ライフサイエンスコーパス: insulator element

1 on this finding, we characterized the Fab-6 insulator element.

2 CCTC-binding factor CTCF bound to the c-myc insulator element.

3 erized silencing activity we measured in the insulator element.

4 he beta-globin locus, including the upstream insulator element.

5 rom chromosomal position effects by flanking insulator elements.

6 s when the transcription unit was flanked by insulator elements.

7 s of H3 acetylation are present over the HS4 insulator elements.

8 ancer blocking activity, a characteristic of insulator elements.

9 stem cells without the need for boundary or insulator elements.

10 The chicken beta-globin 5'HS4 insulator element acts as a barrier to the encroachment

11 Insulator elements affect gene expression by preventing

12 Chromatin boundaries or insulator elements affect the interaction between enhanc

13 cent SIX5 regulatory region extends into the insulator element and is converted into 21 nucleotide (n

14 repeats are a component of a CTCF-dependent insulator element and that repeat expansion results in c

15 hromatin interactions, both between the CTCF insulator elements and between the LCR distal enhancer a

16 kb flanked by CTCF-binding enhancer-blocking insulator elements and is regulated by cell-type-specifi

17 Insulator elements and matrix attachment regions are ess

18 We compare Fab-7 to the su(Hw) insulator element, and show that Fab-7 enhancer blocking

19 is report we show that both CTCF and the HS4 insulator element are incorporated in the matrix; HS4 in

20 Boundary or insulator elements are emerging as key players in the es

21 Because transgenes flanked by insulator elements are shielded from position effects in

22 The insulator element at the 5' end of the chicken beta-glob

23 al role for CTG/CAG repeats as components of insulator elements at multiple sites in the human genome

24 The CCCTC-binding factor, CTCF, binds to the insulator elements at the 5' and 3' boundaries of the lo

25 sites that flank the CTG repeat and form an insulator element between DMPK and SIX5.

26 promoter sequence to interact with and that insulator elements block further tracking of enhancers.

27 to restrict enhancer action is a feature of insulator elements, but unlike previously described insu

28 Insulator elements can act as barriers to the spread of

29 it for two copies of the chicken beta-globin insulator element, (Ch beta GI)(2), in mice.

30 h an internal cellular promoter and flanking insulator elements did not activate the LMO2 gene.

31 ologous Drosophila melanogaster scs and scs' insulator elements do not require chromosomal context to

32 ulatory element interactions with the MHC-II insulator elements, events that are required for maximal

33 Addition of the insulator element from 5'HS4 of the chicken beta-globin

34 Transcriptional "border," or "insulator," elements have been implicated in mediating t

35 ding sites, RNA polymerase II regulation and insulator elements; however, comprehensive annotation of

36 ons, quite different from those of the gypsy insulator element in Drosophila, may generate similar lo

37 uggest that the maternal ICR functions as an insulator element in regulating mutually exclusive expre

38 e functionally similar to chromatin boundary/insulator elements in metazoans that delimit functional

39 obal epigenetic alterations at enhancers and insulator elements in prostate and breast cancer cells u

40 ix attachment regions (MARs) can function as insulator elements in vivo.

41 ata indicate that human MARs can function as insulator elements in vivo.

42 irst example of chromatin domain boundary or insulator elements in yeast.

43 sv exhibits significant cobinding to class I insulator elements, indicating that it may also contribu

44 riginal LTR-GFP cassette with one flanked by insulator elements leading to a several fold reduction i

45 DNA methylation controls the activity of an insulator element located between the two linked genes b

46 te receptor region, which suggests that this insulator element may harbor a high concentration of his

47 This region harbors the c-myc insulator element (MINE), which contains at least two ph

48 A single insulator element partially blocks enhancer-activated tr

49 Insulator elements play a role in gene regulation that i

50 ay be due to the incorporation of Drosophila insulator elements (SCS and SCS') into the transgenic ve

51 titutive focus of hyperacetylation at the 5' insulator element separating the globin locus from the f

52 Boundary or insulator elements set up independent territories of gen

53 map to DNA elements that resemble classical insulator elements: short genomic regions sensitive to D

54 ing (SIN) lentiviral vectors with or without insulator elements should provide a safe and effective t

55 he integrated reporter gene is surrounded by insulator elements, stably transformed cell lines displa

56 er communication in Abdominal-B by bypassing insulator elements such as Frontabdominal-7 and Frontabd

57 d by the tandem arrangement (pairing) of the insulator elements, suggesting that interactions between

58 foamy virus long terminal repeats contain an insulator element that binds CCCTC-binding factor and re

59 We propose that the RO is a specialized insulator element that organizes the tandem array of rRN

60 sy retrotransposon of Drosophila contains an insulator element that represses enhancer-promoter inter

61 and the transcripts do not spread across the insulator elements that delineate the iab regions.

62 moters, but their activity is constrained by insulator elements that prevent indiscriminate activatio

63 found to be associated with transcriptional insulators, elements that are associated with the organi

64 or elements, but unlike previously described insulator elements the RO does not block enhancer action

65 rom chromosomal position effects by flanking insulator elements, the suppressor Hairy-wing protein bi

66 The Drosophila Abdominal-B locus uses insulator elements to organize its large regulatory regi

67 genome complexity necessitates boundary and insulator elements to partition genomic content into dis

68 grated multigene vectors by incorporation of insulator elements to prevent promoter interference seen

69 K562 cell line confirmed the ability of cHS4 insulator elements to protect DsRed and IHK-beta-globin

70 To accomplish this, the gypsy insulator element was used to block bidirectional action

71 We determined that the presence of insulator elements was not required for reporter gene ex

72 sites [su(Hw)BSs] are potent transcriptional insulator elements which can block enhancer action, as w

73 rmethylation susceptibility of enhancers and insulator elements, which in turn may contribute to an a