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1 eral (dl)PFC], and a salience network (e.g., insula).
2  the anterior cingulate cortex and bilateral insula.
3 te/presupplemental motor area or by anterior insula.
4 nd paralimbic areas such as the amygdala and insula.
5 ors within the ventral striatum and anterior insula.
6 ht inferior parietal cortex and the anterior insula.
7 ex (OFC), and another was found in posterior insula.
8  posterior and mid-/anterior portions of the insula.
9 ng their respective effects via the anterior insula.
10 , the intraparietal sulcus, and the anterior insula.
11 ntal cortex, anterior cingulate and anterior insula.
12 ulate cortex, hippocampus, hypothalamus, and insula.
13 frontal pole, cingulate cortex, and anterior insula.
14 or social behavior, such as the amygdala and insula.
15 reased in some brain regions, including left insula.
16 preferences in anterior cingulate cortex and insula.
17  error across the whole brain and within the insula.
18 l anterior cingulate, right insula, and left insula.
19 C between the DLPFC and the left putamen and insula.
20 f TSPO VT in the prefrontal cortex, ACC, and insula.
21 roanterior and ventral middle regions of the insula.
22 e in thalamus, caudate nucleus, and anterior insula.
23 reased GBCr in the lateral PFC, caudate, and insula.
24 ula, as well as bilateral regions of the mid-insula.
25 precuneus, superior temporal gyrus (STG) and insula.
26 rmalities of the frontal lobe, amygdala, and insula.
27 obtained by direct stimulation of mid-dorsal insula.
28 mical and histological features of the human insula.
29 ng potential increased in right amygdala and insula.
30 neural responses to laughter in the anterior insula.
31 responses to SS in the precentral cortex and insula.
32 ucleus accumbens, and anterior and posterior insula, 2) to unexpected reward receipt in the anterior
33  lateral pallium-originated areas (e.g., the insula) [5, 6].
34                                          The insula, a structure involved in higher order representat
35              Although increased amygdala and insula activation is associated with impaired emotion re
36                                 Furthermore, insula activation mediates the effect of experience on t
37 avioral observation was strongly mediated by insula activity during sunk cost decision-making.
38                                              Insula activity elevated during stress compared with res
39                      Furthermore, a shift in insula activity occurred during the recovery period, aft
40                                          Mid-insula activity was negatively correlated with food plea
41 rienced traders exhibit lower right anterior insula activity, but no differences in nucleus accumbens
42             Neural responses in the anterior insula (AI) (but not temporoparietal junction [TPJ]) enc
43                                 The anterior insula (AI) and mid-anterior cingulate cortex (mACC) hav
44 amine volumetric alterations in the anterior insula (AI) as a potential biomarker for the course of c
45 to the ventral striatum (VS) or the anterior insula (AI) during reward anticipation regardless of mot
46 nterior cingulate cortex (dACC) and anterior insula (AI), have been shown to be equally sensitive to
47 ith narcissistic features, in right anterior insula (AI).
48 s that nucleus accumbens (NAcc) and anterior insula (AIns) activity inversely predict risky choice, s
49  mu-opioid system activation in the anterior insula (aINS), the amygdala (AMY), the NAc, the thalamus
50 CL homolog represents a field homolog of the insula, although additional studies are required to unde
51 cortices) and emotional and limbic activity (insula, amygdala).
52 tively correlated with responsiveness of the insula, amygdala, and dorsomedial prefrontal cortex duri
53  and anxiety (such as the prefrontal cortex, insula, amygdala, and hippocampus).
54 s also exhibited significantly decreased mid-insula, amygdala, and orbitofrontal activity while atten
55 identified gray matter reductions within the insula, amygdala, frontal and temporal regions in youths
56  The ventromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray
57 xts was not reflected in the activity of the insula-amygdala of the antOFC or vlPFC-lesioned hemisphe
58  volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region enc
59 pronounced cortical thinning in the anterior insula and a greater increase in the thickness of the ve
60  cortex and thalamus, as well as in the left insula and adjacent temporo-parietal areas.
61      [(18)F]fluorodeoxyglucose uptake in the insula and amygdala of the intact hemisphere was signifi
62            Activations in the right anterior insula and amygdala were markedly reduced when participa
63 ience-related limbic activity, including the insula and amygdala, were attenuated at 4 weeks.
64  prefrontal cortex and the salience network (insula and anterior cingulate cortex).
65 g distraction and conflict, including in the insula and anterior cingulate.
66  several forebrain structures, including the insula and attentional activation of the PAG.
67 a pervasive disconnection involving anterior insula and attentional networks compared with participan
68 ctural connectivity between the amygdala and insula and between the rACC/vmPFC and cognitive control
69 s showed hyperactivity in the right anterior insula and bilateral cerebellum, and hypoactivity in the
70 ontal cortex of the reward circuit; anterior insula and cingulate of the salience network; and a subr
71 ymptom severity, increased activation in the insula and DLPFC, and decreased DLPFC Glx.
72  Two distinct regions of the insula-anterior insula and dorsal mid-insula-exhibited a significant (p<
73 pruning was associated with the responses of insula and dorsolateral prefrontal cortices to the recei
74   Reduced effective connectivity between the insula and executive networks was found in individuals w
75 stimuli correlated with left dorsal anterior insula and frontal pole atrophy.
76 ized reductions, with the largest effects in insula and frontotemporal regions; and Biotype3, small r
77 significantly increased in temporal regions, insula and fusiform gyrus, consistent with those areas k
78        Lower cortical thickness in bilateral insula and higher thickness in bilateral temporal pole w
79 on of prediction error responses in anterior insula and insula-vmPFC connectivity during self-esteem
80 icipated guilt was modulated in the anterior insula and interpersonal psychopathic traits: anterior i
81                   Tight coupling between the insula and lateral prefrontal cortex was also observed d
82  correlated with BOLD reduction in the right insula and left paracentral cortex in response to SS.
83 ization at two such loci: the right anterior insula and left ventral hippocampus.
84  increased connectivity between the anterior insula and medial PFC (mPFC) in the uncontrollable and i
85 BA 3a), and with cortical thickness in their insula and medial prefrontal cortex.
86 al insula regions and ventral striatum, left insula and middle orbitofrontal cortex (OFC), and right
87  contraction over time in a region including insula and orbitofrontal, rostral, and dorsolateral pref
88 e medial prefrontal cortex with the anterior insula and other pain-processing regions.
89 rtex, premotor cortex, primary motor cortex, insula and posterior parietal cortex, as well as in cont
90 work regions, as well as within the anterior insula and presupplementary/supplementary motor areas, c
91 ed, in the preterm brain, regions around the insula and putamen using neonatal deformation-based morp
92  They also presented reductions in the right insula and right ACC compared to nonamnestic MCI patient
93 correlated with atrophy in right ventral mid-insula and right amygdala.
94      Self-esteem had an impact on precuneus, insula and STG activation during stress across the whole
95 ntral gyrus) and decreased activation in the insula and superior temporal gyrus (P < 0.01 for all).
96 arietal junction), pain processing (anterior insula and supplementary motor area), and identification
97 tex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10
98  explained by reduced perfusion to posterior insula and thalamus.
99 ir minds more showed less BOLD signal in the insula and the amygdala when evaluating counterevidence.
100                            More broadly, the insula and the dorsal anterior cingulate cortex (dACC) a
101 ience network (SN), anchored in the anterior insula and the dorsal anterior cingulate cortex, plays a
102 ith the pre-treatment activities of the left insula and the left rostral and pregenual anterior cingu
103  pretrial activity within bilateral anterior insula and the presupplementary motor area/supplementary
104 -known areas of the central pain matrix: the insula and the somatosensory cortex.
105 tate functional connectivity between the mid-insula and the ventral striatum and ventral pallidum.
106 summarize the physiological functions of the insula and underscore its pathological roles in psychiat
107 toparietal attention, and bilateral anterior insula) and inferred spontaneous interactions among thes
108 ial prefrontal cortex, cingulate cortex, and insula) and lower activation in self-reference regions (
109 aving and interoceptive processing (anterior insula), and conflict monitoring (e.g., anterior cingula
110  and thalamus), salience detection (anterior insula), and learning and memory (caudate and parahippoc
111 reward receipt in the anterior and posterior insula, and 3) to unexpected reward omission in the caud
112  during anxious rumination in the dorsal mid-insula, and activation in this region during stomach int
113                        Finally, higher dACC, insula, and amygdala activation before treatment were si
114 trophy involving the mesial temporal cortex, insula, and amygdala, regions previously suggested to be
115 ectivity with intraparietal sulcus, anterior insula, and dACC seeds.
116 including temporal pole, fusiform gyrus, and insula, and extending into occipital cortex (left hemisp
117  of regions including the amygdala, anterior insula, and fusiform cortex, even after accounting for p
118 e variable) RSFC between MPFC and regions of insula, and higher severity of depression was related to
119 )C]DASB binding potential in right amygdala, insula, and hippocampus, whereas [(18)F]MPPF binding pot
120          Activity in the parietal operculum, insula, and inferior and superior frontal gyri was posit
121 egions: the dorsal anterior cingulate, right insula, and left insula.
122 ctivation of bilateral putamen and posterior insula, and machine learning algorithms identified robus
123 udate, nucleus accumbens, amygdala, anterior insula, and orbitofrontal cortex (n = 18 had analyzable
124 bic regions and from the anterior cingulate, insula, and orbitofrontal cortical areas.
125 N than male nonsmokers in prefrontal cortex, insula, and precuneus, but the BEN sex difference in smo
126 bstance disorders, with a focus on amygdala, insula, and prefrontal cortex activation and their funct
127 duced a bilateral deactivation of claustrum, insula, and putamen, areas activated during itch process
128 rk, left dorsolateral prefrontal cortex, and insula, and reduced connectivity between the hippocampus
129 ala, striatum, hypothalamus, midbrain, right insula, and right dorsolateral prefrontal cortex (DLPFC)
130 the superior temporal gyrus, Heschl's gyrus, insula, and striatum in the right hemisphere, clearly di
131 matosensory representation in the mid-dorsal insula, and suggest that this part of the insula may be
132            We found that anterior cingulate, insula, and superior temporal gyrus correlated with emot
133 anterior cingulate cortex, caudate, anterior insula, and thalamus were more likely to exhibit problem
134 salience network (dorsal anterior cingulate, insula, and thalamus) showed early learning task-related
135 ward processing, including ventral striatum, insula, and thalamus.
136 as the superior and middle frontal gyri, the insula, and the occipital cortex.
137 est association), amygdala, parahippocampus, insula, anterior and posterior cingulate cortex, and sev
138 ition suggest that regions such as amygdala, insula, anterior cingulate cortex, and hippocampus play
139 ctivation of pain-processing regions such as insula, anterior cingulate cortex, and thalamus.
140 escents displayed an increased activation of insula, anterior cingulate, and prefrontal cortex in res
141                  Two distinct regions of the insula-anterior insula and dorsal mid-insula-exhibited a
142 in frontal and temporal lobes, amygdala, and insula are less consistent.
143 g; and add to the literature implicating the insula as a key brain region in addiction.
144  anterior and posterior sectors of the right insula, as well as bilateral regions of the mid-insula.
145 onnectivity measurements of the amygdala and insula at the earliest stage of development.
146 sures, we noted differences earliest for the insula (at 10 years before expected symptom onset, mean
147 ault and salience network regions (bilateral insula) at the beginning of the task, followed by increa
148 somedial prefrontal cortex (dmPFC), anterior insula, bed nucleus of the stria terminalis, thalamus, a
149 ngulate cortex (ACC), prefrontal cortex, and insula between 14 medication-free patients in a major de
150 abitual action selection activated bilateral insula, bilateral dorsal caudate and left precentral gyr
151 mus, primary somatosensory cortex, bilateral insula, bilateral striatum, and key structures of the de
152 osterior OFC through the anterior and middle insula, bracketed by the two cortical hotspots.
153 ss commodities, particularly in the anterior insula, caudate, anterior cingulate, medial frontal gyru
154 tified dorsal mPFC and a region in posterior insula/caudate in which female but not male PG participa
155 and temporoparietal junction, as well as the insula, cingulate cortex, and fusiform gyrus, a regional
156 ost of the default mode network, such as the insula, cingulate cortices, temporal lobe, parietal lobe
157 tion in a network of cortical (motor cortex, insula, cingulate, amygdala) and sub-cortical (putamen,
158 antly stronger inter-subject correlations in insula, cingulate, medial and lateral prefrontal, superi
159 ng of tonal information and reduced auditory-insula connectivity are critical determinants of social
160 althy comparison groups differed in amygdala-insula connectivity during the threat-attention task.
161 tory-level dysfunction and impaired auditory/insula connectivity in the pathophysiology of social cog
162 esses associated with dysfunctional amygdala-insula connectivity that are not targeted by CBT alone.
163 reas rsfMRI analyses showed reduced auditory-insula connectivity.
164 ffective for patients with abnormal amygdala-insula connectivity.
165  in the subgenual anterior cingulate cortex, insula cortex, and left amygdala, brain regions involved
166 tween auditory and medial temporal (anterior insula) cortex.
167      In an independent cohort, we found that insula-dACC connectivity was stable over 1-h delay and w
168                                      Greater insula-dACC coupling at rest was significantly correlate
169 igh-ED cues compared with low-ED cues in the insula, declive, and precentral gyrus were negatively re
170 of multiple regions with precuneus, anterior insula, dorsal anterior cingulate cortex (dACC), and lef
171 owed hyperresponsiveness of the amygdala and insula during fear conditioning, as well as hyporesponsi
172 m hypoactivation of the cuneus and posterior insula during reward processing.
173  occipital and parietal cortex and bilateral insula during sustained inhibition in both groups.
174 l rewards; reduced activation in putamen and insula during the anticipation of potential losses; and
175 e predictive coding model, whereas posterior insula encoded stimulus intensity.
176 of the insula-anterior insula and dorsal mid-insula-exhibited a significant (p<0.05) interaction betw
177 motions, as is the amygdala for fear and the insula for disgust.
178 ity disruptions within the amygdala-frontal, insula-frontal, and insula-sensorimotor circuits.
179 e language network, namely the left anterior insula/frontal operculum (AI/FO) and the visual word for
180 RI offers a powerful approach for evaluating insula function, and could be a useful probe for examini
181 ce imaging (fMRI) to examine whether altered insula functioning underlies visceral interoception in A
182 in additional hedonic (orbitofrontal cortex, insula, globus pallidus, putamen, hippocampus, and amygd
183 ed and ranked as follows: cingulate cortex > insula &gt; caudate/putamen > frontal cortex > temporal cor
184 visceral interoceptive processing within the insula has been hypothesized to be an important mechanis
185 r volume in the striatum, prefrontal cortex, insula, hippocampus and temporal cortex in methamphetami
186     Both hubs were biased by inputs from the insula identified from seed-based connectivity.
187 ed hypoactivation within a region of the mid-insula implicated in interoception, with no difference o
188 ults suggest a central role for the anterior insula in coding the anticipation of guilt regarding pot
189 Neuroimaging studies indicate a role for the insula in connecting the interoceptive awareness of toba
190 ual awareness, demonstrating the role of the insula in integrating interoceptive and exteroceptive si
191 brain and striatum, orbitofrontal cortex and insula in methamphetamine-dependent participants, but a
192 h increased structure and function in BG and insula in OCD patients, but a reduction in ASD patients,
193 ulate gyrus, cuneus and occipital gyrus, and insula in response to milkshake receipt predicted greate
194 ctivity between dorsolateral PFC (dlPFC) and insula in the controllable task were observed.
195 , we demonstrate aberrant involvement of the insula in the default mode network and the frontal front
196 t projections from the prefrontal cortex and insula, including glutamate, to the basal ganglia and ex
197 a key node of the salience network (anterior insula) increased linearly across the lifespan across da
198 otable decrease in the diversity of anterior insula intermodular-interconnections (participation coef
199 e conclude that the dorsocentral part of the insula is a key element of the system that modulates the
200          These results confirm the right mid-insula is a key node in the interoceptive network, and i
201 ed by recent human neuroimaging studies, the insula is re-emerging as an important brain area not onl
202               Moreover, the ventral anterior insula is required for both processes.
203 d with decreased grey matter in the anterior insula, lateral orbitofrontal cortex, anterior cingulate
204 significant differences in ventromedial PFC, insula, lateral PFC, pre-SMA, and dmPFC.
205 and cortical regions including the striatum, insula, lateral prefrontal cortex and anterior cingulate
206 (pHPC; F(2,685)=3.74, p<0.024) and bilateral insula (left: F(2,685)=6.87, p=0.0011; right: F(2,685)=5
207 mes in anterior cingulate cortex (ACC), left insula, left secondary somatosensory cortex, bilateral t
208 ain responses in the left and right anterior insula, left ventral hippocampus, dorsolateral and dorso
209 timulation of a relatively delimited zone of insula, located in its mid-dorsal part (posterior short
210 al insula, and suggest that this part of the insula may be an integrated oral sensory region that pla
211 ble strategies through which the role of the insula may be further understood for both basic and clin
212 E and 9.3 [2.2] in controls), and 33% in the insula (mean [SD] TSPO VT, 12.9 [3.7] in patients with M
213 cated bilaterally and appeared in the medial insula, medial cingulate cortex, secondary somatosensory
214  connectivity involving the caudate nucleus, insula, medial prefrontal cortex and other domain-specif
215  widespread brain network (superior frontal, insula, middle and superior temporal, putamen, lingual,
216  interpersonal psychopathic traits: anterior insula modulation of anticipated guilt was weaker in ind
217 ctivity between the right frontoparietal and insula networks was present in participants with melanch
218 ior frontal gyrus of DMN, and right anterior insula of SN.
219  wherein interoceptive processing in the mid-insula of withdrawal signals from the body potentiates t
220  the strength of the causal influence of the insula on the dorsolateral prefrontal cortex in cocaine
221 ural and hemodynamic activity shows that the insula, one of the most densely connected hubs in the de
222 ability of receiving such stimulation in the insula only in stimulation-avoidant individuals.
223 here with ipsilateral BOLD activation in the insula only; and in the right hemisphere in both the ins
224 8-.79; P = .010) and lesions outside the TL, insula, or cingulate (OR, 0.37; 95% CI, .18-.74; P = .00
225  reward, and emotional processing (thalamus, insula, orbitofrontal cortex, hippocampus, and anterior
226 x 10(-17)); they most often connected to the insula (P < 6 x 10(-17)).
227 out, most robustly in the ACC (p = .008) and insula (p = .023).
228 ntal cortex (p = .342, Cohen's d = 0.38) and insula (p = .466, Cohen's d = 0.29).
229 a distributed network of regions such as the insula, parietal cortex, and somatosensory areas, which
230                                          The insula plays a critical role in maintaining nicotine dep
231 n interoceptive activity within the left mid-insula predicted the increase in smoker's pleasantness r
232 ly associated with gray-matter volume in the insula, prefrontal cortex, amygdala, temporal cortex, oc
233 middle orbitofrontal cortex (OFC), and right insula projecting to gyrus rectus and medial OFC.
234             The taste cortex in the anterior insula provides separate and combined representations of
235                 Finally, we also showed that insula reactivity to smoking cues correlates with a rise
236  white matter connectivity between bilateral insula regions and ventral striatum, left insula and mid
237 between auditory cortex and medial temporal (insula) regions was assessed in 55 patients/51 controls.
238     Specifically, gray matter volumes of the insula relate to brain energy content in obese participa
239  and function of left basal ganglia (BG) and insula relative to control subjects and ASD patients, wh
240 on of olfactogustatory representation in the insula remains controversial.
241  dorsal anterior cingulate cortex (dACC) and insula response to negative pictures compared with remit
242 art accounted for by the attenuated anterior insula response.
243           The enhancement of empathy-related insula responses by the neural prediction error signal w
244 in conductance, pupil dilation, and anterior insula responses to cued pain stimuli strictly followed
245 = -0.218; P < .001) (extending into anterior insula), right insula (SDM estimate = -0.174; P < .001)
246 mporal gyrus; increased grey matter in right insula, right putamen, left temporal pole, and bilateral
247  increases in activation in the putamen, mid-insula, Rolandic operculum, and precuneus to a cue signa
248 de a more network-level understanding of the insula's role in nicotine dependence and shows a relatio
249 hroughout the entire SN, indicating that the insula's role in smoking cue-reactivity is not functiona
250        Furthermore, these decreases in right insula/salience network connectivity correlated with bas
251             Results revealed decreased right insula/salience network functional connectivity under MD
252 001) (extending into anterior insula), right insula (SDM estimate = -0.174; P < .001) (extending vent
253  identified reduced GMV in the left anterior insula (SDM estimate = -0.232; P < .001) (extending into
254 was isolated to the right and left posterior insula seed regions.
255 cuits including within the salience network (insula seeds) and between temporal pole and elements of
256 in the amygdala-frontal, insula-frontal, and insula-sensorimotor circuits.
257  at the whole-brain level and in NAcc, LPFC, insula, sgACC, and mPFC.
258   At the same time, activity in the anterior insula showed an increase in coding the negative ESV of
259 In contrast, anterior lateral ventricles and insula showed an isotropic stretch pattern.
260          Post-mortem studies of the anterior insula showed that the reduced anterior insular volume m
261 rther, in smokers, this task-modulated right insula showed weaker functional connectivity with the su
262 ns (NAcc), lateral prefrontal cortex (LPFC), insula, subgenual anterior cingulate cortex (sgACC), and
263 dels proposing specific processing roles for insula subregions during homeostatic inference.
264 ex (dACC), left DLPFC, hippocampus, and left insula, suggested a stress adaptation response network.
265 implicated in addictive disorders, including insula, superior temporal gyrus, and anterior/mid-cingul
266 nalysis showed hypoactivity in the posterior insula, superior temporal, and Heschl's gyrus in PTSD.
267  generation surrounding the lateral fissure (insula, superior temporal, parietal, middle frontal), wh
268 nt in three brain areas (i.e., hypothalamus, insula/superior temporal gyrus, medial prefrontal cortex
269 on in the bilateral putamen, anterior-dorsal insula, supplementary motor area, and anterior cingulate
270 in processing network, particularly anterior insula, supporting the view that pain empathy partly rel
271 hat the serotonin1A binding potential of the insula (t = 2.41; P = .04), anterior cingulate (t = 2.27
272  reviewed 651 electrical stimulations of the insula that were performed in 221 patients, using stereo
273 ich often indicate activity in the "anterior insula" that may arise, in part, from claustrum and/or p
274 hoc analyses revealed that in the dorsal mid-insula the interaction was driven by group differences d
275 nferroni corrected), whereas in the anterior insula the interaction was driven by group differences d
276 areas (the P1 component) and in the anterior insula (the pP1 component) appear to compensate for this
277 eft anterior ventrolateral prefrontal cortex/insula, the dorsal midbrain, and the left ventromedial p
278 ft prefrontal cortex as well as the anterior insula, the right ventrolateral prefrontal cortex, the r
279 d connectivity of tracts projecting from the insula to ventral striatum and OFC.
280  in several brain regions, ranging from 11% (insula) to 14% (striatum).
281 l dissociation of pain processing within the insula together with previously observed alterations in
282 ction error responses in anterior insula and insula-vmPFC connectivity during self-esteem updates.
283                                     Enhanced insula-vmPFC connectivity during updating of those belie
284 d ASD patients, who had reduced right BG and insula volumes versus OCD patients.
285 onsistent with our hypothesis, the right mid-insula was maximally responsive during the peak period o
286 Es (minus PNEs) on brain activation in right insula was positively correlated with the effect of PSEs
287 that increased dynamic RSFC between MPFC and insula was related to higher levels of recent rumination
288         However, reduced activation in right insula was seen only in smokers and only when processing
289 closely coupled to functions of the anterior insula, we suspected laughter to be associated primarily
290 rbito-frontal, anterior cingulate and fronto-insula) were applied to 257 scans (two raters), and to a
291 an area of overlap in the bilateral anterior insula where decreased gray matter volume was associated
292  perfusion in the left frontal operculum and insula, whereas fear symptoms were associated with less
293 dipoles in both auditory cortex and anterior insula, whereas rsfMRI analyses showed reduced auditory-
294  control demand is estimated by the anterior insula, which in turn optimizes the prediction of forthc
295 , orbital frontal cortex, temporal pole, and insula, which were correlated with cognitive function.
296 01) abnormalities in bilateral basal ganglia/insula, which were decreased in GMV and function in pati
297 igher in the left inferior frontal gyrus and insula, while GMV was significantly lower in the bilater
298  integrity was lower in Recovered AN in most insula white matter tracts, as was whole-brain FA in par
299 buse specifically associated in the anterior insula with a downregulation of the kappa opioid recepto
300 ed by pretreatment connectivity of the right insula with the right middle temporal gyrus and the left

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