may be conserved and is an instructive part of planarian posterior regeneration.

148 newly or previously sequenced evolutionarily instructive pathogenic Escherichia coli O157:H7, O157:H(

149 at chromosomal locations, consistent with an instructive pattern of methylation, and were in part det

150 he developing brain provide an assortment of instructive patterning cues, including Sonic hedgehog (S

151 cieties have dealt with acute stress, a more instructive perspective for the future than is offered b

152 This paper describes a simple, remarkably instructive physical model for examining the eruption of

153 At the end of the instructive placebo procedure, the two experimental grou

154 Instructive polymer scaffolds with a wide range of prope

155 These data demonstrate an instructive positional role for Hofstenia muscle and thi

156 olarization more often occurs as the initial instructive process for patterning ACD especially in the

157 that thymic Treg cell development is a 'TCR-instructive' process involving a niche that can be satur

158 ectories of syntax assembly, suggesting that instructive processes contribute to syntax ontogeny.

159 tor groups, further illustrating the role of instructive processes.

160 tage of NK cell maturation and hinged on the instructive recognition of allogeneic ligand by the acti

161 Retinal waves provide instructive retinotopic information for the anatomical o

162 tatory and inhibitory neurons, suggesting an instructive role and a common downstream synapse additio

163 of an individual animal's experience play an instructive role and influence the tuning parameters of

164 anism, in which VEGF-FLK1 signaling plays an instructive role by promoting Etv2 threshold expression.

165 Retinoic acid was thought to play a key instructive role during limb bud initiation and subseque

166 ce shows that extracellular cues can play an instructive role during neuronal polarization in vitro a

167 f Gata4 to cardiac genes, indicating a novel instructive role for BAF complexes in tissue-specific re

168 ties of spontaneous activity, suggesting its instructive role for generating functional variability i

169 in an Ir25a-dependent manner, suggesting an instructive role for IR21a in thermosensing.

170 These data reveal a new, instructive role for membrane voltage during embryogenes

171 This work reveals an instructive role for patterned spontaneous activity in g

172 eres with cardiac fusion, consistent with an instructive role for PDGF signaling.

173 Our findings demonstrate an instructive role for serotonin in axon guidance acting t

174 ir maintenance, consistent with a transient, instructive role for simple spikes during cerebellar lea

175 issue of Neuron, Timofeev et al. describe an instructive role for the guidance molecule Netrin and it

176 Our findings support an instructive role for the interneuron AVB in controlling

177 ur data suggest that beta1 integrins play an instructive role in CNS myelination by promoting myelin

178 output of a tectal neuron plays an important instructive role in development of its receptive field p

179 rimordium, suggesting that CNC cells play an instructive role in guiding tongue muscle development.

180 inherent histone amplifier activity with an instructive role in impacting the epigenetic landscape,

181 cription factor Tramtrack69 (Ttk69) plays an instructive role in inhibiting the growth of R7 photorec

182 e expression, indicating that EGL-5 plays an instructive role in male gonadal fate determination.

183 circuitry involving miR-9/9*-124 can have an instructive role in neural fate determination.

184 D-induced changes in FS interneurons play an instructive role in ocular dominance plasticity, causing

185 We show that MES-1/Src signaling plays an instructive role in P(2) for asymmetric GPR-1/2 localiza

186 results demonstrate that Rho-kinase plays an instructive role in planar polarity by targeting Baz/Par

187 ence in teleosts that the notochord plays an instructive role in segmental patterning, alongside the

188 s suggest that CySCs do not have a necessary instructive role in specifying GSC self-renewal and that

189 lt plasticity, precise spike timing plays an instructive role in synaptic modification.

190 Thus, our data propose that Nxph1 plays an instructive role in synaptic short-term plasticity and t

191 canonical Notch signaling plays a positive, instructive role in the differentiation of SCs.

192 lated by synaptic activity and thus plays an instructive role in the turnover of synaptic membrane pr

193 on extension, indicating that Ttk69 plays an instructive role in this process.

194 Epo, therefore, has a lineage instructive role in vivo, through suppression of non-ery

195 herefore support a permissive rather than an instructive role of inhibition in ocular dominance plast

196 These results underscore the instructive role of intrinsic mechanisms in synapse form

197 However, the instructive role of microRNAs (miRNAs) in neurogenesis r

198 that provide promising insights into the the instructive role of the bone marrow microenvironment in

199 lls and provides additional insight into the instructive role of the mechanical tumor microenvironmen

200 genous plate to orient correctly, showing an instructive role of the plate in establishing directiona

201 e unable to form biliary tubes, revealing an instructive role of the vasculature in liver development

202 These observations provide evidence for the instructive role of Wnt ligands in vertebrate PCP.

203 ting that the TCR affinity does not play the instructive role, and that restricted presentation of pe

204 thylation and as a modified DNA base with an instructive role.

205 ient to induce this program, revealing a key instructive role.

206 AP NF1 is mutated, showing that Ras plays an instructive role.

207 ell microenvironment from a 'hostile' to an 'instructive' role, thus facilitating the healing or rege

208 dermal origin of Gryllus PGCs and absence of instructive roles for vasa and piwi in PGC formation are

209 Regulated calcium signals play conserved instructive roles in neuronal repair, but how localized

210 lthough it is known that the centrioles play instructive roles in pericentriolar material (PCM) assem

211 ve, indeed, been proposed to exhibit active, instructive roles in the formation of synapses.

212 thetic functional biomaterials have revealed instructive roles of individual extracellular biophysica

213 However, the process by which these instructive roles play out during synaptogenesis is not

214 Such information is useful in designing instructive scaffolds or supporting substrates for neura

215 ze that dextran-based hydrogels can serve as instructive scaffolds to promote neovascularization and

216 ences have already found their way into cell-instructive scaffolds, while others remain largely unexp

217 (GSCs), with CySCs as the proposed source of instructive self-renewal signals.

218 ctions, we asked whether spike timing is the instructive signal at inputs competing for synaptic spac

219 After MET, Notch provides an instructive signal directing cells towards the proximal

220 B, post-crossing commissural axons lacked an instructive signal directing them rostrally along the co

221 of the periocular airpuff that served as the instructive signal for eyeblink conditioning.

222 ic Protein (BMP) family member, provides the instructive signal for initiating vn expression.

223 peed of change of ligand concentration is an instructive signal for patterning.

224 je cells, climbing fiber synapses provide an instructive signal for plasticity at parallel fiber syna

225 These neurons could provide a common instructive signal for reward-seeking and information-se

226 , these data suggest that TNFalpha is not an instructive signal for scaling but rather is critical fo

227 Fluctuating inputs therefore act as an instructive signal for seeds, enhancing the accuracy wit

228 These results identify WntA as an instructive signal for the prepatterning of a biological

229 Auxin acts as an instructive signal in leaf initiation, and its transport

230 ays are involved in transmitting the lineage-instructive signal in primary bone marrow-derived GM pro

231 ve been shown to encode a particular type of instructive signal known as a temporal difference predic

232 climbing fiber (CF) coactivation provides an instructive signal that further enhances calcium transie

233 ior forebrain pathway (AFP), may generate an instructive signal that improves performance in the moto

234 tput of Purkinje cells as well as provide an instructive signal to guide long-term plasticity.

235 is sufficient to transmit the CSF-1 lineage instructive signal.

236 file of mature microglia requires continuous instructive signaling from the intact CNS.

237 To investigate how these instructive signals are encoded, we recorded the activit

238 ar, nonlinear effects on the putative neural instructive signals carried by cerebellar climbing fiber

239 In contrast, putative neural instructive signals carried by the simple spikes of Purk

240 Instructive signals determine whether LTP or LTD is indu

241 l RNAs and suggest they can serve as mobile, instructive signals during development.

242 Tissue-explant experiments uncovered instructive signals emanating from the neighbouring late

243 aminergic neurons ultimately provide the key instructive signals for both appetitive and aversive lea

244 CA1 pyramidal neurons through the PP provide instructive signals for hippocampal long-term synaptic p

245 The same graded impact of instructive signals for plasticity and learning might oc

246 al HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differenti

247 Neural circuits in the spinal cord transform instructive signals from the brain into well-coordinated

248 esults suggest that MyD88 signaling mediates instructive signals in DCs and secretion of IL-1beta and

249 as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation an

250 ays in the chick are unsuitable for studying instructive signals in neural induction.

251 in erythroblasts, sensitizing HSCs to T-cell instructive signals in the BM.

252 Our results indicate that instructive signals in the climbing fibers are not neces

253 gned training conditions that did not elicit instructive signals in the climbing fibers, but neverthe

254 However, recent work on the ChP and instructive signals in the CSF have sparked new hypothes

255 uggesting that Wnt5 and Sfrp proteins act as instructive signals in this process.

256 Instructive signals mediated by changes in resting poten

257 tion of HSCs is dependent on the presence of instructive signals on the ventral side of the vessel.

258 cell help for cellular immunity is guided by instructive signals received during DC maturation, as we

259 The dermal papilla (DP) provide instructive signals required to activate epithelial prog

260 are thought to be involved in generating the instructive signals that drive cerebellar learning.

261 the cerebellar cortex is thought to provide instructive signals that drive the induction of motor sk

262 e we show that bitter and sweet TRCs provide instructive signals to bitter and sweet target neurons v

263 gether groups of Purkinje neurons to provide instructive signals to downstream sites in the cerebella

264 an important part of the pathway that relays instructive signals to the amygdala.

265 ABSTRACT: The inferior olive conveys instructive signals to the cerebellum that drive sensori

266 erived permissive signal with stress-induced instructive signals, adjusting ISC proliferation to envi

267 ack to a pluripotent state under appropriate instructive signals.

268 Charney has provided an instructive snapshot of where we are in meeting this cha

269 this information metric is quantified in an instructive statistically exactly solvable test model wi

270 Finally, an instructive statistically nonlinear model with many degr

271 ndritic calcium that marks the occurrence of instructive stimuli during cerebellar learning.

272 sponses to periocular airpuffs that serve as instructive stimuli during cerebellar-dependent eyeblink

273 log information that encodes the strength of instructive stimuli trial-by-trial.

274 are all-or-none and only signal whether the instructive stimulus has occurred, without providing par

275 hat reduce inhibition, when combined with an instructive stimulus, could facilitate restructuring of

276 er linking cellular hierarchy regulation and instructive stromal elements.

277 Radial glia therefore provide an instructive structural matrix to coordinate the generati

278 er time, and its nuclear translocation is an instructive switch that allows the animal to ignore pers

279 lity that targeted presynaptic modulation of instructive synapses could provide a general mechanism f

280 axial motoneurons that progressively rely on instructive synaptic drive to shape their oscillatory ac

281 The information presented here is instructive to clinicians, basic science investigators,

282 gside in vivo and in vitro techniques, it is instructive to consider in vacuo methodologies: for exam

283 role in the etiology of human cancer, it is instructive to consider mechanisms underlying normal GAT

284 ocesses and their relative importance, it is instructive to develop physiologically representative ma

285 al failures of mouse genetic modeling can be instructive to human tumor biology.

286 e absence of new drug development, it may be instructive to look back at the research methods used du

287 DA) receptor-dependent Ca(2+) transients are instructive to minicolumn organization because Crispr/Ca

288 These results are instructive to the development and improvement of predic

289 hese lineage-specific molecular programs are instructive to the development of distinct vascular arch

290 pertinent for aging in general and that are instructive to understand naive T cell dysfunction.

291 kine-driven ES-DC development and acts as an instructive tool for the generation of mature DCs with e

292 ntials sweep across the retina, providing an instructive topographic signal based on the correlations

293 Using a combinatorial screen for lineage-instructive transcription factors, we identified a pool

294 n in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP ident

295 Theory and evidence suggest that instructive UCS inputs to the amygdala will be inhibited

296 In addition to the instructive value of our study, we believe that the insi

297 as FGRS), and then propagated on serum-free instructive vascular niche monolayers to induce outgrowt

298 nutrients and oxygen, but also establish an instructive vascular niche, which through elaboration of

299 An instructive way to investigate the relationship between

300 minus and a well-folded core that differs in instructive ways from the crystal structure of a PaePE*M